ID   PKHJ1_HUMAN             Reviewed;         149 AA.
AC   Q9NW61; B3KUQ9; D6W604;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   24-JAN-2024, entry version 164.
DE   RecName: Full=Pleckstrin homology domain-containing family J member 1;
DE            Short=PH domain-containing family J member 1;
DE   AltName: Full=Guanine nucleotide-releasing protein x;
GN   Name=PLEKHJ1; Synonyms=GNRPX;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Muscle;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   TISSUE SPECIFICITY.
RX   PubMed=11602354; DOI=10.1016/s0378-1119(01)00690-4;
RA   Dresser D.W., Jamin S.P., Atkins C.J., Guerrier D.;
RT   "An expressed GNRP-like gene shares a bi-directional promoter with SF3A2
RT   (SAP62) immediately upstream of AMH.";
RL   Gene 277:163-173(2001).
CC   -!- INTERACTION:
CC       Q9NW61; Q14657: LAGE3; NbExp=3; IntAct=EBI-1057560, EBI-1052105;
CC       Q9NW61; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-1057560, EBI-741158;
CC       Q9NW61; Q8N4B1-4: PHETA1; NbExp=3; IntAct=EBI-1057560, EBI-14131832;
CC       Q9NW61; Q6ICB4: PHETA2; NbExp=4; IntAct=EBI-1057560, EBI-11081747;
CC       Q9NW61; Q8WWB5: PIH1D2; NbExp=3; IntAct=EBI-1057560, EBI-10232538;
CC   -!- TISSUE SPECIFICITY: Expressed in testis and liver.
CC       {ECO:0000269|PubMed:11602354}.
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DR   EMBL; AK001159; BAA91525.1; -; mRNA.
DR   EMBL; AK097723; BAG53521.1; -; mRNA.
DR   EMBL; CR457253; CAG33534.1; -; mRNA.
DR   EMBL; CH471139; EAW69405.1; -; Genomic_DNA.
DR   EMBL; CH471139; EAW69406.1; -; Genomic_DNA.
DR   EMBL; BC003084; AAH03084.1; -; mRNA.
DR   EMBL; BC008966; AAH08966.1; -; mRNA.
DR   CCDS; CCDS12083.1; -.
DR   RefSeq; NP_060519.1; NM_018049.2.
DR   AlphaFoldDB; Q9NW61; -.
DR   SMR; Q9NW61; -.
DR   BioGRID; 120421; 31.
DR   IntAct; Q9NW61; 11.
DR   MINT; Q9NW61; -.
DR   STRING; 9606.ENSP00000464955; -.
DR   iPTMnet; Q9NW61; -.
DR   PhosphoSitePlus; Q9NW61; -.
DR   BioMuta; PLEKHJ1; -.
DR   DMDM; 74753007; -.
DR   EPD; Q9NW61; -.
DR   MassIVE; Q9NW61; -.
DR   MaxQB; Q9NW61; -.
DR   PaxDb; 9606-ENSP00000464955; -.
DR   PeptideAtlas; Q9NW61; -.
DR   ProteomicsDB; 82896; -.
DR   Pumba; Q9NW61; -.
DR   Antibodypedia; 22945; 145 antibodies from 25 providers.
DR   DNASU; 55111; -.
DR   Ensembl; ENST00000326631.7; ENSP00000318075.2; ENSG00000104886.12.
DR   Ensembl; ENST00000589097.6; ENSP00000465391.1; ENSG00000104886.12.
DR   GeneID; 55111; -.
DR   KEGG; hsa:55111; -.
DR   MANE-Select; ENST00000326631.7; ENSP00000318075.2; NM_018049.3; NP_060519.1.
DR   UCSC; uc002lvf.2; human.
DR   AGR; HGNC:18211; -.
DR   CTD; 55111; -.
DR   GeneCards; PLEKHJ1; -.
DR   HGNC; HGNC:18211; PLEKHJ1.
DR   HPA; ENSG00000104886; Low tissue specificity.
DR   MIM; 617834; gene.
DR   neXtProt; NX_Q9NW61; -.
DR   PharmGKB; PA134936152; -.
DR   VEuPathDB; HostDB:ENSG00000104886; -.
DR   eggNOG; KOG0017; Eukaryota.
DR   GeneTree; ENSGT00390000005235; -.
DR   HOGENOM; CLU_141382_0_0_1; -.
DR   InParanoid; Q9NW61; -.
DR   OMA; EEQCKEW; -.
DR   OrthoDB; 5312390at2759; -.
DR   PhylomeDB; Q9NW61; -.
DR   PathwayCommons; Q9NW61; -.
DR   SignaLink; Q9NW61; -.
DR   BioGRID-ORCS; 55111; 33 hits in 1154 CRISPR screens.
DR   ChiTaRS; PLEKHJ1; human.
DR   GenomeRNAi; 55111; -.
DR   Pharos; Q9NW61; Tdark.
DR   PRO; PR:Q9NW61; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q9NW61; Protein.
DR   Bgee; ENSG00000104886; Expressed in mucosa of transverse colon and 98 other cell types or tissues.
DR   ExpressionAtlas; Q9NW61; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IEA:GOC.
DR   GO; GO:0005769; C:early endosome; IBA:GO_Central.
DR   GO; GO:0055037; C:recycling endosome; IBA:GO_Central.
DR   GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR   GO; GO:0007032; P:endosome organization; IBA:GO_Central.
DR   GO; GO:0001881; P:receptor recycling; IBA:GO_Central.
DR   GO; GO:0042147; P:retrograde transport, endosome to Golgi; IBA:GO_Central.
DR   CDD; cd13258; PH_PLEKHJ1; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR045188; Boi1/Boi2-like.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR22902:SF9; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY J MEMBER 1; 1.
DR   PANTHER; PTHR22902; SESQUIPEDALIAN; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   Genevisible; Q9NW61; HS.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..149
FT                   /note="Pleckstrin homology domain-containing family J
FT                   member 1"
FT                   /id="PRO_0000309230"
FT   DOMAIN          15..108
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
SQ   SEQUENCE   149 AA;  17551 MW;  14FB8E77A88C4C7E CRC64;
     MRYNEKELQA LSRQPAEMAA ELGMRGPKKG SVLKRRLVKL VVNFLFYFRT DEAEPVGALL
     LERCRVVREE PGTFSISFIE DPERKYHFEC SSEEQCQEWM EALRRASYEF MRRSLIFYRN
     EIRKVTGKDP LEQFGISEEA RFQLSGLQA
//