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Protein

Androgen-induced gene 1 protein

Gene

AIG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in androgen-regulated growth of hair follicles.

Names & Taxonomyi

Protein namesi
Recommended name:
Androgen-induced gene 1 protein
Short name:
AIG-1
Gene namesi
Name:AIG1
ORF Names:CGI-103
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:21607. AIG1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalSequence AnalysisAdd
BLAST
Transmembranei39 – 5921HelicalSequence AnalysisAdd
BLAST
Transmembranei88 – 10821HelicalSequence AnalysisAdd
BLAST
Transmembranei124 – 14421HelicalSequence AnalysisAdd
BLAST
Transmembranei167 – 18721HelicalSequence AnalysisAdd
BLAST
Transmembranei197 – 21721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134991331.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 245245Androgen-induced gene 1 proteinPRO_0000190098Add
BLAST

Proteomic databases

MaxQBiQ9NVV5.
PaxDbiQ9NVV5.
PRIDEiQ9NVV5.

PTM databases

PhosphoSiteiQ9NVV5.

Expressioni

Tissue specificityi

Highly expressed in heart, ovary, testis, liver, and kidney, at lower levels in spleen, prostate, brain, skeletal muscle, pancreas, small intestine and colon, and undetected in peripheral blood leukocytes, thymus, lung and placenta. AIG1 expression is higher in hair follicles from males than from females.1 Publication

Inductioni

By dihydrotestosterone (DHT).1 Publication

Gene expression databases

BgeeiQ9NVV5.
CleanExiHS_AIG1.
ExpressionAtlasiQ9NVV5. baseline and differential.
GenevestigatoriQ9NVV5.

Organism-specific databases

HPAiHPA060766.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RCHY1Q96PM54EBI-3942989,EBI-947779

Protein-protein interaction databases

BioGridi119519. 1 interaction.
IntActiQ9NVV5. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9NVV5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIG1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG311793.
GeneTreeiENSGT00390000012526.
HOVERGENiHBG050468.
InParanoidiQ9NVV5.
OMAiWDTQRSK.
PhylomeDBiQ9NVV5.
TreeFamiTF318170.

Family and domain databases

InterProiIPR006838. Far-17a_AIG1.
[Graphical view]
PfamiPF04750. Far-17a_AIG1. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NVV5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALVPCQVLR MAILLSYCSI LCNYKAIEMP SHQTYGGSWK FLTFIDLVIQ
60 70 80 90 100
AVFFGICVLT DLSSLLTRGS GNQEQERQLK KLISLRDWML AVLAFPVGVF
110 120 130 140 150
VVAVFWIIYA YDREMIYPKL LDNFIPGWLN HGMHTTVLPF ILIEMRTSHH
160 170 180 190 200
QYPSRSSGLT AICTFSVGYI LWVCWVHHVT GMWVYPFLEH IGPGARIIFF
210 220 230 240
GSTTILMNFL YLLGEVLNNY IWDTQKKPPS WQDMKIKFMY LGPSS
Length:245
Mass (Da):28,222
Last modified:December 21, 2004 - v2
Checksum:i06C0C8A6BDBF3694
GO
Isoform 2 (identifier: Q9NVV5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     227-245: KPPSWQDMKIKFMYLGPSS → SMEEEKEKPKLE

Show »
Length:238
Mass (Da):27,458
Checksum:iDF5D5B8FC41A2C95
GO
Isoform 3 (identifier: Q9NVV5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-99: Missing.
     227-245: KPPSWQDMKIKFMYLGPSS → SMEEEKEKPKLE

Show »
Length:186
Mass (Da):21,715
Checksum:i77322CC43C44F5C2
GO
Isoform 4 (identifier: Q9NVV5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: Missing.
     227-245: KPPSWQDMKIKFMYLGPSS → SMEEEKEKPKLE

Note: No experimental confirmation available.

Show »
Length:228
Mass (Da):26,347
Checksum:i761CD65BB7F9F159
GO
Isoform 5 (identifier: Q9NVV5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     135-137: TTV → FKA
     138-245: Missing.

