Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

HAUS augmin-like complex subunit 2

Gene

HAUS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.2 Publications

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • centrosome organization Source: UniProtKB
  • G2/M transition of mitotic cell cycle Source: Reactome
  • mitotic nuclear division Source: UniProtKB-KW
  • spindle assembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-HSA-380259. Loss of Nlp from mitotic centrosomes.
R-HSA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-HSA-5620912. Anchoring of the basal body to the plasma membrane.
R-HSA-8854518. AURKA Activation by TPX2.

Names & Taxonomyi

Protein namesi
Recommended name:
HAUS augmin-like complex subunit 2
Alternative name(s):
Centrosomal protein of 27 kDa
Short name:
Cep27
Gene namesi
Name:HAUS2
Synonyms:C15orf25, CEP27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:25530. HAUS2.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: UniProtKB
  • cytoplasm Source: HPA
  • cytosol Source: Reactome
  • Golgi apparatus Source: HPA
  • HAUS complex Source: UniProtKB
  • nucleoplasm Source: HPA
  • spindle microtubule Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165479051.

Polymorphism and mutation databases

BioMutaiHAUS2.
DMDMi56748883.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235HAUS augmin-like complex subunit 2PRO_0000089484Add
BLAST

Proteomic databases

EPDiQ9NVX0.
MaxQBiQ9NVX0.
PaxDbiQ9NVX0.
PRIDEiQ9NVX0.

PTM databases

iPTMnetiQ9NVX0.
PhosphoSiteiQ9NVX0.

Expressioni

Gene expression databases

BgeeiQ9NVX0.
CleanExiHS_CEP27.
ExpressionAtlasiQ9NVX0. baseline and differential.
GenevisibleiQ9NVX0. HS.

Organism-specific databases

HPAiHPA039965.

Interactioni

Subunit structurei

Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly.2 Publications

Protein-protein interaction databases

BioGridi120445. 98 interactions.
DIPiDIP-48836N.
IntActiQ9NVX0. 40 interactions.
MINTiMINT-1411879.
STRINGi9606.ENSP00000260372.

Structurei

3D structure databases

ProteinModelPortaliQ9NVX0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili51 – 11565Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the HAUS2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJMS. Eukaryota.
ENOG410Y2SI. LUCA.
GeneTreeiENSGT00390000004927.
HOGENOMiHOG000231602.
InParanoidiQ9NVX0.
KOiK16585.
OrthoDBiEOG7ZD1X2.
PhylomeDBiQ9NVX0.
TreeFamiTF333194.

Family and domain databases

InterProiIPR028346. HAUS2.
IPR026242. HAUS2_metazoa.
[Graphical view]
PfamiPF15003. HAUS2. 1 hit.
[Graphical view]
PRINTSiPR02088. HAUSAUGMINL2.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NVX0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAANPWDPA SAPNGAGLVL GHFIASGMVN QEMLNMSKKT VSCFVNFTRL
60 70 80 90 100
QQITNIQAEI YQKNLEIELL KLEKDTADVV HPFFLAQKCH TLQSMNNHLE
110 120 130 140 150
AVLKEKRSLR QRLLKPMCQE NLPIEAVYHR YMVHLLELAV TFIERLETHL
160 170 180 190 200
ETIRNIPHLA ANLKKMNQAL AKMDILVTET EELAENILKW RKQQNEVSSC
210 220 230
IPKILAEESY LYKHDIIMPP LPFTSKVHVQ TINAK
Length:235
Mass (Da):26,933
Last modified:October 1, 2000 - v1
Checksum:iE1475D00313FCA7F
GO
Isoform 2 (identifier: Q9NVX0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: Missing.

Show »
Length:141
Mass (Da):16,533
Checksum:i0A9CA3B4A8DDC4DF
GO
Isoform 3 (identifier: Q9NVX0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-62: Missing.

Note: No experimental confirmation available.
Show »
Length:204
Mass (Da):23,272
Checksum:i3924B4985516FE61
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti76 – 761T → P.
Corresponds to variant rs34678957 [ dbSNP | Ensembl ].
VAR_050793

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9494Missing in isoform 2. 1 PublicationVSP_012223Add
BLAST
Alternative sequencei32 – 6231Missing in isoform 3. CuratedVSP_040918Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001322 mRNA. Translation: BAA91623.1.
AK022939 mRNA. Translation: BAB14319.1.
AC018362 Genomic DNA. No translation available.
BC010903 mRNA. Translation: AAH10903.1.
CCDSiCCDS10090.1. [Q9NVX0-1]
CCDS45247.1. [Q9NVX0-3]
RefSeqiNP_001123919.1. NM_001130447.1. [Q9NVX0-3]
NP_060567.1. NM_018097.2. [Q9NVX0-1]
XP_006720663.1. XM_006720600.2. [Q9NVX0-2]
UniGeneiHs.14347.

Genome annotation databases

EnsembliENST00000260372; ENSP00000260372; ENSG00000137814. [Q9NVX0-1]
ENST00000568876; ENSP00000456578; ENSG00000137814. [Q9NVX0-3]
GeneIDi55142.
KEGGihsa:55142.
UCSCiuc001zqe.4. human. [Q9NVX0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001322 mRNA. Translation: BAA91623.1.
AK022939 mRNA. Translation: BAB14319.1.
AC018362 Genomic DNA. No translation available.
BC010903 mRNA. Translation: AAH10903.1.
CCDSiCCDS10090.1. [Q9NVX0-1]
CCDS45247.1. [Q9NVX0-3]
RefSeqiNP_001123919.1. NM_001130447.1. [Q9NVX0-3]
NP_060567.1. NM_018097.2. [Q9NVX0-1]
XP_006720663.1. XM_006720600.2. [Q9NVX0-2]
UniGeneiHs.14347.

3D structure databases

ProteinModelPortaliQ9NVX0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120445. 98 interactions.
DIPiDIP-48836N.
IntActiQ9NVX0. 40 interactions.
MINTiMINT-1411879.
STRINGi9606.ENSP00000260372.

PTM databases

iPTMnetiQ9NVX0.
PhosphoSiteiQ9NVX0.

Polymorphism and mutation databases

BioMutaiHAUS2.
DMDMi56748883.

Proteomic databases

EPDiQ9NVX0.
MaxQBiQ9NVX0.
PaxDbiQ9NVX0.
PRIDEiQ9NVX0.

Protocols and materials databases

DNASUi55142.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260372; ENSP00000260372; ENSG00000137814. [Q9NVX0-1]
ENST00000568876; ENSP00000456578; ENSG00000137814. [Q9NVX0-3]
GeneIDi55142.
KEGGihsa:55142.
UCSCiuc001zqe.4. human. [Q9NVX0-1]

Organism-specific databases

CTDi55142.
GeneCardsiHAUS2.
HGNCiHGNC:25530. HAUS2.
HPAiHPA039965.
MIMi613429. gene.
neXtProtiNX_Q9NVX0.
PharmGKBiPA165479051.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJMS. Eukaryota.
ENOG410Y2SI. LUCA.
GeneTreeiENSGT00390000004927.
HOGENOMiHOG000231602.
InParanoidiQ9NVX0.
KOiK16585.
OrthoDBiEOG7ZD1X2.
PhylomeDBiQ9NVX0.
TreeFamiTF333194.

Enzyme and pathway databases

ReactomeiR-HSA-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-HSA-380259. Loss of Nlp from mitotic centrosomes.
R-HSA-380270. Recruitment of mitotic centrosome proteins and complexes.
R-HSA-5620912. Anchoring of the basal body to the plasma membrane.
R-HSA-8854518. AURKA Activation by TPX2.

Miscellaneous databases

ChiTaRSiHAUS2. human.
GenomeRNAii55142.
PROiQ9NVX0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NVX0.
CleanExiHS_CEP27.
ExpressionAtlasiQ9NVX0. baseline and differential.
GenevisibleiQ9NVX0. HS.

Family and domain databases

InterProiIPR028346. HAUS2.
IPR026242. HAUS2_metazoa.
[Graphical view]
PfamiPF15003. HAUS2. 1 hit.
[Graphical view]
PRINTSiPR02088. HAUSAUGMINL2.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Teratocarcinoma.
  2. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. "Proteomic characterization of the human centrosome by protein correlation profiling."
    Andersen J.S., Wilkinson C.J., Mayor T., Mortensen P., Nigg E.A., Mann M.
    Nature 426:570-574(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Lymphoblast.
  5. Cited for: IDENTIFICATION IN THE HAUS AUGMIN-LIKE COMPLEX, FUNCTION, SUBCELLULAR LOCATION.
  6. "The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells."
    Uehara R., Nozawa R.-S., Tomioka A., Petry S., Vale R.D., Obuse C., Goshima G.
    Proc. Natl. Acad. Sci. U.S.A. 106:6998-7003(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE HAUS AUGMIN-LIKE COMPLEX, FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiHAUS2_HUMAN
AccessioniPrimary (citable) accession number: Q9NVX0
Secondary accession number(s): C9JH36, Q9H9B3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.