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Q9NW13

- RBM28_HUMAN

UniProt

Q9NW13 - RBM28_HUMAN

Protein

RNA-binding protein 28

Gene

RBM28

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Nucleolar component of the spliceosomal ribonucleoprotein complexes.1 Publication

    GO - Molecular functioni

    1. nucleotide binding Source: InterPro
    2. poly(A) RNA binding Source: UniProtKB

    GO - Biological processi

    1. mRNA processing Source: UniProtKB-KW
    2. RNA splicing Source: UniProtKB-KW

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA-binding protein 28
    Alternative name(s):
    RNA-binding motif protein 28
    Gene namesi
    Name:RBM28
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:21863. RBM28.

    Subcellular locationi

    Nucleusnucleolus 3 Publications

    GO - Cellular componenti

    1. nucleolus Source: HPA
    2. spliceosomal complex Source: UniProtKB-KW

    Keywords - Cellular componenti

    Nucleus, Spliceosome

    Pathology & Biotechi

    Involvement in diseasei

    Alopecia, neurologic defects, and endocrinopathy syndrome (ANES) [MIM:612079]: Affected individuals have hair loss of variable severity, ranging from complete alopecia to near-normal scalp hair with absence of body hair. All have moderate to severe mental retardation, progressive motor deterioration and central hypogonadotropic hypogonadism with delayed or absent puberty and central adrenal insufficiency. Additional features included short stature, microcephaly, gynecomastia, pigmentary anomalies, hypodontia, kyphoscoliosis, ulnar deviation of the hands, and loss of subcutaneous fat.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti351 – 3511L → P in ANES. 1 Publication
    VAR_045655

    Keywords - Diseasei

    Disease mutation, Mental retardation

    Organism-specific databases

    MIMi612079. phenotype.
    Orphaneti157954. ANE syndrome.
    PharmGKBiPA134867266.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 759758RNA-binding protein 28PRO_0000081785Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei122 – 1221Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9NW13.
    PaxDbiQ9NW13.
    PeptideAtlasiQ9NW13.
    PRIDEiQ9NW13.

    2D gel databases

    SWISS-2DPAGEQ9NW13.

    PTM databases

    PhosphoSiteiQ9NW13.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed.1 Publication

    Gene expression databases

    ArrayExpressiQ9NW13.
    BgeeiQ9NW13.
    CleanExiHS_RBM28.
    GenevestigatoriQ9NW13.

    Organism-specific databases

    HPAiHPA019058.
    HPA026672.
    HPA031519.

    Interactioni

    Subunit structurei

    Interacts with U1, U2, U4, U5, and U6 spliceosomal small nuclear RNAs (snRNAs).1 Publication

    Protein-protein interaction databases

    BioGridi120437. 23 interactions.
    IntActiQ9NW13. 5 interactions.
    MINTiMINT-3051761.
    STRINGi9606.ENSP00000223073.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NW13.
    SMRiQ9NW13. Positions 3-189, 327-424.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 8077RRM 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini114 – 19178RRM 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini335 – 41985RRM 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini487 – 597111RRM 4PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi224 – 25835Asp/Glu-rich (acidic)Add
    BLAST

    Sequence similaritiesi

    Contains 4 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0724.
    HOGENOMiHOG000124666.
    HOVERGENiHBG073213.
    InParanoidiQ9NW13.
    KOiK14573.
    OMAiPWSIKEP.
    OrthoDBiEOG70ZZMT.
    PhylomeDBiQ9NW13.
    TreeFamiTF312798.

    Family and domain databases

    Gene3Di3.30.70.330. 4 hits.
    InterProiIPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view]
    PfamiPF00076. RRM_1. 3 hits.
    [Graphical view]
    SMARTiSM00360. RRM. 4 hits.
    [Graphical view]
    PROSITEiPS50102. RRM. 4 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NW13-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGLTLFVGR LPPSARSEQL EELFSQVGPV KQCFVVTEKG SKACRGFGYV    50
    TFSMLEDVQR ALKEITTFEG CKINVTVAKK KLRNKTKEKG KNENSECPKK 100
    EPKAKKAKVA DKKARLIIRN LSFKCSEDDL KTVFAQFGAV LEVNIPRKPD 150
    GKMRGFGFVQ FKNLLEAGKA LKGMNMKEIK GRTVAVDWAV AKDKYKDTQS 200
    VSAIGEEKSH ESKHQESVKK KGREEEDMEE EENDDDDDDD DEEDGVFDDE 250
    DEEEENIESK VTKPVQIQKR AVKRPAPAKS SDHSEEDSDL EESDSIDDGE 300
    ELAQSDTSTE EQEDKAVQVS NKKKRKLPSD VNEGKTVFIR NLSFDSEEEE 350
    LGELLQQFGE LKYVRIVLHP DTEHSKGCAF AQFMTQEAAQ KCLLAASPEN 400
    EAGGLKLDGR QLKVDLAVTR DEAAKLQTTK VKKPTGTRNL YLAREGLIRA 450
    GTKAAEGVSA ADMAKRERFE LLKHQKLKDQ NIFVSRTRLC LHNLPKAVDD 500
    KQLRKLLLSA TSGEKGVRIK ECRVMRDLKG VHGNMKGQSL GYAFAEFQEH 550
    EHALKALRLI NNNPEIFGPL KRPIVEFSLE DRRKLKMKEL RIQRSLQKMR 600
    SKPATGEPQK GQPEPAKDQQ QKAAQHHTEE QSKVPPEQKR KAGSTSWTGF 650
    QTKAEVEQVE LPDGKKRRKV LALPSHRGPK IRLRDKGKVK PVHPKKPKPQ 700
    INQWKQEKQQ LSSEQVSRKK AKGNKTETRF NQLVEQYKQK LLGPSKGAPL 750
    AKRSKWFDS 759
    Length:759
    Mass (Da):85,738
    Last modified:January 23, 2007 - v3
    Checksum:iB477EDB9561D6771
    GO
    Isoform 2 (identifier: Q9NW13-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         39-179: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:618
    Mass (Da):69,923
    Checksum:i324AB7A8031B9838
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti21 – 211E → G in BAD96436. 1 PublicationCurated
    Sequence conflicti361 – 3611L → P in BAG62214. (PubMed:14702039)Curated
    Sequence conflicti668 – 6681R → K in BAG62214. (PubMed:14702039)Curated
    Sequence conflicti739 – 7391Q → R in BAA91575. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti253 – 2531E → Q.
    Corresponds to variant rs11554671 [ dbSNP | Ensembl ].
    VAR_045654
    Natural varianti351 – 3511L → P in ANES. 1 Publication
    VAR_045655

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei39 – 179141Missing in isoform 2. 1 PublicationVSP_046111Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001239 mRNA. Translation: BAA91575.1.
    AK300500 mRNA. Translation: BAG62214.1.
    AK222716 mRNA. Translation: BAD96436.1.
    AC010655 Genomic DNA. No translation available.
    AC018635 Genomic DNA. No translation available.
    CH236947 Genomic DNA. Translation: EAL24314.1.
    CH471070 Genomic DNA. Translation: EAW83643.1.
    BC013889 mRNA. Translation: AAH13889.1.
    CCDSiCCDS55159.1. [Q9NW13-2]
    CCDS5801.1. [Q9NW13-1]
    RefSeqiNP_001159607.1. NM_001166135.1. [Q9NW13-2]
    NP_060547.2. NM_018077.2. [Q9NW13-1]
    UniGeneiHs.274263.

    Genome annotation databases

    EnsembliENST00000223073; ENSP00000223073; ENSG00000106344. [Q9NW13-1]
    ENST00000415472; ENSP00000390517; ENSG00000106344. [Q9NW13-2]
    GeneIDi55131.
    KEGGihsa:55131.
    UCSCiuc003vmp.2. human. [Q9NW13-1]

    Polymorphism databases

    DMDMi55976611.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001239 mRNA. Translation: BAA91575.1 .
    AK300500 mRNA. Translation: BAG62214.1 .
    AK222716 mRNA. Translation: BAD96436.1 .
    AC010655 Genomic DNA. No translation available.
    AC018635 Genomic DNA. No translation available.
    CH236947 Genomic DNA. Translation: EAL24314.1 .
    CH471070 Genomic DNA. Translation: EAW83643.1 .
    BC013889 mRNA. Translation: AAH13889.1 .
    CCDSi CCDS55159.1. [Q9NW13-2 ]
    CCDS5801.1. [Q9NW13-1 ]
    RefSeqi NP_001159607.1. NM_001166135.1. [Q9NW13-2 ]
    NP_060547.2. NM_018077.2. [Q9NW13-1 ]
    UniGenei Hs.274263.

    3D structure databases

    ProteinModelPortali Q9NW13.
    SMRi Q9NW13. Positions 3-189, 327-424.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120437. 23 interactions.
    IntActi Q9NW13. 5 interactions.
    MINTi MINT-3051761.
    STRINGi 9606.ENSP00000223073.

    PTM databases

    PhosphoSitei Q9NW13.

    Polymorphism databases

    DMDMi 55976611.

    2D gel databases

    SWISS-2DPAGE Q9NW13.

    Proteomic databases

    MaxQBi Q9NW13.
    PaxDbi Q9NW13.
    PeptideAtlasi Q9NW13.
    PRIDEi Q9NW13.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000223073 ; ENSP00000223073 ; ENSG00000106344 . [Q9NW13-1 ]
    ENST00000415472 ; ENSP00000390517 ; ENSG00000106344 . [Q9NW13-2 ]
    GeneIDi 55131.
    KEGGi hsa:55131.
    UCSCi uc003vmp.2. human. [Q9NW13-1 ]

    Organism-specific databases

    CTDi 55131.
    GeneCardsi GC07M127951.
    HGNCi HGNC:21863. RBM28.
    HPAi HPA019058.
    HPA026672.
    HPA031519.
    MIMi 612074. gene.
    612079. phenotype.
    neXtProti NX_Q9NW13.
    Orphaneti 157954. ANE syndrome.
    PharmGKBi PA134867266.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0724.
    HOGENOMi HOG000124666.
    HOVERGENi HBG073213.
    InParanoidi Q9NW13.
    KOi K14573.
    OMAi PWSIKEP.
    OrthoDBi EOG70ZZMT.
    PhylomeDBi Q9NW13.
    TreeFami TF312798.

    Miscellaneous databases

    ChiTaRSi RBM28. human.
    GeneWikii RBM28.
    GenomeRNAii 55131.
    NextBioi 58802.
    PROi Q9NW13.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NW13.
    Bgeei Q9NW13.
    CleanExi HS_RBM28.
    Genevestigatori Q9NW13.

    Family and domain databases

    Gene3Di 3.30.70.330. 4 hits.
    InterProi IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view ]
    Pfami PF00076. RRM_1. 3 hits.
    [Graphical view ]
    SMARTi SM00360. RRM. 4 hits.
    [Graphical view ]
    PROSITEi PS50102. RRM. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Prostate and Teratocarcinoma.
    2. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Colon.
    3. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Skin.
    7. Bienvenut W.V.
      Submitted (OCT-2004) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-10; 155-162; 183-192; 197-208; 454-465; 506-515; 559-571 AND 730-738, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Cervix carcinoma.
    8. "Human RBM28 protein is a specific nucleolar component of the spliceosomal snRNPs."
      Damianov A., Kann M., Lane W.S., Bindereif A.
      Biol. Chem. 387:1455-1460(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 17-31; 326-335; 477-486 AND 601-610, FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION IN A COMPLEX WITH SPLICEOSOMAL SNRNAS U1; U2; U4; U5 AND U6.
    9. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-122, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Alopecia, neurological defects, and endocrinopathy syndrome caused by decreased expression of RBM28, a nucleolar protein associated with ribosome biogenesis."
      Nousbeck J., Spiegel R., Ishida-Yamamoto A., Indelman M., Shani-Adir A., Adir N., Lipkin E., Bercovici S., Geiger D., van Steensel M.A., Steijlen P.M., Bergman R., Bindereif A., Choder M., Shalev S., Sprecher E.
      Am. J. Hum. Genet. 82:1114-1121(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT ANES PRO-351, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiRBM28_HUMAN
    AccessioniPrimary (citable) accession number: Q9NW13
    Secondary accession number(s): A4D100
    , B4DU52, E9PDD9, Q53H65, Q96CV3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 118 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3