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Q9NW08

- RPC2_HUMAN

UniProt

Q9NW08 - RPC2_HUMAN

Protein

DNA-directed RNA polymerase III subunit RPC2

Gene

POLR3B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 2 (28 Mar 2003)
      Previous versions | rss
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    Functioni

    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft By similarity. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.By similarity2 Publications

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi1080 – 10801ZincBy similarity
    Metal bindingi1083 – 10831ZincBy similarity
    Metal bindingi1092 – 10921ZincBy similarity
    Metal bindingi1095 – 10951ZincBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri1080 – 109516C4-typeAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. DNA-directed RNA polymerase activity Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW
    4. ribonucleoside binding Source: InterPro

    GO - Biological processi

    1. defense response to virus Source: UniProtKB-KW
    2. gene expression Source: Reactome
    3. innate immune response Source: Reactome
    4. positive regulation of innate immune response Source: UniProtKB
    5. positive regulation of interferon-beta production Source: UniProtKB
    6. positive regulation of type I interferon production Source: Reactome
    7. termination of RNA polymerase III transcription Source: Reactome
    8. transcription elongation from RNA polymerase III promoter Source: Reactome
    9. transcription from RNA polymerase III promoter Source: Reactome

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Antiviral defense, Immunity, Innate immunity, Transcription

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_1036. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
    REACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
    REACT_347. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
    REACT_571. RNA Polymerase III Transcription Initiation From Type 3 Promoter.
    REACT_63. RNA Polymerase III Transcription Termination.
    REACT_756. RNA Polymerase III Chain Elongation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA-directed RNA polymerase III subunit RPC2 (EC:2.7.7.6)
    Short name:
    RNA polymerase III subunit C2
    Alternative name(s):
    C128
    DNA-directed RNA polymerase III 127.6 kDa polypeptide
    DNA-directed RNA polymerase III subunit B
    Gene namesi
    Name:POLR3B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:30348. POLR3B.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. DNA-directed RNA polymerase III complex Source: MGI
    3. nucleoplasm Source: Reactome

    Keywords - Cellular componenti

    DNA-directed RNA polymerase, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Leukodystrophy, hypomyelinating, 8, with or without oligodontia and/or hypogonadotropic hypogonadism (HLD8) [MIM:614381]: An autosomal recessive neurodegenerative disorder characterized by early childhood onset of cerebellar ataxia and mild intellectual disabilities associated with diffuse hypomyelination apparent on brain MRI. Variable features include oligodontia and/or hypogonadotropic hypogonadism.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti503 – 5031T → K in HLD8. 1 Publication
    VAR_067005
    Natural varianti523 – 5231V → E in HLD8. 1 Publication
    VAR_067006
    Natural varianti620 – 65233Missing in HLD8.
    VAR_067007Add
    BLAST
    Natural varianti768 – 7681R → H in HLD8. 1 Publication
    VAR_067008
    Natural varianti926 – 9261D → E in HLD8. 1 Publication
    VAR_067009

    Keywords - Diseasei

    Disease mutation, Leukodystrophy

    Organism-specific databases

    MIMi614381. phenotype.
    Orphaneti88637. Hypomyelination - hypogonadotropic hypogonadism - hypodontia.
    PharmGKBiPA134867680.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11331133DNA-directed RNA polymerase III subunit RPC2PRO_0000048092Add
    BLAST

    Proteomic databases

    MaxQBiQ9NW08.
    PaxDbiQ9NW08.
    PRIDEiQ9NW08.

    PTM databases

    PhosphoSiteiQ9NW08.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NW08.
    BgeeiQ9NW08.
    CleanExiHS_POLR3B.
    GenevestigatoriQ9NW08.

    Organism-specific databases

    HPAiHPA036466.

    Interactioni

    Subunit structurei

    Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.By similarity

    Protein-protein interaction databases

    BioGridi120828. 14 interactions.
    IntActiQ9NW08. 1 interaction.
    STRINGi9606.ENSP00000228347.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NW08.
    SMRiQ9NW08. Positions 31-498, 880-952, 964-1073.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RNA polymerase beta chain family.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri1080 – 109516C4-typeAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG0085.
    HOGENOMiHOG000222962.
    HOVERGENiHBG017744.
    InParanoidiQ9NW08.
    KOiK03021.
    OMAiDMIMNPH.
    OrthoDBiEOG7288QK.
    PhylomeDBiQ9NW08.
    TreeFamiTF103047.

    Family and domain databases

    Gene3Di2.40.270.10. 2 hits.
    2.40.50.150. 1 hit.
    3.90.1110.10. 1 hit.
    InterProiIPR015712. DNA-dir_RNA_pol_su2.
    IPR007120. DNA-dir_RNA_pol_su2_6.
    IPR007121. RNA_pol_bsu_CS.
    IPR007644. RNA_pol_bsu_protrusion.
    IPR007642. RNA_pol_Rpb2_2.
    IPR007645. RNA_pol_Rpb2_3.
    IPR007646. RNA_pol_Rpb2_4.
    IPR007647. RNA_pol_Rpb2_5.
    IPR007641. RNA_pol_Rpb2_7.
    IPR014724. RNA_pol_RPB2_OB-fold.
    [Graphical view]
    PANTHERiPTHR20856. PTHR20856. 1 hit.
    PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
    PF04561. RNA_pol_Rpb2_2. 1 hit.
    PF04565. RNA_pol_Rpb2_3. 1 hit.
    PF04566. RNA_pol_Rpb2_4. 1 hit.
    PF04567. RNA_pol_Rpb2_5. 1 hit.
    PF00562. RNA_pol_Rpb2_6. 1 hit.
    PF04560. RNA_pol_Rpb2_7. 1 hit.
    [Graphical view]
    PROSITEiPS01166. RNA_POL_BETA. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NW08-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDVLAEEFGN LTPEQLAAPI PTVEEKWRLL PAFLKVKGLV KQHIDSFNYF     50
    INVEIKKIMK ANEKVTSDAD PMWYLKYLNI YVGLPDVEES FNVTRPVSPH 100
    ECRLRDMTYS APITVDIEYT RGSQRIIRNA LPIGRMPIML RSSNCVLTGK 150
    TPAEFAKLNE CPLDPGGYFI VKGVEKVILI QEQLSKNRII VEADRKGAVG 200
    ASVTSSTHEK KSRTNMAVKQ GRFYLRHNTL SEDIPIVIIF KAMGVESDQE 250
    IVQMIGTEEH VMAAFGPSLE ECQKAQIFTQ MQALKYIGNK VRRQRMWGGG 300
    PKKTKIEEAR ELLASTILTH VPVKEFNFRA KCIYTAVMVR RVILAQGDNK 350
    VDDRDYYGNK RLELAGQLLS LLFEDLFKKF NSEMKKIADQ VIPKQRAAQF 400
    DVVKHMRQDQ ITNGMVNAIS TGNWSLKRFK MDRQGVTQVL SRLSYISALG 450
    MMTRISSQFE KTRKVSGPRS LQPSQWGMLC PSDTPEGEAC GLVKNLALMT 500
    HITTDMEDGP IVKLASNLGV EDVNLLCGEE LSYPNVFLVF LNGNILGVIR 550
    DHKKLVNTFR LMRRAGYINE FVSISTNLTD RCVYISSDGG RLCRPYIIVK 600
    KQKPAVTNKH MEELAQGYRN FEDFLHESLV EYLDVNEEND CNIALYEHTI 650
    NKDTTHLEIE PFTLLGVCAG LIPYPHHNQS PRNTYQCAMG KQAMGTIGYN 700
    QRNRIDTLMY LLAYPQKPMV KTKTIELIEF EKLPAGQNAT VAVMSYSGYD 750
    IEDALVLNKA SLDRGFGRCL VYKNAKCTLK RYTNQTFDKV MGPMLDAATR 800
    KPIWRHEILD ADGICSPGEK VENKQVLVNK SMPTVTQIPL EGSNVPQQPQ 850
    YKDVPITYKG ATDSYIEKVM ISSNAEDAFL IKMLLRQTRR PEIGDKFSSR 900
    HGQKGVCGLI VPQEDMPFCD SGICPDIIMN PHGFPSRMTV GKLIELLAGK 950
    AGVLDGRFHY GTAFGGSKVK DVCEDLVRHG YNYLGKDYVT SGITGEPLEA 1000
    YIYFGPVYYQ KLKHMVLDKM HARARGPRAV LTRQPTEGRS RDGGLRLGEM 1050
    ERDCLIGYGA SMLLLERLMI SSDAFEVDVC GQCGLLGYSG WCHYCKSSCH 1100
    VSSLRIPYAC KLLFQELQSM NIIPRLKLSK YNE 1133
    Length:1,133
    Mass (Da):127,785
    Last modified:March 28, 2003 - v2
    Checksum:iF0B3AFF892DDED7D
    GO
    Isoform 2 (identifier: Q9NW08-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-58: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,075
    Mass (Da):121,120
    Checksum:i48188014A09A87FA
    GO

    Sequence cautioni

    The sequence BAA91527.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAA91581.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti258 – 2581E → A in AAM18214. (PubMed:12391170)Curated
    Sequence conflicti607 – 6071T → I in BAG53685. (PubMed:14702039)Curated
    Sequence conflicti978 – 9781R → C in BAA91527. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti503 – 5031T → K in HLD8. 1 Publication
    VAR_067005
    Natural varianti523 – 5231V → E in HLD8. 1 Publication
    VAR_067006
    Natural varianti620 – 65233Missing in HLD8.
    VAR_067007Add
    BLAST
    Natural varianti740 – 7401T → A.
    Corresponds to variant rs17038460 [ dbSNP | Ensembl ].
    VAR_057255
    Natural varianti768 – 7681R → H in HLD8. 1 Publication
    VAR_067008
    Natural varianti926 – 9261D → E in HLD8. 1 Publication
    VAR_067009

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 5858Missing in isoform 2. 1 PublicationVSP_045286Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY092084 mRNA. Translation: AAM18214.1.
    AK001161 mRNA. Translation: BAA91527.1. Different initiation.
    AK001250 mRNA. Translation: BAA91581.1. Different initiation.
    AK122713 mRNA. Translation: BAG53685.1.
    AK291635 mRNA. Translation: BAF84324.1.
    AC009721 Genomic DNA. No translation available.
    AC078992 Genomic DNA. No translation available.
    AC080012 Genomic DNA. No translation available.
    CH471054 Genomic DNA. Translation: EAW97780.1.
    BC046238 mRNA. Translation: AAH46238.1.
    CCDSiCCDS53824.1. [Q9NW08-2]
    CCDS9105.1. [Q9NW08-1]
    RefSeqiNP_001154180.1. NM_001160708.1. [Q9NW08-2]
    NP_060552.4. NM_018082.5. [Q9NW08-1]
    UniGeneiHs.610795.
    Hs.62696.

    Genome annotation databases

    EnsembliENST00000228347; ENSP00000228347; ENSG00000013503. [Q9NW08-1]
    ENST00000539066; ENSP00000445721; ENSG00000013503. [Q9NW08-2]
    GeneIDi55703.
    KEGGihsa:55703.
    UCSCiuc001tlp.3. human. [Q9NW08-1]

    Polymorphism databases

    DMDMi29428029.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY092084 mRNA. Translation: AAM18214.1 .
    AK001161 mRNA. Translation: BAA91527.1 . Different initiation.
    AK001250 mRNA. Translation: BAA91581.1 . Different initiation.
    AK122713 mRNA. Translation: BAG53685.1 .
    AK291635 mRNA. Translation: BAF84324.1 .
    AC009721 Genomic DNA. No translation available.
    AC078992 Genomic DNA. No translation available.
    AC080012 Genomic DNA. No translation available.
    CH471054 Genomic DNA. Translation: EAW97780.1 .
    BC046238 mRNA. Translation: AAH46238.1 .
    CCDSi CCDS53824.1. [Q9NW08-2 ]
    CCDS9105.1. [Q9NW08-1 ]
    RefSeqi NP_001154180.1. NM_001160708.1. [Q9NW08-2 ]
    NP_060552.4. NM_018082.5. [Q9NW08-1 ]
    UniGenei Hs.610795.
    Hs.62696.

    3D structure databases

    ProteinModelPortali Q9NW08.
    SMRi Q9NW08. Positions 31-498, 880-952, 964-1073.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120828. 14 interactions.
    IntActi Q9NW08. 1 interaction.
    STRINGi 9606.ENSP00000228347.

    PTM databases

    PhosphoSitei Q9NW08.

    Polymorphism databases

    DMDMi 29428029.

    Proteomic databases

    MaxQBi Q9NW08.
    PaxDbi Q9NW08.
    PRIDEi Q9NW08.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000228347 ; ENSP00000228347 ; ENSG00000013503 . [Q9NW08-1 ]
    ENST00000539066 ; ENSP00000445721 ; ENSG00000013503 . [Q9NW08-2 ]
    GeneIDi 55703.
    KEGGi hsa:55703.
    UCSCi uc001tlp.3. human. [Q9NW08-1 ]

    Organism-specific databases

    CTDi 55703.
    GeneCardsi GC12P106751.
    GeneReviewsi POLR3B.
    H-InvDB HIX0037055.
    HGNCi HGNC:30348. POLR3B.
    HPAi HPA036466.
    MIMi 614366. gene.
    614381. phenotype.
    neXtProti NX_Q9NW08.
    Orphaneti 88637. Hypomyelination - hypogonadotropic hypogonadism - hypodontia.
    PharmGKBi PA134867680.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0085.
    HOGENOMi HOG000222962.
    HOVERGENi HBG017744.
    InParanoidi Q9NW08.
    KOi K03021.
    OMAi DMIMNPH.
    OrthoDBi EOG7288QK.
    PhylomeDBi Q9NW08.
    TreeFami TF103047.

    Enzyme and pathway databases

    Reactomei REACT_1036. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
    REACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
    REACT_347. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
    REACT_571. RNA Polymerase III Transcription Initiation From Type 3 Promoter.
    REACT_63. RNA Polymerase III Transcription Termination.
    REACT_756. RNA Polymerase III Chain Elongation.

    Miscellaneous databases

    GenomeRNAii 55703.
    NextBioi 60549.
    PROi Q9NW08.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NW08.
    Bgeei Q9NW08.
    CleanExi HS_POLR3B.
    Genevestigatori Q9NW08.

    Family and domain databases

    Gene3Di 2.40.270.10. 2 hits.
    2.40.50.150. 1 hit.
    3.90.1110.10. 1 hit.
    InterProi IPR015712. DNA-dir_RNA_pol_su2.
    IPR007120. DNA-dir_RNA_pol_su2_6.
    IPR007121. RNA_pol_bsu_CS.
    IPR007644. RNA_pol_bsu_protrusion.
    IPR007642. RNA_pol_Rpb2_2.
    IPR007645. RNA_pol_Rpb2_3.
    IPR007646. RNA_pol_Rpb2_4.
    IPR007647. RNA_pol_Rpb2_5.
    IPR007641. RNA_pol_Rpb2_7.
    IPR014724. RNA_pol_RPB2_OB-fold.
    [Graphical view ]
    PANTHERi PTHR20856. PTHR20856. 1 hit.
    Pfami PF04563. RNA_pol_Rpb2_1. 1 hit.
    PF04561. RNA_pol_Rpb2_2. 1 hit.
    PF04565. RNA_pol_Rpb2_3. 1 hit.
    PF04566. RNA_pol_Rpb2_4. 1 hit.
    PF04567. RNA_pol_Rpb2_5. 1 hit.
    PF00562. RNA_pol_Rpb2_6. 1 hit.
    PF04560. RNA_pol_Rpb2_7. 1 hit.
    [Graphical view ]
    PROSITEi PS01166. RNA_POL_BETA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits."
      Hu P., Wu S., Sun Y., Yuan C.-C., Kobayashi R., Myers M.P., Hernandez N.
      Mol. Cell. Biol. 22:8044-8055(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), IDENTIFICATION IN THE RNA POL III COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Placenta, Teratocarcinoma and Tongue.
    3. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Muscle.
    6. "RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway."
      Chiu Y.-H., Macmillan J.B., Chen Z.J.
      Cell 138:576-591(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate."
      Ablasser A., Bauernfeind F., Hartmann G., Latz E., Fitzgerald K.A., Hornung V.
      Nat. Immunol. 10:1065-1072(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Mutations in POLR3A and POLR3B encoding RNA Polymerase III subunits cause an autosomal-recessive hypomyelinating leukoencephalopathy."
      Saitsu H., Osaka H., Sasaki M., Takanashi J., Hamada K., Yamashita A., Shibayama H., Shiina M., Kondo Y., Nishiyama K., Tsurusaki Y., Miyake N., Doi H., Ogata K., Inoue K., Matsumoto N.
      Am. J. Hum. Genet. 89:644-651(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS HLD8 620-ASN--LYS-652 DEL; HIS-768 AND GLU-926.
    10. "Recessive mutations in POLR3B, encoding the second largest subunit of Pol III, cause a rare hypomyelinating leukodystrophy."
      Tetreault M., Choquet K., Orcesi S., Tonduti D., Balottin U., Teichmann M., Fribourg S., Schiffmann R., Brais B., Vanderver A., Bernard G.
      Am. J. Hum. Genet. 89:652-655(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS HLD8 LYS-503 AND GLU-523.

    Entry informationi

    Entry nameiRPC2_HUMAN
    AccessioniPrimary (citable) accession number: Q9NW08
    Secondary accession number(s): A8K6H0
    , B3KV73, F5H1E6, Q9NW59
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 28, 2003
    Last sequence update: March 28, 2003
    Last modified: October 1, 2014
    This is version 126 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3