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Q9NW61

- PKHJ1_HUMAN

UniProt

Q9NW61 - PKHJ1_HUMAN

Protein

Pleckstrin homology domain-containing family J member 1

Gene

PLEKHJ1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pleckstrin homology domain-containing family J member 1
    Short name:
    PH domain-containing family J member 1
    Alternative name(s):
    Guanine nucleotide-releasing protein x
    Gene namesi
    Name:PLEKHJ1
    Synonyms:GNRPX
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:18211. PLEKHJ1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134936152.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 149149Pleckstrin homology domain-containing family J member 1PRO_0000309230Add
    BLAST

    Proteomic databases

    MaxQBiQ9NW61.
    PaxDbiQ9NW61.
    PRIDEiQ9NW61.

    PTM databases

    PhosphoSiteiQ9NW61.

    Expressioni

    Tissue specificityi

    Expressed in testis and liver.1 Publication

    Gene expression databases

    BgeeiQ9NW61.
    CleanExiHS_PLEKHJ1.
    GenevestigatoriQ9NW61.

    Organism-specific databases

    HPAiHPA048989.

    Interactioni

    Protein-protein interaction databases

    BioGridi120421. 9 interactions.
    IntActiQ9NW61. 4 interactions.
    MINTiMINT-8247591.
    STRINGi9606.ENSP00000318075.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NW61.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini15 – 10894PHPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PH domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG70623.
    HOGENOMiHOG000039973.
    HOVERGENiHBG098015.
    InParanoidiQ9NW61.
    PhylomeDBiQ9NW61.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view]
    PfamiPF00169. PH. 1 hit.
    [Graphical view]
    SMARTiSM00233. PH. 1 hit.
    [Graphical view]
    PROSITEiPS50003. PH_DOMAIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NW61-1 [UniParc]FASTAAdd to Basket

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    MRYNEKELQA LSRQPAEMAA ELGMRGPKKG SVLKRRLVKL VVNFLFYFRT    50
    DEAEPVGALL LERCRVVREE PGTFSISFIE DPERKYHFEC SSEEQCQEWM 100
    EALRRASYEF MRRSLIFYRN EIRKVTGKDP LEQFGISEEA RFQLSGLQA 149
    Length:149
    Mass (Da):17,551
    Last modified:October 1, 2000 - v1
    Checksum:i14FB8E77A88C4C7E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001159 mRNA. Translation: BAA91525.1.
    AK097723 mRNA. Translation: BAG53521.1.
    CR457253 mRNA. Translation: CAG33534.1.
    CH471139 Genomic DNA. Translation: EAW69405.1.
    CH471139 Genomic DNA. Translation: EAW69406.1.
    BC003084 mRNA. Translation: AAH03084.1.
    BC008966 mRNA. Translation: AAH08966.1.
    CCDSiCCDS12083.1.
    RefSeqiNP_060519.1. NM_018049.1.
    UniGeneiHs.501353.

    Genome annotation databases

    EnsembliENST00000326631; ENSP00000318075; ENSG00000104886.
    ENST00000589097; ENSP00000465391; ENSG00000104886.
    GeneIDi55111.
    KEGGihsa:55111.
    UCSCiuc002lvf.1. human.

    Polymorphism databases

    DMDMi74753007.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001159 mRNA. Translation: BAA91525.1 .
    AK097723 mRNA. Translation: BAG53521.1 .
    CR457253 mRNA. Translation: CAG33534.1 .
    CH471139 Genomic DNA. Translation: EAW69405.1 .
    CH471139 Genomic DNA. Translation: EAW69406.1 .
    BC003084 mRNA. Translation: AAH03084.1 .
    BC008966 mRNA. Translation: AAH08966.1 .
    CCDSi CCDS12083.1.
    RefSeqi NP_060519.1. NM_018049.1.
    UniGenei Hs.501353.

    3D structure databases

    ProteinModelPortali Q9NW61.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120421. 9 interactions.
    IntActi Q9NW61. 4 interactions.
    MINTi MINT-8247591.
    STRINGi 9606.ENSP00000318075.

    PTM databases

    PhosphoSitei Q9NW61.

    Polymorphism databases

    DMDMi 74753007.

    Proteomic databases

    MaxQBi Q9NW61.
    PaxDbi Q9NW61.
    PRIDEi Q9NW61.

    Protocols and materials databases

    DNASUi 55111.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000326631 ; ENSP00000318075 ; ENSG00000104886 .
    ENST00000589097 ; ENSP00000465391 ; ENSG00000104886 .
    GeneIDi 55111.
    KEGGi hsa:55111.
    UCSCi uc002lvf.1. human.

    Organism-specific databases

    CTDi 55111.
    GeneCardsi GC19M002233.
    HGNCi HGNC:18211. PLEKHJ1.
    HPAi HPA048989.
    neXtProti NX_Q9NW61.
    PharmGKBi PA134936152.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG70623.
    HOGENOMi HOG000039973.
    HOVERGENi HBG098015.
    InParanoidi Q9NW61.
    PhylomeDBi Q9NW61.

    Miscellaneous databases

    ChiTaRSi PLEKHJ1. human.
    GenomeRNAii 55111.
    NextBioi 58732.
    PROi Q9NW61.

    Gene expression databases

    Bgeei Q9NW61.
    CleanExi HS_PLEKHJ1.
    Genevestigatori Q9NW61.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    [Graphical view ]
    Pfami PF00169. PH. 1 hit.
    [Graphical view ]
    SMARTi SM00233. PH. 1 hit.
    [Graphical view ]
    PROSITEi PS50003. PH_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Muscle.
    5. "An expressed GNRP-like gene shares a bi-directional promoter with SF3A2 (SAP62) immediately upstream of AMH."
      Dresser D.W., Jamin S.P., Atkins C.J., Guerrier D.
      Gene 277:163-173(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiPKHJ1_HUMAN
    AccessioniPrimary (citable) accession number: Q9NW61
    Secondary accession number(s): B3KUQ9, D6W604
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3