Q9NVV5 (AIG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Androgen-induced gene 1 protein
Short name=AIG-1

Gene names

Name:	AIG1
ORF Names:	CGI-103

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	245 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in androgen-regulated growth of hair follicles.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	Highly expressed in heart, ovary, testis, liver, and kidney, at lower levels in spleen, prostate, brain, skeletal muscle, pancreas, small intestine and colon, and undetected in peripheral blood leukocytes, thymus, lung and placenta. AIG1 expression is higher in hair follicles from males than from females. Ref.1
Induction	By dihydrotestosterone (DHT). Ref.1
Sequence similarities	Belongs to the AIG1 family.
Sequence caution	The sequence AAD34098.1 differs from that shown. Reason: Frameshift at positions 182, 193 and 223. The sequence CAE45823.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
RCHY1	Q96PM5	4	EBI-3942989,EBI-947779

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NVV5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NVV5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     227-245: KPPSWQDMKIKFMYLGPSS → SMEEEKEKPKLE

Isoform 3 (identifier: Q9NVV5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     48-99: Missing.
     227-245: KPPSWQDMKIKFMYLGPSS → SMEEEKEKPKLE

Isoform 4 (identifier: Q9NVV5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: Missing.
     227-245: KPPSWQDMKIKFMYLGPSS → SMEEEKEKPKLE

Note: No experimental confirmation available.

Isoform 5 (identifier: Q9NVV5-5)

