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Protein

Kelch-like protein 11

Gene

KLHL11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.By similarity

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 11
Gene namesi
Name:KLHL11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:19008. KLHL11.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38777.

Polymorphism and mutation databases

BioMutaiKLHL11.
DMDMi74734542.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Sequence AnalysisAdd
BLAST
Chaini16 – 708693Kelch-like protein 11PRO_0000243918Add
BLAST

Proteomic databases

MaxQBiQ9NVR0.
PaxDbiQ9NVR0.
PRIDEiQ9NVR0.

PTM databases

PhosphoSiteiQ9NVR0.

Expressioni

Gene expression databases

BgeeiQ9NVR0.
CleanExiHS_KLHL11.
ExpressionAtlasiQ9NVR0. baseline and differential.
GenevisibleiQ9NVR0. HS.

Organism-specific databases

HPAiHPA023021.
HPA054269.

Interactioni

Subunit structurei

Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (By similarity). Homodimer. Interacts with CUL3.By similarity1 Publication

Protein-protein interaction databases

BioGridi120474. 9 interactions.
IntActiQ9NVR0. 2 interactions.

Structurei

Secondary structure

1
708
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi68 – 725Combined sources
Helixi76 – 8914Combined sources
Turni90 – 934Combined sources
Beta strandi96 – 994Combined sources
Beta strandi107 – 1104Combined sources
Helixi112 – 1187Combined sources
Helixi123 – 1253Combined sources
Beta strandi128 – 1303Combined sources
Helixi132 – 1354Combined sources
Beta strandi137 – 1393Combined sources
Helixi151 – 16313Combined sources
Beta strandi164 – 1696Combined sources
Turni170 – 1723Combined sources
Helixi173 – 18210Combined sources
Helixi186 – 19914Combined sources
Turni202 – 2043Combined sources
Helixi205 – 21410Combined sources
Helixi218 – 23013Combined sources
Helixi232 – 2354Combined sources
Helixi240 – 2434Combined sources
Helixi246 – 2538Combined sources
Helixi263 – 27513Combined sources
Helixi278 – 2814Combined sources
Turni282 – 2843Combined sources
Helixi285 – 2895Combined sources
Helixi294 – 2963Combined sources
Helixi299 – 3046Combined sources
Turni305 – 3084Combined sources
Helixi310 – 3134Combined sources
Helixi316 – 33116Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3I3NX-ray2.60A/B67-340[»]
4AP2X-ray2.80A67-340[»]
4APFX-ray3.10A67-340[»]
ProteinModelPortaliQ9NVR0.
SMRiQ9NVR0. Positions 67-334, 366-534.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NVR0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini94 – 17077BTBPROSITE-ProRule annotationAdd
BLAST
Domaini205 – 307103BACKAdd
BLAST
Repeati360 – 40748Kelch 1Add
BLAST
Repeati408 – 45346Kelch 2Add
BLAST
Repeati455 – 50147Kelch 3Add
BLAST
Repeati503 – 55654Kelch 4Add
BLAST
Repeati610 – 66152Kelch 5Add
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 5 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat, Signal

Phylogenomic databases

eggNOGiNOG307870.
GeneTreeiENSGT00790000122944.
HOGENOMiHOG000113235.
HOVERGENiHBG066980.
InParanoidiQ9NVR0.
KOiK10449.
OMAiERYNPNR.
OrthoDBiEOG7X6KZJ.
PhylomeDBiQ9NVR0.
TreeFamiTF331981.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 3 hits.
[Graphical view]
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 4 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NVR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAVAAAA AAAAAASLQV LEMESMETAA AGSAGLAAEV RGSGTVDFGP
60 70 80 90 100
GPGISAMEAS GGDPGPEAED FECSSHCSEL SWRQNEQRRQ GLFCDITLCF
110 120 130 140 150
GGAGGREFRA HRSVLAAATE YFTPLLSGQF SESRSGRVEM RKWSSEPGPE
160 170 180 190 200
PDTVEAVIEY MYTGRIRVST GSVHEVLELA DRFLLIRLKE FCGEFLKKKL
210 220 230 240 250
HLSNCVAIHS LAHMYTLSQL ALKAADMIRR NFHKVIQDEE FYTLPFHLIR
260 270 280 290 300
DWLSDLEITV DSEEVLFETV LKWVQRNAEE RERYFEELFK LLRLSQMKPT
310 320 330 340 350
YLTRHVKPER LVANNEVCVK LVADAVERHA LRAENIQSGT CQHPTSHVSL
360 370 380 390 400
LPRYGQNMDV IMVIGGVSEG GDYLSECVGY FVDEDRWVNL PHIHNHLDGH
410 420 430 440 450
AVAVTESYVY VAGSMEPGFA KTVERYNPNL NTWEHVCSLM TRKHSFGLTE
460 470 480 490 500
VKGKLYSIGG HGNFSPGFKD VTVYNPELDK WHNLESAPKI LRDVKALAIE
510 520 530 540 550
DRFVYIAART PVDRDTEDGL KAVITCYDTE TRQWQDVESL PLIDNYCFFQ
560 570 580 590 600
MSVVNSNFYQ TASCCPKSYC LENEEAVRKI ASQVSDEILE SLPPEVLSIE
610 620 630 640 650
GAAICYYKDD VFIIGGWKNS DDIDKQYRKE AYRYCAERKR WMLLPPMPQP
660 670 680 690 700
RCRATACHVR IPYRYLHGTQ RYPMPQNLMW QKDRIRQMQE IHRHALNMRR

VPSSQIEC
Length:708
Mass (Da):80,148
Last modified:October 1, 2000 - v1
Checksum:i38733CE875172E12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001434 mRNA. Translation: BAA91689.1.
BC034470 mRNA. Translation: AAH34470.1.
CCDSiCCDS11411.1.
RefSeqiNP_060613.1. NM_018143.2.
UniGeneiHs.13268.
Hs.592134.

Genome annotation databases

EnsembliENST00000319121; ENSP00000314608; ENSG00000178502.
GeneIDi55175.
KEGGihsa:55175.
UCSCiuc002hyf.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001434 mRNA. Translation: BAA91689.1.
BC034470 mRNA. Translation: AAH34470.1.
CCDSiCCDS11411.1.
RefSeqiNP_060613.1. NM_018143.2.
UniGeneiHs.13268.
Hs.592134.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3I3NX-ray2.60A/B67-340[»]
4AP2X-ray2.80A67-340[»]
4APFX-ray3.10A67-340[»]
ProteinModelPortaliQ9NVR0.
SMRiQ9NVR0. Positions 67-334, 366-534.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120474. 9 interactions.
IntActiQ9NVR0. 2 interactions.

PTM databases

PhosphoSiteiQ9NVR0.

Polymorphism and mutation databases

BioMutaiKLHL11.
DMDMi74734542.

Proteomic databases

MaxQBiQ9NVR0.
PaxDbiQ9NVR0.
PRIDEiQ9NVR0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319121; ENSP00000314608; ENSG00000178502.
GeneIDi55175.
KEGGihsa:55175.
UCSCiuc002hyf.1. human.

Organism-specific databases

CTDi55175.
GeneCardsiGC17M040009.
HGNCiHGNC:19008. KLHL11.
HPAiHPA023021.
HPA054269.
neXtProtiNX_Q9NVR0.
PharmGKBiPA38777.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG307870.
GeneTreeiENSGT00790000122944.
HOGENOMiHOG000113235.
HOVERGENiHBG066980.
InParanoidiQ9NVR0.
KOiK10449.
OMAiERYNPNR.
OrthoDBiEOG7X6KZJ.
PhylomeDBiQ9NVR0.
TreeFamiTF331981.

Miscellaneous databases

EvolutionaryTraceiQ9NVR0.
GenomeRNAii55175.
NextBioi58971.
PROiQ9NVR0.

Gene expression databases

BgeeiQ9NVR0.
CleanExiHS_KLHL11.
ExpressionAtlasiQ9NVR0. baseline and differential.
GenevisibleiQ9NVR0. HS.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 3 hits.
[Graphical view]
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 4 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF OF 67-340 IN COMPLEX WITH CUL3, SUBUNIT, INTERACTION WITH CUL3.

Entry informationi

Entry nameiKLH11_HUMAN
AccessioniPrimary (citable) accession number: Q9NVR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 1, 2000
Last modified: June 24, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.