Q9NVQ4 (FAIM1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fas apoptotic inhibitory molecule 1

Gene names

Name:	FAIM
Synonyms:	FAIM1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	179 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the FAIM1 family.
Sequence caution	The sequence BAC86174.1 differs from that shown. Reason: Intron retention.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of apoptotic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NVQ4-1)

Also known as: FAIM-S;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NVQ4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLLPFIRTLPLLCYNHLLVSPDSATLSPPYSLEKM

Isoform 3 (identifier: Q9NVQ4-3)

Also known as: FAIM-L;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MASGDDSPIFEDDESPPYSLEKM

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 179

179

Fas apoptotic inhibitory molecule 1

PRO_0000087173

Natural variations

Alternative sequence

1

1

M → MLLPFIRTLPLLCYNHLLVS PDSATLSPPYSLEKM in isoform 2.

VSP_008991

Alternative sequence

1

1

M → MASGDDSPIFEDDESPPYSL EKM in isoform 3.

VSP_038095

Natural variant

117

1

A → T. Ref.2 Ref.5
Corresponds to variant rs641320 [ dbSNP | Ensembl ].

VAR_024314

Natural variant

127

1

L → S. Ref.5
Corresponds to variant rs13043 [ dbSNP | Ensembl ].

VAR_024315

Experimental info

Sequence conflict

32

1

V → L in BQ638715. Ref.5

Sequence conflict

66

1

N → S in CAG33403. Ref.2

Secondary structure

1

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179

Helix Strand Turn

Details...

Beta strand

4 – 12

9

Beta strand

15 – 23

9

Turn

25 – 27

3

Beta strand

30 – 34

5

Beta strand

37 – 42

6

Beta strand

50 – 56

7

Turn

57 – 60

4

Beta strand

61 – 70

10

Turn

71 – 73

3

Beta strand

74 – 81

8

Beta strand

84 – 88

5

Beta strand

98 – 104

7

Beta strand

107 – 114

8

Turn

115 – 118

4

Beta strand

119 – 122

4

Beta strand

125 – 127

3

Beta strand

130 – 134

5

Beta strand

137 – 144

8

Beta strand

147 – 154

8

Beta strand

157 – 160

4

Beta strand

164 – 169

6

Beta strand

172 – 174

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (FAIM-S) [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 129E7E4525535C72	FASTA	179	20,215
	10 20 30 40 50 60 MTDLVAVWDV ALSDGVHKIE FEHGTTSGKR VVYVDGKEEI RKEWMFKLVG KETFYVGAAK 70 80 90 100 110 120 TKATINIDAI SGFAYEYTLE INGKSLKKYM EDRSKTTNTW VLHMDGENFR IVLEKDAMDV 130 140 150 160 170 WCNGKKLETA GEFVDDGTET HFSIGNHDCY IKAVSSGKRK EGIIHTLIVD NREIPEIAS
	Isoform 2 [UniParc]. Checksum: F4350AA22E14A727	FASTA	213	24,041
	10 20 30 40 50 60 MLLPFIRTLP LLCYNHLLVS PDSATLSPPY SLEKMTDLVA VWDVALSDGV HKIEFEHGTT 70 80 90 100 110 120 SGKRVVYVDG KEEIRKEWMF KLVGKETFYV GAAKTKATIN IDAISGFAYE YTLEINGKSL 130 140 150 160 170 180 KKYMEDRSKT TNTWVLHMDG ENFRIVLEKD AMDVWCNGKK LETAGEFVDD GTETHFSIGN 190 200 210 HDCYIKAVSS GKRKEGIIHT LIVDNREIPE IAS
	Isoform 3 (FAIM-L) [UniParc]. Checksum: 785BB238F63F4568	FASTA	201	22,626
	10 20 30 40 50 60 MASGDDSPIF EDDESPPYSL EKMTDLVAVW DVALSDGVHK IEFEHGTTSG KRVVYVDGKE 70 80 90 100 110 120 EIRKEWMFKL VGKETFYVGA AKTKATINID AISGFAYEYT LEINGKSLKK YMEDRSKTTN 130 140 150 160 170 180 TWVLHMDGEN FRIVLEKDAM DVWCNGKKLE TAGEFVDDGT ETHFSIGNHD CYIKAVSSGK 190 200 RKEGIIHTLI VDNREIPEIA S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-130 (ISOFORM 2). Tissue: Brain.
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT THR-117.
[3]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis.
[5]	"Expressed sequence tag analysis of human retina for the NEIBank project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts." Wistow G., Berstein S.L., Wyatt M.K., Ray S., Behal A., Touchman J.W., Bouffard G., Smith D., Peterson K. Mol. Vis. 8:196-204(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-151 (ISOFORM 3), VARIANTS THR-117 AND SER-127. Tissue: Retina.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AK001444 mRNA. Translation: BAA91695.1.
AK125477 mRNA. Translation: BAC86174.1. Sequence problems.
CR457122 mRNA. Translation: CAG33403.1.
AC020890 Genomic DNA. No translation available.
BC012478 mRNA. Translation: AAH12478.1.
BQ638715 mRNA. No translation available.

IPI

IPI00018733.
IPI00394989.
IPI00651712.

RefSeq

NP_001028202.1. NM_001033030.1.
NP_001028203.1. NM_001033031.1.
NP_001028204.1. NM_001033032.1.
NP_060617.1. NM_018147.3.

UniGene

Hs.173438.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2KW1	NMR	-	A	91-179	[»]
3MX7	X-ray	1.76	A	1-90	[»]

ProteinModelPortal

Q9NVQ4.

ModBase

Search...

PTM databases

PhosphoSite

Q9NVQ4.

Polymorphism databases

DMDM

38503210.

Proteomic databases

PaxDb

Q9NVQ4.

PRIDE

Q9NVQ4.

Protocols and materials databases

DNASU

55179.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000338446; ENSP00000342805; ENSG00000158234.
ENST00000360570; ENSP00000353775; ENSG00000158234.
ENST00000393034; ENSP00000376754; ENSG00000158234.
ENST00000393035; ENSP00000376755; ENSG00000158234.
ENST00000464668; ENSP00000417642; ENSG00000158234.

GeneID

55179.

KEGG

hsa:55179.

UCSC

uc003eso.1. human.
uc003esq.3. human.
uc003esr.3. human.

Organism-specific databases

CTD

55179.

GeneCards

GC03P138327.

HGNC

HGNC:18703. FAIM.

HPA

HPA042440.
HPA052209.

neXtProt

NX_Q9NVQ4.

PharmGKB

PA38647.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG296668.

HOGENOM

HOG000007913.

HOVERGEN

HBG051543.

InParanoid

Q9NVQ4.

OMA

GKKMETA.

OrthoDB

EOG49CQ8M.

PhylomeDB

Q9NVQ4.

Enzyme and pathway databases

Pathway_Interaction_DB

trkrpathway. Neurotrophic factor-mediated Trk receptor signaling.

Gene expression databases

ArrayExpress

Q9NVQ4.

Bgee

Q9NVQ4.

CleanEx

HS_FAIM.

Genevestigator

Q9NVQ4.

GermOnline

ENSG00000158234. Homo sapiens.

Family and domain databases

InterPro

IPR010695. FAIM.
[Graphical view]

PANTHER

PTHR13088. PTHR13088. 1 hit.

Pfam

PF06905. FAIM1. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

FAIM. human.

GenomeRNAi

55179.

NextBio

58987.

Entry information

Entry name

FAIM1_HUMAN

Accession

Primary (citable) accession number: Q9NVQ4
Secondary accession number(s): Q6IAN2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 21, 2003
Last sequence update:	October 1, 2000
Last modified:	May 29, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.