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Q9NVR2

- INT10_HUMAN

UniProt

Q9NVR2 - INT10_HUMAN

Protein

Integrator complex subunit 10

Gene

INTS10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (16 May 2006)
      Previous versions | rss
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    Functioni

    Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.

    GO - Molecular functioni

    1. protein binding Source: HGNC

    GO - Biological processi

    1. snRNA processing Source: HGNC

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Integrator complex subunit 10
    Short name:
    Int10
    Gene namesi
    Name:INTS10
    Synonyms:C8orf35
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:25548. INTS10.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. integrator complex Source: HGNC

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672354.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 710710Integrator complex subunit 10PRO_0000235687Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei231 – 2311Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9NVR2.
    PaxDbiQ9NVR2.
    PRIDEiQ9NVR2.

    PTM databases

    PhosphoSiteiQ9NVR2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NVR2.
    BgeeiQ9NVR2.
    CleanExiHS_INTS10.
    GenevestigatoriQ9NVR2.

    Organism-specific databases

    HPAiHPA039129.

    Interactioni

    Subunit structurei

    Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12. Interacts with POLR2A.1 Publication

    Protein-protein interaction databases

    BioGridi120473. 22 interactions.
    DIPiDIP-34063N.
    IntActiQ9NVR2. 2 interactions.
    STRINGi9606.ENSP00000381064.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NVR2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi132 – 1365Poly-Leu

    Sequence similaritiesi

    Belongs to the Integrator subunit 10 family.Curated

    Phylogenomic databases

    eggNOGiNOG77227.
    HOGENOMiHOG000285960.
    HOVERGENiHBG081797.
    InParanoidiQ9NVR2.
    KOiK13147.
    OMAiYMVLPIQ.
    OrthoDBiEOG7DC23X.
    PhylomeDBiQ9NVR2.
    TreeFamiTF323935.

    Family and domain databases

    InterProiIPR026164. Int_cplx_su10.
    [Graphical view]
    PANTHERiPTHR16055. PTHR16055. 1 hit.
    PRINTSiPR02106. INTSUBUNIT10.

    Sequencei

    Sequence statusi: Complete.

    Q9NVR2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAQGDCEFL VQRARELVPQ DLWAAKAWLI TARSLYPADF NIQYEMYTIE    50
    RNAERTATAG RLLYDMFVNF PDQPVVWREI SIITSALRND SQDKQTQFLR 100
    SLFETLPGRV QCEMLLKVTE QCFNTLERSE MLLLLLRRFP ETVVQHGVGL 150
    GEALLEAETI EEQESPVNCF RKLFVCDVLP LIINNHDVRL PANLLYKYLN 200
    KAAEFYINYV TRSTQIENQH QGAQDTSDLM SPSKRSSQKY IIEGLTEKSS 250
    QIVDPWERLF KILNVVGMRC EWQMDKGRRS YGDILHRMKD LCRYMNNFDS 300
    EAHAKYKNQV VYSTMLVFFK NAFQYVNSIQ PSLFQGPNAP SQVPLVLLED 350
    VSNVYGDVEI DRNKHIHKKR KLAEGREKTM SSDDEDCSAK GRNRHIVVNK 400
    AELANSTEVL ESFKLARESW ELLYSLEFLD KEFTRICLAW KTDTWLWLRI 450
    FLTDMIIYQG QYKKAIASLH HLAALQGSIS QPQITGQGTL EHQRALIQLA 500
    TCHFALGEYR MTCEKVLDLM CYMVLPIQDG GKSQEEPSKV KPKFRKGSDL 550
    KLLPCTSKAI MPYCLHLMLA CFKLRAFTDN RDDMALGHVI VLLQQEWPRG 600
    ENLFLKAVNK ICQQGNFQYE NFFNYVTNID MLEEFAYLRT QEGGKIHLEL 650
    LPNQGMLIKH HTVTRGITKG VKEDFRLAME RQVSRCGENL MVVLHRFCIN 700
    EKILLLQTLT 710
    Length:710
    Mass (Da):82,236
    Last modified:May 16, 2006 - v2
    Checksum:i3E9945064EC4BEFB
    GO

    Sequence cautioni

    The sequence BAA91687.1 differs from that shown. Reason: Frameshift at position 90.
    The sequence CAG33543.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti412 – 4121S → N in CAG33543. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001431 mRNA. Translation: BAA91687.1. Frameshift.
    BC001915 mRNA. Translation: AAH01915.2.
    BC006209 mRNA. Translation: AAH06209.2.
    BC051282 mRNA. Translation: AAH51282.2.
    CR457262 mRNA. Translation: CAG33543.1. Different initiation.
    AL442078 mRNA. Translation: CAC09444.1.
    BK005727 mRNA. Translation: DAA05727.1. Frameshift.
    CCDSiCCDS6011.2.
    RefSeqiNP_060612.2. NM_018142.2.
    UniGeneiHs.512627.

    Genome annotation databases

    EnsembliENST00000397977; ENSP00000381064; ENSG00000104613.
    GeneIDi55174.
    KEGGihsa:55174.
    UCSCiuc003wzj.3. human.

    Polymorphism databases

    DMDMi97052274.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001431 mRNA. Translation: BAA91687.1 . Frameshift.
    BC001915 mRNA. Translation: AAH01915.2 .
    BC006209 mRNA. Translation: AAH06209.2 .
    BC051282 mRNA. Translation: AAH51282.2 .
    CR457262 mRNA. Translation: CAG33543.1 . Different initiation.
    AL442078 mRNA. Translation: CAC09444.1 .
    BK005727 mRNA. Translation: DAA05727.1 . Frameshift.
    CCDSi CCDS6011.2.
    RefSeqi NP_060612.2. NM_018142.2.
    UniGenei Hs.512627.

    3D structure databases

    ProteinModelPortali Q9NVR2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120473. 22 interactions.
    DIPi DIP-34063N.
    IntActi Q9NVR2. 2 interactions.
    STRINGi 9606.ENSP00000381064.

    PTM databases

    PhosphoSitei Q9NVR2.

    Polymorphism databases

    DMDMi 97052274.

    Proteomic databases

    MaxQBi Q9NVR2.
    PaxDbi Q9NVR2.
    PRIDEi Q9NVR2.

    Protocols and materials databases

    DNASUi 55174.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000397977 ; ENSP00000381064 ; ENSG00000104613 .
    GeneIDi 55174.
    KEGGi hsa:55174.
    UCSCi uc003wzj.3. human.

    Organism-specific databases

    CTDi 55174.
    GeneCardsi GC08P019674.
    HGNCi HGNC:25548. INTS10.
    HPAi HPA039129.
    MIMi 611353. gene.
    neXtProti NX_Q9NVR2.
    PharmGKBi PA142672354.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG77227.
    HOGENOMi HOG000285960.
    HOVERGENi HBG081797.
    InParanoidi Q9NVR2.
    KOi K13147.
    OMAi YMVLPIQ.
    OrthoDBi EOG7DC23X.
    PhylomeDBi Q9NVR2.
    TreeFami TF323935.

    Miscellaneous databases

    ChiTaRSi IntS10. human.
    GenomeRNAii 55174.
    NextBioi 58967.
    PROi Q9NVR2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NVR2.
    Bgeei Q9NVR2.
    CleanExi HS_INTS10.
    Genevestigatori Q9NVR2.

    Family and domain databases

    InterProi IPR026164. Int_cplx_su10.
    [Graphical view ]
    PANTHERi PTHR16055. PTHR16055. 1 hit.
    PRINTSi PR02106. INTSUBUNIT10.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Teratocarcinoma.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 74-710.
      Tissue: Lung and Neuroblastoma.
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 114-710.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 377-710.
      Tissue: Lymph node.
    5. "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II."
      Baillat D., Hakimi M.-A., Naeaer A.M., Shilatifard A., Cooch N., Shiekhattar R.
      Cell 123:265-276(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE INTEGRATOR COMPLEX, SUBCELLULAR LOCATION.
    6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-231, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiINT10_HUMAN
    AccessioniPrimary (citable) accession number: Q9NVR2
    Secondary accession number(s): Q6IA93
    , Q7L538, Q7L8C8, Q9H3W8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2006
    Last sequence update: May 16, 2006
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3