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Q9NVP4 (DZAN1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Double zinc ribbon and ankyrin repeat-containing protein 1
Gene names
Name:DZANK1
Synonyms:C20orf12, C20orf84
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length752 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 2 ANK repeats.

Contains 2 DZANK-type zinc fingers.

Sequence caution

The sequence BAA91706.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAB70949.1 differs from that shown. Reason: Erroneous termination at position 569. Translated as Trp.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainANK repeat
Repeat
Zinc-finger
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentintracellular

Inferred from electronic annotation. Source: InterPro

   Molecular functionzinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NVP4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NVP4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-173: Missing.
     174-180: RPPTRQS → MLTLESF
     414-414: E → EPRCAWQ
Note: No experimental confirmation available.
Isoform 3 (identifier: Q9NVP4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     538-574: NLYLNKAVNFSDHLLSSAAEGDGGLCGSRSSWVSDYS → VRKLRLREVKQPASSKGTKLVSGRPRIHTWQPETFPS
     575-752: Missing.
Isoform 4 (identifier: Q9NVP4-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-114: Missing.
     115-180: NVENVLKDSS...SGSRPPTRQS → MLTLESFQRV...GRTLFRRLLF
Isoform 5 (identifier: Q9NVP4-5)

The sequence of this isoform differs from the canonical sequence as follows:
     319-359: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 752752Double zinc ribbon and ankyrin repeat-containing protein 1
PRO_0000066986

Regions

Repeat605 – 63632ANK 1
Repeat640 – 66930ANK 2
Zinc finger211 – 27060DZANK-type 1
Zinc finger339 – 38749DZANK-type 2

Natural variations

Alternative sequence1 – 173173Missing in isoform 2.
VSP_042090
Alternative sequence1 – 114114Missing in isoform 4.
VSP_042091
Alternative sequence115 – 18066NVENV…PTRQS → MLTLESFQRVHWKSQLMVED QVLDHPPASPRQDTVPFTFK SFLFGHSMEIRPWKRKGRTL FRRLLF in isoform 4.
VSP_042092
Alternative sequence174 – 1807RPPTRQS → MLTLESF in isoform 2.
VSP_042093
Alternative sequence319 – 35941Missing in isoform 5.
VSP_042094
Alternative sequence4141E → EPRCAWQ in isoform 2.
VSP_042095
Alternative sequence538 – 57437NLYLN…VSDYS → VRKLRLREVKQPASSKGTKL VSGRPRIHTWQPETFPS in isoform 3.
VSP_042096
Alternative sequence575 – 752178Missing in isoform 3.
VSP_042097

Experimental info

Sequence conflict2721A → V in BAB70949. Ref.1
Sequence conflict6031I → L in AAZ13595. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 14, 2011. Version 3.
Checksum: CF2DCF2969706264

FASTA75282,192
        10         20         30         40         50         60 
MTAGSVCVPQ IIPLRVPQPG KANHEIDNNT LLEMKSDTPD VNIYYTLDGS KPEFLKRIGY 

        70         80         90        100        110        120 
GENNTFKYIK PITLPDGKIQ VKAIAVSKDC RQSGIVTKVF HVDYEPPNIV SPEDNVENVL 

       130        140        150        160        170        180 
KDSSRQEFKN GFVGSKLKKK YKNSENQRSW NVNLRKFPES PLEIPAYGGG SGSRPPTRQS 

       190        200        210        220        230        240 
QSPGFAHVSG QKCLTSTEIM RIQRETDFLK CAHCLAPRPS DPFARFCQEC GSPVPPIFGC 

       250        260        270        280        290        300 
RLPPPEGAQM GLCAECRSLV PMNTPICVVC EAPLALQLQP QASLHLKEKV ICRACGTGNP 

       310        320        330        340        350        360 
AHLRYCVTCE GALPSSQESM CSGDKAPPPP TQKGGTISCY RCGRWNLWEA SFCGWCGAML 

       370        380        390        400        410        420 
GIPAGCSVCP KCGASNHLSA RFCGSCGICV KSLVKLSLDR SLALAAEEPR PFSESLNIPL 

       430        440        450        460        470        480 
PRSDVGTKRD IGTQTVGLFY PSGKLLAKKE QELASQKQRQ EKMSDHKPLL TAISPGRGYW 

       490        500        510        520        530        540 
RRQLDHISAH LRCYAQNNPE FRALIAEPRM GKLISATVHE DGCEVSIRLN YSQVSNKNLY 

       550        560        570        580        590        600 
LNKAVNFSDH LLSSAAEGDG GLCGSRSSWV SDYSQSTSDT IEKIKRIKNF KTKTFQEKKE 

       610        620        630        640        650        660 
QLIPENRLLL KEVGPTGEGR VSVIEQLLDE GADPNCCDED NRPVITVAVM NKHHEAIPVL 

       670        680        690        700        710        720 
VQRGADIDQQ WGPLRNTALH EATLLGLAGR ESTATLLGCN ASIQKKNAGG QTAYDLALNT 

       730        740        750 
GDDLVTSLFA AKFGQGLEDQ LAQTRSLSLD DC 

« Hide

Isoform 2 [UniParc].

Checksum: 76E4D520E669D34E
Show »

FASTA58563,651
Isoform 3 [UniParc].

Checksum: 99D98A3A81100CF2
Show »

FASTA57463,163
Isoform 4 [UniParc].

Checksum: 25C63FE48F1B0E6E
Show »

FASTA63870,071
Isoform 5 [UniParc].

Checksum: C4E442BA47D34D5E
Show »

FASTA71177,769

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
Tissue: Hair follicle dermal papilla, Neuron and Testis.
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Tissue: Fetal brain.
[3]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed: 11780052] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[6]Zhou G., Nong W., Li H., Ke R., Shen C., Zhong G., Zheng Z., Liang M., Huang B., Lin L., Yang S.
Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 250-752 (ISOFORM 5).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK001462 mRNA. Translation: BAA91706.1. Different initiation.
AK055544 mRNA. Translation: BAB70949.1. Sequence problems.
AK131451 mRNA. Translation: BAD18596.1.
CR749327 mRNA. Translation: CAH18182.1.
AL049646, AL121893 Genomic DNA. Translation: CAI21830.1.
AL049646, AL121893 Genomic DNA. Translation: CAI21831.1.
AL121893, AL049646 Genomic DNA. Translation: CAI12510.1.
AL121893, AL049646 Genomic DNA. Translation: CAI12511.1.
CH471133 Genomic DNA. Translation: EAX10244.1.
BC144153 mRNA. Translation: AAI44154.1.
DQ104738 mRNA. Translation: AAZ13595.1.
IPIIPI00470914.
IPI00472239.
IPI00514911.
IPI00744796.
IPI00749404.
IPI01008837.
RefSeqNP_001092877.1. NM_001099407.1.
UniGeneHs.472225.

3D structure databases

ProteinModelPortalQ9NVP4.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9NVP4. 1 interaction.
MINTMINT-2874146.

PTM databases

PhosphoSiteQ9NVP4.

Polymorphism databases

DMDM25090013.

Proteomic databases

PRIDEQ9NVP4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000262547; ENSP00000262547; ENSG00000089091.
ENST00000357236; ENSP00000349774; ENSG00000089091.
GeneID55184.
KEGGhsa:55184.
UCSCuc002wqs.2. human.

Organism-specific databases

CTD55184.
GeneCardsGC20M018312.
HGNCHGNC:15858. DZANK1.
neXtProtNX_Q9NVP4.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG11834.
GeneTreeENSGT00390000000549.
HOVERGENHBG063313.
OMAITVAVMN.

Gene expression databases

ArrayExpressQ9NVP4.
BgeeQ9NVP4.
CleanExHS_C20orf12.
GenevestigatorQ9NVP4.
GermOnlineENSG00000089091. Homo sapiens.

Family and domain databases

InterProIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001876. Znf_RanBP2.
[Graphical view]
Gene3DG3DSA:1.25.40.20. ANK. 1 hit.
PfamPF12796. Ank_2. 1 hit.
[Graphical view]
SMARTSM00248. ANK. 2 hits.
SM00547. ZnF_RBZ. 2 hits.
[Graphical view]
SUPFAMSSF48403. ANK. 1 hit.
PROSITEPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. False negative.
[Graphical view]
ProtoNetSearch...

Other

NextBio59019.

Entry information

Entry nameDZAN1_HUMAN
AccessionPrimary (citable) accession number: Q9NVP4
Secondary accession number(s): B7ZLZ4 expand/collapse secondary AC list , Q4F7X1, Q5QPD9, Q5QPE0, Q68DN8, Q6ZMX9, Q96NF0, Q9H1E0, Q9H442
Entry history
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: December 14, 2011
Last modified: January 25, 2012
This is version 88 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM

SIMILARITY comments

Index of protein domains and families