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Q9NVR7 (TBCC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
TBCC domain-containing protein 1
Gene names
Name:TBCCD1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length557 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a role in the regulation of centrosome and Golgi apparatus positioning, with consequences on cell shape and cell migration. Ref.5

Subcellular location

Cytoplasmcytoskeletonmicrotubule organizing centercentrosome. Cytoplasmcytoskeletonspindle pole. Note: Localizes at the spindle midzone, midbody and basal bodies of primary and motile cilia. Ref.5

Sequence similarities

Belongs to the TBCC family.

Contains 1 C-CAP/cofactor C-like domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NVR7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NVR7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MDQSRVLLWVKAEPFI → MTDRLKFGFGFHRFLV
     17-112: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 557557TBCC domain-containing protein 1
PRO_0000304944

Regions

Domain290 – 435146C-CAP/cofactor C-like

Natural variations

Alternative sequence1 – 1616MDQSR…AEPFI → MTDRLKFGFGFHRFLV in isoform 2.
VSP_054000
Alternative sequence17 – 11296Missing in isoform 2.
VSP_054001
Natural variant1491K → R.
Corresponds to variant rs7619912 [ dbSNP | Ensembl ].
VAR_035123

Experimental info

Sequence conflict1161D → G in BAG54031. Ref.1
Sequence conflict4551T → A in BAG54031. Ref.1
Sequence conflict5261E → D in BAG54031. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 8485765F466DCC95

FASTA55763,530
        10         20         30         40         50         60 
MDQSRVLLWV KAEPFIVGAL QVPPPSKFSL HYLRKISTYV QIRATEGAYP RLYWSTWRHI 

        70         80         90        100        110        120 
ACGKLQLAKD LAWLYFEIFD SLSMKTPEER LEWSEVLSNC MSEEEVEKQR NQLSVDTLQF 

       130        140        150        160        170        180 
LLFLYIQQLN KVSLRTSLIG EEWPSPRNKS QSPDLTEKSN CHNKNWNDYS HQAFVYDHLS 

       190        200        210        220        230        240 
DLLELLLDPK QLTASFHSTH SSLVSREAVV ALSFLIEGTI SRARKIYPLH ELALWQPLHA 

       250        260        270        280        290        300 
DSGFSKISKT FSFYKLETWL RSCLTGNPFG TSACLKSGKK LAWAHQVEGT TKRAKIACNT 

       310        320        330        340        350        360 
HVAPRMHRLV VMSQVYKQTL AKSSDTLAGA HVKIHRCNES FIYLLSPLRS VTIEKCRNSI 

       370        380        390        400        410        420 
FVLGPVGTTL HLHSCDNVKV IAVCHRLSIS STTGCIFHVL TPTRPLILSG NQTVTFAPFH 

       430        440        450        460        470        480 
THYPMLEDHM ARTGLATVPN YWDNPMVVCR ENSDTRVFQL LPPCEFYVFI IPFEMEGDTT 

       490        500        510        520        530        540 
EIPGGLPSVY QKALGQREQK IQIWQKTVKE AHLTKDQRKQ FQVLVENKFY EWLINTGHRQ 

       550 
QLDSLVPPAA GSKQAAG 

« Hide

Isoform 2 [UniParc].

Checksum: BB893F7C94E52485
Show »

FASTA46152,263

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Teratocarcinoma and Uterus.
[2]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[5]"TBCCD1, a new centrosomal protein, is required for centrosome and Golgi apparatus positioning."
Goncalves J., Nolasco S., Nascimento R., Lopez Fanarraga M., Zabala J.C., Soares H.
EMBO Rep. 11:194-200(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK001422 mRNA. Translation: BAA91682.1.
AK124362 mRNA. Translation: BAG54031.1.
AC068631 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW78191.1.
CH471052 Genomic DNA. Translation: EAW78192.1.
CH471052 Genomic DNA. Translation: EAW78193.1.
BC025748 mRNA. Translation: AAH25748.1.
RefSeqNP_001127887.1. NM_001134415.1.
NP_001273678.1. NM_001286749.1.
NP_060608.1. NM_018138.4.
UniGeneHs.518469.

3D structure databases

ProteinModelPortalQ9NVR7.
SMRQ9NVR7. Positions 310-473.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120470. 1 interaction.
IntActQ9NVR7. 2 interactions.
MINTMINT-7716720.
STRING9606.ENSP00000341652.

PTM databases

PhosphoSiteQ9NVR7.

Polymorphism databases

DMDM74734544.

Proteomic databases

PaxDbQ9NVR7.
PRIDEQ9NVR7.

Protocols and materials databases

DNASU55171.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000338733; ENSP00000341652; ENSG00000113838.
ENST00000424280; ENSP00000411253; ENSG00000113838.
ENST00000446782; ENSP00000397091; ENSG00000113838.
GeneID55171.
KEGGhsa:55171.
UCSCuc003fqg.3. human.

Organism-specific databases

CTD55171.
GeneCardsGC03M186263.
HGNCHGNC:25546. TBCCD1.
neXtProtNX_Q9NVR7.
PharmGKBPA143485628.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG274981.
HOGENOMHOG000008162.
HOVERGENHBG108549.
InParanoidQ9NVR7.
KOK16810.
OMAEWPSPRN.
OrthoDBEOG71P29F.
PhylomeDBQ9NVR7.
TreeFamTF329418.

Gene expression databases

ArrayExpressQ9NVR7.
BgeeQ9NVR7.
CleanExHS_TBCCD1.
GenevestigatorQ9NVR7.

Family and domain databases

Gene3D2.160.20.70. 1 hit.
InterProIPR013912. Adenylate_cyclase-assoc_CAP_C.
IPR017901. C-CAP_CF_C-like.
IPR016098. CAP/MinC_C.
IPR006599. CARP_motif.
IPR012945. Tubulin-bd_cofactor_C_dom.
[Graphical view]
PfamPF07986. TBCC. 1 hit.
[Graphical view]
SMARTSM00673. CARP. 2 hits.
[Graphical view]
SUPFAMSSF69340. SSF69340. 1 hit.
PROSITEPS51329. C_CAP_COFACTOR_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi55171.
NextBio58953.
PROQ9NVR7.

Entry information

Entry nameTBCC1_HUMAN
AccessionPrimary (citable) accession number: Q9NVR7
Secondary accession number(s): B3KW69, D3DNU6, G5E9J4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM