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Q9NW15

- ANO10_HUMAN

UniProt

Q9NW15 - ANO10_HUMAN

Protein

Anoctamin-10

Gene

ANO10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (29 May 2007)
      Previous versions | rss
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    Functioni

    Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1.2 Publications

    GO - Molecular functioni

    1. calcium activated cation channel activity Source: UniProt
    2. intracellular calcium activated chloride channel activity Source: UniProt

    GO - Biological processi

    1. cation transport Source: UniProt
    2. cell death Source: UniProtKB-KW
    3. chloride transmembrane transport Source: GOC
    4. chloride transport Source: UniProt
    5. ion transmembrane transport Source: Reactome
    6. transmembrane transport Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_160189. Stimuli-sensing channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Anoctamin-10
    Alternative name(s):
    Transmembrane protein 16K
    Gene namesi
    Name:ANO10
    Synonyms:TMEM16K
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:25519. ANO10.

    Subcellular locationi

    Cell membrane 3 Publications; Multi-pass membrane protein 3 Publications
    Note: Shows predominantly an intracellular localization with a weak expression in the cell membrane.

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. intracellular Source: UniProtKB
    3. membrane Source: UniProtKB
    4. plasma membrane Source: UniProt

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Spinocerebellar ataxia, autosomal recessive, 10 (SCAR10) [MIM:613728]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR10 is characterized by onset in the teenage or young adult years of gait and limb ataxia, dysarthria, and nystagmus associated with marked cerebellar atrophy on brain imaging.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti510 – 5101L → R in SCAR10. 1 Publication
    VAR_064888

    Keywords - Diseasei

    Disease mutation, Neurodegeneration

    Organism-specific databases

    MIMi613728. phenotype.
    Orphaneti284289. Adult-onset autosomal recessive cerebellar ataxia.
    PharmGKBiPA164715433.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 660660Anoctamin-10PRO_0000289957Add
    BLAST

    Proteomic databases

    MaxQBiQ9NW15.
    PaxDbiQ9NW15.
    PRIDEiQ9NW15.

    PTM databases

    PhosphoSiteiQ9NW15.

    Expressioni

    Tissue specificityi

    Highly expressed in the brain. Intermediate levels in the retina and heart and low levels in the placenta, liver, lung, duodenum, kidney, testis and spleen. In brain areas, highest expression in the frontal and occipital cortices and in the cerebellum. Lower expression in the fetal brain than in the adult brain.1 Publication

    Gene expression databases

    ArrayExpressiQ9NW15.
    BgeeiQ9NW15.
    CleanExiHS_ANO10.
    GenevestigatoriQ9NW15.

    Organism-specific databases

    HPAiHPA051569.

    Interactioni

    Protein-protein interaction databases

    BioGridi120435. 1 interaction.
    STRINGi9606.ENSP00000292246.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NW15.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 207207CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini229 – 24012ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini262 – 31655CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini338 – 35215ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini374 – 40027CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini422 – 50079ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini522 – 55332CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini575 – 59016ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini612 – 66049CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei208 – 22821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei241 – 26121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei317 – 33721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei353 – 37321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei401 – 42121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei501 – 52121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei554 – 57421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei591 – 61121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the anoctamin family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG300207.
    HOVERGENiHBG071385.
    OMAiWGTLLMK.
    OrthoDBiEOG7FNC6Q.
    PhylomeDBiQ9NW15.
    TreeFamiTF314265.

    Family and domain databases

    InterProiIPR007632. Anoctamin.
    [Graphical view]
    PANTHERiPTHR12308. PTHR12308. 1 hit.
    PfamiPF04547. Anoctamin. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NW15-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKVTLSALDT SESSFTPLVV IELAQDVKEE TKEWLKNRII AKKKDGGAQL    50
    LFRPLLNKYE QETLENQNLY LVGASKIRML LGAEAVGLVK ECNDNTMRAF 100
    TYRTRQNFKG FDDNNDDFLT MAECQFIIKH ELENLRAKDE KMIPGYPQAK 150
    LYPGKSLLRR LLTSGIVIQV FPLHDSEALK KLEDTWYTRF ALKYQPIDSI 200
    RGYFGETIAL YFGFLEYFTF ALIPMAVIGL PYYLFVWEDY DKYVIFASFN 250
    LIWSTVILEL WKRGCANMTY RWGTLLMKRK FEEPRPGFHG VLGINSITGK 300
    EEPLYPSYKR QLRIYLVSLP FVCLCLYFSL YVMMIYFDME VWALGLHENS 350
    GSEWTSVLLY VPSIIYAIVI EIMNRLYRYA AEFLTSWENH RLESAYQNHL 400
    ILKVLVFNFL NCFASLFYIA FVLKDMKLLR QSLATLLITS QILNQIMESF 450
    LPYWLQRKHG VRVKRKVQAL KADIDATLYE QVILEKEMGT YLGTFDDYLE 500
    LFLQFGYVSL FSCVYPLAAA FAVLNNFTEV NSDALKMCRV FKRPFSEPSA 550
    NIGVWQLAFE TMSVISVVTN CALIGMSPQV NAVFPESKAD LILIVVAVEH 600
    ALLALKFILA FAIPDKPRHI QMKLARLEFE SLEALKQQQM KLVTENLKEE 650
    PMESGKEKAT 660
    Length:660
    Mass (Da):76,329
    Last modified:May 29, 2007 - v2
    Checksum:i21582D364497ADFD
    GO
    Isoform 2 (identifier: Q9NW15-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         198-387: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:470
    Mass (Da):53,843
    Checksum:iE19D897F9DE194AE
    GO
    Isoform 3 (identifier: Q9NW15-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         47-112: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:594
    Mass (Da):68,748
    Checksum:iC9DEE8503AC34E78
    GO
    Isoform 4 (identifier: Q9NW15-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         47-158: GAQLLFRPLL...AKLYPGKSLL → V

    Note: No experimental confirmation available.

    Show »
    Length:549
    Mass (Da):63,526
    Checksum:i2BDE5BF63C2BD6E0
    GO
    Isoform 5 (identifier: Q9NW15-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         600-660: HALLALKFIL...PMESGKEKAT → AASCKLVSLPRYSWSTNSVPGTVIGPGV

    Note: No experimental confirmation available.Curated

    Show »
    Length:627
    Mass (Da):72,144
    Checksum:i3758F65009CEDDE7
    GO

    Sequence cautioni

    The sequence BAA91573.1 differs from that shown. Reason: Contaminating sequence.
    The sequence BC038855 differs from that shown. Reason: Frameshift at position 42.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Isoform 5 (identifier: Q9NW15-5)
    Sequence conflicti607 – 6071S → P in BAG60264. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti462 – 4621R → Q.1 Publication
    Corresponds to variant rs3772165 [ dbSNP | Ensembl ].
    VAR_032638
    Natural varianti510 – 5101L → R in SCAR10. 1 Publication
    VAR_064888
    Natural varianti561 – 5611T → M.1 Publication
    Corresponds to variant rs17409162 [ dbSNP | Ensembl ].
    VAR_032639
    Natural varianti583 – 5831V → A.1 Publication
    Corresponds to variant rs17853862 [ dbSNP | Ensembl ].
    VAR_032640

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei47 – 158112GAQLL…GKSLL → V in isoform 4. 1 PublicationVSP_038211Add
    BLAST
    Alternative sequencei47 – 11266Missing in isoform 3. 1 PublicationVSP_038212Add
    BLAST
    Alternative sequencei198 – 387190Missing in isoform 2. 1 PublicationVSP_026033Add
    BLAST
    Alternative sequencei600 – 66061HALLA…KEKAT → AASCKLVSLPRYSWSTNSVP GTVIGPGV in isoform 5. 1 PublicationVSP_045885Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001237 mRNA. Translation: BAA91573.1. Sequence problems.
    AK096302 mRNA. Translation: BAG53253.1.
    AK131223 mRNA. Translation: BAG54755.1.
    AK292368 mRNA. Translation: BAF85057.1.
    AK295969 mRNA. Translation: BAG58745.1.
    AK297949 mRNA. Translation: BAG60264.1.
    AC097638 Genomic DNA. No translation available.
    AC104184 Genomic DNA. No translation available.
    AC105903 Genomic DNA. No translation available.
    AC135852 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW64696.1.
    CH471055 Genomic DNA. Translation: EAW64697.1.
    BC038855 mRNA. No translation available.
    CCDSiCCDS2710.2. [Q9NW15-1]
    CCDS56247.1. [Q9NW15-4]
    CCDS56248.1. [Q9NW15-3]
    CCDS56249.1. [Q9NW15-2]
    CCDS56250.1. [Q9NW15-5]
    RefSeqiNP_001191760.1. NM_001204831.1. [Q9NW15-5]
    NP_001191761.1. NM_001204832.1. [Q9NW15-3]
    NP_001191762.1. NM_001204833.1. [Q9NW15-4]
    NP_001191763.1. NM_001204834.1. [Q9NW15-2]
    NP_060545.3. NM_018075.3. [Q9NW15-1]
    UniGeneiHs.656657.

    Genome annotation databases

    EnsembliENST00000292246; ENSP00000292246; ENSG00000160746. [Q9NW15-1]
    ENST00000350459; ENSP00000327767; ENSG00000160746. [Q9NW15-2]
    ENST00000396091; ENSP00000379398; ENSG00000160746. [Q9NW15-3]
    ENST00000414522; ENSP00000396990; ENSG00000160746. [Q9NW15-5]
    ENST00000451430; ENSP00000394119; ENSG00000160746. [Q9NW15-4]
    GeneIDi55129.
    KEGGihsa:55129.
    UCSCiuc003cmv.3. human. [Q9NW15-1]
    uc003cmw.3. human. [Q9NW15-3]
    uc010hil.3. human. [Q9NW15-2]
    uc011azt.2. human. [Q9NW15-4]

    Polymorphism databases

    DMDMi148887071.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001237 mRNA. Translation: BAA91573.1 . Sequence problems.
    AK096302 mRNA. Translation: BAG53253.1 .
    AK131223 mRNA. Translation: BAG54755.1 .
    AK292368 mRNA. Translation: BAF85057.1 .
    AK295969 mRNA. Translation: BAG58745.1 .
    AK297949 mRNA. Translation: BAG60264.1 .
    AC097638 Genomic DNA. No translation available.
    AC104184 Genomic DNA. No translation available.
    AC105903 Genomic DNA. No translation available.
    AC135852 Genomic DNA. No translation available.
    CH471055 Genomic DNA. Translation: EAW64696.1 .
    CH471055 Genomic DNA. Translation: EAW64697.1 .
    BC038855 mRNA. No translation available.
    CCDSi CCDS2710.2. [Q9NW15-1 ]
    CCDS56247.1. [Q9NW15-4 ]
    CCDS56248.1. [Q9NW15-3 ]
    CCDS56249.1. [Q9NW15-2 ]
    CCDS56250.1. [Q9NW15-5 ]
    RefSeqi NP_001191760.1. NM_001204831.1. [Q9NW15-5 ]
    NP_001191761.1. NM_001204832.1. [Q9NW15-3 ]
    NP_001191762.1. NM_001204833.1. [Q9NW15-4 ]
    NP_001191763.1. NM_001204834.1. [Q9NW15-2 ]
    NP_060545.3. NM_018075.3. [Q9NW15-1 ]
    UniGenei Hs.656657.

    3D structure databases

    ProteinModelPortali Q9NW15.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120435. 1 interaction.
    STRINGi 9606.ENSP00000292246.

    PTM databases

    PhosphoSitei Q9NW15.

    Polymorphism databases

    DMDMi 148887071.

    Proteomic databases

    MaxQBi Q9NW15.
    PaxDbi Q9NW15.
    PRIDEi Q9NW15.

    Protocols and materials databases

    DNASUi 55129.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000292246 ; ENSP00000292246 ; ENSG00000160746 . [Q9NW15-1 ]
    ENST00000350459 ; ENSP00000327767 ; ENSG00000160746 . [Q9NW15-2 ]
    ENST00000396091 ; ENSP00000379398 ; ENSG00000160746 . [Q9NW15-3 ]
    ENST00000414522 ; ENSP00000396990 ; ENSG00000160746 . [Q9NW15-5 ]
    ENST00000451430 ; ENSP00000394119 ; ENSG00000160746 . [Q9NW15-4 ]
    GeneIDi 55129.
    KEGGi hsa:55129.
    UCSCi uc003cmv.3. human. [Q9NW15-1 ]
    uc003cmw.3. human. [Q9NW15-3 ]
    uc010hil.3. human. [Q9NW15-2 ]
    uc011azt.2. human. [Q9NW15-4 ]

    Organism-specific databases

    CTDi 55129.
    GeneCardsi GC03M043396.
    HGNCi HGNC:25519. ANO10.
    HPAi HPA051569.
    MIMi 613726. gene.
    613728. phenotype.
    neXtProti NX_Q9NW15.
    Orphaneti 284289. Adult-onset autosomal recessive cerebellar ataxia.
    PharmGKBi PA164715433.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG300207.
    HOVERGENi HBG071385.
    OMAi WGTLLMK.
    OrthoDBi EOG7FNC6Q.
    PhylomeDBi Q9NW15.
    TreeFami TF314265.

    Enzyme and pathway databases

    Reactomei REACT_160189. Stimuli-sensing channels.

    Miscellaneous databases

    ChiTaRSi ANO10. human.
    GenomeRNAii 55129.
    NextBioi 58794.
    PROi Q9NW15.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NW15.
    Bgeei Q9NW15.
    CleanExi HS_ANO10.
    Genevestigatori Q9NW15.

    Family and domain databases

    InterProi IPR007632. Anoctamin.
    [Graphical view ]
    PANTHERi PTHR12308. PTHR12308. 1 hit.
    Pfami PF04547. Anoctamin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 4 AND 5), VARIANT GLN-462.
      Tissue: Substantia nigra, Teratocarcinoma, Testis and Urinary bladder.
    2. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS MET-561 AND ALA-583.
      Tissue: Leukocyte.
    5. Cited for: FUNCTION, SUBCELLULAR LOCATION.
    6. "Physiological roles and diseases of Tmem16/Anoctamin proteins: are they all chloride channels?"
      Duran C., Hartzell H.C.
      Acta Pharmacol. Sin. 32:685-692(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    7. Cited for: REVIEW.
    8. "ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins."
      Duran C., Qu Z., Osunkoya A.O., Cui Y., Hartzell H.C.
      Am. J. Physiol. 302:C482-C493(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    9. "The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age."
      Winpenny J.P., Gray M.A.
      Exp. Physiol. 97:175-176(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    10. "The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels."
      Scudieri P., Sondo E., Ferrera L., Galietta L.J.
      Exp. Physiol. 97:177-183(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW, ABSENCE OF CALCIUM-ACTIVATED CHLORIDE CHANNEL ACTIVITY.
    11. "Anoctamins are a family of Ca2+ activated Cl- channels."
      Tian Y., Schreiber R., Kunzelmann K.
      J. Cell Sci. 125:4991-4998(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    12. Cited for: VARIANT SCAR10 ARG-510, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiANO10_HUMAN
    AccessioniPrimary (citable) accession number: Q9NW15
    Secondary accession number(s): A8K8K3
    , A8MV74, B3KTZ1, B3KY93, B4DJ83, B4DNK2, B7WP12, C9JHS1, Q8IXX9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: May 29, 2007
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3