Note: No experimental confirmation available.

Show »
Length:137
Mass (Da):15,713
Checksum:i7EEF2A92A3787CA3
GO
Isoform 6 (identifier: Q9NVV5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     134-245: HTTVLPFILI...IKFMYLGPSS → L

Note: No experimental confirmation available.

Show »
Length:134
Mass (Da):15,342
Checksum:i6463787CA31E154B
GO

Sequence cautioni

The sequence AAD34098.1 differs from that shown. Reason: Frameshift at positions 182, 193 and 223. Curated
The sequence CAE45823.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti70 – 701S → I in AAD41087 (PubMed:11266118).Curated
Sequence conflicti191 – 1911I → F in BAA91640 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti151 – 1511Q → E.
Corresponds to variant rs1053193 [ dbSNP | Ensembl ].
VAR_057502

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1010Missing in isoform 4. 1 PublicationVSP_012314
Alternative sequencei48 – 9952Missing in isoform 3. 1 PublicationVSP_012315Add
BLAST
Alternative sequencei134 – 245112HTTVL…LGPSS → L in isoform 6. 1 PublicationVSP_054641Add
BLAST
Alternative sequencei135 – 1373TTV → FKA in isoform 5. 1 PublicationVSP_012316
Alternative sequencei138 – 245108Missing in isoform 5. 1 PublicationVSP_012317Add
BLAST
Alternative sequencei227 – 24519KPPSW…LGPSS → SMEEEKEKPKLE in isoform 2, isoform 3 and isoform 4. 4 PublicationsVSP_012318Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153605 mRNA. Translation: AAD41087.1.
AF151861 mRNA. Translation: AAD34098.1. Frameshift.
AK001347 mRNA. Translation: BAA91640.1.
BX538067 mRNA. Translation: CAD97997.1.
BX640703 mRNA. Translation: CAE45823.1. Different initiation.
AK298533 mRNA. Translation: BAG60734.1.
AL391726, AL023581, AL136116 Genomic DNA. Translation: CAI16930.1.
AL023581, AL136116, AL391726 Genomic DNA. Translation: CAI21392.1.
AL023581, AL136116, AL391726 Genomic DNA. Translation: CAI21393.1.
AL136116, AL023581, AL391726 Genomic DNA. Translation: CAI23451.1.
AL136116, AL023581, AL391726 Genomic DNA. Translation: CAI23452.1.
AL391726, AL023581, AL136116 Genomic DNA. Translation: CAI16931.1.
AL450335 Genomic DNA. No translation available.
BC025278 mRNA. Translation: AAH25278.1.
CCDSiCCDS5198.1. [Q9NVV5-2]
CCDS69216.1. [Q9NVV5-5]
RefSeqiNP_001273516.1. NM_001286587.1. [Q9NVV5-4]
NP_001273517.1. NM_001286588.1. [Q9NVV5-6]
NP_001273518.1. NM_001286589.1. [Q9NVV5-5]
NP_057192.2. NM_016108.3. [Q9NVV5-2]
XP_005267067.1. XM_005267010.2. [Q9NVV5-1]
UniGeneiHs.567501.

Genome annotation databases

EnsembliENST00000275235; ENSP00000275235; ENSG00000146416. [Q9NVV5-1]
ENST00000357847; ENSP00000350509; ENSG00000146416. [Q9NVV5-2]
ENST00000494282; ENSP00000473952; ENSG00000146416. [Q9NVV5-5]
GeneIDi51390.
KEGGihsa:51390.
UCSCiuc003qjf.3. human. [Q9NVV5-4]
uc003qjg.3. human. [Q9NVV5-5]
uc003qjh.3. human. [Q9NVV5-2]
uc003qji.3. human. [Q9NVV5-3]
uc011edw.1. human.

Polymorphism databases

DMDMi56748615.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF153605 mRNA. Translation: AAD41087.1.
AF151861 mRNA. Translation: AAD34098.1. Frameshift.
AK001347 mRNA. Translation: BAA91640.1.
BX538067 mRNA. Translation: CAD97997.1.
BX640703 mRNA. Translation: CAE45823.1. Different initiation.
AK298533 mRNA. Translation: BAG60734.1.
AL391726, AL023581, AL136116 Genomic DNA. Translation: CAI16930.1.
AL023581, AL136116, AL391726 Genomic DNA. Translation: CAI21392.1.
AL023581, AL136116, AL391726 Genomic DNA. Translation: CAI21393.1.
AL136116, AL023581, AL391726 Genomic DNA. Translation: CAI23451.1.
AL136116, AL023581, AL391726 Genomic DNA. Translation: CAI23452.1.
AL391726, AL023581, AL136116 Genomic DNA. Translation: CAI16931.1.
AL450335 Genomic DNA. No translation available.
BC025278 mRNA. Translation: AAH25278.1.
CCDSiCCDS5198.1. [Q9NVV5-2]
CCDS69216.1. [Q9NVV5-5]
RefSeqiNP_001273516.1. NM_001286587.1. [Q9NVV5-4]
NP_001273517.1. NM_001286588.1. [Q9NVV5-6]
NP_001273518.1. NM_001286589.1. [Q9NVV5-5]
NP_057192.2. NM_016108.3. [Q9NVV5-2]
XP_005267067.1. XM_005267010.2. [Q9NVV5-1]
UniGeneiHs.567501.

3D structure databases

ProteinModelPortaliQ9NVV5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119519. 1 interaction.
IntActiQ9NVV5. 1 interaction.

PTM databases

PhosphoSiteiQ9NVV5.

Polymorphism databases

DMDMi56748615.

Proteomic databases

MaxQBiQ9NVV5.
PaxDbiQ9NVV5.
PRIDEiQ9NVV5.

Protocols and materials databases

DNASUi51390.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275235; ENSP00000275235; ENSG00000146416. [Q9NVV5-1]
ENST00000357847; ENSP00000350509; ENSG00000146416. [Q9NVV5-2]
ENST00000494282; ENSP00000473952; ENSG00000146416. [Q9NVV5-5]
GeneIDi51390.
KEGGihsa:51390.
UCSCiuc003qjf.3. human. [Q9NVV5-4]
uc003qjg.3. human. [Q9NVV5-5]
uc003qjh.3. human. [Q9NVV5-2]
uc003qji.3. human. [Q9NVV5-3]
uc011edw.1. human.

Organism-specific databases

CTDi51390.
GeneCardsiGC06P143423.
HGNCiHGNC:21607. AIG1.
HPAiHPA060766.
MIMi608514. gene.
neXtProtiNX_Q9NVV5.
PharmGKBiPA134991331.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG311793.
GeneTreeiENSGT00390000012526.
HOVERGENiHBG050468.
InParanoidiQ9NVV5.
OMAiWDTQRSK.
PhylomeDBiQ9NVV5.
TreeFamiTF318170.

Miscellaneous databases

ChiTaRSiAIG1. human.
GeneWikiiAIG1.
GenomeRNAii51390.
NextBioi35473988.
PROiQ9NVV5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NVV5.
CleanExiHS_AIG1.
ExpressionAtlasiQ9NVV5. baseline and differential.
GenevestigatoriQ9NVV5.

Family and domain databases

InterProiIPR006838. Far-17a_AIG1.
[Graphical view]
PfamiPF04750. Far-17a_AIG1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of androgen-inducible gene 1 (AIG1) from human dermal papilla cells."
    Seo J., Kim J., Kim M.
    Mol. Cells 11:35-40(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, INDUCTION.
    Tissue: Hair follicle dermal papilla.
  2. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 6).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 5).
    Tissue: Prostate and Rectum tumor.
  5. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Skin.

Entry informationi

Entry nameiAIG1_HUMAN
AccessioniPrimary (citable) accession number: Q9NVV5
Secondary accession number(s): B4DPX2
, C9J569, Q5T2H2, Q6N047, Q7Z378, Q8TB14, Q9Y3A9, Q9Y5B4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 21, 2004
Last modified: March 4, 2015
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.