The sequence of this isoform differs from the canonical sequence as follows:
     135-137: TTV → FKA
     138-245: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 245	245	Androgen-induced gene 1 protein		PRO_0000190098
Regions
	Transmembrane	1 – 21	21	Helical; Potential
	Transmembrane	39 – 59	21	Helical; Potential
	Transmembrane	88 – 108	21	Helical; Potential
	Transmembrane	124 – 144	21	Helical; Potential
	Transmembrane	167 – 187	21	Helical; Potential
	Transmembrane	197 – 217	21	Helical; Potential
Natural variations
	Alternative sequence	1 – 10	10	Missing in isoform 4.		VSP_012314
	Alternative sequence	48 – 99	52	Missing in isoform 3.		VSP_012315
	Alternative sequence	135 – 137	3	TTV → FKA in isoform 5.		VSP_012316
	Alternative sequence	138 – 245	108	Missing in isoform 5.		VSP_012317
	Alternative sequence	227 – 245	19	KPPSW…LGPSS → SMEEEKEKPKLE in isoform 2, isoform 3 and isoform 4.		VSP_012318
	Natural variant	151	1	Q → E. Corresponds to variant rs1053193 [ dbSNP | Ensembl ].		VAR_057502
Experimental info
	Sequence conflict	70	1	S → I in AAD41087. Ref.1
	Sequence conflict	191	1	I → F in BAA91640. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 21, 2004. Version 2. Checksum: 06C0C8A6BDBF3694	FASTA	245	28,222
	10 20 30 40 50 60 MALVPCQVLR MAILLSYCSI LCNYKAIEMP SHQTYGGSWK FLTFIDLVIQ AVFFGICVLT 70 80 90 100 110 120 DLSSLLTRGS GNQEQERQLK KLISLRDWML AVLAFPVGVF VVAVFWIIYA YDREMIYPKL 130 140 150 160 170 180 LDNFIPGWLN HGMHTTVLPF ILIEMRTSHH QYPSRSSGLT AICTFSVGYI LWVCWVHHVT 190 200 210 220 230 240 GMWVYPFLEH IGPGARIIFF GSTTILMNFL YLLGEVLNNY IWDTQKKPPS WQDMKIKFMY LGPSS
	Isoform 2 [UniParc]. Checksum: DF5D5B8FC41A2C95	FASTA	238	27,458
	10 20 30 40 50 60 MALVPCQVLR MAILLSYCSI LCNYKAIEMP SHQTYGGSWK FLTFIDLVIQ AVFFGICVLT 70 80 90 100 110 120 DLSSLLTRGS GNQEQERQLK KLISLRDWML AVLAFPVGVF VVAVFWIIYA YDREMIYPKL 130 140 150 160 170 180 LDNFIPGWLN HGMHTTVLPF ILIEMRTSHH QYPSRSSGLT AICTFSVGYI LWVCWVHHVT 190 200 210 220 230 GMWVYPFLEH IGPGARIIFF GSTTILMNFL YLLGEVLNNY IWDTQKSMEE EKEKPKLE
	Isoform 3 [UniParc]. Checksum: 77322CC43C44F5C2	FASTA	186	21,715
	10 20 30 40 50 60 MALVPCQVLR MAILLSYCSI LCNYKAIEMP SHQTYGGSWK FLTFIDLFVV AVFWIIYAYD 70 80 90 100 110 120 REMIYPKLLD NFIPGWLNHG MHTTVLPFIL IEMRTSHHQY PSRSSGLTAI CTFSVGYILW 130 140 150 160 170 180 VCWVHHVTGM WVYPFLEHIG PGARIIFFGS TTILMNFLYL LGEVLNNYIW DTQKSMEEEK EKPKLE
	Isoform 4 [UniParc]. Checksum: 761CD65BB7F9F159	FASTA	228	26,347
	10 20 30 40 50 60 MAILLSYCSI LCNYKAIEMP SHQTYGGSWK FLTFIDLVIQ AVFFGICVLT DLSSLLTRGS 70 80 90 100 110 120 GNQEQERQLK KLISLRDWML AVLAFPVGVF VVAVFWIIYA YDREMIYPKL LDNFIPGWLN 130 140 150 160 170 180 HGMHTTVLPF ILIEMRTSHH QYPSRSSGLT AICTFSVGYI LWVCWVHHVT GMWVYPFLEH 190 200 210 220 IGPGARIIFF GSTTILMNFL YLLGEVLNNY IWDTQKSMEE EKEKPKLE
	Isoform 5 [UniParc]. Checksum: 7EEF2A92A3787CA3	FASTA	137	15,713
	10 20 30 40 50 60 MALVPCQVLR MAILLSYCSI LCNYKAIEMP SHQTYGGSWK FLTFIDLVIQ AVFFGICVLT 70 80 90 100 110 120 DLSSLLTRGS GNQEQERQLK KLISLRDWML AVLAFPVGVF VVAVFWIIYA YDREMIYPKL 130 LDNFIPGWLN HGMHFKA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of androgen-inducible gene 1 (AIG1) from human dermal papilla cells." Seo J., Kim J., Kim M. Mol. Cells 11:35-40(2001) [PubMed: 11266118] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, INDUCTION. Tissue: Hair follicle dermal papilla.
[2]	"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics." Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C. Genome Res. 10:703-713(2000) [PubMed: 10810093] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 5). Tissue: Prostate and Rectum tumor.
[5]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Skin.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF153605 mRNA. Translation: AAD41087.1. AF151861 mRNA. Translation: AAD34098.1. Frameshift. AK001347 mRNA. Translation: BAA91640.1. BX538067 mRNA. Translation: CAD97997.1. BX640703 mRNA. Translation: CAE45823.1. Different initiation. AL391726, AL023581, AL136116 Genomic DNA. Translation: CAI16930.1. AL023581, AL136116, AL391726 Genomic DNA. Translation: CAI21392.1. AL023581, AL136116, AL391726 Genomic DNA. Translation: CAI21393.1. AL136116, AL023581, AL391726 Genomic DNA. Translation: CAI23451.1. AL136116, AL023581, AL391726 Genomic DNA. Translation: CAI23452.1. AL391726, AL023581, AL136116 Genomic DNA. Translation: CAI16931.1. BC025278 mRNA. Translation: AAH25278.1.
IPI	IPI00384950. IPI00513794. IPI00514471. IPI00827524. IPI00844231.
RefSeq	NP_057192.2. NM_016108.2.
UniGene	Hs.567501.
3D structure databases
ProteinModelPortal	Q9NVV5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NVV5. 1 interaction.
STRING	Q9NVV5.
Polymorphism databases
DMDM	56748615.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000275235; ENSP00000275235; ENSG00000146416.
GeneID	51390.
KEGG	hsa:51390.
UCSC	uc003qjf.1. human. uc003qjg.2. human. uc003qji.1. human.
Organism-specific databases
CTD	51390.
GeneCards	GC06P143423.
HGNC	HGNC:21607. AIG1.
MIM	608514. gene.
neXtProt	NX_Q9NVV5.
PharmGKB	PA134991331.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000012526.
HOGENOM	HBG714170.
HOVERGEN	HBG050468.
InParanoid	Q9NVV5.
OMA	YIWDTQK.
PhylomeDB	Q9NVV5.
Gene expression databases
ArrayExpress	Q9NVV5.
Bgee	Q9NVV5.
CleanEx	HS_AIG1.
Genevestigator	Q9NVV5.
GermOnline	ENSG00000146416. Homo sapiens.
Family and domain databases
InterPro	IPR006838. Far-17a_AIG1. [Graphical view]
Pfam	PF04750. Far-17a_AIG1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	54921.
SOURCE	Search...

Entry information

Entry name

AIG1_HUMAN

Accession

Primary (citable) accession number: Q9NVV5
Secondary accession number(s): Q5T2H2 , Q6N047, Q7Z378, Q8TB14, Q9Y3A9, Q9Y5B4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 21, 2004
Last sequence update:	December 21, 2004
Last modified:	January 25, 2012
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.