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Protein

Uncharacterized protein C14orf105

Gene

C14orf105

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C14orf105
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20189. C14orf105.

Pathology & Biotechi

Organism-specific databases

DisGeNETi55195.
OpenTargetsiENSG00000100557.
PharmGKBiPA134868494.

Polymorphism and mutation databases

BioMutaiC14orf105.
DMDMi160332322.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000899131 – 296Uncharacterized protein C14orf105Add BLAST296

Proteomic databases

EPDiQ9NVL8.
PaxDbiQ9NVL8.
PRIDEiQ9NVL8.

PTM databases

iPTMnetiQ9NVL8.
PhosphoSitePlusiQ9NVL8.

Expressioni

Gene expression databases

BgeeiENSG00000100557.
CleanExiHS_C14orf105.
ExpressionAtlasiQ9NVL8. baseline and differential.
GenevisibleiQ9NVL8. HS.

Organism-specific databases

HPAiHPA029202.

Interactioni

Protein-protein interaction databases

BioGridi120492. 19 interactors.
IntActiQ9NVL8. 1 interactor.
STRINGi9606.ENSP00000216445.

Structurei

3D structure databases

ProteinModelPortaliQ9NVL8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IE4S. Eukaryota.
ENOG410YY0W. LUCA.
GeneTreeiENSGT00390000001071.
HOGENOMiHOG000024829.
HOVERGENiHBG081272.
InParanoidiQ9NVL8.
PhylomeDBiQ9NVL8.
TreeFamiTF336148.

Family and domain databases

InterProiView protein in InterPro
IPR029235. DUF4619.
PfamiView protein in Pfam
PF15398. DUF4619. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NVL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLSHSKTHL RVIKVAPLQN KEVETPSAGR VDFAFNQNLE EKTSYSLARL
60 70 80 90 100
QDQNKALEGQ LPPLQENWYG RYSTASRDMY FDIPLEHRET SIIKRHPPQR
110 120 130 140 150
LQKLEPIDLP RVITSGRLLS QREARTMHKA KQVLEKKMQT PMYTSENRQY
160 170 180 190 200
LHKMQVLEMI RKRQEAQMEL KKSLHGEARI NKQSPRDHKA KKTLQSTPRN
210 220 230 240 250
DDHDLLTMLP DEILNRGPGN SKNTEFLKHQ AVNNYCPWKI GKMETWLHEQ
260 270 280 290
EAQGQLLWDS SSSDSDEQGK DEKKPRALVR TRTERIPLFD EFFDQE
Length:296
Mass (Da):34,690
Last modified:November 13, 2007 - v2
Checksum:i6718547F055B1C49
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti132Missing in AAI17406 (PubMed:15489334).Curated1
Sequence conflicti132Missing in AAI43567 (PubMed:15489334).Curated1
Sequence conflicti132Missing in EAW80707 (Ref. 4) Curated1
Sequence conflicti223N → D in BAA91732 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024310235Y → C4 PublicationsCorresponds to variant dbSNP:rs1152530Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001512 mRNA. Translation: BAA91732.1.
AK223127 mRNA. Translation: BAD96847.1.
AL161804 Genomic DNA. No translation available.
AL355834 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW80707.1.
BC117405 mRNA. Translation: AAI17406.1.
BC143566 mRNA. Translation: AAI43567.1.
CCDSiCCDS9730.1.
RefSeqiNP_001269985.1. NM_001283056.1.
NP_001269986.1. NM_001283057.1.
NP_001269987.1. NM_001283058.1.
NP_001269988.1. NM_001283059.1.
NP_060638.2. NM_018168.3.
UniGeneiHs.659706.

Genome annotation databases

EnsembliENST00000216445; ENSP00000216445; ENSG00000100557.
GeneIDi55195.
KEGGihsa:55195.
UCSCiuc001xcy.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCN105_HUMAN
AccessioniPrimary (citable) accession number: Q9NVL8
Secondary accession number(s): Q17R99, Q53G04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: November 13, 2007
Last modified: June 7, 2017
This is version 89 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations