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Protein

Armadillo repeat-containing protein 1

Gene

ARMC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ9NVT9.

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo repeat-containing protein 1
Gene namesi
Name:ARMC1
Synonyms:ARCP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:17684. ARMC1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134882659.

Polymorphism and mutation databases

BioMutaiARMC1.
DMDMi74734555.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282Armadillo repeat-containing protein 1PRO_0000240882Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei246 – 2461PhosphoserineBy similarity
Modified residuei260 – 2601PhosphoserineCombined sources
Modified residuei267 – 2671PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NVT9.
MaxQBiQ9NVT9.
PaxDbiQ9NVT9.
PeptideAtlasiQ9NVT9.
PRIDEiQ9NVT9.

PTM databases

iPTMnetiQ9NVT9.
PhosphoSiteiQ9NVT9.

Expressioni

Gene expression databases

BgeeiQ9NVT9.
CleanExiHS_ARMC1.
ExpressionAtlasiQ9NVT9. baseline and differential.
GenevisibleiQ9NVT9. HS.

Organism-specific databases

HPAiHPA026085.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MTFR1LQ9H0193EBI-3506974,EBI-2824497

Protein-protein interaction databases

BioGridi120458. 43 interactions.
IntActiQ9NVT9. 2 interactions.
STRINGi9606.ENSP00000276569.

Structurei

3D structure databases

ProteinModelPortaliQ9NVT9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati39 – 8143ARMAdd
BLAST

Sequence similaritiesi

Contains 1 ARM repeat.Curated

Phylogenomic databases

eggNOGiENOG410II16. Eukaryota.
ENOG4111EGZ. LUCA.
GeneTreeiENSGT00390000014100.
HOGENOMiHOG000007530.
HOVERGENiHBG055281.
InParanoidiQ9NVT9.
KOiK17306.
OMAiDNVNEMN.
OrthoDBiEOG7VQJFC.
PhylomeDBiQ9NVT9.
TreeFamiTF316742.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR006121. HMA_dom.
IPR016617. UCP013899_metal-bd.
[Graphical view]
PfamiPF00514. Arm. 1 hit.
[Graphical view]
PIRSFiPIRSF013899. UCP013899. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF55008. SSF55008. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NVT9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNSSTSTMSE EPDALSVVNQ LRDLAADPLN RRAIVQDQGC LPGLILFMDH
60 70 80 90 100
PNPPVVHSAL LALRYLAECR ANREKMKGEL GMMLSLQNVI QKTTTPGETK
110 120 130 140 150
LLASEIYDIL QSSNMADGDS FNEMNSRRRK AQFFLGTTNK RAKTVVLHID
160 170 180 190 200
GLDDTSRRNL CEEALLKIKG VISFTFQMAV QRCVVRIRSD LKAEALASAI
210 220 230 240 250
ASTKVMKAQQ VVKSESGEEM LVPFQDTPVE VEQNTELPDY LPEDESPTKE
260 270 280
QDKAVSRVGS HPEGGASWLS TAANFLSRSF YW
Length:282
Mass (Da):31,281
Last modified:October 1, 2000 - v1
Checksum:i9CDF2DCFEC6C3A08
GO
Isoform 2 (identifier: Q9NVT9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MNSSTSTMSE...LILFMDHPNP → MSAWPYFIYG...DVELTKCYTE
     54-155: Missing.

Note: No experimental confirmation available.
Show »
Length:180
Mass (Da):20,312
Checksum:iB03391AF948371C2
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5353MNSST…DHPNP → MSAWPYFIYGPSQPSSRPLR FACSSILGRMPCKQRKDERR TGYDVELTKCYTE in isoform 2. 1 PublicationVSP_054645Add
BLAST
Alternative sequencei54 – 155102Missing in isoform 2. 1 PublicationVSP_054646Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001373 mRNA. Translation: BAA91656.1.
AK024053 mRNA. Translation: BAB14803.1.
AK304463 mRNA. Translation: BAG65279.1.
AC055822 Genomic DNA. No translation available.
AC100814 Genomic DNA. No translation available.
BC011607 mRNA. Translation: AAH11607.1.
AL512767 mRNA. Translation: CAC21684.1.
CCDSiCCDS6181.1. [Q9NVT9-1]
CCDS69490.1. [Q9NVT9-2]
RefSeqiNP_001273631.1. NM_001286702.1. [Q9NVT9-2]
NP_060590.1. NM_018120.5. [Q9NVT9-1]
XP_006716521.1. XM_006716458.2. [Q9NVT9-1]
UniGeneiHs.269542.

