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Protein

DnaJ homolog subfamily C member 17

Gene

DNAJC17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May negatively affect PAX8-induced thyroglobulin/TG transcription.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000104129-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 17
Gene namesi
Name:DNAJC17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:25556. DNAJC17.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Predominantly nuclear.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000104129.
PharmGKBiPA142671965.

Polymorphism and mutation databases

BioMutaiDNAJC17.
DMDMi74761740.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002471181 – 304DnaJ homolog subfamily C member 17Add BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei112PhosphoserineCombined sources1
Modified residuei264N6-methyllysineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ9NVM6.
MaxQBiQ9NVM6.
PaxDbiQ9NVM6.
PeptideAtlasiQ9NVM6.
PRIDEiQ9NVM6.

PTM databases

iPTMnetiQ9NVM6.
PhosphoSitePlusiQ9NVM6.

Expressioni

Gene expression databases

BgeeiENSG00000104129.
CleanExiHS_DNAJC17.
ExpressionAtlasiQ9NVM6. baseline and differential.
GenevisibleiQ9NVM6. HS.

Organism-specific databases

HPAiHPA040914.
HPA041187.

Interactioni

Protein-protein interaction databases

BioGridi120489. 13 interactors.
IntActiQ9NVM6. 1 interactor.
MINTiMINT-4650891.
STRINGi9606.ENSP00000220496.

Structurei

Secondary structure

1304
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi172 – 176Combined sources5
Helixi191 – 199Combined sources9
Beta strandi204 – 222Combined sources19
Helixi224 – 232Combined sources9
Beta strandi238 – 241Combined sources4
Beta strandi243 – 245Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D9ONMR-A168-254[»]
ProteinModelPortaliQ9NVM6.
SMRiQ9NVM6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NVM6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 76JPROSITE-ProRule annotationAdd BLAST66
Domaini178 – 249RRMAdd BLAST72

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi111 – 117Poly-Glu7

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0691. Eukaryota.
COG2214. LUCA.
GeneTreeiENSGT00550000074688.
HOGENOMiHOG000239711.
HOVERGENiHBG062744.
InParanoidiQ9NVM6.
KOiK09537.
OMAiKMKWKAE.
OrthoDBiEOG091G0L2J.
PhylomeDBiQ9NVM6.
TreeFamiTF321770.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
3.30.70.330. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF54928. SSF54928. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NVM6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVTKELLQM DLYALLGIEE KAADKEVKKA YRQKALSCHP DKNPDNPRAA
60 70 80 90 100
ELFHQLSQAL EVLTDAAARA AYDKVRKAKK QAAERTQKLD EKRKKVKLDL
110 120 130 140 150
EARERQAQAQ ESEEEEESRS TRTLEQEIER LREEGSRQLE EQQRLIREQI
160 170 180 190 200
RQERDQRLRG KAENTEGQGT PKLKLKWKCK KEDESKGGYS KDVLLRLLQK
210 220 230 240 250
YGEVLNLVLS SKKPGTAVVE FATVKAAELA VQNEVGLVDN PLKISWLEGQ
260 270 280 290 300
PQDAVGRSHS GLSKGSVLSE RDYESLVMMR MRQAAERQQL IARMQQEDQE

GPPT
Length:304
Mass (Da):34,687
Last modified:October 1, 2000 - v1
Checksum:i98A1BA8ABFF4120E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001496 mRNA. Translation: BAA91724.1.
BC000048 mRNA. Translation: AAH00048.1.
CCDSiCCDS10065.1.
RefSeqiNP_060633.1. NM_018163.2.
UniGeneiHs.511069.

Genome annotation databases

EnsembliENST00000220496; ENSP00000220496; ENSG00000104129.
GeneIDi55192.
KEGGihsa:55192.
UCSCiuc001zms.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001496 mRNA. Translation: BAA91724.1.
BC000048 mRNA. Translation: AAH00048.1.
CCDSiCCDS10065.1.
RefSeqiNP_060633.1. NM_018163.2.
UniGeneiHs.511069.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D9ONMR-A168-254[»]
ProteinModelPortaliQ9NVM6.
SMRiQ9NVM6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120489. 13 interactors.
IntActiQ9NVM6. 1 interactor.
MINTiMINT-4650891.
STRINGi9606.ENSP00000220496.

PTM databases

iPTMnetiQ9NVM6.
PhosphoSitePlusiQ9NVM6.

Polymorphism and mutation databases

BioMutaiDNAJC17.
DMDMi74761740.

Proteomic databases

EPDiQ9NVM6.
MaxQBiQ9NVM6.
PaxDbiQ9NVM6.
PeptideAtlasiQ9NVM6.
PRIDEiQ9NVM6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000220496; ENSP00000220496; ENSG00000104129.
GeneIDi55192.
KEGGihsa:55192.
UCSCiuc001zms.3. human.

Organism-specific databases

CTDi55192.
GeneCardsiDNAJC17.
HGNCiHGNC:25556. DNAJC17.
HPAiHPA040914.
HPA041187.
MIMi616844. gene.
neXtProtiNX_Q9NVM6.
OpenTargetsiENSG00000104129.
PharmGKBiPA142671965.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0691. Eukaryota.
COG2214. LUCA.
GeneTreeiENSGT00550000074688.
HOGENOMiHOG000239711.
HOVERGENiHBG062744.
InParanoidiQ9NVM6.
KOiK09537.
OMAiKMKWKAE.
OrthoDBiEOG091G0L2J.
PhylomeDBiQ9NVM6.
TreeFamiTF321770.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000104129-MONOMER.

Miscellaneous databases

ChiTaRSiDNAJC17. human.
EvolutionaryTraceiQ9NVM6.
GenomeRNAii55192.
PROiQ9NVM6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000104129.
CleanExiHS_DNAJC17.
ExpressionAtlasiQ9NVM6. baseline and differential.
GenevisibleiQ9NVM6. HS.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
3.30.70.330. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF54928. SSF54928. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDJC17_HUMAN
AccessioniPrimary (citable) accession number: Q9NVM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.