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Q9NVR0

- KLH11_HUMAN

UniProt

Q9NVR0 - KLH11_HUMAN

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Protein

Kelch-like protein 11

Gene

KLHL11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.By similarity

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 11
Gene namesi
Name:KLHL11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:19008. KLHL11.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38777.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Sequence AnalysisAdd
BLAST
Chaini16 – 708693Kelch-like protein 11PRO_0000243918Add
BLAST

Proteomic databases

MaxQBiQ9NVR0.
PaxDbiQ9NVR0.
PRIDEiQ9NVR0.

PTM databases

PhosphoSiteiQ9NVR0.

Expressioni

Gene expression databases

BgeeiQ9NVR0.
CleanExiHS_KLHL11.
GenevestigatoriQ9NVR0.

Organism-specific databases

HPAiHPA023021.

Interactioni

Subunit structurei

Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (By similarity). Homodimer. Interacts with CUL3.By similarity1 Publication

Protein-protein interaction databases

BioGridi120474. 6 interactions.
IntActiQ9NVR0. 2 interactions.
STRINGi9606.ENSP00000314608.

Structurei

Secondary structure

1
708
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi68 – 725Combined sources
Helixi76 – 8914Combined sources
Turni90 – 934Combined sources
Beta strandi96 – 994Combined sources
Beta strandi107 – 1104Combined sources
Helixi112 – 1187Combined sources
Helixi123 – 1253Combined sources
Beta strandi128 – 1303Combined sources
Helixi132 – 1354Combined sources
Beta strandi137 – 1393Combined sources
Helixi151 – 16313Combined sources
Beta strandi164 – 1696Combined sources
Turni170 – 1723Combined sources
Helixi173 – 18210Combined sources
Helixi186 – 19914Combined sources
Turni202 – 2043Combined sources
Helixi205 – 21410Combined sources
Helixi218 – 23013Combined sources
Helixi232 – 2354Combined sources
Helixi240 – 2434Combined sources
Helixi246 – 2538Combined sources
Helixi263 – 27513Combined sources
Helixi278 – 2814Combined sources
Turni282 – 2843Combined sources
Helixi285 – 2895Combined sources
Helixi294 – 2963Combined sources
Helixi299 – 3046Combined sources
Turni305 – 3084Combined sources
Helixi310 – 3134Combined sources
Helixi316 – 33116Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3I3NX-ray2.60A/B67-340[»]
4AP2X-ray2.80A67-340[»]
4APFX-ray3.10A67-340[»]
ProteinModelPortaliQ9NVR0.
SMRiQ9NVR0. Positions 67-334, 366-534.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NVR0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini94 – 17077BTBPROSITE-ProRule annotationAdd
BLAST
Domaini205 – 307103BACKAdd
BLAST
Repeati360 – 40748Kelch 1Add
BLAST
Repeati408 – 45346Kelch 2Add
BLAST
Repeati455 – 50147Kelch 3Add
BLAST
Repeati503 – 55654Kelch 4Add
BLAST
Repeati610 – 66152Kelch 5Add
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 5 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat, Signal

Phylogenomic databases

eggNOGiNOG307870.
GeneTreeiENSGT00770000120613.
HOGENOMiHOG000113235.
HOVERGENiHBG066980.
InParanoidiQ9NVR0.
KOiK10449.
OMAiERYNPNR.
OrthoDBiEOG7X6KZJ.
PhylomeDBiQ9NVR0.
TreeFamiTF331981.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
3.30.710.10. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 3 hits.
[Graphical view]
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 4 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NVR0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAAAVAAAA AAAAAASLQV LEMESMETAA AGSAGLAAEV RGSGTVDFGP
60 70 80 90 100
GPGISAMEAS GGDPGPEAED FECSSHCSEL SWRQNEQRRQ GLFCDITLCF
110 120 130 140 150
GGAGGREFRA HRSVLAAATE YFTPLLSGQF SESRSGRVEM RKWSSEPGPE
160 170 180 190 200
PDTVEAVIEY MYTGRIRVST GSVHEVLELA DRFLLIRLKE FCGEFLKKKL
210 220 230 240 250
HLSNCVAIHS LAHMYTLSQL ALKAADMIRR NFHKVIQDEE FYTLPFHLIR
260 270 280 290 300
DWLSDLEITV DSEEVLFETV LKWVQRNAEE RERYFEELFK LLRLSQMKPT
310 320 330 340 350
YLTRHVKPER LVANNEVCVK LVADAVERHA LRAENIQSGT CQHPTSHVSL
360 370 380 390 400
LPRYGQNMDV IMVIGGVSEG GDYLSECVGY FVDEDRWVNL PHIHNHLDGH
410 420 430 440 450
AVAVTESYVY VAGSMEPGFA KTVERYNPNL NTWEHVCSLM TRKHSFGLTE
460 470 480 490 500
VKGKLYSIGG HGNFSPGFKD VTVYNPELDK WHNLESAPKI LRDVKALAIE
510 520 530 540 550
DRFVYIAART PVDRDTEDGL KAVITCYDTE TRQWQDVESL PLIDNYCFFQ
560 570 580 590 600
MSVVNSNFYQ TASCCPKSYC LENEEAVRKI ASQVSDEILE SLPPEVLSIE
610 620 630 640 650
GAAICYYKDD VFIIGGWKNS DDIDKQYRKE AYRYCAERKR WMLLPPMPQP
660 670 680 690 700
RCRATACHVR IPYRYLHGTQ RYPMPQNLMW QKDRIRQMQE IHRHALNMRR

VPSSQIEC
Length:708
Mass (Da):80,148
Last modified:October 1, 2000 - v1
Checksum:i38733CE875172E12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001434 mRNA. Translation: BAA91689.1.
BC034470 mRNA. Translation: AAH34470.1.
CCDSiCCDS11411.1.
RefSeqiNP_060613.1. NM_018143.1.
UniGeneiHs.592134.

Genome annotation databases

EnsembliENST00000319121; ENSP00000314608; ENSG00000178502.
GeneIDi55175.
KEGGihsa:55175.
UCSCiuc002hyf.1. human.

Polymorphism databases

DMDMi74734542.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001434 mRNA. Translation: BAA91689.1 .
BC034470 mRNA. Translation: AAH34470.1 .
CCDSi CCDS11411.1.
RefSeqi NP_060613.1. NM_018143.1.
UniGenei Hs.592134.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3I3N X-ray 2.60 A/B 67-340 [» ]
4AP2 X-ray 2.80 A 67-340 [» ]
4APF X-ray 3.10 A 67-340 [» ]
ProteinModelPortali Q9NVR0.
SMRi Q9NVR0. Positions 67-334, 366-534.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120474. 6 interactions.
IntActi Q9NVR0. 2 interactions.
STRINGi 9606.ENSP00000314608.

PTM databases

PhosphoSitei Q9NVR0.

Polymorphism databases

DMDMi 74734542.

Proteomic databases

MaxQBi Q9NVR0.
PaxDbi Q9NVR0.
PRIDEi Q9NVR0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000319121 ; ENSP00000314608 ; ENSG00000178502 .
GeneIDi 55175.
KEGGi hsa:55175.
UCSCi uc002hyf.1. human.

Organism-specific databases

CTDi 55175.
GeneCardsi GC17M040009.
HGNCi HGNC:19008. KLHL11.
HPAi HPA023021.
neXtProti NX_Q9NVR0.
PharmGKBi PA38777.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG307870.
GeneTreei ENSGT00770000120613.
HOGENOMi HOG000113235.
HOVERGENi HBG066980.
InParanoidi Q9NVR0.
KOi K10449.
OMAi ERYNPNR.
OrthoDBi EOG7X6KZJ.
PhylomeDBi Q9NVR0.
TreeFami TF331981.

Miscellaneous databases

EvolutionaryTracei Q9NVR0.
GenomeRNAii 55175.
NextBioi 58971.
PROi Q9NVR0.

Gene expression databases

Bgeei Q9NVR0.
CleanExi HS_KLHL11.
Genevestigatori Q9NVR0.

Family and domain databases

Gene3Di 2.120.10.80. 2 hits.
3.30.710.10. 1 hit.
InterProi IPR011705. BACK.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
[Graphical view ]
Pfami PF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 3 hits.
[Graphical view ]
SMARTi SM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 4 hits.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
PROSITEi PS50097. BTB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF OF 67-340 IN COMPLEX WITH CUL3, SUBUNIT, INTERACTION WITH CUL3.

Entry informationi

Entry nameiKLH11_HUMAN
AccessioniPrimary (citable) accession number: Q9NVR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3