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Q9NW61

- PKHJ1_HUMAN

UniProt

Q9NW61 - PKHJ1_HUMAN

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Protein
Pleckstrin homology domain-containing family J member 1
Gene
PLEKHJ1, GNRPX
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Pleckstrin homology domain-containing family J member 1
Short name:
PH domain-containing family J member 1
Alternative name(s):
Guanine nucleotide-releasing protein x
Gene namesi
Name:PLEKHJ1
Synonyms:GNRPX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:18211. PLEKHJ1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134936152.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 149149Pleckstrin homology domain-containing family J member 1
PRO_0000309230Add
BLAST

Proteomic databases

MaxQBiQ9NW61.
PaxDbiQ9NW61.
PRIDEiQ9NW61.

PTM databases

PhosphoSiteiQ9NW61.

Expressioni

Tissue specificityi

Expressed in testis and liver.1 Publication

Gene expression databases

BgeeiQ9NW61.
CleanExiHS_PLEKHJ1.
GenevestigatoriQ9NW61.

Organism-specific databases

HPAiHPA048989.

Interactioni

Protein-protein interaction databases

BioGridi120421. 9 interactions.
IntActiQ9NW61. 4 interactions.
MINTiMINT-8247591.
STRINGi9606.ENSP00000318075.

Structurei

3D structure databases

ProteinModelPortaliQ9NW61.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 10894PH
Add
BLAST

Sequence similaritiesi

Contains 1 PH domain.

Phylogenomic databases

eggNOGiNOG70623.
HOGENOMiHOG000039973.
HOVERGENiHBG098015.
InParanoidiQ9NW61.
PhylomeDBiQ9NW61.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NW61-1 [UniParc]FASTAAdd to Basket

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MRYNEKELQA LSRQPAEMAA ELGMRGPKKG SVLKRRLVKL VVNFLFYFRT    50
DEAEPVGALL LERCRVVREE PGTFSISFIE DPERKYHFEC SSEEQCQEWM 100
EALRRASYEF MRRSLIFYRN EIRKVTGKDP LEQFGISEEA RFQLSGLQA 149
Length:149
Mass (Da):17,551
Last modified:October 1, 2000 - v1
Checksum:i14FB8E77A88C4C7E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK001159 mRNA. Translation: BAA91525.1.
AK097723 mRNA. Translation: BAG53521.1.
CR457253 mRNA. Translation: CAG33534.1.
CH471139 Genomic DNA. Translation: EAW69405.1.
CH471139 Genomic DNA. Translation: EAW69406.1.
BC003084 mRNA. Translation: AAH03084.1.
BC008966 mRNA. Translation: AAH08966.1.
CCDSiCCDS12083.1.
RefSeqiNP_060519.1. NM_018049.1.
UniGeneiHs.501353.

Genome annotation databases

EnsembliENST00000326631; ENSP00000318075; ENSG00000104886.
ENST00000589097; ENSP00000465391; ENSG00000104886.
GeneIDi55111.
KEGGihsa:55111.
UCSCiuc002lvf.1. human.

Polymorphism databases

DMDMi74753007.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK001159 mRNA. Translation: BAA91525.1 .
AK097723 mRNA. Translation: BAG53521.1 .
CR457253 mRNA. Translation: CAG33534.1 .
CH471139 Genomic DNA. Translation: EAW69405.1 .
CH471139 Genomic DNA. Translation: EAW69406.1 .
BC003084 mRNA. Translation: AAH03084.1 .
BC008966 mRNA. Translation: AAH08966.1 .
CCDSi CCDS12083.1.
RefSeqi NP_060519.1. NM_018049.1.
UniGenei Hs.501353.

3D structure databases

ProteinModelPortali Q9NW61.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120421. 9 interactions.
IntActi Q9NW61. 4 interactions.
MINTi MINT-8247591.
STRINGi 9606.ENSP00000318075.

PTM databases

PhosphoSitei Q9NW61.

Polymorphism databases

DMDMi 74753007.

Proteomic databases

MaxQBi Q9NW61.
PaxDbi Q9NW61.
PRIDEi Q9NW61.

Protocols and materials databases

DNASUi 55111.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000326631 ; ENSP00000318075 ; ENSG00000104886 .
ENST00000589097 ; ENSP00000465391 ; ENSG00000104886 .
GeneIDi 55111.
KEGGi hsa:55111.
UCSCi uc002lvf.1. human.

Organism-specific databases

CTDi 55111.
GeneCardsi GC19M002233.
HGNCi HGNC:18211. PLEKHJ1.
HPAi HPA048989.
neXtProti NX_Q9NW61.
PharmGKBi PA134936152.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG70623.
HOGENOMi HOG000039973.
HOVERGENi HBG098015.
InParanoidi Q9NW61.
PhylomeDBi Q9NW61.

Miscellaneous databases

ChiTaRSi PLEKHJ1. human.
GenomeRNAii 55111.
NextBioi 58732.
PROi Q9NW61.

Gene expression databases

Bgeei Q9NW61.
CleanExi HS_PLEKHJ1.
Genevestigatori Q9NW61.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view ]
Pfami PF00169. PH. 1 hit.
[Graphical view ]
SMARTi SM00233. PH. 1 hit.
[Graphical view ]
PROSITEi PS50003. PH_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  5. "An expressed GNRP-like gene shares a bi-directional promoter with SF3A2 (SAP62) immediately upstream of AMH."
    Dresser D.W., Jamin S.P., Atkins C.J., Guerrier D.
    Gene 277:163-173(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiPKHJ1_HUMAN
AccessioniPrimary (citable) accession number: Q9NW61
Secondary accession number(s): B3KUQ9, D6W604
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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