Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pleckstrin homology domain-containing family J member 1

Gene

PLEKHJ1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology domain-containing family J member 1
Short name:
PH domain-containing family J member 1
Alternative name(s):
Guanine nucleotide-releasing protein x
Gene namesi
Name:PLEKHJ1
Synonyms:GNRPX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:18211. PLEKHJ1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134936152.

Polymorphism and mutation databases

BioMutaiPLEKHJ1.
DMDMi74753007.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 149149Pleckstrin homology domain-containing family J member 1PRO_0000309230Add
BLAST

Proteomic databases

MaxQBiQ9NW61.
PaxDbiQ9NW61.
PRIDEiQ9NW61.

PTM databases

PhosphoSiteiQ9NW61.

Expressioni

Tissue specificityi

Expressed in testis and liver.1 Publication

Gene expression databases

BgeeiQ9NW61.
CleanExiHS_PLEKHJ1.
ExpressionAtlasiQ9NW61. baseline.
GenevisibleiQ9NW61. HS.

Organism-specific databases

HPAiHPA048989.

Interactioni

Protein-protein interaction databases

BioGridi120421. 7 interactions.
IntActiQ9NW61. 4 interactions.
MINTiMINT-8247591.

Structurei

3D structure databases

ProteinModelPortaliQ9NW61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 10894PHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG70623.
GeneTreeiENSGT00390000005235.
HOGENOMiHOG000039973.
HOVERGENiHBG098015.
InParanoidiQ9NW61.
PhylomeDBiQ9NW61.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH-like_dom.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NW61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYNEKELQA LSRQPAEMAA ELGMRGPKKG SVLKRRLVKL VVNFLFYFRT
60 70 80 90 100
DEAEPVGALL LERCRVVREE PGTFSISFIE DPERKYHFEC SSEEQCQEWM
110 120 130 140
EALRRASYEF MRRSLIFYRN EIRKVTGKDP LEQFGISEEA RFQLSGLQA
Length:149
Mass (Da):17,551
Last modified:October 1, 2000 - v1
Checksum:i14FB8E77A88C4C7E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001159 mRNA. Translation: BAA91525.1.
AK097723 mRNA. Translation: BAG53521.1.
CR457253 mRNA. Translation: CAG33534.1.
CH471139 Genomic DNA. Translation: EAW69405.1.
CH471139 Genomic DNA. Translation: EAW69406.1.
BC003084 mRNA. Translation: AAH03084.1.
BC008966 mRNA. Translation: AAH08966.1.
CCDSiCCDS12083.1.
RefSeqiNP_060519.1. NM_018049.1.
UniGeneiHs.501353.
Hs.713641.

Genome annotation databases

EnsembliENST00000326631; ENSP00000318075; ENSG00000104886.
ENST00000589097; ENSP00000465391; ENSG00000104886.
GeneIDi55111.
KEGGihsa:55111.
UCSCiuc002lvf.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001159 mRNA. Translation: BAA91525.1.
AK097723 mRNA. Translation: BAG53521.1.
CR457253 mRNA. Translation: CAG33534.1.
CH471139 Genomic DNA. Translation: EAW69405.1.
CH471139 Genomic DNA. Translation: EAW69406.1.
BC003084 mRNA. Translation: AAH03084.1.
BC008966 mRNA. Translation: AAH08966.1.
CCDSiCCDS12083.1.
RefSeqiNP_060519.1. NM_018049.1.
UniGeneiHs.501353.
Hs.713641.

3D structure databases

ProteinModelPortaliQ9NW61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120421. 7 interactions.
IntActiQ9NW61. 4 interactions.
MINTiMINT-8247591.

PTM databases

PhosphoSiteiQ9NW61.

Polymorphism and mutation databases

BioMutaiPLEKHJ1.
DMDMi74753007.

Proteomic databases

MaxQBiQ9NW61.
PaxDbiQ9NW61.
PRIDEiQ9NW61.

Protocols and materials databases

DNASUi55111.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326631; ENSP00000318075; ENSG00000104886.
ENST00000589097; ENSP00000465391; ENSG00000104886.
GeneIDi55111.
KEGGihsa:55111.
UCSCiuc002lvf.1. human.

Organism-specific databases

CTDi55111.
GeneCardsiGC19M002233.
HGNCiHGNC:18211. PLEKHJ1.
HPAiHPA048989.
neXtProtiNX_Q9NW61.
PharmGKBiPA134936152.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG70623.
GeneTreeiENSGT00390000005235.
HOGENOMiHOG000039973.
HOVERGENiHBG098015.
InParanoidiQ9NW61.
PhylomeDBiQ9NW61.

Miscellaneous databases

ChiTaRSiPLEKHJ1. human.
GenomeRNAii55111.
NextBioi58732.
PROiQ9NW61.

Gene expression databases

BgeeiQ9NW61.
CleanExiHS_PLEKHJ1.
ExpressionAtlasiQ9NW61. baseline.
GenevisibleiQ9NW61. HS.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH-like_dom.
IPR001849. PH_domain.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  5. "An expressed GNRP-like gene shares a bi-directional promoter with SF3A2 (SAP62) immediately upstream of AMH."
    Dresser D.W., Jamin S.P., Atkins C.J., Guerrier D.
    Gene 277:163-173(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiPKHJ1_HUMAN
AccessioniPrimary (citable) accession number: Q9NW61
Secondary accession number(s): B3KUQ9, D6W604
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 1, 2000
Last modified: July 22, 2015
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.