Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Armadillo repeat-containing protein 1

Gene

ARMC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000104442-MONOMER.
SignaLinkiQ9NVT9.

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo repeat-containing protein 1
Gene namesi
Name:ARMC1
Synonyms:ARCP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:17684. ARMC1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi55156.
OpenTargetsiENSG00000104442.
PharmGKBiPA134882659.

Polymorphism and mutation databases

BioMutaiARMC1.
DMDMi74734555.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002408821 – 282Armadillo repeat-containing protein 1Add BLAST282

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei137PhosphothreonineCombined sources1
Modified residuei189PhosphoserineCombined sources1
Modified residuei246PhosphoserineBy similarity1
Modified residuei260PhosphoserineCombined sources1
Modified residuei267PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NVT9.
MaxQBiQ9NVT9.
PaxDbiQ9NVT9.
PeptideAtlasiQ9NVT9.
PRIDEiQ9NVT9.

PTM databases

iPTMnetiQ9NVT9.
PhosphoSitePlusiQ9NVT9.

Expressioni

Gene expression databases

BgeeiENSG00000104442.
CleanExiHS_ARMC1.
ExpressionAtlasiQ9NVT9. baseline and differential.
GenevisibleiQ9NVT9. HS.

Organism-specific databases

HPAiHPA026085.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MTFR1LQ9H0193EBI-3506974,EBI-2824497

Protein-protein interaction databases

BioGridi120458. 43 interactors.
IntActiQ9NVT9. 2 interactors.
STRINGi9606.ENSP00000276569.

Structurei

3D structure databases

ProteinModelPortaliQ9NVT9.
SMRiQ9NVT9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati39 – 81ARMAdd BLAST43

Sequence similaritiesi

Contains 1 ARM repeat.Curated

Phylogenomic databases

eggNOGiENOG410II16. Eukaryota.
ENOG4111EGZ. LUCA.
GeneTreeiENSGT00390000014100.
HOGENOMiHOG000007530.
HOVERGENiHBG055281.
InParanoidiQ9NVT9.
KOiK17306.
OMAiDNVNEMN.
OrthoDBiEOG091G0G9T.
PhylomeDBiQ9NVT9.
TreeFamiTF316742.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR006121. HMA_dom.
IPR016617. UCP013899_metal-bd.
[Graphical view]
PfamiPF00514. Arm. 1 hit.
[Graphical view]
PIRSFiPIRSF013899. UCP013899. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF55008. SSF55008. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NVT9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNSSTSTMSE EPDALSVVNQ LRDLAADPLN RRAIVQDQGC LPGLILFMDH
60 70 80 90 100
PNPPVVHSAL LALRYLAECR ANREKMKGEL GMMLSLQNVI QKTTTPGETK
110 120 130 140 150
LLASEIYDIL QSSNMADGDS FNEMNSRRRK AQFFLGTTNK RAKTVVLHID
160 170 180 190 200
GLDDTSRRNL CEEALLKIKG VISFTFQMAV QRCVVRIRSD LKAEALASAI
210 220 230 240 250
ASTKVMKAQQ VVKSESGEEM LVPFQDTPVE VEQNTELPDY LPEDESPTKE
260 270 280
QDKAVSRVGS HPEGGASWLS TAANFLSRSF YW
Length:282
Mass (Da):31,281
Last modified:October 1, 2000 - v1
Checksum:i9CDF2DCFEC6C3A08
GO
Isoform 2 (identifier: Q9NVT9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MNSSTSTMSE...LILFMDHPNP → MSAWPYFIYG...DVELTKCYTE
     54-155: Missing.

Note: No experimental confirmation available.
Show »
Length:180
Mass (Da):20,312
Checksum:iB03391AF948371C2
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0546451 – 53MNSST…DHPNP → MSAWPYFIYGPSQPSSRPLR FACSSILGRMPCKQRKDERR TGYDVELTKCYTE in isoform 2. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_05464654 – 155Missing in isoform 2. 1 PublicationAdd BLAST102

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001373 mRNA. Translation: BAA91656.1.
AK024053 mRNA. Translation: BAB14803.1.
AK304463 mRNA. Translation: BAG65279.1.
AC055822 Genomic DNA. No translation available.
AC100814 Genomic DNA. No translation available.
BC011607 mRNA. Translation: AAH11607.1.
AL512767 mRNA. Translation: CAC21684.1.
CCDSiCCDS6181.1. [Q9NVT9-1]
CCDS69490.1. [Q9NVT9-2]
RefSeqiNP_001273631.1. NM_001286702.1. [Q9NVT9-2]
NP_060590.1. NM_018120.5. [Q9NVT9-1]
XP_016869094.1. XM_017013605.1. [Q9NVT9-1]
UniGeneiHs.269542.

Genome annotation databases

EnsembliENST00000276569; ENSP00000276569; ENSG00000104442. [Q9NVT9-1]
ENST00000458464; ENSP00000388572; ENSG00000104442. [Q9NVT9-2]
GeneIDi55156.
KEGGihsa:55156.
UCSCiuc003xvl.4. human. [Q9NVT9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001373 mRNA. Translation: BAA91656.1.
AK024053 mRNA. Translation: BAB14803.1.
AK304463 mRNA. Translation: BAG65279.1.
AC055822 Genomic DNA. No translation available.
AC100814 Genomic DNA. No translation available.
BC011607 mRNA. Translation: AAH11607.1.
AL512767 mRNA. Translation: CAC21684.1.
CCDSiCCDS6181.1. [Q9NVT9-1]
CCDS69490.1. [Q9NVT9-2]
RefSeqiNP_001273631.1. NM_001286702.1. [Q9NVT9-2]
NP_060590.1. NM_018120.5. [Q9NVT9-1]
XP_016869094.1. XM_017013605.1. [Q9NVT9-1]
UniGeneiHs.269542.

3D structure databases

ProteinModelPortaliQ9NVT9.
SMRiQ9NVT9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120458. 43 interactors.
IntActiQ9NVT9. 2 interactors.
STRINGi9606.ENSP00000276569.

PTM databases

iPTMnetiQ9NVT9.
PhosphoSitePlusiQ9NVT9.

Polymorphism and mutation databases

BioMutaiARMC1.
DMDMi74734555.

Proteomic databases

EPDiQ9NVT9.
MaxQBiQ9NVT9.
PaxDbiQ9NVT9.
PeptideAtlasiQ9NVT9.
PRIDEiQ9NVT9.

Protocols and materials databases

DNASUi55156.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276569; ENSP00000276569; ENSG00000104442. [Q9NVT9-1]
ENST00000458464; ENSP00000388572; ENSG00000104442. [Q9NVT9-2]
GeneIDi55156.
KEGGihsa:55156.
UCSCiuc003xvl.4. human. [Q9NVT9-1]

Organism-specific databases

CTDi55156.
DisGeNETi55156.
GeneCardsiARMC1.
HGNCiHGNC:17684. ARMC1.
HPAiHPA026085.
neXtProtiNX_Q9NVT9.
OpenTargetsiENSG00000104442.
PharmGKBiPA134882659.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II16. Eukaryota.
ENOG4111EGZ. LUCA.
GeneTreeiENSGT00390000014100.
HOGENOMiHOG000007530.
HOVERGENiHBG055281.
InParanoidiQ9NVT9.
KOiK17306.
OMAiDNVNEMN.
OrthoDBiEOG091G0G9T.
PhylomeDBiQ9NVT9.
TreeFamiTF316742.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000104442-MONOMER.
SignaLinkiQ9NVT9.

Miscellaneous databases

ChiTaRSiARMC1. human.
GenomeRNAii55156.
PROiQ9NVT9.

Gene expression databases

BgeeiENSG00000104442.
CleanExiHS_ARMC1.
ExpressionAtlasiQ9NVT9. baseline and differential.
GenevisibleiQ9NVT9. HS.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR006121. HMA_dom.
IPR016617. UCP013899_metal-bd.
[Graphical view]
PfamiPF00514. Arm. 1 hit.
[Graphical view]
PIRSFiPIRSF013899. UCP013899. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF55008. SSF55008. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiARMC1_HUMAN
AccessioniPrimary (citable) accession number: Q9NVT9
Secondary accession number(s): B4E2W7, Q9H018, Q9H820
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.