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Protein

RNA-binding protein 28

Gene

RBM28

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Nucleolar component of the spliceosomal ribonucleoprotein complexes.1 Publication

GO - Molecular functioni

  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 28
Alternative name(s):
RNA-binding motif protein 28
Gene namesi
Name:RBM28
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21863. RBM28.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Involvement in diseasei

Alopecia, neurologic defects, and endocrinopathy syndrome (ANES)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAffected individuals have hair loss of variable severity, ranging from complete alopecia to near-normal scalp hair with absence of body hair. All have moderate to severe mental retardation, progressive motor deterioration and central hypogonadotropic hypogonadism with delayed or absent puberty and central adrenal insufficiency. Additional features included short stature, microcephaly, gynecomastia, pigmentary anomalies, hypodontia, kyphoscoliosis, ulnar deviation of the hands, and loss of subcutaneous fat.

See also OMIM:612079
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti351 – 3511L → P in ANES. 1 Publication
VAR_045655

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

MIMi612079. phenotype.
Orphaneti157954. ANE syndrome.
PharmGKBiPA134867266.

Polymorphism and mutation databases

BioMutaiRBM28.
DMDMi55976611.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 759758RNA-binding protein 28PRO_0000081785Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei122 – 1221Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9NW13.
PaxDbiQ9NW13.
PeptideAtlasiQ9NW13.
PRIDEiQ9NW13.

2D gel databases

SWISS-2DPAGEQ9NW13.

PTM databases

PhosphoSiteiQ9NW13.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiQ9NW13.
CleanExiHS_RBM28.
ExpressionAtlasiQ9NW13. baseline and differential.
GenevestigatoriQ9NW13.

Organism-specific databases

HPAiHPA019058.
HPA026672.
HPA031519.

Interactioni

Subunit structurei

Interacts with U1, U2, U4, U5, and U6 spliceosomal small nuclear RNAs (snRNAs).1 Publication

Protein-protein interaction databases

BioGridi120437. 39 interactions.
IntActiQ9NW13. 7 interactions.
MINTiMINT-3051761.
STRINGi9606.ENSP00000223073.

Structurei

3D structure databases

ProteinModelPortaliQ9NW13.
SMRiQ9NW13. Positions 3-189, 327-424, 487-579.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 8077RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini114 – 19178RRM 2PROSITE-ProRule annotationAdd
BLAST
Domaini335 – 41985RRM 3PROSITE-ProRule annotationAdd
BLAST
Domaini487 – 597111RRM 4PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi224 – 25835Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Contains 4 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0724.
GeneTreeiENSGT00550000074976.
HOGENOMiHOG000124666.
HOVERGENiHBG073213.
InParanoidiQ9NW13.
KOiK14573.
OMAiDFKTEMD.
OrthoDBiEOG70ZZMT.
PhylomeDBiQ9NW13.
TreeFamiTF312798.

Family and domain databases

Gene3Di3.30.70.330. 4 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
SMARTiSM00360. RRM. 4 hits.
[Graphical view]
PROSITEiPS50102. RRM. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NW13-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGLTLFVGR LPPSARSEQL EELFSQVGPV KQCFVVTEKG SKACRGFGYV
60 70 80 90 100
TFSMLEDVQR ALKEITTFEG CKINVTVAKK KLRNKTKEKG KNENSECPKK
110 120 130 140 150
EPKAKKAKVA DKKARLIIRN LSFKCSEDDL KTVFAQFGAV LEVNIPRKPD
160 170 180 190 200
GKMRGFGFVQ FKNLLEAGKA LKGMNMKEIK GRTVAVDWAV AKDKYKDTQS
210 220 230 240 250
VSAIGEEKSH ESKHQESVKK KGREEEDMEE EENDDDDDDD DEEDGVFDDE
260 270 280 290 300
DEEEENIESK VTKPVQIQKR AVKRPAPAKS SDHSEEDSDL EESDSIDDGE
310 320 330 340 350
ELAQSDTSTE EQEDKAVQVS NKKKRKLPSD VNEGKTVFIR NLSFDSEEEE
360 370 380 390 400
LGELLQQFGE LKYVRIVLHP DTEHSKGCAF AQFMTQEAAQ KCLLAASPEN
410 420 430 440 450
EAGGLKLDGR QLKVDLAVTR DEAAKLQTTK VKKPTGTRNL YLAREGLIRA
460 470 480 490 500
GTKAAEGVSA ADMAKRERFE LLKHQKLKDQ NIFVSRTRLC LHNLPKAVDD
510 520 530 540 550
KQLRKLLLSA TSGEKGVRIK ECRVMRDLKG VHGNMKGQSL GYAFAEFQEH
560 570 580 590 600
EHALKALRLI NNNPEIFGPL KRPIVEFSLE DRRKLKMKEL RIQRSLQKMR
610 620 630 640 650
SKPATGEPQK GQPEPAKDQQ QKAAQHHTEE QSKVPPEQKR KAGSTSWTGF
660 670 680 690 700
QTKAEVEQVE LPDGKKRRKV LALPSHRGPK IRLRDKGKVK PVHPKKPKPQ
710 720 730 740 750
INQWKQEKQQ LSSEQVSRKK AKGNKTETRF NQLVEQYKQK LLGPSKGAPL

AKRSKWFDS
Length:759
Mass (Da):85,738
Last modified:January 23, 2007 - v3
Checksum:iB477EDB9561D6771
GO
Isoform 2 (identifier: Q9NW13-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-179: Missing.

Note: No experimental confirmation available.

Show »
Length:618
Mass (Da):69,923
Checksum:i324AB7A8031B9838
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 211E → G in BAD96436 (Ref. 2) Curated
Sequence conflicti361 – 3611L → P in BAG62214 (PubMed:14702039).Curated
Sequence conflicti668 – 6681R → K in BAG62214 (PubMed:14702039).Curated
Sequence conflicti739 – 7391Q → R in BAA91575 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti253 – 2531E → Q.
Corresponds to variant rs11554671 [ dbSNP | Ensembl ].
VAR_045654
Natural varianti351 – 3511L → P in ANES. 1 Publication
VAR_045655

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei39 – 179141Missing in isoform 2. 1 PublicationVSP_046111Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001239 mRNA. Translation: BAA91575.1.
AK300500 mRNA. Translation: BAG62214.1.
AK222716 mRNA. Translation: BAD96436.1.
AC010655 Genomic DNA. No translation available.
AC018635 Genomic DNA. No translation available.
CH236947 Genomic DNA. Translation: EAL24314.1.
CH471070 Genomic DNA. Translation: EAW83643.1.
BC013889 mRNA. Translation: AAH13889.1.
CCDSiCCDS55159.1. [Q9NW13-2]
CCDS5801.1. [Q9NW13-1]
RefSeqiNP_001159607.1. NM_001166135.1. [Q9NW13-2]
NP_060547.2. NM_018077.2. [Q9NW13-1]
UniGeneiHs.274263.

Genome annotation databases

EnsembliENST00000223073; ENSP00000223073; ENSG00000106344. [Q9NW13-1]
ENST00000415472; ENSP00000390517; ENSG00000106344. [Q9NW13-2]
GeneIDi55131.
KEGGihsa:55131.
UCSCiuc003vmp.2. human. [Q9NW13-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001239 mRNA. Translation: BAA91575.1.
AK300500 mRNA. Translation: BAG62214.1.
AK222716 mRNA. Translation: BAD96436.1.
AC010655 Genomic DNA. No translation available.
AC018635 Genomic DNA. No translation available.
CH236947 Genomic DNA. Translation: EAL24314.1.
CH471070 Genomic DNA. Translation: EAW83643.1.
BC013889 mRNA. Translation: AAH13889.1.
CCDSiCCDS55159.1. [Q9NW13-2]
CCDS5801.1. [Q9NW13-1]
RefSeqiNP_001159607.1. NM_001166135.1. [Q9NW13-2]
NP_060547.2. NM_018077.2. [Q9NW13-1]
UniGeneiHs.274263.