Genome annotation databases

EnsembliENST00000276569; ENSP00000276569; ENSG00000104442. [Q9NVT9-1]
ENST00000458464; ENSP00000388572; ENSG00000104442. [Q9NVT9-2]
GeneIDi55156.
KEGGihsa:55156.
UCSCiuc003xvl.4. human. [Q9NVT9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001373 mRNA. Translation: BAA91656.1.
AK024053 mRNA. Translation: BAB14803.1.
AK304463 mRNA. Translation: BAG65279.1.
AC055822 Genomic DNA. No translation available.
AC100814 Genomic DNA. No translation available.
BC011607 mRNA. Translation: AAH11607.1.
AL512767 mRNA. Translation: CAC21684.1.
CCDSiCCDS6181.1. [Q9NVT9-1]
CCDS69490.1. [Q9NVT9-2]
RefSeqiNP_001273631.1. NM_001286702.1. [Q9NVT9-2]
NP_060590.1. NM_018120.5. [Q9NVT9-1]
XP_006716521.1. XM_006716458.2. [Q9NVT9-1]
UniGeneiHs.269542.

3D structure databases

ProteinModelPortaliQ9NVT9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120458. 43 interactions.
IntActiQ9NVT9. 2 interactions.
STRINGi9606.ENSP00000276569.

PTM databases

iPTMnetiQ9NVT9.
PhosphoSiteiQ9NVT9.

Polymorphism and mutation databases

BioMutaiARMC1.
DMDMi74734555.

Proteomic databases

EPDiQ9NVT9.
MaxQBiQ9NVT9.
PaxDbiQ9NVT9.
PeptideAtlasiQ9NVT9.
PRIDEiQ9NVT9.

Protocols and materials databases

DNASUi55156.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276569; ENSP00000276569; ENSG00000104442. [Q9NVT9-1]
ENST00000458464; ENSP00000388572; ENSG00000104442. [Q9NVT9-2]
GeneIDi55156.
KEGGihsa:55156.
UCSCiuc003xvl.4. human. [Q9NVT9-1]

Organism-specific databases

CTDi55156.
GeneCardsiARMC1.
HGNCiHGNC:17684. ARMC1.
HPAiHPA026085.
neXtProtiNX_Q9NVT9.
PharmGKBiPA134882659.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II16. Eukaryota.
ENOG4111EGZ. LUCA.
GeneTreeiENSGT00390000014100.
HOGENOMiHOG000007530.
HOVERGENiHBG055281.
InParanoidiQ9NVT9.
KOiK17306.
OMAiDNVNEMN.
OrthoDBiEOG7VQJFC.
PhylomeDBiQ9NVT9.
TreeFamiTF316742.

Enzyme and pathway databases

SignaLinkiQ9NVT9.

Miscellaneous databases

ChiTaRSiARMC1. human.
GenomeRNAii55156.
PROiQ9NVT9.

Gene expression databases

BgeeiQ9NVT9.
CleanExiHS_ARMC1.
ExpressionAtlasiQ9NVT9. baseline and differential.
GenevisibleiQ9NVT9. HS.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR006121. HMA_dom.
IPR016617. UCP013899_metal-bd.
[Graphical view]
PfamiPF00514. Arm. 1 hit.
[Graphical view]
PIRSFiPIRSF013899. UCP013899. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF55008. SSF55008. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Stomach.
  2. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 78-282 (ISOFORM 1).
    Tissue: Lymph node.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-260, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiARMC1_HUMAN
AccessioniPrimary (citable) accession number: Q9NVT9
Secondary accession number(s): B4E2W7, Q9H018, Q9H820
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.