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Protein

Anoctamin-10

Gene

ANO10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1.2 Publications

GO - Molecular functioni

  • calcium activated cation channel activity Source: UniProtKB
  • intracellular calcium activated chloride channel activity Source: UniProtKB

GO - Biological processi

  • cation transport Source: UniProtKB
  • chloride transport Source: UniProtKB
  • ion transmembrane transport Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160746-MONOMER.
ReactomeiR-HSA-2672351. Stimuli-sensing channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Anoctamin-10
Alternative name(s):
Transmembrane protein 16K
Gene namesi
Name:ANO10
Synonyms:TMEM16K
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:25519. ANO10.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 207CytoplasmicSequence analysisAdd BLAST207
Transmembranei208 – 228HelicalSequence analysisAdd BLAST21
Topological domaini229 – 240ExtracellularSequence analysisAdd BLAST12
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Topological domaini262 – 316CytoplasmicSequence analysisAdd BLAST55
Transmembranei317 – 337HelicalSequence analysisAdd BLAST21
Topological domaini338 – 352ExtracellularSequence analysisAdd BLAST15
Transmembranei353 – 373HelicalSequence analysisAdd BLAST21
Topological domaini374 – 400CytoplasmicSequence analysisAdd BLAST27
Transmembranei401 – 421HelicalSequence analysisAdd BLAST21
Topological domaini422 – 500ExtracellularSequence analysisAdd BLAST79
Transmembranei501 – 521HelicalSequence analysisAdd BLAST21
Topological domaini522 – 553CytoplasmicSequence analysisAdd BLAST32
Transmembranei554 – 574HelicalSequence analysisAdd BLAST21
Topological domaini575 – 590ExtracellularSequence analysisAdd BLAST16
Transmembranei591 – 611HelicalSequence analysisAdd BLAST21
Topological domaini612 – 660CytoplasmicSequence analysisAdd BLAST49

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • intracellular Source: UniProtKB
  • membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Spinocerebellar ataxia, autosomal recessive, 10 (SCAR10)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionSpinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR10 is characterized by onset in the teenage or young adult years of gait and limb ataxia, dysarthria, and nystagmus associated with marked cerebellar atrophy on brain imaging.
See also OMIM:613728
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_064888510L → R in SCAR10. 1 PublicationCorresponds to variant rs387907089dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation, Neurodegeneration

Organism-specific databases

DisGeNETi55129.
MalaCardsiANO10.
MIMi613728. phenotype.
OpenTargetsiENSG00000160746.
Orphaneti284289. Adult-onset autosomal recessive cerebellar ataxia.
PharmGKBiPA164715433.

Polymorphism and mutation databases

BioMutaiANO10.
DMDMi148887071.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002899571 – 660Anoctamin-10Add BLAST660

Proteomic databases

EPDiQ9NW15.
MaxQBiQ9NW15.
PaxDbiQ9NW15.
PeptideAtlasiQ9NW15.
PRIDEiQ9NW15.

PTM databases

iPTMnetiQ9NW15.
PhosphoSitePlusiQ9NW15.

Expressioni

Tissue specificityi

Highly expressed in the brain. Intermediate levels in the retina and heart and low levels in the placenta, liver, lung, duodenum, kidney, testis and spleen. In brain areas, highest expression in the frontal and occipital cortices and in the cerebellum. Lower expression in the fetal brain than in the adult brain.1 Publication

Gene expression databases

BgeeiENSG00000160746.
CleanExiHS_ANO10.
ExpressionAtlasiQ9NW15. baseline and differential.
GenevisibleiQ9NW15. HS.

Organism-specific databases

HPAiHPA051569.

Interactioni

Protein-protein interaction databases

BioGridi120435. 3 interactors.
IntActiQ9NW15. 3 interactors.
STRINGi9606.ENSP00000292246.

Structurei

3D structure databases

ProteinModelPortaliQ9NW15.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the anoctamin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2513. Eukaryota.
ENOG410XPYE. LUCA.
GeneTreeiENSGT00760000119015.
HOGENOMiHOG000007605.
HOVERGENiHBG071385.
InParanoidiQ9NW15.
KOiK19327.
OMAiLENQNLY.
OrthoDBiEOG091G06A3.
PhylomeDBiQ9NW15.
TreeFamiTF314265.

Family and domain databases

InterProiIPR007632. Anoctamin.
IPR031291. Anoctamin-10.
[Graphical view]
PANTHERiPTHR12308. PTHR12308. 1 hit.
PTHR12308:SF40. PTHR12308:SF40. 1 hit.
PfamiPF04547. Anoctamin. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NW15-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKVTLSALDT SESSFTPLVV IELAQDVKEE TKEWLKNRII AKKKDGGAQL
60 70 80 90 100
LFRPLLNKYE QETLENQNLY LVGASKIRML LGAEAVGLVK ECNDNTMRAF
110 120 130 140 150
TYRTRQNFKG FDDNNDDFLT MAECQFIIKH ELENLRAKDE KMIPGYPQAK
160 170 180 190 200
LYPGKSLLRR LLTSGIVIQV FPLHDSEALK KLEDTWYTRF ALKYQPIDSI
210 220 230 240 250
RGYFGETIAL YFGFLEYFTF ALIPMAVIGL PYYLFVWEDY DKYVIFASFN
260 270 280 290 300
LIWSTVILEL WKRGCANMTY RWGTLLMKRK FEEPRPGFHG VLGINSITGK
310 320 330 340 350
EEPLYPSYKR QLRIYLVSLP FVCLCLYFSL YVMMIYFDME VWALGLHENS
360 370 380 390 400
GSEWTSVLLY VPSIIYAIVI EIMNRLYRYA AEFLTSWENH RLESAYQNHL
410 420 430 440 450
ILKVLVFNFL NCFASLFYIA FVLKDMKLLR QSLATLLITS QILNQIMESF
460 470 480 490 500
LPYWLQRKHG VRVKRKVQAL KADIDATLYE QVILEKEMGT YLGTFDDYLE
510 520 530 540 550
LFLQFGYVSL FSCVYPLAAA FAVLNNFTEV NSDALKMCRV FKRPFSEPSA
560 570 580 590 600
NIGVWQLAFE TMSVISVVTN CALIGMSPQV NAVFPESKAD LILIVVAVEH
610 620 630 640 650
ALLALKFILA FAIPDKPRHI QMKLARLEFE SLEALKQQQM KLVTENLKEE
660
PMESGKEKAT
Length:660
Mass (Da):76,329
Last modified:May 29, 2007 - v2
Checksum:i21582D364497ADFD
GO
Isoform 2 (identifier: Q9NW15-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     198-387: Missing.

Note: No experimental confirmation available.
Show »
Length:470
Mass (Da):53,843
Checksum:iE19D897F9DE194AE
GO
Isoform 3 (identifier: Q9NW15-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-112: Missing.

Note: No experimental confirmation available.
Show »
Length:594
Mass (Da):68,748
Checksum:iC9DEE8503AC34E78
GO
Isoform 4 (identifier: Q9NW15-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-158: GAQLLFRPLL...AKLYPGKSLL → V

Note: No experimental confirmation available.
Show »
Length:549
Mass (Da):63,526
Checksum:i2BDE5BF63C2BD6E0
GO
Isoform 5 (identifier: Q9NW15-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     600-660: HALLALKFIL...PMESGKEKAT → AASCKLVSLPRYSWSTNSVPGTVIGPGV

Note: No experimental confirmation available.Curated
Show »
Length:627
Mass (Da):72,144
Checksum:i3758F65009CEDDE7
GO

Sequence cautioni

The sequence BAA91573 differs from that shown. Contaminating sequence.Curated
The sequence BC038855 differs from that shown. Reason: Frameshift at position 42.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 5 (identifier: Q9NW15-5)
Sequence conflicti607S → P in BAG60264 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032638462R → Q.1 PublicationCorresponds to variant rs3772165dbSNPEnsembl.1
Natural variantiVAR_064888510L → R in SCAR10. 1 PublicationCorresponds to variant rs387907089dbSNPEnsembl.1
Natural variantiVAR_032639561T → M.1 PublicationCorresponds to variant rs17409162dbSNPEnsembl.1
Natural variantiVAR_032640583V → A.1 PublicationCorresponds to variant rs17853862dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03821147 – 158GAQLL…GKSLL → V in isoform 4. 1 PublicationAdd BLAST112
Alternative sequenceiVSP_03821247 – 112Missing in isoform 3. 1 PublicationAdd BLAST66
Alternative sequenceiVSP_026033198 – 387Missing in isoform 2. 1 PublicationAdd BLAST190
Alternative sequenceiVSP_045885600 – 660HALLA…KEKAT → AASCKLVSLPRYSWSTNSVP GTVIGPGV in isoform 5. 1 PublicationAdd BLAST61

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001237 mRNA. Translation: BAA91573.1. Sequence problems.
AK096302 mRNA. Translation: BAG53253.1.
AK131223 mRNA. Translation: BAG54755.1.
AK292368 mRNA. Translation: BAF85057.1.
AK295969 mRNA. Translation: BAG58745.1.
AK297949 mRNA. Translation: BAG60264.1.
AC097638 Genomic DNA. No translation available.
AC104184 Genomic DNA. No translation available.
AC105903 Genomic DNA. No translation available.
AC135852 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64696.1.
CH471055 Genomic DNA. Translation: EAW64697.1.
BC038855 mRNA. No translation available.
CCDSiCCDS2710.2. [Q9NW15-1]
CCDS56247.1. [Q9NW15-4]
CCDS56248.1. [Q9NW15-3]
CCDS56249.1. [Q9NW15-2]
CCDS56250.1. [Q9NW15-5]
RefSeqiNP_001191760.1. NM_001204831.1. [Q9NW15-5]
NP_001191761.1. NM_001204832.1. [Q9NW15-3]
NP_001191762.1. NM_001204833.1. [Q9NW15-4]
NP_001191763.1. NM_001204834.1. [Q9NW15-2]
NP_060545.3. NM_018075.3. [Q9NW15-1]
XP_016862210.1. XM_017006721.1. [Q9NW15-3]
XP_016862211.1. XM_017006722.1. [Q9NW15-3]
UniGeneiHs.656657.

Genome annotation databases

EnsembliENST00000292246; ENSP00000292246; ENSG00000160746. [Q9NW15-1]
ENST00000350459; ENSP00000327767; ENSG00000160746. [Q9NW15-2]
ENST00000396091; ENSP00000379398; ENSG00000160746. [Q9NW15-3]
ENST00000414522; ENSP00000396990; ENSG00000160746. [Q9NW15-5]
ENST00000451430; ENSP00000394119; ENSG00000160746. [Q9NW15-4]
GeneIDi55129.
KEGGihsa:55129.
UCSCiuc003cmv.4. human. [Q9NW15-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001237 mRNA. Translation: BAA91573.1. Sequence problems.
AK096302 mRNA. Translation: BAG53253.1.
AK131223 mRNA. Translation: BAG54755.1.
AK292368 mRNA. Translation: BAF85057.1.
AK295969 mRNA. Translation: BAG58745.1.
AK297949 mRNA. Translation: BAG60264.1.
AC097638 Genomic DNA. No translation available.
AC104184 Genomic DNA. No translation available.
AC105903 Genomic DNA. No translation available.
AC135852 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64696.1.
CH471055 Genomic DNA. Translation: EAW64697.1.
BC038855 mRNA. No translation available.
CCDSiCCDS2710.2. [Q9NW15-1]
CCDS56247.1. [Q9NW15-4]
CCDS56248.1. [Q9NW15-3]
CCDS56249.1. [Q9NW15-2]
CCDS56250.1. [Q9NW15-5]
RefSeqiNP_001191760.1. NM_001204831.1. [Q9NW15-5]
NP_001191761.1. NM_001204832.1. [Q9NW15-3]
NP_001191762.1. NM_001204833.1. [Q9NW15-4]
NP_001191763.1. NM_001204834.1. [Q9NW15-2]
NP_060545.3. NM_018075.3. [Q9NW15-1]
XP_016862210.1. XM_017006721.1. [Q9NW15-3]
XP_016862211.1. XM_017006722.1. [Q9NW15-3]
UniGeneiHs.656657.

3D structure databases

ProteinModelPortaliQ9NW15.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120435. 3 interactors.
IntActiQ9NW15. 3 interactors.
STRINGi9606.ENSP00000292246.

PTM databases

iPTMnetiQ9NW15.
PhosphoSitePlusiQ9NW15.

Polymorphism and mutation databases

BioMutaiANO10.
DMDMi148887071.

Proteomic databases

EPDiQ9NW15.
MaxQBiQ9NW15.
PaxDbiQ9NW15.
PeptideAtlasiQ9NW15.
PRIDEiQ9NW15.

Protocols and materials databases

DNASUi55129.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292246; ENSP00000292246; ENSG00000160746. [Q9NW15-1]
ENST00000350459; ENSP00000327767; ENSG00000160746. [Q9NW15-2]
ENST00000396091; ENSP00000379398; ENSG00000160746. [Q9NW15-3]
ENST00000414522; ENSP00000396990; ENSG00000160746. [Q9NW15-5]
ENST00000451430; ENSP00000394119; ENSG00000160746. [Q9NW15-4]
GeneIDi55129.
KEGGihsa:55129.
UCSCiuc003cmv.4. human. [Q9NW15-1]

Organism-specific databases

CTDi55129.
DisGeNETi55129.
GeneCardsiANO10.
HGNCiHGNC:25519. ANO10.
HPAiHPA051569.
MalaCardsiANO10.
MIMi613726. gene.
613728. phenotype.
neXtProtiNX_Q9NW15.
OpenTargetsiENSG00000160746.
Orphaneti284289. Adult-onset autosomal recessive cerebellar ataxia.
PharmGKBiPA164715433.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2513. Eukaryota.
ENOG410XPYE. LUCA.
GeneTreeiENSGT00760000119015.
HOGENOMiHOG000007605.
HOVERGENiHBG071385.
InParanoidiQ9NW15.
KOiK19327.
OMAiLENQNLY.
OrthoDBiEOG091G06A3.
PhylomeDBiQ9NW15.
TreeFamiTF314265.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160746-MONOMER.
ReactomeiR-HSA-2672351. Stimuli-sensing channels.

Miscellaneous databases

ChiTaRSiANO10. human.
GenomeRNAii55129.
PROiQ9NW15.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000160746.
CleanExiHS_ANO10.
ExpressionAtlasiQ9NW15. baseline and differential.
GenevisibleiQ9NW15. HS.

Family and domain databases

InterProiIPR007632. Anoctamin.
IPR031291. Anoctamin-10.
[Graphical view]
PANTHERiPTHR12308. PTHR12308. 1 hit.
PTHR12308:SF40. PTHR12308:SF40. 1 hit.
PfamiPF04547. Anoctamin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANO10_HUMAN
AccessioniPrimary (citable) accession number: Q9NW15
Secondary accession number(s): A8K8K3
, A8MV74, B3KTZ1, B3KY93, B4DJ83, B4DNK2, B7WP12, C9JHS1, Q8IXX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: November 2, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.