Q9NVS2 (RT18A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
28S ribosomal protein S18a, mitochondrial
Short name=MRP-S18-a
Short name=Mrps18a
Short name=S18mt-a

Alternative name(s):
28S ribosomal protein S18-3, mitochondrial
Short name=MRP-S18-3

Gene names

Name:

MRPS18A

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	196 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
Subcellular location	Mitochondrion Ref.7.
Sequence similarities	Belongs to the ribosomal protein S18P family. UniProtKB P80382

Ontologies

Keywords
Cellular component	Mitochondrion
Coding sequence diversity	Alternative splicing
Domain	Transit peptide
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	translation Non-traceable author statement Ref.7. Source: UniProtKB
Cellular_component	mitochondrial small ribosomal subunit Inferred from direct assay Ref.7. Source: UniProtKB
Molecular_function	structural constituent of ribosome Non-traceable author statement Ref.7. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NVS2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NVS2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     125-125: A → AGRRPWGPRG...QRLSPLPRHS

Isoform 3 (identifier: Q9NVS2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     127-196: LLPNHRPRLPEGVVPKSKPQLNRYLTRWAPGSVKPIYKKGPRWNRVRMPVGSPLLRDNVCYSRTPWKLYH → T

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 34	34	Mitochondrion By similarity
	Chain	35 – 196	162	28S ribosomal protein S18a, mitochondrial		PRO_0000030625
Natural variations
	Alternative sequence	125	1	A → AGRRPWGPRGAEGCRHSLPT QLPHVSAPPGRKVDIRSVNY THHPMPTFPLPWAFPLAPSE LQRELQRLSPLPRHS in isoform 2.		VSP_041245
	Alternative sequence	127 – 196	70	LLPNH…WKLYH → T in isoform 3.		VSP_043496

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: CC086B8FC27242D6	FASTA	196	22,184
	10 20 30 40 50 60 MAALKALVSG CGRLLRGLLA GPAATSWSRL PARGFREVVE TQEGKTTIIE GRITATPKES 70 80 90 100 110 120 PNPPNPSGQC PICRWNLKHK YNYDDVLLLS QFIRPHGGML PRKITGLCQE EHRKIEECVK 130 140 150 160 170 180 MAHRAGLLPN HRPRLPEGVV PKSKPQLNRY LTRWAPGSVK PIYKKGPRWN RVRMPVGSPL 190 LRDNVCYSRT PWKLYH
	Isoform 2 [UniParc]. Checksum: 2EEB47D86FC277F0	FASTA	270	30,540
	10 20 30 40 50 60 MAALKALVSG CGRLLRGLLA GPAATSWSRL PARGFREVVE TQEGKTTIIE GRITATPKES 70 80 90 100 110 120 PNPPNPSGQC PICRWNLKHK YNYDDVLLLS QFIRPHGGML PRKITGLCQE EHRKIEECVK 130 140 150 160 170 180 MAHRAGRRPW GPRGAEGCRH SLPTQLPHVS APPGRKVDIR SVNYTHHPMP TFPLPWAFPL 190 200 210 220 230 240 APSELQRELQ RLSPLPRHSG LLPNHRPRLP EGVVPKSKPQ LNRYLTRWAP GSVKPIYKKG 250 260 270 PRWNRVRMPV GSPLLRDNVC YSRTPWKLYH
	Isoform 3 [UniParc]. Checksum: C5BA5F97CADB7D87	FASTA	127	14,030
	10 20 30 40 50 60 MAALKALVSG CGRLLRGLLA GPAATSWSRL PARGFREVVE TQEGKTTIIE GRITATPKES 70 80 90 100 110 120 PNPPNPSGQC PICRWNLKHK YNYDDVLLLS QFIRPHGGML PRKITGLCQE EHRKIEECVK MAHRAGT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit." Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K. J. Biol. Chem. 276:33181-33195(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"A computer system platform used to predict novel genes." Yu Z., Zheng Z., Tang T., Fu Y. Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Prostate.
[7]	"The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present." Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L. J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB049952 mRNA. Translation: BAB41005.1. DQ884400 mRNA. Translation: ABI63367.1. AK001410 mRNA. Translation: BAA91675.1. AK300757 mRNA. Translation: BAG62423.1. AL136131 Genomic DNA. Translation: CAC19510.1. AL136131 Genomic DNA. Translation: CAI19964.1. CH471081 Genomic DNA. Translation: EAX04225.1. BC010364 mRNA. Translation: AAH10364.1.
IPI	IPI00018691. IPI00513805. IPI00642295.
RefSeq	NP_001180272.1. NM_001193343.1. NP_060605.1. NM_018135.3.
UniGene	Hs.520149.
3D structure databases
ProteinModelPortal	Q9NVS2.
SMR	Q9NVS2. Positions 84-132.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000361206.
PTM databases
PhosphoSite	Q9NVS2.
Polymorphism databases
DMDM	24212201.
Proteomic databases
PaxDb	Q9NVS2.
PRIDE	Q9NVS2.
Protocols and materials databases
DNASU	55168.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000372116; ENSP00000361188; ENSG00000096080. ENST00000372133; ENSP00000361206; ENSG00000096080.
GeneID	55168.
KEGG	hsa:55168.
UCSC	uc003ovy.2. human. uc003owa.2. human.
Organism-specific databases
CTD	55168.
GeneCards	GC06M043639.
HGNC	HGNC:14515. MRPS18A.
HPA	HPA035450. HPA035451.
MIM	611981. gene.
neXtProt	NX_Q9NVS2.
PharmGKB	PA31003.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG249629.
HOGENOM	HOG000139370.
HOVERGEN	HBG058800.
KO	K02963.
OMA	HRPRLPE.
OrthoDB	EOG4CNQS4.
PhylomeDB	Q9NVS2.
Gene expression databases
ArrayExpress	Q9NVS2.
Bgee	Q9NVS2.
CleanEx	HS_MRPS18A.
Genevestigator	Q9NVS2.
GermOnline	ENSG00000096080. Homo sapiens.
Family and domain databases
Gene3D	4.10.640.10. 1 hit.
InterPro	IPR001648. Ribosomal_S18. [Graphical view]
Pfam	PF01084. Ribosomal_S18. 1 hit. [Graphical view]
ProDom	PD002239. Ribosomal_S18. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF46911. Ribosomal_S18. 1 hit.
PROSITE	PS00057. RIBOSOMAL_S18. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	55168.
NextBio	58945.
SOURCE	Search...

Entry information

Entry name

RT18A_HUMAN

Accession

Primary (citable) accession number: Q9NVS2
Secondary accession number(s): A6XND3, Q5QPA4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.