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Q9NVI7

- ATD3A_HUMAN

UniProt

Q9NVI7 - ATD3A_HUMAN

Protein

ATPase family AAA domain-containing protein 3A

Gene

ATAD3A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important in mitochondrial protein synthesis. May also participate in mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability. Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis.3 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi400 – 4078ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. nucleoside-triphosphatase activity Source: InterPro

    GO - Biological processi

    1. cell growth Source: UniProtKB
    2. negative regulation of apoptotic process Source: UniProtKB

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATPase family AAA domain-containing protein 3A
    Gene namesi
    Name:ATAD3A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:25567. ATAD3A.

    Subcellular locationi

    Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion matrixmitochondrion nucleoid
    Note: In the mitochondrial inner membrane, enriched in sites with the potential to form contacts with the outer membrane. The N-terminal domain interacts with the inner surface of the mitochondrial outer membrane and the C-terminal domain localizes in a specific matrix compartment, where it is associated with nucleoids.

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. mitochondrial nucleoid Source: UniProtKB-SubCell
    4. mitochondrion Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane, Mitochondrion nucleoid

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi341 – 3411V → S: Loss of S100B-binding; when associated with S-345. 1 Publication
    Mutagenesisi345 – 3451L → S: Loss of S100B-binding; when associated with S-341. 1 Publication
    Mutagenesisi349 – 3502Missing: Decrease in S100B-binding.
    Mutagenesisi406 – 4061K → E: No effect on homooligomerization. Immediate fragmentation of the mitochondrial network. 1 Publication
    Mutagenesisi459 – 4591D → Q: No effect on homooligomerization. Immediate fragmentation of the mitochondrial network. 1 Publication

    Organism-specific databases

    PharmGKBiPA134872099.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 634633ATPase family AAA domain-containing protein 3APRO_0000084799Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication
    Modified residuei539 – 5391N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9NVI7.
    PaxDbiQ9NVI7.
    PRIDEiQ9NVI7.

    PTM databases

    PhosphoSiteiQ9NVI7.

    Expressioni

    Tissue specificityi

    Overexpressed in lung adenocarcinomas (at protein level).1 Publication

    Inductioni

    Up-regulated by Angiotensin/AGT.2 Publications

    Gene expression databases

    ArrayExpressiQ9NVI7.
    BgeeiQ9NVI7.
    CleanExiHS_ATAD3A.
    GenevestigatoriQ9NVI7.

    Interactioni

    Subunit structurei

    Can form homooligomers. Homodimer formation at the N-terminus may be regulated by ATP and is required for the interaction with the inner surface of the mitochondrial outer membrane and correct mitochondrial homeostasis. Interacts with components of the mitochondrial ribosome and with other proteins involved in mitochondrial RNA metabolism. May also interact with protein involved in lipid metabolism, including STARD9. May interact with FAM210A. Interacts with GADD45GIP1. Interacts with S100B in a Ca(+2)- and Zn(+2)-dependent manner; this interaction probably occurs in the cytosol prior to mitochondrial targeting. S100B could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. Interacts with HSP60/HSPD1. Forms heterooligomers with ATAD3B; this interaction may affect ATAD3A activity.3 Publications

    Protein-protein interaction databases

    BioGridi120506. 33 interactions.
    DIPiDIP-33194N.
    IntActiQ9NVI7. 16 interactions.
    MINTiMINT-1148423.
    STRINGi9606.ENSP00000368030.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NVI7.
    SMRiQ9NVI7. Positions 337-629.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 294293Mitochondrial intermembraneSequence AnalysisAdd
    BLAST
    Topological domaini313 – 634322Mitochondrial matrixSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei295 – 31218HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 5049Required for interaction with the inner surface of the mitochondrial outer membraneAdd
    BLAST
    Regioni338 – 35316S100B-bindingAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili139 – 267129Sequence AnalysisAdd
    BLAST

    Domaini

    The transmembrane domain and a C-terminal adjacent region contain all information necessary for mitochondrial targeting.1 Publication

    Sequence similaritiesi

    Belongs to the AAA ATPase family.Curated

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1223.
    HOGENOMiHOG000231291.
    HOVERGENiHBG058506.
    InParanoidiQ9NVI7.
    KOiK17681.
    OMAiMQEESAI.
    OrthoDBiEOG7J9VP8.
    PhylomeDBiQ9NVI7.
    TreeFamiTF313922.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR021911. DUF3523.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00004. AAA. 1 hit.
    PF12037. DUF3523. 2 hits.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NVI7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSWLFGINKG PKGEGAGPPP PLPPAQPGAE GGGDRGLGDR PAPKDKWSNF    50
    DPTGLERAAK AARELEHSRY AKDALNLAQM QEQTLQLEQQ SKLKMRLEAL 100
    SLLHTLVWAW SLCRAGAVQT QERLSGSASP EQVPAGECCA LQEYEAAVEQ 150
    LKSEQIRAQA EERRKTLSEE TRQHQARAQY QDKLARQRYE DQLKQQQLLN 200
    EENLRKQEES VQKQEAMRRA TVEREMELRH KNEMLRVEAE ARARAKAERE 250
    NADIIREQIR LKAAEHRQTV LESIRTAGTL FGEGFRAFVT DWDKVTATVA 300
    GLTLLAVGVY SAKNATLVAG RFIEARLGKP SLVRETSRIT VLEALRHPIQ 350
    VSRRLLSRPQ DALEGVVLSP SLEARVRDIA IATRNTKKNR SLYRNILMYG 400
    PPGTGKTLFA KKLALHSGMD YAIMTGGDVA PMGREGVTAM HKLFDWANTS 450
    RRGLLLFVDE ADAFLRKRAT EKISEDLRAT LNAFLYRTGQ HSNKFMLVLA 500
    SNQPEQFDWA INDRINEMVH FDLPGQEERE RLVRMYFDKY VLKPATEGKQ 550
    RLKLAQFDYG RKCSEVARLT EGMSGREIAQ LAVSWQATAY ASEDGVLTEA 600
    MMDTRVQDAV QQHQQKMCWL KAEGPGRGDE PSPS 634
    Length:634
    Mass (Da):71,369
    Last modified:September 13, 2005 - v2
    Checksum:i47E765629B6F3267
    GO
    Isoform 2 (identifier: Q9NVI7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         95-142: Missing.

    Note: May be the predominant ATAD3A form.

    Show »
    Length:586
    Mass (Da):66,218
    Checksum:i1E83D08AE33D550F
    GO
    Isoform 3 (identifier: Q9NVI7-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-79: Missing.
         95-142: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:507
    Mass (Da):57,948
    Checksum:i759827DA09CDDC15
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti224 – 2241R → Q in BAG51625. (PubMed:14702039)Curated
    Sequence conflicti255 – 2551I → T in BAC03595. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti15 – 151G → D.1 Publication
    Corresponds to variant rs2274435 [ dbSNP | Ensembl ].
    VAR_023526
    Natural varianti101 – 1011S → N.
    Corresponds to variant rs1619896 [ dbSNP | Ensembl ].
    VAR_055468

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7979Missing in isoform 3. 1 PublicationVSP_044145Add
    BLAST
    Alternative sequencei95 – 14248Missing in isoform 2 and isoform 3. 3 PublicationsVSP_015636Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GU189416 mRNA. Translation: ACZ80514.1.
    AK001571 mRNA. Translation: BAA91764.1.
    AK056099 mRNA. Translation: BAG51625.1.
    AK091144 mRNA. Translation: BAC03595.1.
    AL645728 Genomic DNA. Translation: CAI22954.1.
    AL645728 Genomic DNA. Translation: CAI22955.1.
    CH471183 Genomic DNA. Translation: EAW56187.1.
    CH471183 Genomic DNA. Translation: EAW56190.1.
    BC007803 mRNA. Translation: AAH07803.1.
    BC011814 mRNA. Translation: AAH11814.1.
    BC014101 mRNA. Translation: AAH14101.1.
    BC033109 mRNA. Translation: AAH33109.1.
    BC063607 mRNA. Translation: AAH63607.1.
    CCDSiCCDS31.1. [Q9NVI7-1]
    CCDS53259.1. [Q9NVI7-2]
    CCDS53260.1. [Q9NVI7-3]
    RefSeqiNP_001164006.1. NM_001170535.1. [Q9NVI7-2]
    NP_001164007.1. NM_001170536.1. [Q9NVI7-3]
    NP_060658.3. NM_018188.3. [Q9NVI7-1]
    UniGeneiHs.23413.

    Genome annotation databases

    EnsembliENST00000378755; ENSP00000368030; ENSG00000197785. [Q9NVI7-1]
    ENST00000378756; ENSP00000368031; ENSG00000197785. [Q9NVI7-2]
    ENST00000536055; ENSP00000439290; ENSG00000197785. [Q9NVI7-3]
    GeneIDi55210.
    KEGGihsa:55210.
    UCSCiuc001afz.2. human. [Q9NVI7-1]
    uc001aga.2. human. [Q9NVI7-2]
    uc001agb.2. human. [Q9NVI7-3]

    Polymorphism databases

    DMDMi84028405.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GU189416 mRNA. Translation: ACZ80514.1 .
    AK001571 mRNA. Translation: BAA91764.1 .
    AK056099 mRNA. Translation: BAG51625.1 .
    AK091144 mRNA. Translation: BAC03595.1 .
    AL645728 Genomic DNA. Translation: CAI22954.1 .
    AL645728 Genomic DNA. Translation: CAI22955.1 .
    CH471183 Genomic DNA. Translation: EAW56187.1 .
    CH471183 Genomic DNA. Translation: EAW56190.1 .
    BC007803 mRNA. Translation: AAH07803.1 .
    BC011814 mRNA. Translation: AAH11814.1 .
    BC014101 mRNA. Translation: AAH14101.1 .
    BC033109 mRNA. Translation: AAH33109.1 .
    BC063607 mRNA. Translation: AAH63607.1 .
    CCDSi CCDS31.1. [Q9NVI7-1 ]
    CCDS53259.1. [Q9NVI7-2 ]
    CCDS53260.1. [Q9NVI7-3 ]
    RefSeqi NP_001164006.1. NM_001170535.1. [Q9NVI7-2 ]
    NP_001164007.1. NM_001170536.1. [Q9NVI7-3 ]
    NP_060658.3. NM_018188.3. [Q9NVI7-1 ]
    UniGenei Hs.23413.

    3D structure databases

    ProteinModelPortali Q9NVI7.
    SMRi Q9NVI7. Positions 337-629.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120506. 33 interactions.
    DIPi DIP-33194N.
    IntActi Q9NVI7. 16 interactions.
    MINTi MINT-1148423.
    STRINGi 9606.ENSP00000368030.

    PTM databases

    PhosphoSitei Q9NVI7.

    Polymorphism databases

    DMDMi 84028405.

    Proteomic databases

    MaxQBi Q9NVI7.
    PaxDbi Q9NVI7.
    PRIDEi Q9NVI7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000378755 ; ENSP00000368030 ; ENSG00000197785 . [Q9NVI7-1 ]
    ENST00000378756 ; ENSP00000368031 ; ENSG00000197785 . [Q9NVI7-2 ]
    ENST00000536055 ; ENSP00000439290 ; ENSG00000197785 . [Q9NVI7-3 ]
    GeneIDi 55210.
    KEGGi hsa:55210.
    UCSCi uc001afz.2. human. [Q9NVI7-1 ]
    uc001aga.2. human. [Q9NVI7-2 ]
    uc001agb.2. human. [Q9NVI7-3 ]

    Organism-specific databases

    CTDi 55210.
    GeneCardsi GC01P001439.
    HGNCi HGNC:25567. ATAD3A.
    MIMi 612316. gene.
    neXtProti NX_Q9NVI7.
    PharmGKBi PA134872099.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1223.
    HOGENOMi HOG000231291.
    HOVERGENi HBG058506.
    InParanoidi Q9NVI7.
    KOi K17681.
    OMAi MQEESAI.
    OrthoDBi EOG7J9VP8.
    PhylomeDBi Q9NVI7.
    TreeFami TF313922.

    Miscellaneous databases

    ChiTaRSi ATAD3A. human.
    GenomeRNAii 55210.
    NextBioi 59150.
    PROi Q9NVI7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NVI7.
    Bgeei Q9NVI7.
    CleanExi HS_ATAD3A.
    Genevestigatori Q9NVI7.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR021911. DUF3523.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00004. AAA. 1 hit.
    PF12037. DUF3523. 2 hits.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "ATPase family AAA domain-containing 3A is a novel anti-apoptotic factor in lung adenocarcinoma cells."
      Fang H.Y., Chang C.L., Hsu S.H., Huang C.Y., Chiang S.F., Chiou S.H., Huang C.H., Hsiao Y.T., Lin T.Y., Chiang I.P., Hsu W.H., Sugano S., Chen C.Y., Lin C.Y., Ko W.J., Chow K.C.
      J. Cell Sci. 123:1171-1180(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Lung adenocarcinoma.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
      Tissue: Teratocarcinoma and Tongue.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ASP-15.
      Tissue: Brain and Skin.
    6. Bienvenut W.V., Heiserich L., Boulahbel H., Gottlieb E.
      Submitted (JUL-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-9; 250-256; 276-286; 339-346; 443-451; 479-487 AND 606-616 (ISOFORMS 1/2), PROTEIN SEQUENCE OF 93-152 (ISOFORM 2), CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Colon carcinoma.
    7. "The AAA+ protein ATAD3 has displacement loop binding properties and is involved in mitochondrial nucleoid organization."
      He J., Mao C.C., Reyes A., Sembongi H., Di Re M., Granycome C., Clippingdale A.B., Fearnley I.M., Harbour M., Robinson A.J., Reichelt S., Spelbrink J.N., Walker J.E., Holt I.J.
      J. Cell Biol. 176:141-146(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, ASSOCIATION WITH NUCLEOIDS.
    8. "The layered structure of human mitochondrial DNA nucleoids."
      Bogenhagen D.F., Rousseau D., Burke S.
      J. Biol. Chem. 283:3665-3675(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TOPOLOGY, ASSOCIATION WITH NUCLEOIDS.
    9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-539, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Topological analysis of ATAD3A insertion in purified human mitochondria."
      Hubstenberger A., Merle N., Charton R., Brandolin G., Rousseau D.
      J. Bioenerg. Biomembr. 42:143-150(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TOPOLOGY.
    12. "The AAA+ ATPase ATAD3A controls mitochondrial dynamics at the interface of the inner and outer membranes."
      Gilquin B., Taillebourg E., Cherradi N., Hubstenberger A., Gay O., Merle N., Assard N., Fauvarque M.O., Tomohiro S., Kuge O., Baudier J.
      Mol. Cell. Biol. 30:1984-1996(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, HOMOOLIGOMERIZATION, INDUCTION, SUBCELLULAR LOCATION, TOPOLOGY, MUTAGENESIS OF LYS-406 AND ASP-459.
    13. "The calcium-dependent interaction between S100B and the mitochondrial AAA ATPase ATAD3A and the role of this complex in the cytoplasmic processing of ATAD3A."
      Gilquin B., Cannon B.R., Hubstenberger A., Moulouel B., Falk E., Merle N., Assard N., Kieffer S., Rousseau D., Wilder P.T., Weber D.J., Baudier J.
      Mol. Cell. Biol. 30:2724-2736(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH S100B, MUTAGENESIS OF VAL-341; LEU-345 AND 349-ILE-GLN-350.
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "ATAD3B is a human embryonic stem cell specific mitochondrial protein, re-expressed in cancer cells, that functions as dominant negative for the ubiquitous ATAD3A."
      Merle N., Feraud O., Gilquin B., Hubstenberger A., Kieffer-Jacquinot S., Assard N., Bennaceur-Griscelli A., Honnorat J., Baudier J.
      Mitochondrion 12:441-448(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ATAD3B AND HSPD1.
    16. Cited for: FUNCTION, INTERACTION WITH PROTEINS INVOLVED IN MITOCHONDRIAL TRANSLATION; RNA METABOLISM; LIPID METABOLISM; GADD45GIP1 AND FAM210A, INDUCTION.

    Entry informationi

    Entry nameiATD3A_HUMAN
    AccessioniPrimary (citable) accession number: Q9NVI7
    Secondary accession number(s): B3KPB3
    , D2K8Q1, G3V1I6, Q5SV23, Q8N275, Q96A50
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2005
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3