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Q9NW15

- ANO10_HUMAN

UniProt

Q9NW15 - ANO10_HUMAN

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Protein
Anoctamin-10
Gene
ANO10, TMEM16K
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1.2 Publications

GO - Molecular functioni

  1. calcium activated cation channel activity Source: UniProt
  2. intracellular calcium activated chloride channel activity Source: UniProt

GO - Biological processi

  1. cation transport Source: UniProt
  2. cell death Source: UniProtKB-KW
  3. chloride transmembrane transport Source: GOC
  4. chloride transport Source: UniProt
  5. ion transmembrane transport Source: Reactome
  6. transmembrane transport Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_160189. Stimuli-sensing channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Anoctamin-10
Alternative name(s):
Transmembrane protein 16K
Gene namesi
Name:ANO10
Synonyms:TMEM16K
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:25519. ANO10.

Subcellular locationi

Cell membrane; Multi-pass membrane protein
Note: Shows predominantly an intracellular localization with a weak expression in the cell membrane.3 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 207207Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei208 – 22821Helical; Reviewed prediction
Add
BLAST
Topological domaini229 – 24012Extracellular Reviewed prediction
Add
BLAST
Transmembranei241 – 26121Helical; Reviewed prediction
Add
BLAST
Topological domaini262 – 31655Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei317 – 33721Helical; Reviewed prediction
Add
BLAST
Topological domaini338 – 35215Extracellular Reviewed prediction
Add
BLAST
Transmembranei353 – 37321Helical; Reviewed prediction
Add
BLAST
Topological domaini374 – 40027Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei401 – 42121Helical; Reviewed prediction
Add
BLAST
Topological domaini422 – 50079Extracellular Reviewed prediction
Add
BLAST
Transmembranei501 – 52121Helical; Reviewed prediction
Add
BLAST
Topological domaini522 – 55332Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei554 – 57421Helical; Reviewed prediction
Add
BLAST
Topological domaini575 – 59016Extracellular Reviewed prediction
Add
BLAST
Transmembranei591 – 61121Helical; Reviewed prediction
Add
BLAST
Topological domaini612 – 66049Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. intracellular Source: UniProtKB
  3. plasma membrane Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Spinocerebellar ataxia, autosomal recessive, 10 (SCAR10) [MIM:613728]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR10 is characterized by onset in the teenage or young adult years of gait and limb ataxia, dysarthria, and nystagmus associated with marked cerebellar atrophy on brain imaging.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti510 – 5101L → R in SCAR10. 1 Publication
VAR_064888

Keywords - Diseasei

Disease mutation, Neurodegeneration

Organism-specific databases

MIMi613728. phenotype.
Orphaneti284289. Adult-onset autosomal recessive cerebellar ataxia.
PharmGKBiPA164715433.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 660660Anoctamin-10
PRO_0000289957Add
BLAST

Proteomic databases

MaxQBiQ9NW15.
PaxDbiQ9NW15.
PRIDEiQ9NW15.

PTM databases

PhosphoSiteiQ9NW15.

Expressioni

Tissue specificityi

Highly expressed in the brain. Intermediate levels in the retina and heart and low levels in the placenta, liver, lung, duodenum, kidney, testis and spleen. In brain areas, highest expression in the frontal and occipital cortices and in the cerebellum. Lower expression in the fetal brain than in the adult brain.1 Publication

Gene expression databases

ArrayExpressiQ9NW15.
BgeeiQ9NW15.
CleanExiHS_ANO10.
GenevestigatoriQ9NW15.

Organism-specific databases

HPAiHPA051569.

Interactioni

Protein-protein interaction databases

BioGridi120435. 1 interaction.
STRINGi9606.ENSP00000292246.

Structurei

3D structure databases

ProteinModelPortaliQ9NW15.

Family & Domainsi

Sequence similaritiesi

Belongs to the anoctamin family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG300207.
HOVERGENiHBG071385.
OMAiWGTLLMK.
OrthoDBiEOG7FNC6Q.
PhylomeDBiQ9NW15.
TreeFamiTF314265.

Family and domain databases

InterProiIPR007632. Anoctamin.
[Graphical view]
PANTHERiPTHR12308. PTHR12308. 1 hit.
PfamiPF04547. Anoctamin. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NW15-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKVTLSALDT SESSFTPLVV IELAQDVKEE TKEWLKNRII AKKKDGGAQL    50
LFRPLLNKYE QETLENQNLY LVGASKIRML LGAEAVGLVK ECNDNTMRAF 100
TYRTRQNFKG FDDNNDDFLT MAECQFIIKH ELENLRAKDE KMIPGYPQAK 150
LYPGKSLLRR LLTSGIVIQV FPLHDSEALK KLEDTWYTRF ALKYQPIDSI 200
RGYFGETIAL YFGFLEYFTF ALIPMAVIGL PYYLFVWEDY DKYVIFASFN 250
LIWSTVILEL WKRGCANMTY RWGTLLMKRK FEEPRPGFHG VLGINSITGK 300
EEPLYPSYKR QLRIYLVSLP FVCLCLYFSL YVMMIYFDME VWALGLHENS 350
GSEWTSVLLY VPSIIYAIVI EIMNRLYRYA AEFLTSWENH RLESAYQNHL 400
ILKVLVFNFL NCFASLFYIA FVLKDMKLLR QSLATLLITS QILNQIMESF 450
LPYWLQRKHG VRVKRKVQAL KADIDATLYE QVILEKEMGT YLGTFDDYLE 500
LFLQFGYVSL FSCVYPLAAA FAVLNNFTEV NSDALKMCRV FKRPFSEPSA 550
NIGVWQLAFE TMSVISVVTN CALIGMSPQV NAVFPESKAD LILIVVAVEH 600
ALLALKFILA FAIPDKPRHI QMKLARLEFE SLEALKQQQM KLVTENLKEE 650
PMESGKEKAT 660
Length:660
Mass (Da):76,329
Last modified:May 29, 2007 - v2
Checksum:i21582D364497ADFD
GO
Isoform 2 (identifier: Q9NW15-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     198-387: Missing.

Note: No experimental confirmation available.

Show »
Length:470
Mass (Da):53,843
Checksum:iE19D897F9DE194AE
GO
Isoform 3 (identifier: Q9NW15-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-112: Missing.

Note: No experimental confirmation available.

Show »
Length:594
Mass (Da):68,748
Checksum:iC9DEE8503AC34E78
GO
Isoform 4 (identifier: Q9NW15-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-158: GAQLLFRPLL...AKLYPGKSLL → V

Note: No experimental confirmation available.

Show »
Length:549
Mass (Da):63,526
Checksum:i2BDE5BF63C2BD6E0
GO
Isoform 5 (identifier: Q9NW15-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     600-660: HALLALKFIL...PMESGKEKAT → AASCKLVSLPRYSWSTNSVPGTVIGPGV

Note: No experimental confirmation available.

Show »
Length:627
Mass (Da):72,144
Checksum:i3758F65009CEDDE7
GO

Sequence cautioni

The sequence BAA91573.1 differs from that shown. Reason: Contaminating sequence.
The sequence BC038855 differs from that shown. Reason: Frameshift at position 42.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti462 – 4621R → Q.1 Publication
Corresponds to variant rs3772165 [ dbSNP | Ensembl ].
VAR_032638
Natural varianti510 – 5101L → R in SCAR10. 1 Publication
VAR_064888
Natural varianti561 – 5611T → M.1 Publication
Corresponds to variant rs17409162 [ dbSNP | Ensembl ].
VAR_032639
Natural varianti583 – 5831V → A.1 Publication
Corresponds to variant rs17853862 [ dbSNP | Ensembl ].
VAR_032640

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei47 – 158112GAQLL…GKSLL → V in isoform 4.
VSP_038211Add
BLAST
Alternative sequencei47 – 11266Missing in isoform 3.
VSP_038212Add
BLAST
Alternative sequencei198 – 387190Missing in isoform 2.
VSP_026033Add
BLAST
Alternative sequencei600 – 66061HALLA…KEKAT → AASCKLVSLPRYSWSTNSVP GTVIGPGV in isoform 5.
VSP_045885Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Isoform 5 (identifier: Q9NW15-5)
Sequence conflicti607 – 6071S → P in BAG60264. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK001237 mRNA. Translation: BAA91573.1. Sequence problems.
AK096302 mRNA. Translation: BAG53253.1.
AK131223 mRNA. Translation: BAG54755.1.
AK292368 mRNA. Translation: BAF85057.1.
AK295969 mRNA. Translation: BAG58745.1.
AK297949 mRNA. Translation: BAG60264.1.
AC097638 Genomic DNA. No translation available.
AC104184 Genomic DNA. No translation available.
AC105903 Genomic DNA. No translation available.
AC135852 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64696.1.
CH471055 Genomic DNA. Translation: EAW64697.1.
BC038855 mRNA. No translation available.
CCDSiCCDS2710.2. [Q9NW15-1]
CCDS56247.1. [Q9NW15-4]
CCDS56248.1. [Q9NW15-3]
CCDS56249.1. [Q9NW15-2]
CCDS56250.1. [Q9NW15-5]
RefSeqiNP_001191760.1. NM_001204831.1. [Q9NW15-5]
NP_001191761.1. NM_001204832.1. [Q9NW15-3]
NP_001191762.1. NM_001204833.1. [Q9NW15-4]
NP_001191763.1. NM_001204834.1. [Q9NW15-2]
NP_060545.3. NM_018075.3. [Q9NW15-1]
UniGeneiHs.656657.

Genome annotation databases

EnsembliENST00000292246; ENSP00000292246; ENSG00000160746. [Q9NW15-1]
ENST00000350459; ENSP00000327767; ENSG00000160746. [Q9NW15-2]
ENST00000396091; ENSP00000379398; ENSG00000160746. [Q9NW15-3]
ENST00000414522; ENSP00000396990; ENSG00000160746. [Q9NW15-5]
ENST00000451430; ENSP00000394119; ENSG00000160746. [Q9NW15-4]
GeneIDi55129.
KEGGihsa:55129.
UCSCiuc003cmv.3. human. [Q9NW15-1]
uc003cmw.3. human. [Q9NW15-3]
uc010hil.3. human. [Q9NW15-2]
uc011azt.2. human. [Q9NW15-4]

Polymorphism databases

DMDMi148887071.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK001237 mRNA. Translation: BAA91573.1 . Sequence problems.
AK096302 mRNA. Translation: BAG53253.1 .
AK131223 mRNA. Translation: BAG54755.1 .
AK292368 mRNA. Translation: BAF85057.1 .
AK295969 mRNA. Translation: BAG58745.1 .
AK297949 mRNA. Translation: BAG60264.1 .
AC097638 Genomic DNA. No translation available.
AC104184 Genomic DNA. No translation available.
AC105903 Genomic DNA. No translation available.
AC135852 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64696.1 .
CH471055 Genomic DNA. Translation: EAW64697.1 .
BC038855 mRNA. No translation available.
CCDSi CCDS2710.2. [Q9NW15-1 ]
CCDS56247.1. [Q9NW15-4 ]
CCDS56248.1. [Q9NW15-3 ]
CCDS56249.1. [Q9NW15-2 ]
CCDS56250.1. [Q9NW15-5 ]
RefSeqi NP_001191760.1. NM_001204831.1. [Q9NW15-5 ]
NP_001191761.1. NM_001204832.1. [Q9NW15-3 ]
NP_001191762.1. NM_001204833.1. [Q9NW15-4 ]
NP_001191763.1. NM_001204834.1. [Q9NW15-2 ]
NP_060545.3. NM_018075.3. [Q9NW15-1 ]
UniGenei Hs.656657.

3D structure databases

ProteinModelPortali Q9NW15.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120435. 1 interaction.
STRINGi 9606.ENSP00000292246.