3D structure databases

ProteinModelPortaliQ9NW13.
SMRiQ9NW13. Positions 3-189, 327-424, 487-579.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120437. 39 interactions.
IntActiQ9NW13. 7 interactions.
MINTiMINT-3051761.
STRINGi9606.ENSP00000223073.

PTM databases

PhosphoSiteiQ9NW13.

Polymorphism and mutation databases

BioMutaiRBM28.
DMDMi55976611.

2D gel databases

SWISS-2DPAGEQ9NW13.

Proteomic databases

MaxQBiQ9NW13.
PaxDbiQ9NW13.
PeptideAtlasiQ9NW13.
PRIDEiQ9NW13.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000223073; ENSP00000223073; ENSG00000106344. [Q9NW13-1]
ENST00000415472; ENSP00000390517; ENSG00000106344. [Q9NW13-2]
GeneIDi55131.
KEGGihsa:55131.
UCSCiuc003vmp.2. human. [Q9NW13-1]

Organism-specific databases

CTDi55131.
GeneCardsiGC07M127939.
HGNCiHGNC:21863. RBM28.
HPAiHPA019058.
HPA026672.
HPA031519.
MIMi612074. gene.
612079. phenotype.
neXtProtiNX_Q9NW13.
Orphaneti157954. ANE syndrome.
PharmGKBiPA134867266.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0724.
GeneTreeiENSGT00550000074976.
HOGENOMiHOG000124666.
HOVERGENiHBG073213.
InParanoidiQ9NW13.
KOiK14573.
OMAiDFKTEMD.
OrthoDBiEOG70ZZMT.
PhylomeDBiQ9NW13.
TreeFamiTF312798.

Miscellaneous databases

ChiTaRSiRBM28. human.
GeneWikiiRBM28.
GenomeRNAii55131.
NextBioi58802.
PROiQ9NW13.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NW13.
CleanExiHS_RBM28.
ExpressionAtlasiQ9NW13. baseline and differential.
GenevestigatoriQ9NW13.

Family and domain databases

Gene3Di3.30.70.330. 4 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
SMARTiSM00360. RRM. 4 hits.
[Graphical view]
PROSITEiPS50102. RRM. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Prostate and Teratocarcinoma.
  2. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon.
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Skin.
  7. Bienvenut W.V.
    Submitted (OCT-2004) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-10; 155-162; 183-192; 197-208; 454-465; 506-515; 559-571 AND 730-738, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Cervix carcinoma.
  8. "Human RBM28 protein is a specific nucleolar component of the spliceosomal snRNPs."
    Damianov A., Kann M., Lane W.S., Bindereif A.
    Biol. Chem. 387:1455-1460(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 17-31; 326-335; 477-486 AND 601-610, FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION IN A COMPLEX WITH SPLICEOSOMAL SNRNAS U1; U2; U4; U5 AND U6.
  9. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-122, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Alopecia, neurological defects, and endocrinopathy syndrome caused by decreased expression of RBM28, a nucleolar protein associated with ribosome biogenesis."
    Nousbeck J., Spiegel R., Ishida-Yamamoto A., Indelman M., Shani-Adir A., Adir N., Lipkin E., Bercovici S., Geiger D., van Steensel M.A., Steijlen P.M., Bergman R., Bindereif A., Choder M., Shalev S., Sprecher E.
    Am. J. Hum. Genet. 82:1114-1121(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ANES PRO-351, TISSUE SPECIFICITY.

Entry informationi

Entry nameiRBM28_HUMAN
AccessioniPrimary (citable) accession number: Q9NW13
Secondary accession number(s): A4D100
, B4DU52, E9PDD9, Q53H65, Q96CV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: January 23, 2007
Last modified: May 27, 2015
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.