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Protein

Zinc finger protein 358

Gene

ZNF358

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri151 – 173C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri179 – 201C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri207 – 229C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri235 – 257C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri263 – 285C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri291 – 313C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri319 – 341C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri347 – 369C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-30754-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 358
Gene namesi
Name:ZNF358
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:16838. ZNF358.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198816.
PharmGKBiPA38189.

Polymorphism and mutation databases

BioMutaiZNF358.
DMDMi251757418.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475471 – 568Zinc finger protein 358Add BLAST568

Proteomic databases

EPDiQ9NW07.
MaxQBiQ9NW07.
PaxDbiQ9NW07.
PeptideAtlasiQ9NW07.
PRIDEiQ9NW07.

PTM databases

iPTMnetiQ9NW07.
PhosphoSitePlusiQ9NW07.

Expressioni

Gene expression databases

BgeeiENSG00000198816.
CleanExiHS_ZNF358.
ExpressionAtlasiQ9NW07. baseline and differential.
GenevisibleiQ9NW07. HS.

Organism-specific databases

HPAiHPA030887.
HPA063624.

Interactioni

Protein-protein interaction databases

BioGridi126619. 6 interactors.
STRINGi9606.ENSP00000377873.

Structurei

3D structure databases

ProteinModelPortaliQ9NW07.
SMRiQ9NW07.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi400 – 416Poly-AlaAdd BLAST17

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri151 – 173C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri179 – 201C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri207 – 229C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri235 – 257C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri263 – 285C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri291 – 313C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri319 – 341C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri347 – 369C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 9PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133835.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9NW07.
OMAiSMMRPGQ.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9NW07.
TreeFamiTF350840.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NW07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRSVLVRNP GHKGLRPVYE ELDSDSEDLD PNPEDLDPVS EDPEPDPEDL
60 70 80 90 100
NTVPEDVDPS YEDLEPVSED LDPDAEAPGS EPQDPDPMSS SFDLDPDVIG
110 120 130 140 150
PVPLILDPNS DTLSPGDPKV DPISSGLTAT PQVLATSPAV LPAPASPPRP
160 170 180 190 200
FSCPDCGRAF RRSSGLSQHR RTHSGEKPYR CPDCGKSFSH GATLAQHRGI
210 220 230 240 250
HTGARPYQCA ACGKAFGWRS TLLKHRSSHS GEKPHHCPVC GKAFGHGSLL
260 270 280 290 300
AQHLRTHGGP RPHKCPVCAK GFGQGSALLK HLRTHTGERP YPCPQCGKAF
310 320 330 340 350
GQSSALLQHQ RTHTAERPYR CPHCGKAFGQ SSNLQHHLRI HTGERPYACP
360 370 380 390 400
HCSKAFGQSS ALLQHLHVHS GERPYRCQLC GKAFGQASSL TKHKRVHEGA
410 420 430 440 450
AAAAAAAAAA AAAAAAGLGL GPGLSPASMM RPGQVSLLGP DAVSVLGSGL
460 470 480 490 500
GLSPGTSSGR NPDPGSGPGT LPDPSSKPLP GSRSTPSPTP VESSDPKAGH
510 520 530 540 550
DAGPDLVPSP DLDPVPSPDP DPVPSPDPNP VSCPDPCSPT RGTVSPALPT
560
GESPEWVQEQ GALLGPDG
Length:568
Mass (Da):59,287
Last modified:July 7, 2009 - v2
Checksum:i347131478D2A5FF8
GO

Sequence cautioni

The sequence AAH14002 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA91582 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti242K → Q in CX782162 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06194432N → S.Corresponds to variant rs11555037dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008878 Genomic DNA. No translation available.
BC003585 mRNA. Translation: AAH03585.1.
BC014002 mRNA. Translation: AAH14002.1. Different initiation.
CX782162 mRNA. No translation available.
AK001252 mRNA. Translation: BAA91582.1. Different initiation.
CCDSiCCDS32890.2.
RefSeqiNP_060553.4. NM_018083.4.
XP_005272517.1. XM_005272460.3.
XP_011525997.1. XM_011527695.1.
UniGeneiHs.133475.

Genome annotation databases

EnsembliENST00000597229; ENSP00000472305; ENSG00000198816.
GeneIDi140467.
KEGGihsa:140467.
UCSCiuc002mgn.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008878 Genomic DNA. No translation available.
BC003585 mRNA. Translation: AAH03585.1.
BC014002 mRNA. Translation: AAH14002.1. Different initiation.
CX782162 mRNA. No translation available.
AK001252 mRNA. Translation: BAA91582.1. Different initiation.
CCDSiCCDS32890.2.
RefSeqiNP_060553.4. NM_018083.4.
XP_005272517.1. XM_005272460.3.
XP_011525997.1. XM_011527695.1.
UniGeneiHs.133475.

3D structure databases

ProteinModelPortaliQ9NW07.
SMRiQ9NW07.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126619. 6 interactors.
STRINGi9606.ENSP00000377873.

PTM databases

iPTMnetiQ9NW07.
PhosphoSitePlusiQ9NW07.

Polymorphism and mutation databases

BioMutaiZNF358.
DMDMi251757418.

Proteomic databases

EPDiQ9NW07.
MaxQBiQ9NW07.
PaxDbiQ9NW07.
PeptideAtlasiQ9NW07.
PRIDEiQ9NW07.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000597229; ENSP00000472305; ENSG00000198816.
GeneIDi140467.
KEGGihsa:140467.
UCSCiuc002mgn.3. human.

Organism-specific databases

CTDi140467.
GeneCardsiZNF358.
HGNCiHGNC:16838. ZNF358.
HPAiHPA030887.
HPA063624.
neXtProtiNX_Q9NW07.
OpenTargetsiENSG00000198816.
PharmGKBiPA38189.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133835.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9NW07.
OMAiSMMRPGQ.
OrthoDBiEOG091G02KC.
PhylomeDBiQ9NW07.
TreeFamiTF350840.

Enzyme and pathway databases

BioCyciZFISH:G66-30754-MONOMER.

Miscellaneous databases

ChiTaRSiZNF358. human.
GenomeRNAii140467.
PROiQ9NW07.

Gene expression databases

BgeeiENSG00000198816.
CleanExiHS_ZNF358.
ExpressionAtlasiQ9NW07. baseline and differential.
GenevisibleiQ9NW07. HS.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 9 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN358_HUMAN
AccessioniPrimary (citable) accession number: Q9NW07
Secondary accession number(s): Q9BTM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: July 7, 2009
Last modified: November 30, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.