Q9NW15 (ANO10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anoctamin-10

Alternative name(s):
Transmembrane protein 16K

Gene names

Name:	ANO10
Synonyms:	TMEM16K

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	660 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1. Ref.5 Ref.11
Subcellular location	Cell membrane; Multi-pass membrane protein. Note: Shows predominantly an intracellular localization with a weak expression in the cell membrane. Ref.5 Ref.8 Ref.11
Tissue specificity	Highly expressed in the brain. Intermediate levels in the retina and heart and low levels in the placenta, liver, lung, duodenum, kidney, testis and spleen. In brain areas, highest expression in the frontal and occipital cortices and in the cerebellum. Lower expression in the fetal brain than in the adult brain. Ref.12
Involvement in disease	Spinocerebellar ataxia, autosomal recessive, 10 (SCAR10) [MIM:613728]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR10 is characterized by onset in the teenage or young adult years of gait and limb ataxia, dysarthria, and nystagmus associated with marked cerebellar atrophy on brain imaging. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.12
Miscellaneous	The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.
Sequence similarities	Belongs to the anoctamin family.
Sequence caution	The sequence BAA91573.1 differs from that shown. Reason: Contaminating sequence. The sequence BC038855 differs from that shown. Reason: Frameshift at position 42.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation Neurodegeneration
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell death Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW intracellular Inferred from direct assay Ref.8. Source: UniProtKB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NW15-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NW15-2)

The sequence of this isoform differs from the canonical sequence as follows:
     198-387: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9NW15-3)

The sequence of this isoform differs from the canonical sequence as follows:
     47-112: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q9NW15-4)

The sequence of this isoform differs from the canonical sequence as follows:
     47-158: GAQLLFRPLL...AKLYPGKSLL → V

Note: No experimental confirmation available.

Isoform 5 (identifier: Q9NW15-5)

The sequence of this isoform differs from the canonical sequence as follows:
     600-660: HALLALKFIL...PMESGKEKAT → AASCKLVSLPRYSWSTNSVPGTVIGPGV

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 660	660	Anoctamin-10		PRO_0000289957
Regions
	Topological domain	1 – 207	207	Cytoplasmic Potential
	Transmembrane	208 – 228	21	Helical; Potential
	Topological domain	229 – 240	12	Extracellular Potential
	Transmembrane	241 – 261	21	Helical; Potential
	Topological domain	262 – 316	55	Cytoplasmic Potential
	Transmembrane	317 – 337	21	Helical; Potential
	Topological domain	338 – 352	15	Extracellular Potential
	Transmembrane	353 – 373	21	Helical; Potential
	Topological domain	374 – 400	27	Cytoplasmic Potential
	Transmembrane	401 – 421	21	Helical; Potential
	Topological domain	422 – 500	79	Extracellular Potential
	Transmembrane	501 – 521	21	Helical; Potential
	Topological domain	522 – 553	32	Cytoplasmic Potential
	Transmembrane	554 – 574	21	Helical; Potential
	Topological domain	575 – 590	16	Extracellular Potential
	Transmembrane	591 – 611	21	Helical; Potential
	Topological domain	612 – 660	49	Cytoplasmic Potential
Natural variations
	Alternative sequence	47 – 158	112	GAQLL…GKSLL → V in isoform 4.		VSP_038211
	Alternative sequence	47 – 112	66	Missing in isoform 3.		VSP_038212
	Alternative sequence	198 – 387	190	Missing in isoform 2.		VSP_026033
	Alternative sequence	600 – 660	61	HALLA…KEKAT → AASCKLVSLPRYSWSTNSVP GTVIGPGV in isoform 5.		VSP_045885
	Natural variant	462	1	R → Q. Ref.1 Corresponds to variant rs3772165 [ dbSNP | Ensembl ].		VAR_032638
	Natural variant	510	1	L → R in SCAR10. Ref.12		VAR_064888
	Natural variant	561	1	T → M. Ref.4 Corresponds to variant rs17409162 [ dbSNP | Ensembl ].		VAR_032639
	Natural variant	583	1	V → A. Ref.4 Corresponds to variant rs17853862 [ dbSNP | Ensembl ].		VAR_032640
Experimental info
Isoform 5:
	Sequence conflict	607	1	S → P in BAG60264. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 29, 2007. Version 2. Checksum: 21582D364497ADFD	FASTA	660	76,329
	10 20 30 40 50 60 MKVTLSALDT SESSFTPLVV IELAQDVKEE TKEWLKNRII AKKKDGGAQL LFRPLLNKYE 70 80 90 100 110 120 QETLENQNLY LVGASKIRML LGAEAVGLVK ECNDNTMRAF TYRTRQNFKG FDDNNDDFLT 130 140 150 160 170 180 MAECQFIIKH ELENLRAKDE KMIPGYPQAK LYPGKSLLRR LLTSGIVIQV FPLHDSEALK 190 200 210 220 230 240 KLEDTWYTRF ALKYQPIDSI RGYFGETIAL YFGFLEYFTF ALIPMAVIGL PYYLFVWEDY 250 260 270 280 290 300 DKYVIFASFN LIWSTVILEL WKRGCANMTY RWGTLLMKRK FEEPRPGFHG VLGINSITGK 310 320 330 340 350 360 EEPLYPSYKR QLRIYLVSLP FVCLCLYFSL YVMMIYFDME VWALGLHENS GSEWTSVLLY 370 380 390 400 410 420 VPSIIYAIVI EIMNRLYRYA AEFLTSWENH RLESAYQNHL ILKVLVFNFL NCFASLFYIA 430 440 450 460 470 480 FVLKDMKLLR QSLATLLITS QILNQIMESF LPYWLQRKHG VRVKRKVQAL KADIDATLYE 490 500 510 520 530 540 QVILEKEMGT YLGTFDDYLE LFLQFGYVSL FSCVYPLAAA FAVLNNFTEV NSDALKMCRV 550 560 570 580 590 600 FKRPFSEPSA NIGVWQLAFE TMSVISVVTN CALIGMSPQV NAVFPESKAD LILIVVAVEH 610 620 630 640 650 660 ALLALKFILA FAIPDKPRHI QMKLARLEFE SLEALKQQQM KLVTENLKEE PMESGKEKAT
	Isoform 2 [UniParc]. Checksum: E19D897F9DE194AE	FASTA	470	53,843
	10 20 30 40 50 60 MKVTLSALDT SESSFTPLVV IELAQDVKEE TKEWLKNRII AKKKDGGAQL LFRPLLNKYE 70 80 90 100 110 120 QETLENQNLY LVGASKIRML LGAEAVGLVK ECNDNTMRAF TYRTRQNFKG FDDNNDDFLT 130 140 150 160 170 180 MAECQFIIKH ELENLRAKDE KMIPGYPQAK LYPGKSLLRR LLTSGIVIQV FPLHDSEALK 190 200 210 220 230 240 KLEDTWYTRF ALKYQPIENH RLESAYQNHL ILKVLVFNFL NCFASLFYIA FVLKDMKLLR 250 260 270 280 290 300 QSLATLLITS QILNQIMESF LPYWLQRKHG VRVKRKVQAL KADIDATLYE QVILEKEMGT 310 320 330 340 350 360 YLGTFDDYLE LFLQFGYVSL FSCVYPLAAA FAVLNNFTEV NSDALKMCRV FKRPFSEPSA 370 380 390 400 410 420 NIGVWQLAFE TMSVISVVTN CALIGMSPQV NAVFPESKAD LILIVVAVEH ALLALKFILA 430 440 450 460 470 FAIPDKPRHI QMKLARLEFE SLEALKQQQM KLVTENLKEE PMESGKEKAT
	Isoform 3 [UniParc]. Checksum: C9DEE8503AC34E78	FASTA	594	68,748
	10 20 30 40 50 60 MKVTLSALDT SESSFTPLVV IELAQDVKEE TKEWLKNRII AKKKDGDNND DFLTMAECQF 70 80 90 100 110 120 IIKHELENLR AKDEKMIPGY PQAKLYPGKS LLRRLLTSGI VIQVFPLHDS EALKKLEDTW 130 140 150 160 170 180 YTRFALKYQP IDSIRGYFGE TIALYFGFLE YFTFALIPMA VIGLPYYLFV WEDYDKYVIF 190 200 210 220 230 240 ASFNLIWSTV ILELWKRGCA NMTYRWGTLL MKRKFEEPRP GFHGVLGINS ITGKEEPLYP 250 260 270 280 290 300 SYKRQLRIYL VSLPFVCLCL YFSLYVMMIY FDMEVWALGL HENSGSEWTS VLLYVPSIIY 310 320 330 340 350 360 AIVIEIMNRL YRYAAEFLTS WENHRLESAY QNHLILKVLV FNFLNCFASL FYIAFVLKDM 370 380 390 400 410 420 KLLRQSLATL LITSQILNQI MESFLPYWLQ RKHGVRVKRK VQALKADIDA TLYEQVILEK 430 440 450 460 470 480 EMGTYLGTFD DYLELFLQFG YVSLFSCVYP LAAAFAVLNN FTEVNSDALK MCRVFKRPFS 490 500 510 520 530 540 EPSANIGVWQ LAFETMSVIS VVTNCALIGM SPQVNAVFPE SKADLILIVV AVEHALLALK 550 560 570 580 590 FILAFAIPDK PRHIQMKLAR LEFESLEALK QQQMKLVTEN LKEEPMESGK EKAT
	Isoform 4 [UniParc]. Checksum: 2BDE5BF63C2BD6E0	FASTA	549	63,526
	10 20 30 40 50 60 MKVTLSALDT SESSFTPLVV IELAQDVKEE TKEWLKNRII AKKKDGVRRL LTSGIVIQVF 70 80 90 100 110 120 PLHDSEALKK LEDTWYTRFA LKYQPIDSIR GYFGETIALY FGFLEYFTFA LIPMAVIGLP 130 140 150 160 170 180 YYLFVWEDYD KYVIFASFNL IWSTVILELW KRGCANMTYR WGTLLMKRKF EEPRPGFHGV 190 200 210 220 230 240 LGINSITGKE EPLYPSYKRQ LRIYLVSLPF VCLCLYFSLY VMMIYFDMEV WALGLHENSG 250 260 270 280 290 300 SEWTSVLLYV PSIIYAIVIE IMNRLYRYAA EFLTSWENHR LESAYQNHLI LKVLVFNFLN 310 320 330 340 350 360 CFASLFYIAF VLKDMKLLRQ SLATLLITSQ ILNQIMESFL PYWLQRKHGV RVKRKVQALK 370 380 390 400 410 420 ADIDATLYEQ VILEKEMGTY LGTFDDYLEL FLQFGYVSLF SCVYPLAAAF AVLNNFTEVN 430 440 450 460 470 480 SDALKMCRVF KRPFSEPSAN IGVWQLAFET MSVISVVTNC ALIGMSPQVN AVFPESKADL 490 500 510 520 530 540 ILIVVAVEHA LLALKFILAF AIPDKPRHIQ MKLARLEFES LEALKQQQMK LVTENLKEEP MESGKEKAT
	Isoform 5 [UniParc]. Checksum: 3758F65009CEDDE7	FASTA	627	72,144
	10 20 30 40 50 60 MKVTLSALDT SESSFTPLVV IELAQDVKEE TKEWLKNRII AKKKDGGAQL LFRPLLNKYE 70 80 90 100 110 120 QETLENQNLY LVGASKIRML LGAEAVGLVK ECNDNTMRAF TYRTRQNFKG FDDNNDDFLT 130 140 150 160 170 180 MAECQFIIKH ELENLRAKDE KMIPGYPQAK LYPGKSLLRR LLTSGIVIQV FPLHDSEALK 190 200 210 220 230 240 KLEDTWYTRF ALKYQPIDSI RGYFGETIAL YFGFLEYFTF ALIPMAVIGL PYYLFVWEDY 250 260 270 280 290 300 DKYVIFASFN LIWSTVILEL WKRGCANMTY RWGTLLMKRK FEEPRPGFHG VLGINSITGK 310 320 330 340 350 360 EEPLYPSYKR QLRIYLVSLP FVCLCLYFSL YVMMIYFDME VWALGLHENS GSEWTSVLLY 370 380 390 400 410 420 VPSIIYAIVI EIMNRLYRYA AEFLTSWENH RLESAYQNHL ILKVLVFNFL NCFASLFYIA 430 440 450 460 470 480 FVLKDMKLLR QSLATLLITS QILNQIMESF LPYWLQRKHG VRVKRKVQAL KADIDATLYE 490 500 510 520 530 540 QVILEKEMGT YLGTFDDYLE LFLQFGYVSL FSCVYPLAAA FAVLNNFTEV NSDALKMCRV 550 560 570 580 590 600 FKRPFSEPSA NIGVWQLAFE TMSVISVVTN CALIGMSPQV NAVFPESKAD LILIVVAVEA 610 620 ASCKLVSLPR YSWSTNSVPG TVIGPGV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3; 4 AND 5), VARIANT GLN-462. Tissue: Substantia nigra, Teratocarcinoma, Testis and Urinary bladder.
[2]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS MET-561 AND ALA-583. Tissue: Leukocyte.
[5]	"Expression and function of epithelial anoctamins." Schreiber R., Uliyakina I., Kongsuphol P., Warth R., Mirza M., Martins J.R., Kunzelmann K. J. Biol. Chem. 285:7838-7845(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[6]	"Physiological roles and diseases of Tmem16/Anoctamin proteins: are they all chloride channels?" Duran C., Hartzell H.C. Acta Pharmacol. Sin. 32:685-692(2011) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[7]	"Anoctamins." Kunzelmann K., Tian Y., Martins J.R., Faria D., Kongsuphol P., Ousingsawat J., Thevenod F., Roussa E., Rock J., Schreiber R. Pflugers Arch. 462:195-208(2011) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[8]	"ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins." Duran C., Qu Z., Osunkoya A.O., Cui Y., Hartzell H.C. Am. J. Physiol. 302:C482-C493(2012) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[9]	"The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age." Winpenny J.P., Gray M.A. Exp. Physiol. 97:175-176(2012) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[10]	"The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels." Scudieri P., Sondo E., Ferrera L., Galietta L.J. Exp. Physiol. 97:177-183(2012) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW, ABSENCE OF CALCIUM-ACTIVATED CHLORIDE CHANNEL ACTIVITY.
[11]	"Anoctamins are a family of Ca2+ activated Cl- channels." Tian Y., Schreiber R., Kunzelmann K. J. Cell Sci. 125:4991-4998(2012) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[12]	"Targeted next-generation sequencing of a 12.5 Mb homozygous region reveals ANO10 mutations in patients with autosomal-recessive cerebellar ataxia." Vermeer S., Hoischen A., Meijer R.P., Gilissen C., Neveling K., Wieskamp N., de Brouwer A., Koenig M., Anheim M., Assoum M., Drouot N., Todorovic S., Milic-Rasic V., Lochmuller H., Stevanin G., Goizet C., David A., Durr A. , Brice A., Kremer B., van de Warrenburg B.P., Schijvenaars M.M., Heister A., Kwint M., Arts P., van der Wijst J., Veltman J., Kamsteeg E.J., Scheffer H., Knoers N. Am. J. Hum. Genet. 87:813-819(2010) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT SCAR10 ARG-510, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK001237 mRNA. Translation: BAA91573.1. Sequence problems. AK096302 mRNA. Translation: BAG53253.1. AK131223 mRNA. Translation: BAG54755.1. AK292368 mRNA. Translation: BAF85057.1. AK295969 mRNA. Translation: BAG58745.1. AK297949 mRNA. Translation: BAG60264.1. AC097638 Genomic DNA. No translation available. AC104184 Genomic DNA. No translation available. AC105903 Genomic DNA. No translation available. AC135852 Genomic DNA. No translation available. CH471055 Genomic DNA. Translation: EAW64696.1. CH471055 Genomic DNA. Translation: EAW64697.1. BC038855 mRNA. No translation available.
IPI	IPI00794169. IPI00797182. IPI00902435. IPI00908702. IPI00925510.
RefSeq	NP_001191760.1. NM_001204831.1. NP_001191761.1. NM_001204832.1. NP_001191762.1. NM_001204833.1. NP_001191763.1. NM_001204834.1. NP_060545.3. NM_018075.3.
UniGene	Hs.656657.
3D structure databases
ProteinModelPortal	Q9NW15.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000292246.
PTM databases
PhosphoSite	Q9NW15.
Polymorphism databases
DMDM	148887071.
Proteomic databases
PaxDb	Q9NW15.
PRIDE	Q9NW15.
Protocols and materials databases
DNASU	55129.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000292246; ENSP00000292246; ENSG00000160746. ENST00000350459; ENSP00000327767; ENSG00000160746. ENST00000396091; ENSP00000379398; ENSG00000160746. ENST00000414522; ENSP00000396990; ENSG00000160746. ENST00000451430; ENSP00000394119; ENSG00000160746.
GeneID	55129.
KEGG	hsa:55129.
UCSC	uc003cmv.3. human. uc003cmw.3. human. uc010hil.3. human. uc011azt.2. human.
Organism-specific databases
CTD	55129.
GeneCards	GC03M043396.
HGNC	HGNC:25519. ANO10.
HPA	HPA051569.
MIM	613726. gene. 613728. phenotype.
neXtProt	NX_Q9NW15.
Orphanet	284289. Adult-onset autosomal recessive cerebellar ataxia.
PharmGKB	PA164715433.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG300207.
HOVERGEN	HBG071385.
OMA	FLPYWLQ.
OrthoDB	EOG42RD6W.
PhylomeDB	Q9NW15.
Gene expression databases
ArrayExpress	Q9NW15.
Bgee	Q9NW15.
CleanEx	HS_ANO10.
Genevestigator	Q9NW15.
Family and domain databases
InterPro	IPR007632. Anoctamin. [Graphical view]
PANTHER	PTHR12308. PTHR12308. 1 hit.
Pfam	PF04547. Anoctamin. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ANO10. human.
GenomeRNAi	55129.
NextBio	58794.
SOURCE	Search...

Entry information

Entry name

ANO10_HUMAN

Accession

Primary (citable) accession number: Q9NW15
Secondary accession number(s): A8K8K3 , A8MV74, B3KTZ1, B3KY93, B4DJ83, B4DNK2, B7WP12, C9JHS1, Q8IXX9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	May 29, 2007
Last modified:	May 1, 2013
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.