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Q9NVU7 (SDA1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein SDA1 homolog
Alternative name(s):
Nucleolar protein 130
SDA1 domain-containing protein 1
Short name=hSDA
Gene names
Name:SDAD1
Synonyms:NUC130
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length687 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for 60S pre-ribosomal subunits export to the cytoplasm By similarity.

Subcellular location

Nucleusnucleolus Ref.5 Ref.6.

Tissue specificity

Highly expressed in testis, kidney, spleen, brain and fetal tissues. Also expressed at lower level in heart, lung, liver, small intestine, ovary, uterus, mammary gland and placenta. Ref.6 Ref.7

Polymorphism

Variations in SDAD1 may be a cause of susceptibility to seasonal allergic rhinitis (SAR). SAR is a common allergic disorder characterized by episodes of sneezing, rhinorrhea, and swelling of the nasal mucosa.

Miscellaneous

DAZL and PUM2 bind its 3'-UTR mRNA, suggesting that these proteins may regulate its translation.

Sequence similarities

Belongs to the SDA1 family.

Sequence caution

The sequence AAI07896.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

The sequence BAA91648.1 differs from that shown. Reason: Frameshift at position 53.

The sequence BAB14177.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAB14790.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

TGIF1Q155831EBI-1043768,EBI-714215

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NVU7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NVU7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 687687Protein SDA1 homolog
PRO_0000287482

Regions

Coiled coil253 – 31563 Potential

Amino acid modifications

Modified residue2321Phosphoserine Ref.12 Ref.16
Modified residue2341Phosphoserine Ref.12 Ref.16
Modified residue2361Phosphoserine Ref.12 Ref.16
Modified residue5851Phosphoserine Ref.9 Ref.10 Ref.11 Ref.12 Ref.14 Ref.16
Modified residue5951Phosphoserine Ref.16

Natural variations

Alternative sequence1 – 9797Missing in isoform 2.
VSP_025505
Natural variant2581K → Q.
Corresponds to variant rs15481 [ dbSNP | Ensembl ].
VAR_032312
Natural variant4901A → D.
Corresponds to variant rs34627298 [ dbSNP | Ensembl ].
VAR_032313
Natural variant5751S → C. Ref.1 Ref.4
Corresponds to variant rs2242471 [ dbSNP | Ensembl ].
VAR_032314
Natural variant6601V → I.
Corresponds to variant rs17001276 [ dbSNP | Ensembl ].
VAR_032315

Experimental info

Sequence conflict1861E → G in CAH18368. Ref.1
Sequence conflict2881H → L in BAA91648. Ref.4
Sequence conflict3191N → S in CAH18368. Ref.1
Sequence conflict3961N → S in CAH18368. Ref.1
Sequence conflict6171A → S in BAB14177. Ref.4
Sequence conflict6341T → A in CAH18368. Ref.1
Sequence conflict6511F → L in CAH18368. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: B01EE09383EA959C

FASTA68779,871
        10         20         30         40         50         60 
MSNRNNNKLP SNLPQLQNLI KRDPPAYIEE FLQQYNHYKS NVEIFKLQPN KPSKELAELV 

        70         80         90        100        110        120 
MFMAQISHCY PEYLSNFPQE VKDLLSCNHT VLDPDLRMTF CKALILLRNK NLINPSSLLE 

       130        140        150        160        170        180 
LFFELFRCHD KLLRKTLYTH IVTDIKNINA KHKNNKVNVV LQNFMYTMLR DSNATAAKMS 

       190        200        210        220        230        240 
LDVMIELYRR NIWNDAKTVN VITTACFSKV TKILVAALTF FLGKDEDEKQ DSDSESEDDG 

       250        260        270        280        290        300 
PTARDLLVQY ATGKKSSKNK KKLEKAMKVL KKQKKKKKPE VFNFSAIHLI HDPQDFAEKL 

       310        320        330        340        350        360 
LKQLECCKER FEVKMMLMNL ISRLVGIHEL FLFNFYPFLQ RFLQPHQREV TKILLFAAQA 

       370        380        390        400        410        420 
SHHLVPPEII QSLLMTVANN FVTDKNSGEV MTVGINAIKE ITARCPLAMT EELLQDLAQY 

       430        440        450        460        470        480 
KTHKDKNVMM SARTLIHLFR TLNPQMLQKK FRGKPTEASI EARVQEYGEL DAKDYIPGAE 

       490        500        510        520        530        540 
VLEVEKEENA ENDEDGWEST SLSEEEDADG EWIDVQHSSD EEQQEISKKL NSMPMEERKA 

       550        560        570        580        590        600 
KAAAISTSRV LTQEDFQKIR MAQMRKELDA APGKSQKRKY IEIDSDEEPR GELLSLRDIE 

       610        620        630        640        650        660 
RLHKKPKSDK ETRLATAMAG KTDRKEFVRK KTKTNPFSSS TNKEKKKQKN FMMMRYSQNV 

       670        680 
RSKNKRSFRE KQLALRDALL KKRKRMK 

« Hide

Isoform 2 [UniParc].

Checksum: 06780B225C43F041
Show »

FASTA59068,455

References

« Hide 'large scale' references
[1]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT CYS-575.
Tissue: Rectum tumor.
[2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-277 (ISOFORM 1).
Tissue: PNS and Uterus.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 50-687 (ISOFORM 1), VARIANT CYS-575.
[5]"Directed proteomic analysis of the human nucleolus."
Andersen J.S., Lyon C.E., Fox A.H., Leung A.K.L., Lam Y.W., Steen H., Mann M., Lamond A.I.
Curr. Biol. 12:1-11(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[6]"Expression and localization studies of hSDA, the human ortholog of the yeast SDA1 gene."
Babbio F., Farinacci M., Saracino F., Carbone M.L., Privitera E.
Cell Cycle 3:486-490(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[7]"Identification and characterization of RNA sequences to which human PUMILIO-2 (PUM2) and deleted in Azoospermia-like (DAZL) bind."
Fox M., Urano J., Reijo Pera R.A.
Genomics 85:92-105(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[8]"Association of a haplotype block spanning SDAD1 gene and CXC chemokine genes with allergic rhinitis."
Zhang J., Noguchi E., Migita O., Yokouchi Y., Nakayama J., Shibasaki M., Arinami T.
J. Allergy Clin. Immunol. 115:548-554(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: POLYMORPHISM.
[9]"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-585, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-585, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[11]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-585, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[12]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-232; SER-234; SER-236 AND SER-585, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[13]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-585, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[15]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[16]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-232; SER-234; SER-236; SER-585 AND SER-595, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR749574 mRNA. Translation: CAH18368.1.
AC110615 Genomic DNA. No translation available.
AC112719 Genomic DNA. No translation available.
AC115628 Genomic DNA. No translation available.
BC054040 mRNA. Translation: AAH54040.1.
BC063797 mRNA. Translation: AAH63797.1.
BC107895 mRNA. Translation: AAI07896.1. Sequence problems.
AK001360 mRNA. Translation: BAA91648.1. Frameshift.
AK022683 mRNA. Translation: BAB14177.1. Different initiation.
AK024031 mRNA. Translation: BAB14790.1. Different initiation.
CCDSCCDS3573.2. [Q9NVU7-1]
RefSeqNP_001275912.1. NM_001288983.1.
NP_001275913.1. NM_001288984.1. [Q9NVU7-2]
NP_060585.2. NM_018115.3. [Q9NVU7-1]
XP_005263162.1. XM_005263105.2. [Q9NVU7-2]
UniGeneHs.632604.

3D structure databases

ProteinModelPortalQ9NVU7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120456. 7 interactions.
IntActQ9NVU7. 4 interactions.
MINTMINT-4994740.
STRING9606.ENSP00000348596.

PTM databases

PhosphoSiteQ9NVU7.

Polymorphism databases

DMDM296452964.

Proteomic databases

MaxQBQ9NVU7.
PaxDbQ9NVU7.
PeptideAtlasQ9NVU7.
PRIDEQ9NVU7.

Protocols and materials databases

DNASU55153.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000356260; ENSP00000348596; ENSG00000198301. [Q9NVU7-1]
GeneID55153.
KEGGhsa:55153.
UCSCuc003hje.4. human. [Q9NVU7-1]

Organism-specific databases

CTD55153.
GeneCardsGC04M076871.
H-InvDBHIX0025559.
HGNCHGNC:25537. SDAD1.
HPAHPA035949.
neXtProtNX_Q9NVU7.
PharmGKBPA134961441.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG292808.
HOGENOMHOG000204601.
HOVERGENHBG059552.
InParanoidQ9NVU7.
KOK14856.
OMAQVAQCYP.
OrthoDBEOG7QG43K.
PhylomeDBQ9NVU7.
TreeFamTF105727.

Gene expression databases

ArrayExpressQ9NVU7.
BgeeQ9NVU7.
CleanExHS_SDAD1.
GenevestigatorQ9NVU7.

Family and domain databases

InterProIPR016024. ARM-type_fold.
IPR027312. Sda1.
IPR007949. SDA1_dom.
IPR012977. Uncharacterised_NUC130/133_N.
[Graphical view]
PANTHERPTHR12730:SF0. PTHR12730:SF0. 1 hit.
PfamPF08158. NUC130_3NT. 1 hit.
PF05285. SDA1. 1 hit.
[Graphical view]
SUPFAMSSF48371. SSF48371. 2 hits.
ProtoNetSearch...

Other

GeneWikiSDAD1.
GenomeRNAi55153.
NextBio58895.
PROQ9NVU7.

Entry information

Entry nameSDA1_HUMAN
AccessionPrimary (citable) accession number: Q9NVU7
Secondary accession number(s): Q32Q11 expand/collapse secondary AC list , Q68D52, Q7Z5U4, Q9H831, Q9H9P6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM