Q9NVR7 (TBCC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
TBCC domain-containing protein 1

Gene names

Name:

TBCCD1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	557 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays a role in the regulation of centrosome and Golgi apparatus positioning, with consequences on cell shape and cell migration. Ref.4
Subcellular location	Cytoplasm › cytoskeleton › centrosome. Cytoplasm › cytoskeleton › spindle pole. Note: Localizes at the spindle midzone, midbody and basal bodies of primary and motile cilia. Ref.4
Sequence similarities	Belongs to the TBCC family. Contains 1 C-CAP/cofactor C-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell morphogenesis Inferred from electronic annotation. Source: InterPro maintenance of Golgi location Inferred from mutant phenotype Ref.4. Source: UniProtKB maintenance of centrosome location Inferred from mutant phenotype Ref.4. Source: UniProtKB regulation of cell migration Inferred from mutant phenotype Ref.4. Source: UniProtKB regulation of cell shape Inferred from mutant phenotype Ref.4. Source: UniProtKB
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW spindle pole centrosome Inferred from direct assay Ref.4. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 557	557	TBCC domain-containing protein 1		PRO_0000304944
Regions
	Domain	290 – 435	146	C-CAP/cofactor C-like
Natural variations
	Natural variant	149	1	K → R. Corresponds to variant rs7619912 [ dbSNP | Ensembl ].		VAR_035123

Sequences

	Sequence		Length	Mass (Da)
	Q9NVR7 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 8485765F466DCC95	FASTA	557	63,530
	10 20 30 40 50 60 MDQSRVLLWV KAEPFIVGAL QVPPPSKFSL HYLRKISTYV QIRATEGAYP RLYWSTWRHI 70 80 90 100 110 120 ACGKLQLAKD LAWLYFEIFD SLSMKTPEER LEWSEVLSNC MSEEEVEKQR NQLSVDTLQF 130 140 150 160 170 180 LLFLYIQQLN KVSLRTSLIG EEWPSPRNKS QSPDLTEKSN CHNKNWNDYS HQAFVYDHLS 190 200 210 220 230 240 DLLELLLDPK QLTASFHSTH SSLVSREAVV ALSFLIEGTI SRARKIYPLH ELALWQPLHA 250 260 270 280 290 300 DSGFSKISKT FSFYKLETWL RSCLTGNPFG TSACLKSGKK LAWAHQVEGT TKRAKIACNT 310 320 330 340 350 360 HVAPRMHRLV VMSQVYKQTL AKSSDTLAGA HVKIHRCNES FIYLLSPLRS VTIEKCRNSI 370 380 390 400 410 420 FVLGPVGTTL HLHSCDNVKV IAVCHRLSIS STTGCIFHVL TPTRPLILSG NQTVTFAPFH 430 440 450 460 470 480 THYPMLEDHM ARTGLATVPN YWDNPMVVCR ENSDTRVFQL LPPCEFYVFI IPFEMEGDTT 490 500 510 520 530 540 EIPGGLPSVY QKALGQREQK IQIWQKTVKE AHLTKDQRKQ FQVLVENKFY EWLINTGHRQ 550 QLDSLVPPAA GSKQAAG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Teratocarcinoma.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"TBCCD1, a new centrosomal protein, is required for centrosome and Golgi apparatus positioning." Goncalves J., Nolasco S., Nascimento R., Lopez Fanarraga M., Zabala J.C., Soares H. EMBO Rep. 11:194-200(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK001422 mRNA. Translation: BAA91682.1. CH471052 Genomic DNA. Translation: EAW78192.1. CH471052 Genomic DNA. Translation: EAW78193.1. BC025748 mRNA. Translation: AAH25748.1.
IPI	IPI00018696.
RefSeq	NP_001127887.1. NM_001134415.1. NP_060608.1. NM_018138.3.
UniGene	Hs.518469.
3D structure databases
ProteinModelPortal	Q9NVR7.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000341652.
PTM databases
PhosphoSite	Q9NVR7.
Polymorphism databases
DMDM	74734544.
Proteomic databases
PaxDb	Q9NVR7.
PRIDE	Q9NVR7.
Protocols and materials databases
DNASU	55171.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000338733; ENSP00000341652; ENSG00000113838. ENST00000424280; ENSP00000411253; ENSG00000113838.
GeneID	55171.
KEGG	hsa:55171.
UCSC	uc003fqg.3. human.
Organism-specific databases
CTD	55171.
GeneCards	GC03M186263.
HGNC	HGNC:25546. TBCCD1.
neXtProt	NX_Q9NVR7.
PharmGKB	PA143485628.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG274981.
HOGENOM	HOG000008162.
HOVERGEN	HBG108549.
InParanoid	Q9NVR7.
KO	K16810.
OMA	RMVVMSQ.
OrthoDB	EOG4BRWKG.
PhylomeDB	Q9NVR7.
Gene expression databases
ArrayExpress	Q9NVR7.
Bgee	Q9NVR7.
CleanEx	HS_TBCCD1.
Genevestigator	Q9NVR7.
Family and domain databases
Gene3D	2.160.20.70. 1 hit.
InterPro	IPR017901. C-CAP_CF_C-like. IPR016098. CAP/MinC_C. IPR006599. CARP_motif. IPR012945. Tubulin-bd_cofactor_C. [Graphical view]
Pfam	PF07986. TBCC. 1 hit. [Graphical view]
SMART	SM00673. CARP. 2 hits. [Graphical view]
PROSITE	PS51329. C_CAP_COFACTOR_C. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	55171.
NextBio	58953.

Entry information

Entry name

TBCC1_HUMAN

Accession

Primary (citable) accession number: Q9NVR7
Secondary accession number(s): D3DNU6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.