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Protein

Kelch-like protein 11

Gene

KLHL11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

BioCyciZFISH:ENSG00000178502-MONOMER.
ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 11
Gene namesi
Name:KLHL11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:19008. KLHL11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000178502.
PharmGKBiPA38777.

Polymorphism and mutation databases

BioMutaiKLHL11.
DMDMi74734542.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_000024391816 – 708Kelch-like protein 11Add BLAST693

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei465PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NVR0.
MaxQBiQ9NVR0.
PaxDbiQ9NVR0.
PeptideAtlasiQ9NVR0.
PRIDEiQ9NVR0.

PTM databases

iPTMnetiQ9NVR0.
PhosphoSitePlusiQ9NVR0.

Expressioni

Gene expression databases

BgeeiENSG00000178502.
CleanExiHS_KLHL11.
ExpressionAtlasiQ9NVR0. baseline and differential.
GenevisibleiQ9NVR0. HS.

Organism-specific databases

HPAiHPA023021.
HPA054269.

Interactioni

Subunit structurei

Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (By similarity). Homodimer. Interacts with CUL3.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120474. 8 interactors.
IntActiQ9NVR0. 5 interactors.
STRINGi9606.ENSP00000314608.

Structurei

Secondary structure

1708
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi68 – 72Combined sources5
Helixi76 – 89Combined sources14
Turni90 – 93Combined sources4
Beta strandi96 – 99Combined sources4
Beta strandi107 – 110Combined sources4
Helixi112 – 118Combined sources7
Helixi123 – 125Combined sources3
Beta strandi128 – 130Combined sources3
Helixi132 – 135Combined sources4
Beta strandi137 – 139Combined sources3
Helixi151 – 163Combined sources13
Beta strandi164 – 169Combined sources6
Turni170 – 172Combined sources3
Helixi173 – 182Combined sources10
Helixi186 – 199Combined sources14
Turni202 – 204Combined sources3
Helixi205 – 214Combined sources10
Helixi218 – 230Combined sources13
Helixi232 – 235Combined sources4
Helixi240 – 243Combined sources4
Helixi246 – 253Combined sources8
Helixi263 – 275Combined sources13
Helixi278 – 281Combined sources4
Turni282 – 284Combined sources3
Helixi285 – 289Combined sources5
Helixi294 – 296Combined sources3
Helixi299 – 304Combined sources6
Turni305 – 308Combined sources4
Helixi310 – 313Combined sources4
Helixi316 – 331Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3I3NX-ray2.60A/B67-340[»]
4AP2X-ray2.80A67-340[»]
4APFX-ray3.10A67-340[»]
ProteinModelPortaliQ9NVR0.
SMRiQ9NVR0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NVR0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini94 – 170BTBPROSITE-ProRule annotationAdd BLAST77
Domaini205 – 307BACKAdd BLAST103
Repeati360 – 407Kelch 1Add BLAST48
Repeati408 – 453Kelch 2Add BLAST46
Repeati455 – 501Kelch 3Add BLAST47
Repeati503 – 556Kelch 4Add BLAST54
Repeati610 – 661Kelch 5Add BLAST52

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 5 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG1072. Eukaryota.
ENOG4110X8D. LUCA.
GeneTreeiENSGT00800000124141.
HOGENOMiHOG000113235.
HOVERGENiHBG066980.
InParanoidiQ9NVR0.
KOiK10449.
OMAiERYNPNR.
OrthoDBiEOG091G02UE.
PhylomeDBiQ9NVR0.
TreeFamiTF331981.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 1 hit.
[Graphical view]
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 4 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NVR0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAVAAAA AAAAAASLQV LEMESMETAA AGSAGLAAEV RGSGTVDFGP
60 70 80 90 100
GPGISAMEAS GGDPGPEAED FECSSHCSEL SWRQNEQRRQ GLFCDITLCF
110 120 130 140 150
GGAGGREFRA HRSVLAAATE YFTPLLSGQF SESRSGRVEM RKWSSEPGPE
160 170 180 190 200
PDTVEAVIEY MYTGRIRVST GSVHEVLELA DRFLLIRLKE FCGEFLKKKL
210 220 230 240 250
HLSNCVAIHS LAHMYTLSQL ALKAADMIRR NFHKVIQDEE FYTLPFHLIR
260 270 280 290 300
DWLSDLEITV DSEEVLFETV LKWVQRNAEE RERYFEELFK LLRLSQMKPT
310 320 330 340 350
YLTRHVKPER LVANNEVCVK LVADAVERHA LRAENIQSGT CQHPTSHVSL
360 370 380 390 400
LPRYGQNMDV IMVIGGVSEG GDYLSECVGY FVDEDRWVNL PHIHNHLDGH
410 420 430 440 450
AVAVTESYVY VAGSMEPGFA KTVERYNPNL NTWEHVCSLM TRKHSFGLTE
460 470 480 490 500
VKGKLYSIGG HGNFSPGFKD VTVYNPELDK WHNLESAPKI LRDVKALAIE
510 520 530 540 550
DRFVYIAART PVDRDTEDGL KAVITCYDTE TRQWQDVESL PLIDNYCFFQ
560 570 580 590 600
MSVVNSNFYQ TASCCPKSYC LENEEAVRKI ASQVSDEILE SLPPEVLSIE
610 620 630 640 650
GAAICYYKDD VFIIGGWKNS DDIDKQYRKE AYRYCAERKR WMLLPPMPQP
660 670 680 690 700
RCRATACHVR IPYRYLHGTQ RYPMPQNLMW QKDRIRQMQE IHRHALNMRR

VPSSQIEC
Length:708
Mass (Da):80,148
Last modified:October 1, 2000 - v1
Checksum:i38733CE875172E12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001434 mRNA. Translation: BAA91689.1.
BC034470 mRNA. Translation: AAH34470.1.
CCDSiCCDS11411.1.
RefSeqiNP_060613.1. NM_018143.2.
UniGeneiHs.13268.
Hs.592134.

Genome annotation databases

EnsembliENST00000319121; ENSP00000314608; ENSG00000178502.
GeneIDi55175.
KEGGihsa:55175.
UCSCiuc002hyf.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001434 mRNA. Translation: BAA91689.1.
BC034470 mRNA. Translation: AAH34470.1.
CCDSiCCDS11411.1.
RefSeqiNP_060613.1. NM_018143.2.
UniGeneiHs.13268.
Hs.592134.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3I3NX-ray2.60A/B67-340[»]
4AP2X-ray2.80A67-340[»]
4APFX-ray3.10A67-340[»]
ProteinModelPortaliQ9NVR0.
SMRiQ9NVR0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120474. 8 interactors.
IntActiQ9NVR0. 5 interactors.
STRINGi9606.ENSP00000314608.

PTM databases

iPTMnetiQ9NVR0.
PhosphoSitePlusiQ9NVR0.

Polymorphism and mutation databases

BioMutaiKLHL11.
DMDMi74734542.

Proteomic databases

EPDiQ9NVR0.
MaxQBiQ9NVR0.
PaxDbiQ9NVR0.
PeptideAtlasiQ9NVR0.
PRIDEiQ9NVR0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319121; ENSP00000314608; ENSG00000178502.
GeneIDi55175.
KEGGihsa:55175.
UCSCiuc002hyf.2. human.

Organism-specific databases

CTDi55175.
GeneCardsiKLHL11.
HGNCiHGNC:19008. KLHL11.
HPAiHPA023021.
HPA054269.
neXtProtiNX_Q9NVR0.
OpenTargetsiENSG00000178502.
PharmGKBiPA38777.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1072. Eukaryota.
ENOG4110X8D. LUCA.
GeneTreeiENSGT00800000124141.
HOGENOMiHOG000113235.
HOVERGENiHBG066980.
InParanoidiQ9NVR0.
KOiK10449.
OMAiERYNPNR.
OrthoDBiEOG091G02UE.
PhylomeDBiQ9NVR0.
TreeFamiTF331981.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000178502-MONOMER.
ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

EvolutionaryTraceiQ9NVR0.
GenomeRNAii55175.
PROiQ9NVR0.

Gene expression databases

BgeeiENSG00000178502.
CleanExiHS_KLHL11.
ExpressionAtlasiQ9NVR0. baseline and differential.
GenevisibleiQ9NVR0. HS.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 1 hit.
[Graphical view]
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 4 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLH11_HUMAN
AccessioniPrimary (citable) accession number: Q9NVR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.