PTM databases

PhosphoSitei Q9NW15.

Polymorphism databases

DMDMi 148887071.

Proteomic databases

MaxQBi Q9NW15.
PaxDbi Q9NW15.
PRIDEi Q9NW15.

Protocols and materials databases

DNASUi 55129.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000292246 ; ENSP00000292246 ; ENSG00000160746 . [Q9NW15-1 ]
ENST00000350459 ; ENSP00000327767 ; ENSG00000160746 . [Q9NW15-2 ]
ENST00000396091 ; ENSP00000379398 ; ENSG00000160746 . [Q9NW15-3 ]
ENST00000414522 ; ENSP00000396990 ; ENSG00000160746 . [Q9NW15-5 ]
ENST00000451430 ; ENSP00000394119 ; ENSG00000160746 . [Q9NW15-4 ]
GeneIDi 55129.
KEGGi hsa:55129.
UCSCi uc003cmv.3. human. [Q9NW15-1 ]
uc003cmw.3. human. [Q9NW15-3 ]
uc010hil.3. human. [Q9NW15-2 ]
uc011azt.2. human. [Q9NW15-4 ]

Organism-specific databases

CTDi 55129.
GeneCardsi GC03M043396.
HGNCi HGNC:25519. ANO10.
HPAi HPA051569.
MIMi 613726. gene.
613728. phenotype.
neXtProti NX_Q9NW15.
Orphaneti 284289. Adult-onset autosomal recessive cerebellar ataxia.
PharmGKBi PA164715433.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG300207.
HOVERGENi HBG071385.
OMAi WGTLLMK.
OrthoDBi EOG7FNC6Q.
PhylomeDBi Q9NW15.
TreeFami TF314265.

Enzyme and pathway databases

Reactomei REACT_160189. Stimuli-sensing channels.

Miscellaneous databases

ChiTaRSi ANO10. human.
GenomeRNAii 55129.
NextBioi 58794.
PROi Q9NW15.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NW15.
Bgeei Q9NW15.
CleanExi HS_ANO10.
Genevestigatori Q9NW15.

Family and domain databases

InterProi IPR007632. Anoctamin.
[Graphical view ]
PANTHERi PTHR12308. PTHR12308. 1 hit.
Pfami PF04547. Anoctamin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 4 AND 5), VARIANT GLN-462.
    Tissue: Substantia nigra, Teratocarcinoma, Testis and Urinary bladder.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS MET-561 AND ALA-583.
    Tissue: Leukocyte.
  5. Cited for: FUNCTION, SUBCELLULAR LOCATION.
  6. "Physiological roles and diseases of Tmem16/Anoctamin proteins: are they all chloride channels?"
    Duran C., Hartzell H.C.
    Acta Pharmacol. Sin. 32:685-692(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  7. Cited for: REVIEW.
  8. "ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins."
    Duran C., Qu Z., Osunkoya A.O., Cui Y., Hartzell H.C.
    Am. J. Physiol. 302:C482-C493(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  9. "The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age."
    Winpenny J.P., Gray M.A.
    Exp. Physiol. 97:175-176(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  10. "The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels."
    Scudieri P., Sondo E., Ferrera L., Galietta L.J.
    Exp. Physiol. 97:177-183(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW, ABSENCE OF CALCIUM-ACTIVATED CHLORIDE CHANNEL ACTIVITY.
  11. "Anoctamins are a family of Ca2+ activated Cl- channels."
    Tian Y., Schreiber R., Kunzelmann K.
    J. Cell Sci. 125:4991-4998(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  12. Cited for: VARIANT SCAR10 ARG-510, TISSUE SPECIFICITY.

Entry informationi

Entry nameiANO10_HUMAN
AccessioniPrimary (citable) accession number: Q9NW15
Secondary accession number(s): A8K8K3
, A8MV74, B3KTZ1, B3KY93, B4DJ83, B4DNK2, B7WP12, C9JHS1, Q8IXX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: September 3, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi