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Protein

Uncharacterized protein C14orf105

Gene

C14orf105

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C14orf105
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20189. C14orf105.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134868494.

Polymorphism and mutation databases

BioMutaiC14orf105.
DMDMi160332322.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 296296Uncharacterized protein C14orf105PRO_0000089913Add
BLAST

Proteomic databases

PaxDbiQ9NVL8.
PRIDEiQ9NVL8.

PTM databases

PhosphoSiteiQ9NVL8.

Expressioni

Gene expression databases

BgeeiQ9NVL8.
CleanExiHS_C14orf105.
ExpressionAtlasiQ9NVL8. baseline and differential.
GenevisibleiQ9NVL8. HS.

Organism-specific databases

HPAiHPA029202.

Interactioni

Protein-protein interaction databases

BioGridi120492. 19 interactions.
STRINGi9606.ENSP00000216445.

Structurei

3D structure databases

ProteinModelPortaliQ9NVL8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IE4S. Eukaryota.
ENOG410YY0W. LUCA.
GeneTreeiENSGT00390000001071.
HOGENOMiHOG000024829.
HOVERGENiHBG081272.
InParanoidiQ9NVL8.
OrthoDBiEOG7TQV1H.
PhylomeDBiQ9NVL8.
TreeFamiTF336148.

Family and domain databases

InterProiIPR029235. DUF4619.
[Graphical view]
PfamiPF15398. DUF4619. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NVL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLSHSKTHL RVIKVAPLQN KEVETPSAGR VDFAFNQNLE EKTSYSLARL
60 70 80 90 100
QDQNKALEGQ LPPLQENWYG RYSTASRDMY FDIPLEHRET SIIKRHPPQR
110 120 130 140 150
LQKLEPIDLP RVITSGRLLS QREARTMHKA KQVLEKKMQT PMYTSENRQY
160 170 180 190 200
LHKMQVLEMI RKRQEAQMEL KKSLHGEARI NKQSPRDHKA KKTLQSTPRN
210 220 230 240 250
DDHDLLTMLP DEILNRGPGN SKNTEFLKHQ AVNNYCPWKI GKMETWLHEQ
260 270 280 290
EAQGQLLWDS SSSDSDEQGK DEKKPRALVR TRTERIPLFD EFFDQE
Length:296
Mass (Da):34,690
Last modified:November 13, 2007 - v2
Checksum:i6718547F055B1C49
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti223 – 2231N → D in BAA91732 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti235 – 2351Y → C.2 Publications
Corresponds to variant rs1152530 [ dbSNP | Ensembl ].
VAR_024310

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001512 mRNA. Translation: BAA91732.1.
AK223127 mRNA. Translation: BAD96847.1.
AL161804 Genomic DNA. No translation available.
AL355834 Genomic DNA. No translation available.
CCDSiCCDS9730.1.
RefSeqiNP_001269985.1. NM_001283056.1.
NP_001269986.1. NM_001283057.1.
NP_001269987.1. NM_001283058.1.
NP_001269988.1. NM_001283059.1.
NP_060638.2. NM_018168.3.
UniGeneiHs.659706.

Genome annotation databases

EnsembliENST00000216445; ENSP00000216445; ENSG00000100557.
GeneIDi55195.
KEGGihsa:55195.
UCSCiuc001xcy.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001512 mRNA. Translation: BAA91732.1.
AK223127 mRNA. Translation: BAD96847.1.
AL161804 Genomic DNA. No translation available.
AL355834 Genomic DNA. No translation available.
CCDSiCCDS9730.1.
RefSeqiNP_001269985.1. NM_001283056.1.
NP_001269986.1. NM_001283057.1.
NP_001269987.1. NM_001283058.1.
NP_001269988.1. NM_001283059.1.
NP_060638.2. NM_018168.3.
UniGeneiHs.659706.

3D structure databases

ProteinModelPortaliQ9NVL8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120492. 19 interactions.
STRINGi9606.ENSP00000216445.

PTM databases

PhosphoSiteiQ9NVL8.

Polymorphism and mutation databases

BioMutaiC14orf105.
DMDMi160332322.

Proteomic databases

PaxDbiQ9NVL8.
PRIDEiQ9NVL8.

Protocols and materials databases

DNASUi55195.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216445; ENSP00000216445; ENSG00000100557.
GeneIDi55195.
KEGGihsa:55195.
UCSCiuc001xcy.4. human.

Organism-specific databases

CTDi55195.
GeneCardsiC14orf105.
HGNCiHGNC:20189. C14orf105.
HPAiHPA029202.
neXtProtiNX_Q9NVL8.
PharmGKBiPA134868494.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE4S. Eukaryota.
ENOG410YY0W. LUCA.
GeneTreeiENSGT00390000001071.
HOGENOMiHOG000024829.
HOVERGENiHBG081272.
InParanoidiQ9NVL8.
OrthoDBiEOG7TQV1H.
PhylomeDBiQ9NVL8.
TreeFamiTF336148.

Miscellaneous databases

GenomeRNAii55195.
NextBioi59063.
PROiQ9NVL8.

Gene expression databases

BgeeiQ9NVL8.
CleanExiHS_C14orf105.
ExpressionAtlasiQ9NVL8. baseline and differential.
GenevisibleiQ9NVL8. HS.

Family and domain databases

InterProiIPR029235. DUF4619.
[Graphical view]
PfamiPF15398. DUF4619. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT CYS-235.
    Tissue: Teratocarcinoma.
  2. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT CYS-235.
    Tissue: Kidney.
  3. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCN105_HUMAN
AccessioniPrimary (citable) accession number: Q9NVL8
Secondary accession number(s): Q53G04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: November 13, 2007
Last modified: March 16, 2016
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.