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Protein

Protein SDA1 homolog

Gene

SDAD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for 60S pre-ribosomal subunits export to the cytoplasm.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Ribosome biogenesis, Transport

Enzyme and pathway databases

BioCyciZFISH:G66-33243-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SDA1 homolog
Alternative name(s):
Nucleolar protein 130
SDA1 domain-containing protein 1
Short name:
hSDA
Gene namesi
Name:SDAD1
Synonyms:NUC130
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:25537. SDAD1.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: UniProtKB
  • nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55153.
OpenTargetsiENSG00000198301.
PharmGKBiPA134961441.

Polymorphism and mutation databases

BioMutaiSDAD1.
DMDMi296452964.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002874821 – 687Protein SDA1 homologAdd BLAST687

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei232PhosphoserineCombined sources1
Modified residuei234PhosphoserineCombined sources1
Modified residuei236PhosphoserineCombined sources1
Modified residuei552PhosphothreonineCombined sources1
Modified residuei585PhosphoserineCombined sources1
Modified residuei595PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NVU7.
MaxQBiQ9NVU7.
PaxDbiQ9NVU7.
PeptideAtlasiQ9NVU7.
PRIDEiQ9NVU7.
TopDownProteomicsiQ9NVU7-1. [Q9NVU7-1]

PTM databases

iPTMnetiQ9NVU7.
PhosphoSitePlusiQ9NVU7.

Expressioni

Tissue specificityi

Highly expressed in testis, kidney, spleen, brain and fetal tissues. Also expressed at lower level in heart, lung, liver, small intestine, ovary, uterus, mammary gland and placenta.2 Publications

Gene expression databases

BgeeiENSG00000198301.
CleanExiHS_SDAD1.
ExpressionAtlasiQ9NVU7. baseline and differential.
GenevisibleiQ9NVU7. HS.

Organism-specific databases

HPAiHPA035949.

Interactioni

Protein-protein interaction databases

BioGridi120456. 31 interactors.
IntActiQ9NVU7. 6 interactors.
MINTiMINT-4994740.
STRINGi9606.ENSP00000348596.

Structurei

3D structure databases

ProteinModelPortaliQ9NVU7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili253 – 315Sequence analysisAdd BLAST63

Sequence similaritiesi

Belongs to the SDA1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2229. Eukaryota.
ENOG410XPHI. LUCA.
GeneTreeiENSGT00390000010355.
HOGENOMiHOG000204601.
HOVERGENiHBG059552.
InParanoidiQ9NVU7.
KOiK14856.
OMAiHLSNFPQ.
OrthoDBiEOG091G03LI.
PhylomeDBiQ9NVU7.
TreeFamiTF105727.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR027312. Sda1.
IPR007949. SDA1_dom.
IPR012977. Uncharacterised_NUC130/133_N.
[Graphical view]
PANTHERiPTHR12730:SF0. PTHR12730:SF0. 1 hit.
PfamiPF08158. NUC130_3NT. 1 hit.
PF05285. SDA1. 2 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NVU7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSNRNNNKLP SNLPQLQNLI KRDPPAYIEE FLQQYNHYKS NVEIFKLQPN
60 70 80 90 100
KPSKELAELV MFMAQISHCY PEYLSNFPQE VKDLLSCNHT VLDPDLRMTF
110 120 130 140 150
CKALILLRNK NLINPSSLLE LFFELFRCHD KLLRKTLYTH IVTDIKNINA
160 170 180 190 200
KHKNNKVNVV LQNFMYTMLR DSNATAAKMS LDVMIELYRR NIWNDAKTVN
210 220 230 240 250
VITTACFSKV TKILVAALTF FLGKDEDEKQ DSDSESEDDG PTARDLLVQY
260 270 280 290 300
ATGKKSSKNK KKLEKAMKVL KKQKKKKKPE VFNFSAIHLI HDPQDFAEKL
310 320 330 340 350
LKQLECCKER FEVKMMLMNL ISRLVGIHEL FLFNFYPFLQ RFLQPHQREV
360 370 380 390 400
TKILLFAAQA SHHLVPPEII QSLLMTVANN FVTDKNSGEV MTVGINAIKE
410 420 430 440 450
ITARCPLAMT EELLQDLAQY KTHKDKNVMM SARTLIHLFR TLNPQMLQKK
460 470 480 490 500
FRGKPTEASI EARVQEYGEL DAKDYIPGAE VLEVEKEENA ENDEDGWEST
510 520 530 540 550
SLSEEEDADG EWIDVQHSSD EEQQEISKKL NSMPMEERKA KAAAISTSRV
560 570 580 590 600
LTQEDFQKIR MAQMRKELDA APGKSQKRKY IEIDSDEEPR GELLSLRDIE
610 620 630 640 650
RLHKKPKSDK ETRLATAMAG KTDRKEFVRK KTKTNPFSSS TNKEKKKQKN
660 670 680
FMMMRYSQNV RSKNKRSFRE KQLALRDALL KKRKRMK
Length:687
Mass (Da):79,871
Last modified:May 18, 2010 - v3
Checksum:iB01EE09383EA959C
GO
Isoform 2 (identifier: Q9NVU7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.

Note: No experimental confirmation available.
Show »
Length:590
Mass (Da):68,455
Checksum:i06780B225C43F041
GO

Sequence cautioni

The sequence AAI07896 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA91648 differs from that shown. Reason: Frameshift at position 53.Curated
The sequence BAB14177 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB14790 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti186E → G in CAH18368 (PubMed:17974005).Curated1
Sequence conflicti288H → L in BAA91648 (PubMed:14702039).Curated1
Sequence conflicti319N → S in CAH18368 (PubMed:17974005).Curated1
Sequence conflicti396N → S in CAH18368 (PubMed:17974005).Curated1
Sequence conflicti617A → S in BAB14177 (PubMed:14702039).Curated1
Sequence conflicti634T → A in CAH18368 (PubMed:17974005).Curated1
Sequence conflicti651F → L in CAH18368 (PubMed:17974005).Curated1

Polymorphismi

Variations in SDAD1 may be a cause of susceptibility to seasonal allergic rhinitis (SAR). SAR is a common allergic disorder characterized by episodes of sneezing, rhinorrhea, and swelling of the nasal mucosa.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032312258K → Q.Corresponds to variant rs15481dbSNPEnsembl.1
Natural variantiVAR_032313490A → D.Corresponds to variant rs34627298dbSNPEnsembl.1
Natural variantiVAR_032314575S → C.2 PublicationsCorresponds to variant rs2242471dbSNPEnsembl.1
Natural variantiVAR_032315660V → I.Corresponds to variant rs17001276dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0255051 – 97Missing in isoform 2. 1 PublicationAdd BLAST97

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR749574 mRNA. Translation: CAH18368.1.
AC110615 Genomic DNA. No translation available.
AC112719 Genomic DNA. No translation available.
AC115628 Genomic DNA. No translation available.
BC054040 mRNA. Translation: AAH54040.1.
BC063797 mRNA. Translation: AAH63797.1.
BC107895 mRNA. Translation: AAI07896.1. Sequence problems.
AK001360 mRNA. Translation: BAA91648.1. Frameshift.
AK022683 mRNA. Translation: BAB14177.1. Different initiation.
AK024031 mRNA. Translation: BAB14790.1. Different initiation.
CCDSiCCDS3573.2. [Q9NVU7-1]
RefSeqiNP_001275912.1. NM_001288983.1.
NP_001275913.1. NM_001288984.1. [Q9NVU7-2]
NP_060585.2. NM_018115.3. [Q9NVU7-1]
XP_005263162.1. XM_005263105.4. [Q9NVU7-2]
UniGeneiHs.632604.

Genome annotation databases

EnsembliENST00000356260; ENSP00000348596; ENSG00000198301. [Q9NVU7-1]
GeneIDi55153.
KEGGihsa:55153.
UCSCiuc003hje.6. human. [Q9NVU7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR749574 mRNA. Translation: CAH18368.1.
AC110615 Genomic DNA. No translation available.
AC112719 Genomic DNA. No translation available.
AC115628 Genomic DNA. No translation available.
BC054040 mRNA. Translation: AAH54040.1.
BC063797 mRNA. Translation: AAH63797.1.
BC107895 mRNA. Translation: AAI07896.1. Sequence problems.
AK001360 mRNA. Translation: BAA91648.1. Frameshift.
AK022683 mRNA. Translation: BAB14177.1. Different initiation.
AK024031 mRNA. Translation: BAB14790.1. Different initiation.
CCDSiCCDS3573.2. [Q9NVU7-1]
RefSeqiNP_001275912.1. NM_001288983.1.
NP_001275913.1. NM_001288984.1. [Q9NVU7-2]
NP_060585.2. NM_018115.3. [Q9NVU7-1]
XP_005263162.1. XM_005263105.4. [Q9NVU7-2]
UniGeneiHs.632604.

3D structure databases

ProteinModelPortaliQ9NVU7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120456. 31 interactors.
IntActiQ9NVU7. 6 interactors.
MINTiMINT-4994740.
STRINGi9606.ENSP00000348596.

PTM databases

iPTMnetiQ9NVU7.
PhosphoSitePlusiQ9NVU7.

Polymorphism and mutation databases

BioMutaiSDAD1.
DMDMi296452964.

Proteomic databases

EPDiQ9NVU7.
MaxQBiQ9NVU7.
PaxDbiQ9NVU7.
PeptideAtlasiQ9NVU7.
PRIDEiQ9NVU7.
TopDownProteomicsiQ9NVU7-1. [Q9NVU7-1]

Protocols and materials databases

DNASUi55153.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356260; ENSP00000348596; ENSG00000198301. [Q9NVU7-1]
GeneIDi55153.
KEGGihsa:55153.
UCSCiuc003hje.6. human. [Q9NVU7-1]

Organism-specific databases

CTDi55153.
DisGeNETi55153.
GeneCardsiSDAD1.
H-InvDBHIX0025559.
HGNCiHGNC:25537. SDAD1.
HPAiHPA035949.
neXtProtiNX_Q9NVU7.
OpenTargetsiENSG00000198301.
PharmGKBiPA134961441.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2229. Eukaryota.
ENOG410XPHI. LUCA.
GeneTreeiENSGT00390000010355.
HOGENOMiHOG000204601.
HOVERGENiHBG059552.
InParanoidiQ9NVU7.
KOiK14856.
OMAiHLSNFPQ.
OrthoDBiEOG091G03LI.
PhylomeDBiQ9NVU7.
TreeFamiTF105727.

Enzyme and pathway databases

BioCyciZFISH:G66-33243-MONOMER.

Miscellaneous databases

GeneWikiiSDAD1.
GenomeRNAii55153.
PROiQ9NVU7.

Gene expression databases

BgeeiENSG00000198301.
CleanExiHS_SDAD1.
ExpressionAtlasiQ9NVU7. baseline and differential.
GenevisibleiQ9NVU7. HS.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR027312. Sda1.
IPR007949. SDA1_dom.
IPR012977. Uncharacterised_NUC130/133_N.
[Graphical view]
PANTHERiPTHR12730:SF0. PTHR12730:SF0. 1 hit.
PfamiPF08158. NUC130_3NT. 1 hit.
PF05285. SDA1. 2 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiSDA1_HUMAN
AccessioniPrimary (citable) accession number: Q9NVU7
Secondary accession number(s): Q32Q11
, Q68D52, Q7Z5U4, Q9H831, Q9H9P6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

DAZL and PUM2 bind its 3'-UTR mRNA, suggesting that these proteins may regulate its translation.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.