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Q9NVV5

- AIG1_HUMAN

UniProt

Q9NVV5 - AIG1_HUMAN

Protein

Androgen-induced gene 1 protein

Gene

AIG1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    May play a role in androgen-regulated growth of hair follicles.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Androgen-induced gene 1 protein
    Short name:
    AIG-1
    Gene namesi
    Name:AIG1
    ORF Names:CGI-103
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:21607. AIG1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134991331.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 245245Androgen-induced gene 1 proteinPRO_0000190098Add
    BLAST

    Proteomic databases

    MaxQBiQ9NVV5.
    PaxDbiQ9NVV5.
    PRIDEiQ9NVV5.

    PTM databases

    PhosphoSiteiQ9NVV5.

    Expressioni

    Tissue specificityi

    Highly expressed in heart, ovary, testis, liver, and kidney, at lower levels in spleen, prostate, brain, skeletal muscle, pancreas, small intestine and colon, and undetected in peripheral blood leukocytes, thymus, lung and placenta. AIG1 expression is higher in hair follicles from males than from females.1 Publication

    Inductioni

    By dihydrotestosterone (DHT).1 Publication

    Gene expression databases

    ArrayExpressiQ9NVV5.
    BgeeiQ9NVV5.
    CleanExiHS_AIG1.
    GenevestigatoriQ9NVV5.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    RCHY1Q96PM54EBI-3942989,EBI-947779

    Protein-protein interaction databases

    BioGridi119519. 1 interaction.
    IntActiQ9NVV5. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NVV5.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei39 – 5921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei88 – 10821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei124 – 14421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei167 – 18721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei197 – 21721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AIG1 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG311793.
    HOVERGENiHBG050468.
    InParanoidiQ9NVV5.
    OMAiVFVVTMF.
    PhylomeDBiQ9NVV5.
    TreeFamiTF318170.

    Family and domain databases

    InterProiIPR006838. Far-17a_AIG1.
    [Graphical view]
    PfamiPF04750. Far-17a_AIG1. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NVV5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MALVPCQVLR MAILLSYCSI LCNYKAIEMP SHQTYGGSWK FLTFIDLVIQ    50
    AVFFGICVLT DLSSLLTRGS GNQEQERQLK KLISLRDWML AVLAFPVGVF 100
    VVAVFWIIYA YDREMIYPKL LDNFIPGWLN HGMHTTVLPF ILIEMRTSHH 150
    QYPSRSSGLT AICTFSVGYI LWVCWVHHVT GMWVYPFLEH IGPGARIIFF 200
    GSTTILMNFL YLLGEVLNNY IWDTQKKPPS WQDMKIKFMY LGPSS 245
    Length:245
    Mass (Da):28,222
    Last modified:December 21, 2004 - v2
    Checksum:i06C0C8A6BDBF3694
    GO
    Isoform 2 (identifier: Q9NVV5-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         227-245: KPPSWQDMKIKFMYLGPSS → SMEEEKEKPKLE

    Show »
    Length:238
    Mass (Da):27,458
    Checksum:iDF5D5B8FC41A2C95
    GO
    Isoform 3 (identifier: Q9NVV5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         48-99: Missing.
         227-245: KPPSWQDMKIKFMYLGPSS → SMEEEKEKPKLE

    Show »
    Length:186
    Mass (Da):21,715
    Checksum:i77322CC43C44F5C2
    GO
    Isoform 4 (identifier: Q9NVV5-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-10: Missing.
         227-245: KPPSWQDMKIKFMYLGPSS → SMEEEKEKPKLE

    Note: No experimental confirmation available.

    Show »
    Length:228
    Mass (Da):26,347
    Checksum:i761CD65BB7F9F159
    GO
    Isoform 5 (identifier: Q9NVV5-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         135-137: TTV → FKA
         138-245: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:137
    Mass (Da):15,713
    Checksum:i7EEF2A92A3787CA3
    GO
    Isoform 6 (identifier: Q9NVV5-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         134-245: HTTVLPFILI...IKFMYLGPSS → L

    Note: No experimental confirmation available.

    Show »
    Length:134
    Mass (Da):15,342
    Checksum:i6463787CA31E154B
    GO

    Sequence cautioni

    The sequence AAD34098.1 differs from that shown. Reason: Frameshift at positions 182, 193 and 223.
    The sequence CAE45823.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti70 – 701S → I in AAD41087. (PubMed:11266118)Curated
    Sequence conflicti191 – 1911I → F in BAA91640. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti151 – 1511Q → E.
    Corresponds to variant rs1053193 [ dbSNP | Ensembl ].
    VAR_057502

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1010Missing in isoform 4. 1 PublicationVSP_012314
    Alternative sequencei48 – 9952Missing in isoform 3. 1 PublicationVSP_012315Add
    BLAST
    Alternative sequencei134 – 245112HTTVL…LGPSS → L in isoform 6. 1 PublicationVSP_054641Add
    BLAST
    Alternative sequencei135 – 1373TTV → FKA in isoform 5. 1 PublicationVSP_012316
    Alternative sequencei138 – 245108Missing in isoform 5. 1 PublicationVSP_012317Add
    BLAST
    Alternative sequencei227 – 24519KPPSW…LGPSS → SMEEEKEKPKLE in isoform 2, isoform 3 and isoform 4. 4 PublicationsVSP_012318Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF153605 mRNA. Translation: AAD41087.1.
    AF151861 mRNA. Translation: AAD34098.1. Frameshift.
    AK001347 mRNA. Translation: BAA91640.1.
    BX538067 mRNA. Translation: CAD97997.1.
    BX640703 mRNA. Translation: CAE45823.1. Different initiation.
    AK298533 mRNA. Translation: BAG60734.1.
    AL391726, AL023581, AL136116 Genomic DNA. Translation: CAI16930.1.
    AL023581, AL136116, AL391726 Genomic DNA. Translation: CAI21392.1.
    AL023581, AL136116, AL391726 Genomic DNA. Translation: CAI21393.1.
    AL136116, AL023581, AL391726 Genomic DNA. Translation: CAI23451.1.
    AL136116, AL023581, AL391726 Genomic DNA. Translation: CAI23452.1.
    AL391726, AL023581, AL136116 Genomic DNA. Translation: CAI16931.1.
    AL450335 Genomic DNA. No translation available.
    BC025278 mRNA. Translation: AAH25278.1.
    CCDSiCCDS5198.1. [Q9NVV5-2]
    CCDS69215.1. [Q9NVV5-6]
    CCDS69216.1. [Q9NVV5-5]
    RefSeqiNP_001273516.1. NM_001286587.1. [Q9NVV5-4]
    NP_001273517.1. NM_001286588.1. [Q9NVV5-6]
    NP_001273518.1. NM_001286589.1. [Q9NVV5-5]
    NP_057192.2. NM_016108.3. [Q9NVV5-2]
    XP_005267067.1. XM_005267010.2. [Q9NVV5-1]
    UniGeneiHs.567501.

    Genome annotation databases

    EnsembliENST00000275235; ENSP00000275235; ENSG00000146416. [Q9NVV5-1]
    ENST00000344492; ENSP00000340090; ENSG00000146416. [Q9NVV5-3]
    ENST00000357847; ENSP00000350509; ENSG00000146416. [Q9NVV5-2]
    ENST00000494282; ENSP00000473952; ENSG00000146416. [Q9NVV5-5]
    GeneIDi51390.
    KEGGihsa:51390.
    UCSCiuc003qjf.3. human. [Q9NVV5-4]
    uc003qjg.3. human. [Q9NVV5-5]
    uc003qjh.3. human. [Q9NVV5-2]
    uc003qji.3. human. [Q9NVV5-3]

    Polymorphism databases

    DMDMi56748615.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF153605 mRNA. Translation: AAD41087.1 .
    AF151861 mRNA. Translation: AAD34098.1 . Frameshift.
    AK001347 mRNA. Translation: BAA91640.1 .
    BX538067 mRNA. Translation: CAD97997.1 .
    BX640703 mRNA. Translation: CAE45823.1 . Different initiation.
    AK298533 mRNA. Translation: BAG60734.1 .
    AL391726 , AL023581 , AL136116 Genomic DNA. Translation: CAI16930.1 .
    AL023581 , AL136116 , AL391726 Genomic DNA. Translation: CAI21392.1 .
    AL023581 , AL136116 , AL391726 Genomic DNA. Translation: CAI21393.1 .
    AL136116 , AL023581 , AL391726 Genomic DNA. Translation: CAI23451.1 .
    AL136116 , AL023581 , AL391726 Genomic DNA. Translation: CAI23452.1 .
    AL391726 , AL023581 , AL136116 Genomic DNA. Translation: CAI16931.1 .
    AL450335 Genomic DNA. No translation available.
    BC025278 mRNA. Translation: AAH25278.1 .
    CCDSi CCDS5198.1. [Q9NVV5-2 ]
    CCDS69215.1. [Q9NVV5-6 ]
    CCDS69216.1. [Q9NVV5-5 ]
    RefSeqi NP_001273516.1. NM_001286587.1. [Q9NVV5-4 ]
    NP_001273517.1. NM_001286588.1. [Q9NVV5-6 ]
    NP_001273518.1. NM_001286589.1. [Q9NVV5-5 ]
    NP_057192.2. NM_016108.3. [Q9NVV5-2 ]
    XP_005267067.1. XM_005267010.2. [Q9NVV5-1 ]
    UniGenei Hs.567501.

    3D structure databases

    ProteinModelPortali Q9NVV5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119519. 1 interaction.
    IntActi Q9NVV5. 1 interaction.

    PTM databases

    PhosphoSitei Q9NVV5.

    Polymorphism databases

    DMDMi 56748615.

    Proteomic databases

    MaxQBi Q9NVV5.
    PaxDbi Q9NVV5.
    PRIDEi Q9NVV5.

    Protocols and materials databases

    DNASUi 51390.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000275235 ; ENSP00000275235 ; ENSG00000146416 . [Q9NVV5-1 ]
    ENST00000344492 ; ENSP00000340090 ; ENSG00000146416 . [Q9NVV5-3 ]
    ENST00000357847 ; ENSP00000350509 ; ENSG00000146416 . [Q9NVV5-2 ]
    ENST00000494282 ; ENSP00000473952 ; ENSG00000146416 . [Q9NVV5-5 ]
    GeneIDi 51390.
    KEGGi hsa:51390.
    UCSCi uc003qjf.3. human. [Q9NVV5-4 ]
    uc003qjg.3. human. [Q9NVV5-5 ]
    uc003qjh.3. human. [Q9NVV5-2 ]
    uc003qji.3. human. [Q9NVV5-3 ]

    Organism-specific databases

    CTDi 51390.
    GeneCardsi GC06P143423.
    HGNCi HGNC:21607. AIG1.
    MIMi 608514. gene.
    neXtProti NX_Q9NVV5.
    PharmGKBi PA134991331.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG311793.
    HOVERGENi HBG050468.
    InParanoidi Q9NVV5.
    OMAi VFVVTMF.
    PhylomeDBi Q9NVV5.
    TreeFami TF318170.

    Miscellaneous databases

    ChiTaRSi AIG1. human.
    GeneWikii AIG1.
    GenomeRNAii 51390.
    NextBioi 35473988.
    PROi Q9NVV5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NVV5.
    Bgeei Q9NVV5.
    CleanExi HS_AIG1.
    Genevestigatori Q9NVV5.

    Family and domain databases

    InterProi IPR006838. Far-17a_AIG1.
    [Graphical view ]
    Pfami PF04750. Far-17a_AIG1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of androgen-inducible gene 1 (AIG1) from human dermal papilla cells."
      Seo J., Kim J., Kim M.
      Mol. Cells 11:35-40(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, INDUCTION.
      Tissue: Hair follicle dermal papilla.
    2. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
      Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
      Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 6).
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 5).
      Tissue: Prostate and Rectum tumor.
    5. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Skin.

    Entry informationi

    Entry nameiAIG1_HUMAN
    AccessioniPrimary (citable) accession number: Q9NVV5
    Secondary accession number(s): B4DPX2
    , C9J569, Q5T2H2, Q6N047, Q7Z378, Q8TB14, Q9Y3A9, Q9Y5B4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 21, 2004
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3