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Protein

Pleckstrin homology domain-containing family J member 1

Gene

PLEKHJ1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology domain-containing family J member 1
Short name:
PH domain-containing family J member 1
Alternative name(s):
Guanine nucleotide-releasing protein x
Gene namesi
Name:PLEKHJ1
Synonyms:GNRPX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000104886.9
HGNCiHGNC:18211 PLEKHJ1
MIMi617834 gene
neXtProtiNX_Q9NW61

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134936152

Polymorphism and mutation databases

BioMutaiPLEKHJ1
DMDMi74753007

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003092301 – 149Pleckstrin homology domain-containing family J member 1Add BLAST149

Proteomic databases

EPDiQ9NW61
MaxQBiQ9NW61
PaxDbiQ9NW61
PeptideAtlasiQ9NW61
PRIDEiQ9NW61
ProteomicsDBi82896

PTM databases

iPTMnetiQ9NW61
PhosphoSitePlusiQ9NW61

Expressioni

Tissue specificityi

Expressed in testis and liver.1 Publication

Gene expression databases

BgeeiENSG00000104886
CleanExiHS_PLEKHJ1
ExpressionAtlasiQ9NW61 baseline and differential
GenevisibleiQ9NW61 HS

Organism-specific databases

HPAiHPA048989

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LAGE3Q146574EBI-1057560,EBI-1052105

Protein-protein interaction databases

BioGridi120421, 30 interactors
IntActiQ9NW61, 8 interactors
MINTiQ9NW61
STRINGi9606.ENSP00000318075

Structurei

3D structure databases

ProteinModelPortaliQ9NW61
SMRiQ9NW61
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 108PHPROSITE-ProRule annotationAdd BLAST94

Phylogenomic databases

eggNOGiENOG410IVQD Eukaryota
ENOG4111IQ7 LUCA
GeneTreeiENSGT00390000005235
HOGENOMiHOG000039973
HOVERGENiHBG098015
InParanoidiQ9NW61
PhylomeDBiQ9NW61

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NW61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYNEKELQA LSRQPAEMAA ELGMRGPKKG SVLKRRLVKL VVNFLFYFRT
60 70 80 90 100
DEAEPVGALL LERCRVVREE PGTFSISFIE DPERKYHFEC SSEEQCQEWM
110 120 130 140
EALRRASYEF MRRSLIFYRN EIRKVTGKDP LEQFGISEEA RFQLSGLQA
Length:149
Mass (Da):17,551
Last modified:October 1, 2000 - v1
Checksum:i14FB8E77A88C4C7E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001159 mRNA Translation: BAA91525.1
AK097723 mRNA Translation: BAG53521.1
CR457253 mRNA Translation: CAG33534.1
CH471139 Genomic DNA Translation: EAW69405.1
CH471139 Genomic DNA Translation: EAW69406.1
BC003084 mRNA Translation: AAH03084.1
BC008966 mRNA Translation: AAH08966.1
CCDSiCCDS12083.1
RefSeqiNP_060519.1, NM_018049.2
UniGeneiHs.501353
Hs.713641

Genome annotation databases

EnsembliENST00000326631; ENSP00000318075; ENSG00000104886
ENST00000589097; ENSP00000465391; ENSG00000104886
GeneIDi55111
KEGGihsa:55111
UCSCiuc002lvf.2 human

Similar proteinsi

Entry informationi

Entry nameiPKHJ1_HUMAN
AccessioniPrimary (citable) accession number: Q9NW61
Secondary accession number(s): B3KUQ9, D6W604
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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