Q9NVR0 (KLH11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Kelch-like protein 11

Gene names

Name:

KLHL11

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	708 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation By similarity.
Subunit structure	Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex By similarity. Homodimer. Interacts with CUL3. Ref.3
Sequence similarities	Contains 1 BACK (BTB/Kelch associated) domain. Contains 1 BTB (POZ) domain. Contains 5 Kelch repeats.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Domain	Kelch repeat Repeat Signal
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 15

15

Potential

Chain

16 – 708

693

Kelch-like protein 11

PRO_0000243918

Regions

Domain

94 – 170

77

BTB

Domain

205 – 307

103

BACK

Repeat

360 – 407

48

Kelch 1

Repeat

408 – 453

46

Kelch 2

Repeat

455 – 501

47

Kelch 3

Repeat

503 – 556

54

Kelch 4

Repeat

610 – 661

52

Kelch 5

Secondary structure

1

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708

Helix Strand Turn

Details...

Beta strand

68 – 72

5

Helix

76 – 89

14

Turn

90 – 93

4

Beta strand

96 – 99

4

Beta strand

107 – 110

4

Helix

112 – 118

7

Helix

123 – 125

3

Beta strand

128 – 130

3

Helix

132 – 135

4

Beta strand

137 – 139

3

Helix

151 – 163

13

Beta strand

164 – 169

6

Turn

170 – 172

3

Helix

173 – 182

10

Helix

186 – 199

14

Turn

202 – 204

3

Helix

205 – 214

10

Helix

218 – 230

13

Helix

232 – 235

4

Helix

240 – 243

4

Helix

246 – 253

8

Helix

263 – 275

13

Helix

278 – 281

4

Turn

282 – 284

3

Helix

285 – 289

5

Helix

294 – 296

3

Helix

299 – 304

6

Turn

305 – 308

4

Helix

310 – 313

4

Helix

316 – 331

16

Sequences

	Sequence		Length	Mass (Da)
	Q9NVR0 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 38733CE875172E12	FASTA	708	80,148
	10 20 30 40 50 60 MAAAAVAAAA AAAAAASLQV LEMESMETAA AGSAGLAAEV RGSGTVDFGP GPGISAMEAS 70 80 90 100 110 120 GGDPGPEAED FECSSHCSEL SWRQNEQRRQ GLFCDITLCF GGAGGREFRA HRSVLAAATE 130 140 150 160 170 180 YFTPLLSGQF SESRSGRVEM RKWSSEPGPE PDTVEAVIEY MYTGRIRVST GSVHEVLELA 190 200 210 220 230 240 DRFLLIRLKE FCGEFLKKKL HLSNCVAIHS LAHMYTLSQL ALKAADMIRR NFHKVIQDEE 250 260 270 280 290 300 FYTLPFHLIR DWLSDLEITV DSEEVLFETV LKWVQRNAEE RERYFEELFK LLRLSQMKPT 310 320 330 340 350 360 YLTRHVKPER LVANNEVCVK LVADAVERHA LRAENIQSGT CQHPTSHVSL LPRYGQNMDV 370 380 390 400 410 420 IMVIGGVSEG GDYLSECVGY FVDEDRWVNL PHIHNHLDGH AVAVTESYVY VAGSMEPGFA 430 440 450 460 470 480 KTVERYNPNL NTWEHVCSLM TRKHSFGLTE VKGKLYSIGG HGNFSPGFKD VTVYNPELDK 490 500 510 520 530 540 WHNLESAPKI LRDVKALAIE DRFVYIAART PVDRDTEDGL KAVITCYDTE TRQWQDVESL 550 560 570 580 590 600 PLIDNYCFFQ MSVVNSNFYQ TASCCPKSYC LENEEAVRKI ASQVSDEILE SLPPEVLSIE 610 620 630 640 650 660 GAAICYYKDD VFIIGGWKNS DDIDKQYRKE AYRYCAERKR WMLLPPMPQP RCRATACHVR 670 680 690 700 IPYRYLHGTQ RYPMPQNLMW QKDRIRQMQE IHRHALNMRR VPSSQIEC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[3]	"Structural basis for Cul3 assembly with the BTB-Kelch family of E3 ubiquitin ligases." Canning P., Cooper C.D., Krojer T., Murray J.W., Pike A.C., Chaikuad A., Keates T., Thangaratnarajah C., Hojzan V., Marsden B.D., Gileadi O., Knapp S., von Delft F., Bullock A.N. J. Biol. Chem. 0:0-0(2013) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF OF 67-340 IN COMPLEX WITH CUL3, SUBUNIT, INTERACTION WITH CUL3.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AK001434 mRNA. Translation: BAA91689.1.
BC034470 mRNA. Translation: AAH34470.1.

IPI

IPI00018726.

RefSeq

NP_060613.1. NM_018143.1.

UniGene

Hs.592134.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3I3N	X-ray	2.60	A/B	67-340	[»]
4AP2	X-ray	2.80	A	67-340	[»]
4APF	X-ray	3.10	A	67-340	[»]

ProteinModelPortal

Q9NVR0.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9NVR0. 1 interaction.

STRING

9606.ENSP00000314608.

PTM databases

PhosphoSite

Q9NVR0.

Polymorphism databases

DMDM

74734542.

Proteomic databases

PaxDb

Q9NVR0.

PRIDE

Q9NVR0.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000319121; ENSP00000314608; ENSG00000178502.
ENST00000569845; ENSP00000457872; ENSG00000259896.

GeneID

55175.

KEGG

hsa:55175.

UCSC

uc002hyf.1. human.

Organism-specific databases

CTD

55175.

GeneCards

GC17M040009.

HGNC

HGNC:19008. KLHL11.

HPA

HPA023021.

neXtProt

NX_Q9NVR0.

PharmGKB

PA38777.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG307870.

HOGENOM

HOG000113235.

HOVERGEN

HBG066980.

InParanoid

Q9NVR0.

KO

K10449.

OMA

ERYNPNR.

OrthoDB

EOG4K6G3Q.

PhylomeDB

Q9NVR0.

Gene expression databases

ArrayExpress

Q9NVR0.

Bgee

Q9NVR0.

CleanEx

HS_KLHL11.

Genevestigator

Q9NVR0.

GermOnline

ENSG00000178502. Homo sapiens.

Family and domain databases

Gene3D

2.120.10.80. 2 hits.
3.30.710.10. 1 hit.

InterPro

IPR011705. BACK.
IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
[Graphical view]

Pfam

PF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 3 hits.
[Graphical view]

SMART

SM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 4 hits.
[Graphical view]

SUPFAM

SSF54695. BTB/POZ_fold. 1 hit.

PROSITE

PS50097. BTB. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q9NVR0.

GenomeRNAi

55175.

NextBio

58971.

Entry information

Entry name

KLH11_HUMAN

Accession

Primary (citable) accession number: Q9NVR0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.