Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9NVR0

- KLH11_HUMAN

UniProt

Q9NVR0 - KLH11_HUMAN

Protein

Kelch-like protein 11

Gene

KLHL11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.By similarity

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kelch-like protein 11
    Gene namesi
    Name:KLHL11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:19008. KLHL11.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38777.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1515Sequence AnalysisAdd
    BLAST
    Chaini16 – 708693Kelch-like protein 11PRO_0000243918Add
    BLAST

    Proteomic databases

    MaxQBiQ9NVR0.
    PaxDbiQ9NVR0.
    PRIDEiQ9NVR0.

    PTM databases

    PhosphoSiteiQ9NVR0.

    Expressioni

    Gene expression databases

    BgeeiQ9NVR0.
    CleanExiHS_KLHL11.
    GenevestigatoriQ9NVR0.

    Organism-specific databases

    HPAiHPA023021.

    Interactioni

    Subunit structurei

    Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex By similarity. Homodimer. Interacts with CUL3.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi120474. 3 interactions.
    IntActiQ9NVR0. 2 interactions.
    STRINGi9606.ENSP00000314608.

    Structurei

    Secondary structure

    1
    708
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi68 – 725
    Helixi76 – 8914
    Turni90 – 934
    Beta strandi96 – 994
    Beta strandi107 – 1104
    Helixi112 – 1187
    Helixi123 – 1253
    Beta strandi128 – 1303
    Helixi132 – 1354
    Beta strandi137 – 1393
    Helixi151 – 16313
    Beta strandi164 – 1696
    Turni170 – 1723
    Helixi173 – 18210
    Helixi186 – 19914
    Turni202 – 2043
    Helixi205 – 21410
    Helixi218 – 23013
    Helixi232 – 2354
    Helixi240 – 2434
    Helixi246 – 2538
    Helixi263 – 27513
    Helixi278 – 2814
    Turni282 – 2843
    Helixi285 – 2895
    Helixi294 – 2963
    Helixi299 – 3046
    Turni305 – 3084
    Helixi310 – 3134
    Helixi316 – 33116

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3I3NX-ray2.60A/B67-340[»]
    4AP2X-ray2.80A67-340[»]
    4APFX-ray3.10A67-340[»]
    ProteinModelPortaliQ9NVR0.
    SMRiQ9NVR0. Positions 67-334, 366-534.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9NVR0.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini94 – 17077BTBPROSITE-ProRule annotationAdd
    BLAST
    Domaini205 – 307103BACKAdd
    BLAST
    Repeati360 – 40748Kelch 1Add
    BLAST
    Repeati408 – 45346Kelch 2Add
    BLAST
    Repeati455 – 50147Kelch 3Add
    BLAST
    Repeati503 – 55654Kelch 4Add
    BLAST
    Repeati610 – 66152Kelch 5Add
    BLAST

    Sequence similaritiesi

    Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
    Contains 5 Kelch repeats.Curated

    Keywords - Domaini

    Kelch repeat, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG307870.
    HOGENOMiHOG000113235.
    HOVERGENiHBG066980.
    InParanoidiQ9NVR0.
    KOiK10449.
    OMAiERYNPNR.
    OrthoDBiEOG7X6KZJ.
    PhylomeDBiQ9NVR0.
    TreeFamiTF331981.

    Family and domain databases

    Gene3Di2.120.10.80. 2 hits.
    3.30.710.10. 1 hit.
    InterProiIPR011705. BACK.
    IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR015915. Kelch-typ_b-propeller.
    IPR006652. Kelch_1.
    [Graphical view]
    PfamiPF07707. BACK. 1 hit.
    PF00651. BTB. 1 hit.
    PF01344. Kelch_1. 3 hits.
    [Graphical view]
    SMARTiSM00875. BACK. 1 hit.
    SM00225. BTB. 1 hit.
    SM00612. Kelch. 4 hits.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.
    PROSITEiPS50097. BTB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9NVR0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAAAVAAAA AAAAAASLQV LEMESMETAA AGSAGLAAEV RGSGTVDFGP    50
    GPGISAMEAS GGDPGPEAED FECSSHCSEL SWRQNEQRRQ GLFCDITLCF 100
    GGAGGREFRA HRSVLAAATE YFTPLLSGQF SESRSGRVEM RKWSSEPGPE 150
    PDTVEAVIEY MYTGRIRVST GSVHEVLELA DRFLLIRLKE FCGEFLKKKL 200
    HLSNCVAIHS LAHMYTLSQL ALKAADMIRR NFHKVIQDEE FYTLPFHLIR 250
    DWLSDLEITV DSEEVLFETV LKWVQRNAEE RERYFEELFK LLRLSQMKPT 300
    YLTRHVKPER LVANNEVCVK LVADAVERHA LRAENIQSGT CQHPTSHVSL 350
    LPRYGQNMDV IMVIGGVSEG GDYLSECVGY FVDEDRWVNL PHIHNHLDGH 400
    AVAVTESYVY VAGSMEPGFA KTVERYNPNL NTWEHVCSLM TRKHSFGLTE 450
    VKGKLYSIGG HGNFSPGFKD VTVYNPELDK WHNLESAPKI LRDVKALAIE 500
    DRFVYIAART PVDRDTEDGL KAVITCYDTE TRQWQDVESL PLIDNYCFFQ 550
    MSVVNSNFYQ TASCCPKSYC LENEEAVRKI ASQVSDEILE SLPPEVLSIE 600
    GAAICYYKDD VFIIGGWKNS DDIDKQYRKE AYRYCAERKR WMLLPPMPQP 650
    RCRATACHVR IPYRYLHGTQ RYPMPQNLMW QKDRIRQMQE IHRHALNMRR 700
    VPSSQIEC 708
    Length:708
    Mass (Da):80,148
    Last modified:October 1, 2000 - v1
    Checksum:i38733CE875172E12
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001434 mRNA. Translation: BAA91689.1.
    BC034470 mRNA. Translation: AAH34470.1.
    CCDSiCCDS11411.1.
    RefSeqiNP_060613.1. NM_018143.1.
    UniGeneiHs.592134.

    Genome annotation databases

    EnsembliENST00000319121; ENSP00000314608; ENSG00000178502.
    GeneIDi55175.
    KEGGihsa:55175.
    UCSCiuc002hyf.1. human.

    Polymorphism databases

    DMDMi74734542.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001434 mRNA. Translation: BAA91689.1 .
    BC034470 mRNA. Translation: AAH34470.1 .
    CCDSi CCDS11411.1.
    RefSeqi NP_060613.1. NM_018143.1.
    UniGenei Hs.592134.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3I3N X-ray 2.60 A/B 67-340 [» ]
    4AP2 X-ray 2.80 A 67-340 [» ]
    4APF X-ray 3.10 A 67-340 [» ]
    ProteinModelPortali Q9NVR0.
    SMRi Q9NVR0. Positions 67-334, 366-534.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120474. 3 interactions.
    IntActi Q9NVR0. 2 interactions.
    STRINGi 9606.ENSP00000314608.

    PTM databases

    PhosphoSitei Q9NVR0.

    Polymorphism databases

    DMDMi 74734542.

    Proteomic databases

    MaxQBi Q9NVR0.
    PaxDbi Q9NVR0.
    PRIDEi Q9NVR0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000319121 ; ENSP00000314608 ; ENSG00000178502 .
    GeneIDi 55175.
    KEGGi hsa:55175.
    UCSCi uc002hyf.1. human.

    Organism-specific databases

    CTDi 55175.
    GeneCardsi GC17M040009.
    HGNCi HGNC:19008. KLHL11.
    HPAi HPA023021.
    neXtProti NX_Q9NVR0.
    PharmGKBi PA38777.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG307870.
    HOGENOMi HOG000113235.
    HOVERGENi HBG066980.
    InParanoidi Q9NVR0.
    KOi K10449.
    OMAi ERYNPNR.
    OrthoDBi EOG7X6KZJ.
    PhylomeDBi Q9NVR0.
    TreeFami TF331981.

    Miscellaneous databases

    EvolutionaryTracei Q9NVR0.
    GenomeRNAii 55175.
    NextBioi 58971.
    PROi Q9NVR0.

    Gene expression databases

    Bgeei Q9NVR0.
    CleanExi HS_KLHL11.
    Genevestigatori Q9NVR0.

    Family and domain databases

    Gene3Di 2.120.10.80. 2 hits.
    3.30.710.10. 1 hit.
    InterProi IPR011705. BACK.
    IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR015915. Kelch-typ_b-propeller.
    IPR006652. Kelch_1.
    [Graphical view ]
    Pfami PF07707. BACK. 1 hit.
    PF00651. BTB. 1 hit.
    PF01344. Kelch_1. 3 hits.
    [Graphical view ]
    SMARTi SM00875. BACK. 1 hit.
    SM00225. BTB. 1 hit.
    SM00612. Kelch. 4 hits.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    PROSITEi PS50097. BTB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF OF 67-340 IN COMPLEX WITH CUL3, SUBUNIT, INTERACTION WITH CUL3.

    Entry informationi

    Entry nameiKLH11_HUMAN
    AccessioniPrimary (citable) accession number: Q9NVR0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3