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Protein

Pleckstrin homology domain-containing family J member 1

Gene

PLEKHJ1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology domain-containing family J member 1
Short name:
PH domain-containing family J member 1
Alternative name(s):
Guanine nucleotide-releasing protein x
Gene namesi
Name:PLEKHJ1
Synonyms:GNRPX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:18211. PLEKHJ1.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134936152.

Polymorphism and mutation databases

BioMutaiPLEKHJ1.
DMDMi74753007.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003092301 – 149Pleckstrin homology domain-containing family J member 1Add BLAST149

Proteomic databases

EPDiQ9NW61.
MaxQBiQ9NW61.
PaxDbiQ9NW61.
PeptideAtlasiQ9NW61.
PRIDEiQ9NW61.

PTM databases

iPTMnetiQ9NW61.
PhosphoSitePlusiQ9NW61.

Expressioni

Tissue specificityi

Expressed in testis and liver.1 Publication

Gene expression databases

BgeeiENSG00000104886.
CleanExiHS_PLEKHJ1.
ExpressionAtlasiQ9NW61. baseline and differential.
GenevisibleiQ9NW61. HS.

Organism-specific databases

HPAiHPA048989.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LAGE3Q146574EBI-1057560,EBI-1052105

Protein-protein interaction databases

BioGridi120421. 30 interactors.
IntActiQ9NW61. 7 interactors.
MINTiMINT-8247591.
STRINGi9606.ENSP00000318075.

Structurei

3D structure databases

ProteinModelPortaliQ9NW61.
SMRiQ9NW61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 108PHPROSITE-ProRule annotationAdd BLAST94

Phylogenomic databases

eggNOGiENOG410IVQD. Eukaryota.
ENOG4111IQ7. LUCA.
GeneTreeiENSGT00390000005235.
HOGENOMiHOG000039973.
HOVERGENiHBG098015.
InParanoidiQ9NW61.
PhylomeDBiQ9NW61.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiView protein in InterPro
IPR011993. PH_dom-like.
IPR001849. PH_domain.
PfamiView protein in Pfam
PF00169. PH. 1 hit.
SMARTiView protein in SMART
SM00233. PH. 1 hit.
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiView protein in PROSITE
PS50003. PH_DOMAIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NW61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYNEKELQA LSRQPAEMAA ELGMRGPKKG SVLKRRLVKL VVNFLFYFRT
60 70 80 90 100
DEAEPVGALL LERCRVVREE PGTFSISFIE DPERKYHFEC SSEEQCQEWM
110 120 130 140
EALRRASYEF MRRSLIFYRN EIRKVTGKDP LEQFGISEEA RFQLSGLQA
Length:149
Mass (Da):17,551
Last modified:October 1, 2000 - v1
Checksum:i14FB8E77A88C4C7E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001159 mRNA. Translation: BAA91525.1.
AK097723 mRNA. Translation: BAG53521.1.
CR457253 mRNA. Translation: CAG33534.1.
CH471139 Genomic DNA. Translation: EAW69405.1.
CH471139 Genomic DNA. Translation: EAW69406.1.
BC003084 mRNA. Translation: AAH03084.1.
BC008966 mRNA. Translation: AAH08966.1.
CCDSiCCDS12083.1.
RefSeqiNP_060519.1. NM_018049.2.
UniGeneiHs.501353.
Hs.713641.

Genome annotation databases

EnsembliENST00000326631; ENSP00000318075; ENSG00000104886.
ENST00000589097; ENSP00000465391; ENSG00000104886.
GeneIDi55111.
KEGGihsa:55111.
UCSCiuc002lvf.2. human.

Similar proteinsi

Entry informationi

Entry nameiPKHJ1_HUMAN
AccessioniPrimary (citable) accession number: Q9NW61
Secondary accession number(s): B3KUQ9, D6W604
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 1, 2000
Last modified: August 30, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM