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Protein

Integrator complex subunit 10

Gene

INTS10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.

GO - Biological processi

  1. snRNA processing Source: HGNC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Integrator complex subunit 10
Short name:
Int10
Gene namesi
Name:INTS10
Synonyms:C8orf35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:25548. INTS10.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. integrator complex Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672354.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 710710Integrator complex subunit 10PRO_0000235687Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei231 – 2311Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9NVR2.
PaxDbiQ9NVR2.
PRIDEiQ9NVR2.

PTM databases

PhosphoSiteiQ9NVR2.

Expressioni

Gene expression databases

BgeeiQ9NVR2.
CleanExiHS_INTS10.
ExpressionAtlasiQ9NVR2. baseline and differential.
GenevestigatoriQ9NVR2.

Organism-specific databases

HPAiHPA039129.
HPA050570.

Interactioni

Subunit structurei

Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12. Interacts with POLR2A.1 Publication

Protein-protein interaction databases

BioGridi120473. 21 interactions.
DIPiDIP-34063N.
IntActiQ9NVR2. 2 interactions.
STRINGi9606.ENSP00000381064.

Structurei

3D structure databases

ProteinModelPortaliQ9NVR2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi132 – 1365Poly-Leu

Sequence similaritiesi

Belongs to the Integrator subunit 10 family.Curated

Phylogenomic databases

eggNOGiNOG77227.
GeneTreeiENSGT00390000010950.
HOGENOMiHOG000285960.
HOVERGENiHBG081797.
InParanoidiQ9NVR2.
KOiK13147.
OMAiYMVLPIQ.
OrthoDBiEOG7DC23X.
PhylomeDBiQ9NVR2.
TreeFamiTF323935.

Family and domain databases

InterProiIPR026164. Int_cplx_su10.
[Graphical view]
PANTHERiPTHR16055. PTHR16055. 1 hit.
PRINTSiPR02106. INTSUBUNIT10.

Sequencei

Sequence statusi: Complete.

Q9NVR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAQGDCEFL VQRARELVPQ DLWAAKAWLI TARSLYPADF NIQYEMYTIE
60 70 80 90 100
RNAERTATAG RLLYDMFVNF PDQPVVWREI SIITSALRND SQDKQTQFLR
110 120 130 140 150
SLFETLPGRV QCEMLLKVTE QCFNTLERSE MLLLLLRRFP ETVVQHGVGL
160 170 180 190 200
GEALLEAETI EEQESPVNCF RKLFVCDVLP LIINNHDVRL PANLLYKYLN
210 220 230 240 250
KAAEFYINYV TRSTQIENQH QGAQDTSDLM SPSKRSSQKY IIEGLTEKSS
260 270 280 290 300
QIVDPWERLF KILNVVGMRC EWQMDKGRRS YGDILHRMKD LCRYMNNFDS
310 320 330 340 350
EAHAKYKNQV VYSTMLVFFK NAFQYVNSIQ PSLFQGPNAP SQVPLVLLED
360 370 380 390 400
VSNVYGDVEI DRNKHIHKKR KLAEGREKTM SSDDEDCSAK GRNRHIVVNK
410 420 430 440 450
AELANSTEVL ESFKLARESW ELLYSLEFLD KEFTRICLAW KTDTWLWLRI
460 470 480 490 500
FLTDMIIYQG QYKKAIASLH HLAALQGSIS QPQITGQGTL EHQRALIQLA
510 520 530 540 550
TCHFALGEYR MTCEKVLDLM CYMVLPIQDG GKSQEEPSKV KPKFRKGSDL
560 570 580 590 600
KLLPCTSKAI MPYCLHLMLA CFKLRAFTDN RDDMALGHVI VLLQQEWPRG
610 620 630 640 650
ENLFLKAVNK ICQQGNFQYE NFFNYVTNID MLEEFAYLRT QEGGKIHLEL
660 670 680 690 700
LPNQGMLIKH HTVTRGITKG VKEDFRLAME RQVSRCGENL MVVLHRFCIN
710
EKILLLQTLT
Length:710
Mass (Da):82,236
Last modified:May 16, 2006 - v2
Checksum:i3E9945064EC4BEFB
GO

Sequence cautioni

The sequence BAA91687.1 differs from that shown. Reason: Frameshift at position 90. Curated
The sequence CAG33543.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti412 – 4121S → N in CAG33543 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001431 mRNA. Translation: BAA91687.1. Frameshift.
BC001915 mRNA. Translation: AAH01915.2.
BC006209 mRNA. Translation: AAH06209.2.
BC051282 mRNA. Translation: AAH51282.2.
CR457262 mRNA. Translation: CAG33543.1. Different initiation.
AL442078 mRNA. Translation: CAC09444.1.
BK005727 mRNA. Translation: DAA05727.1. Frameshift.
CCDSiCCDS6011.2.
RefSeqiNP_060612.2. NM_018142.2.
UniGeneiHs.512627.

Genome annotation databases

EnsembliENST00000397977; ENSP00000381064; ENSG00000104613.
GeneIDi55174.
KEGGihsa:55174.
UCSCiuc003wzj.3. human.

Polymorphism databases

DMDMi97052274.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001431 mRNA. Translation: BAA91687.1. Frameshift.
BC001915 mRNA. Translation: AAH01915.2.
BC006209 mRNA. Translation: AAH06209.2.
BC051282 mRNA. Translation: AAH51282.2.
CR457262 mRNA. Translation: CAG33543.1. Different initiation.
AL442078 mRNA. Translation: CAC09444.1.
BK005727 mRNA. Translation: DAA05727.1. Frameshift.
CCDSiCCDS6011.2.
RefSeqiNP_060612.2. NM_018142.2.
UniGeneiHs.512627.

3D structure databases

ProteinModelPortaliQ9NVR2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120473. 21 interactions.
DIPiDIP-34063N.
IntActiQ9NVR2. 2 interactions.
STRINGi9606.ENSP00000381064.

PTM databases

PhosphoSiteiQ9NVR2.

Polymorphism databases

DMDMi97052274.

Proteomic databases

MaxQBiQ9NVR2.
PaxDbiQ9NVR2.
PRIDEiQ9NVR2.

Protocols and materials databases

DNASUi55174.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397977; ENSP00000381064; ENSG00000104613.
GeneIDi55174.
KEGGihsa:55174.
UCSCiuc003wzj.3. human.

Organism-specific databases

CTDi55174.
GeneCardsiGC08P019674.
HGNCiHGNC:25548. INTS10.
HPAiHPA039129.
HPA050570.
MIMi611353. gene.
neXtProtiNX_Q9NVR2.
PharmGKBiPA142672354.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG77227.
GeneTreeiENSGT00390000010950.
HOGENOMiHOG000285960.
HOVERGENiHBG081797.
InParanoidiQ9NVR2.
KOiK13147.
OMAiYMVLPIQ.
OrthoDBiEOG7DC23X.
PhylomeDBiQ9NVR2.
TreeFamiTF323935.

Miscellaneous databases

ChiTaRSiINTS10. human.
GenomeRNAii55174.
NextBioi58967.
PROiQ9NVR2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NVR2.
CleanExiHS_INTS10.
ExpressionAtlasiQ9NVR2. baseline and differential.
GenevestigatoriQ9NVR2.

Family and domain databases

InterProiIPR026164. Int_cplx_su10.
[Graphical view]
PANTHERiPTHR16055. PTHR16055. 1 hit.
PRINTSiPR02106. INTSUBUNIT10.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 74-710.
    Tissue: Lung and Neuroblastoma.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 114-710.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 377-710.
    Tissue: Lymph node.
  5. "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II."
    Baillat D., Hakimi M.-A., Naeaer A.M., Shilatifard A., Cooch N., Shiekhattar R.
    Cell 123:265-276(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE INTEGRATOR COMPLEX, SUBCELLULAR LOCATION.
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiINT10_HUMAN
AccessioniPrimary (citable) accession number: Q9NVR2
Secondary accession number(s): Q6IA93
, Q7L538, Q7L8C8, Q9H3W8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 16, 2006
Last modified: March 4, 2015
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.