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Protein

ADP-ribosylation factor-like protein 8B

Gene

ARL8B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in lysosome motility (PubMed:16537643). May play a role in chromosome segregation (PubMed:15331635).2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi29 – 357GTP
Nucleotide bindingi71 – 755GTPBy similarity
Nucleotide bindingi130 – 1334GTP

GO - Molecular functioni

  1. alpha-tubulin binding Source: UniProtKB
  2. beta-tubulin binding Source: UniProtKB
  3. GDP binding Source: UniProtKB
  4. GTPase activity Source: UniProtKB
  5. GTP binding Source: UniProtKB

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. chromosome segregation Source: UniProtKB
  4. metabolic process Source: GOC
  5. small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 8B
Alternative name(s):
ADP-ribosylation factor-like protein 10C
Novel small G protein indispensable for equal chromosome segregation 1
Gene namesi
Name:ARL8B
Synonyms:ARL10C, GIE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:25564. ARL8B.

Subcellular locationi

  1. Late endosome membrane
  2. Lysosome membrane
  3. Cytoplasmcytoskeletonspindle

  4. Note: According to PubMed:15331635, it localizes with microtubules at the spindle mid-zone during mitosis.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Intramembranei1 – 1919Note=Mediates targeting to membranesAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. extracellular vesicular exosome Source: UniProtKB
  3. late endosome membrane Source: UniProtKB-SubCell
  4. lysosomal membrane Source: UniProtKB-SubCell
  5. membrane Source: UniProtKB
  6. midbody Source: UniProtKB
  7. spindle midzone Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endosome, Lysosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi2 – 21L → A: Diffuse cytoplasmic distribution and loss of localization to lysosomes. No effect on acetylation. 1 Publication
Mutagenesisi2 – 21L → F: No effect on localization and acetylation. 1 Publication
Mutagenesisi5 – 128ISRLLDWF → ASRALDWA: Diffuse cytoplasmic distribution and loss of localization to lysosomes. No effect on acetylation. 1 Publication
Mutagenesisi34 – 341T → N: Preferentially binds GDP. Alters chromosome segregation. 1 Publication
Mutagenesisi49 – 5810Missing : Alters chromosome segregation. 1 Publication
Mutagenesisi70 – 701W → R: Preferentially binds GTP. 1 Publication
Mutagenesisi74 – 8512Missing : Alters chromosome segregation. 1 PublicationAdd
BLAST
Mutagenesisi75 – 751Q → L: Prevents GTP hydrolysis. No effect on localization. Alters lysosomes cellular distribution and motility. 1 Publication
Mutagenesisi130 – 1301N → I: Loss of GTP/GDP-binding. Affects chromosome segregation. 1 Publication

Organism-specific databases

PharmGKBiPA134959531.

Polymorphism and mutation databases

BioMutaiARL8B.
DMDMi74752996.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 186186ADP-ribosylation factor-like protein 8BPRO_0000232921Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine3 Publications

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9NVJ2.
PaxDbiQ9NVJ2.
PRIDEiQ9NVJ2.

PTM databases

PhosphoSiteiQ9NVJ2.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiQ9NVJ2.
CleanExiHS_ARL8B.
ExpressionAtlasiQ9NVJ2. baseline and differential.
GenevestigatoriQ9NVJ2.

Organism-specific databases

HPAiHPA038759.
HPA040515.
HPA045924.

Interactioni

Subunit structurei

Interacts with tubulin.2 Publications

Protein-protein interaction databases

BioGridi120503. 24 interactions.
IntActiQ9NVJ2. 7 interactions.
MINTiMINT-1429448.
STRINGi9606.ENSP00000256496.

Structurei

Secondary structure

1
186
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi19 – 268Combined sources
Helixi33 – 408Combined sources
Beta strandi55 – 628Combined sources
Beta strandi65 – 728Combined sources
Helixi76 – 816Combined sources
Helixi82 – 865Combined sources
Beta strandi90 – 978Combined sources
Helixi101 – 1033Combined sources
Helixi104 – 11512Combined sources
Helixi118 – 1203Combined sources
Beta strandi125 – 1306Combined sources
Helixi140 – 1467Combined sources
Helixi149 – 1513Combined sources
Beta strandi157 – 1615Combined sources
Turni164 – 1674Combined sources
Helixi170 – 1789Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2AL7X-ray1.85A18-184[»]
ProteinModelPortaliQ9NVJ2.
SMRiQ9NVJ2. Positions 18-182.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NVJ2.

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00780000121865.
HOGENOMiHOG000163692.
HOVERGENiHBG105214.
InParanoidiQ9NVJ2.
KOiK07955.
OMAiIGRILEW.
OrthoDBiEOG7F24V2.
PhylomeDBiQ9NVJ2.
TreeFamiTF105470.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SMARTiSM00177. ARF. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NVJ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLALISRLLD WFRSLFWKEE MELTLVGLQY SGKTTFVNVI ASGQFSEDMI
60 70 80 90 100
PTVGFNMRKV TKGNVTIKIW DIGGQPRFRS MWERYCRGVN AIVYMIDAAD
110 120 130 140 150
REKIEASRNE LHNLLDKPQL QGIPVLVLGN KRDLPNALDE KQLIEKMNLS
160 170 180
AIQDREICCY SISCKEKDNI DITLQWLIQH SKSRRS
Length:186
Mass (Da):21,539
Last modified:October 1, 2000 - v1
Checksum:i5030B01AFD749223
GO
Isoform 2 (identifier: Q9NVJ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     125-186: VLVLGNKRDL...LIQHSKSRRS → ISHFSGLFSI...ILELLSVPLK

Note: No experimental confirmation available.

Show »
Length:163
Mass (Da):18,642
Checksum:iBAD320672EA343D5
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei125 – 18662VLVLG…KSRRS → ISHFSGLFSIQNLEEAEASP EVFQSFLAIILELLSVPLK in isoform 2. 1 PublicationVSP_056238Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB118751 mRNA. Translation: BAD23992.1.
AK001564 mRNA. Translation: BAA91759.1.
AK295465 mRNA. Translation: BAG58397.1.
CR457264 mRNA. Translation: CAG33545.1.
AC021999 Genomic DNA. No translation available.
AC026202 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW63919.1.
BC013131 mRNA. Translation: AAH13131.1.
BC063125 mRNA. Translation: AAH63125.1.
CCDSiCCDS2566.1. [Q9NVJ2-1]
RefSeqiNP_060654.1. NM_018184.2. [Q9NVJ2-1]
XP_005265352.1. XM_005265295.3. [Q9NVJ2-2]
UniGeneiHs.250009.

Genome annotation databases

EnsembliENST00000256496; ENSP00000256496; ENSG00000134108. [Q9NVJ2-1]
ENST00000419534; ENSP00000402996; ENSG00000134108. [Q9NVJ2-2]
ENST00000611208; ENSP00000479202; ENSG00000134108. [Q9NVJ2-1]
GeneIDi55207.
KEGGihsa:55207.
UCSCiuc003bqg.3. human. [Q9NVJ2-1]
uc011asy.2. human.

Polymorphism and mutation databases

BioMutaiARL8B.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB118751 mRNA. Translation: BAD23992.1.
AK001564 mRNA. Translation: BAA91759.1.
AK295465 mRNA. Translation: BAG58397.1.
CR457264 mRNA. Translation: CAG33545.1.
AC021999 Genomic DNA. No translation available.
AC026202 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW63919.1.
BC013131 mRNA. Translation: AAH13131.1.
BC063125 mRNA. Translation: AAH63125.1.
CCDSiCCDS2566.1. [Q9NVJ2-1]
RefSeqiNP_060654.1. NM_018184.2. [Q9NVJ2-1]
XP_005265352.1. XM_005265295.3. [Q9NVJ2-2]
UniGeneiHs.250009.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2AL7X-ray1.85A18-184[»]
ProteinModelPortaliQ9NVJ2.
SMRiQ9NVJ2. Positions 18-182.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120503. 24 interactions.
IntActiQ9NVJ2. 7 interactions.
MINTiMINT-1429448.
STRINGi9606.ENSP00000256496.

PTM databases

PhosphoSiteiQ9NVJ2.

Polymorphism and mutation databases

BioMutaiARL8B.
DMDMi74752996.

Proteomic databases

MaxQBiQ9NVJ2.
PaxDbiQ9NVJ2.
PRIDEiQ9NVJ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256496; ENSP00000256496; ENSG00000134108. [Q9NVJ2-1]
ENST00000419534; ENSP00000402996; ENSG00000134108. [Q9NVJ2-2]
ENST00000611208; ENSP00000479202; ENSG00000134108. [Q9NVJ2-1]
GeneIDi55207.
KEGGihsa:55207.
UCSCiuc003bqg.3. human. [Q9NVJ2-1]
uc011asy.2. human.

Organism-specific databases

CTDi55207.
GeneCardsiGC03P005163.
HGNCiHGNC:25564. ARL8B.
HPAiHPA038759.
HPA040515.
HPA045924.
neXtProtiNX_Q9NVJ2.
PharmGKBiPA134959531.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00780000121865.
HOGENOMiHOG000163692.
HOVERGENiHBG105214.
InParanoidiQ9NVJ2.
KOiK07955.
OMAiIGRILEW.
OrthoDBiEOG7F24V2.
PhylomeDBiQ9NVJ2.
TreeFamiTF105470.

Miscellaneous databases

ChiTaRSiARL8B. human.
EvolutionaryTraceiQ9NVJ2.
GeneWikiiARL8B.
GenomeRNAii55207.
NextBioi35472212.
PROiQ9NVJ2.

Gene expression databases

BgeeiQ9NVJ2.
CleanExiHS_ARL8B.
ExpressionAtlasiQ9NVJ2. baseline and differential.
GenevestigatoriQ9NVJ2.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SMARTiSM00177. ARF. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Novel small GTPase subfamily capable of associating with tubulin is required for chromosome segregation."
    Okai T., Araki Y., Tada M., Tateno T., Kontani K., Katada T.
    J. Cell Sci. 117:4705-4715(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF THR-34; 49-MET--ARG-58; TRP-70; 74-GLY--TYR-85 AND ASN-130, SUBCELLULAR LOCATION, INTERACTION WITH TUBULIN.
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Hippocampus and Teratocarcinoma.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Embryonic carcinoma and Testis.
  7. Bienvenut W.V.
    Submitted (JUN-2005) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 69-77; 147-155 AND 166-182, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: B-cell lymphoma.
  8. "An N-terminally acetylated Arf-like GTPase is localised to lysosomes and affects their motility."
    Hofmann I., Munro S.
    J. Cell Sci. 119:1494-1503(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, ACETYLATION AT MET-1, MUTAGENESIS OF LEU-2; 5-ILE--PHE-12 AND GLN-75.
  9. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Placenta.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  14. "GTP-like conformation of GDP-bound ARL10C GTPase."
    Structural genomics consortium (SGC)
    Submitted (AUG-2005) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 18-184 IN COMPLEX WITH GDP.

Entry informationi

Entry nameiARL8B_HUMAN
AccessioniPrimary (citable) accession number: Q9NVJ2
Secondary accession number(s): B4DI85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: October 1, 2000
Last modified: April 29, 2015
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.