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Q9NVV5 (AIG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Androgen-induced gene 1 protein

Short name=AIG-1
Gene names
Name:AIG1
ORF Names:CGI-103
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length245 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in androgen-regulated growth of hair follicles.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Highly expressed in heart, ovary, testis, liver, and kidney, at lower levels in spleen, prostate, brain, skeletal muscle, pancreas, small intestine and colon, and undetected in peripheral blood leukocytes, thymus, lung and placenta. AIG1 expression is higher in hair follicles from males than from females. Ref.1

Induction

By dihydrotestosterone (DHT). Ref.1

Sequence similarities

Belongs to the AIG1 family.

Sequence caution

The sequence AAD34098.1 differs from that shown. Reason: Frameshift at positions 182, 193 and 223.

The sequence CAE45823.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

RCHY1Q96PM54EBI-3942989,EBI-947779

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NVV5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NVV5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     227-245: KPPSWQDMKIKFMYLGPSS → SMEEEKEKPKLE
Isoform 3 (identifier: Q9NVV5-3)

The sequence of this isoform differs from the canonical sequence as follows:
     48-99: Missing.
     227-245: KPPSWQDMKIKFMYLGPSS → SMEEEKEKPKLE
Isoform 4 (identifier: Q9NVV5-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: Missing.
     227-245: KPPSWQDMKIKFMYLGPSS → SMEEEKEKPKLE
Note: No experimental confirmation available.
Isoform 5 (identifier: Q9NVV5-5)

The sequence of this isoform differs from the canonical sequence as follows:
     135-137: TTV → FKA
     138-245: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 245245Androgen-induced gene 1 protein
PRO_0000190098

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane39 – 5921Helical; Potential
Transmembrane88 – 10821Helical; Potential
Transmembrane124 – 14421Helical; Potential
Transmembrane167 – 18721Helical; Potential
Transmembrane197 – 21721Helical; Potential

Natural variations

Alternative sequence1 – 1010Missing in isoform 4.
VSP_012314
Alternative sequence48 – 9952Missing in isoform 3.
VSP_012315
Alternative sequence135 – 1373TTV → FKA in isoform 5.
VSP_012316
Alternative sequence138 – 245108Missing in isoform 5.
VSP_012317
Alternative sequence227 – 24519KPPSW…LGPSS → SMEEEKEKPKLE in isoform 2, isoform 3 and isoform 4.
VSP_012318
Natural variant1511Q → E.
Corresponds to variant rs1053193 [ dbSNP | Ensembl ].
VAR_057502

Experimental info

Sequence conflict701S → I in AAD41087. Ref.1
Sequence conflict1911I → F in BAA91640. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 21, 2004. Version 2.
Checksum: 06C0C8A6BDBF3694

FASTA24528,222
        10         20         30         40         50         60 
MALVPCQVLR MAILLSYCSI LCNYKAIEMP SHQTYGGSWK FLTFIDLVIQ AVFFGICVLT 

        70         80         90        100        110        120 
DLSSLLTRGS GNQEQERQLK KLISLRDWML AVLAFPVGVF VVAVFWIIYA YDREMIYPKL 

       130        140        150        160        170        180 
LDNFIPGWLN HGMHTTVLPF ILIEMRTSHH QYPSRSSGLT AICTFSVGYI LWVCWVHHVT 

       190        200        210        220        230        240 
GMWVYPFLEH IGPGARIIFF GSTTILMNFL YLLGEVLNNY IWDTQKKPPS WQDMKIKFMY 


LGPSS 

« Hide

Isoform 2 [UniParc].

Checksum: DF5D5B8FC41A2C95
Show »

FASTA23827,458
Isoform 3 [UniParc].

Checksum: 77322CC43C44F5C2
Show »

FASTA18621,715
Isoform 4 [UniParc].

Checksum: 761CD65BB7F9F159
Show »

FASTA22826,347
Isoform 5 [UniParc].

Checksum: 7EEF2A92A3787CA3
Show »

FASTA13715,713

References

« Hide 'large scale' references
[1]"Cloning of androgen-inducible gene 1 (AIG1) from human dermal papilla cells."
Seo J., Kim J., Kim M.
Mol. Cells 11:35-40(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, INDUCTION.
Tissue: Hair follicle dermal papilla.
[2]"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 5).
Tissue: Prostate and Rectum tumor.
[5]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Skin.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF153605 mRNA. Translation: AAD41087.1.
AF151861 mRNA. Translation: AAD34098.1. Frameshift.
AK001347 mRNA. Translation: BAA91640.1.
BX538067 mRNA. Translation: CAD97997.1.
BX640703 mRNA. Translation: CAE45823.1. Different initiation.
AL391726, AL023581, AL136116 Genomic DNA. Translation: CAI16930.1.
AL023581, AL136116, AL391726 Genomic DNA. Translation: CAI21392.1.
AL023581, AL136116, AL391726 Genomic DNA. Translation: CAI21393.1.
AL136116, AL023581, AL391726 Genomic DNA. Translation: CAI23451.1.
AL136116, AL023581, AL391726 Genomic DNA. Translation: CAI23452.1.
AL391726, AL023581, AL136116 Genomic DNA. Translation: CAI16931.1.
BC025278 mRNA. Translation: AAH25278.1.
RefSeqNP_001273516.1. NM_001286587.1.
NP_001273517.1. NM_001286588.1.
NP_001273518.1. NM_001286589.1.
NP_057192.2. NM_016108.3.
XP_005267067.1. XM_005267010.2.
UniGeneHs.567501.

3D structure databases

ProteinModelPortalQ9NVV5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119519. 1 interaction.
IntActQ9NVV5. 1 interaction.

PTM databases

PhosphoSiteQ9NVV5.

Polymorphism databases

DMDM56748615.

Proteomic databases

PaxDbQ9NVV5.
PRIDEQ9NVV5.

Protocols and materials databases

DNASU51390.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000275235; ENSP00000275235; ENSG00000146416. [Q9NVV5-1]
ENST00000344492; ENSP00000340090; ENSG00000146416. [Q9NVV5-3]
ENST00000357847; ENSP00000350509; ENSG00000146416. [Q9NVV5-2]
ENST00000494282; ENSP00000473952; ENSG00000146416. [Q9NVV5-5]
GeneID51390.
KEGGhsa:51390.
UCSCuc003qjf.3. human. [Q9NVV5-4]
uc003qjg.3. human. [Q9NVV5-5]
uc003qjh.3. human. [Q9NVV5-2]
uc003qji.3. human. [Q9NVV5-3]

Organism-specific databases

CTD51390.
GeneCardsGC06P143423.
HGNCHGNC:21607. AIG1.
MIM608514. gene.
neXtProtNX_Q9NVV5.
PharmGKBPA134991331.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG311793.
HOVERGENHBG050468.
InParanoidQ9NVV5.
OMAVFVVTMF.
PhylomeDBQ9NVV5.
TreeFamTF318170.

Gene expression databases

ArrayExpressQ9NVV5.
BgeeQ9NVV5.
CleanExHS_AIG1.
GenevestigatorQ9NVV5.

Family and domain databases

InterProIPR006838. Far-17a_AIG1.
[Graphical view]
PfamPF04750. Far-17a_AIG1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSAIG1. human.
GeneWikiAIG1.
GenomeRNAi51390.
NextBio54921.
PROQ9NVV5.
SOURCESearch...

Entry information

Entry nameAIG1_HUMAN
AccessionPrimary (citable) accession number: Q9NVV5
Secondary accession number(s): Q5T2H2 expand/collapse secondary AC list , Q6N047, Q7Z378, Q8TB14, Q9Y3A9, Q9Y5B4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 21, 2004
Last modified: April 16, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM