Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9NVH2 (INT7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Integrator complex subunit 7

Short name=Int7
Gene names
Name:INTS7
Synonyms:C1orf73
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length962 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Plays a role in DNA damage response (DDR) signaling during the S phase. Ref.11

Subunit structure

Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12. Interacts with NABP2. Ref.7 Ref.11

Subcellular location

Nucleus. Chromosome. Note: Localizes to sites of DNA damage in a H2AX-independent manner. Ref.11

Sequence similarities

Belongs to the Integrator subunit 7 family.

Sequence caution

The sequence BAA91650.1 differs from that shown. Reason: Erroneous termination at position 618. Translated as Cys.

The sequence BAB14116.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Biological processDNA damage
   Cellular componentChromosome
Nucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA damage checkpoint

Inferred from mutant phenotype Ref.11. Source: UniProtKB

cellular response to ionizing radiation

Inferred from direct assay Ref.11. Source: UniProtKB

snRNA processing

Inferred from direct assay Ref.7. Source: HGNC

   Cellular_componentchromosome

Inferred from direct assay Ref.11. Source: UniProtKB

integrator complex

Inferred from direct assay Ref.7. Source: HGNC

   Molecular_functionprotein binding

Inferred from physical interaction Ref.7Ref.11. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NVH2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NVH2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     759-772: Missing.
Isoform 3 (identifier: Q9NVH2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     773-792: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q9NVH2-4)

The sequence of this isoform differs from the canonical sequence as follows:
     76-124: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 962962Integrator complex subunit 7
PRO_0000259549

Regions

Compositional bias937 – 95519Gln-rich

Natural variations

Alternative sequence76 – 12449Missing in isoform 4.
VSP_043201
Alternative sequence759 – 77214Missing in isoform 2.
VSP_021463
Alternative sequence773 – 79220Missing in isoform 3.
VSP_021464
Natural variant4251H → R. Ref.2 Ref.5
Corresponds to variant rs17851788 [ dbSNP | Ensembl ].
VAR_028963

Experimental info

Sequence conflict8051K → T in BAB14116. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 45253FE31FD5B96D

FASTA962106,834
        10         20         30         40         50         60 
MASNSTKSFL ADAGYGEQEL DANSALMELD KGLRSGKLGE QCEAVVRFPR LFQKYPFPIL 

        70         80         90        100        110        120 
INSAFLKLAD VFRVGNNFLR LCVLKVTQQS EKHLEKILNV DEFVKRIFSV IHSNDPVARA 

       130        140        150        160        170        180 
ITLRMLGSLA SIIPERKNAH HSIRQSLDSH DNVEVEAAVF AAANFSAQSK DFAVGICNKI 

       190        200        210        220        230        240 
SEMIQGLATP VDLKLKLIPI LQHMHHDAIL ASSARQLLQQ LVTSYPSTKM VIVSLHTFTL 

       250        260        270        280        290        300 
LAASSLVDTP KQIQLLLQYL KNDPRKAVKR LAIQDLKLLA NKTPHTWSRE NIQALCECAL 

       310        320        330        340        350        360 
QTPYDSLKLG MLSVLSTLSG TIAIKHYFSI VPGNVSSSPR SSDLVKLAQE CCYHNNRGIA 

       370        380        390        400        410        420 
AHGVRVLTNI TVSCQEKDLL ALEQDAVFGL ESLLVLCSQD DSPGAQATLK IALNCMVKLA 

       430        440        450        460        470        480 
KGRPHLSQSV VETLLTQLHS AQDAARILMC HCLAAIAMQL PVLGDGMLGD LMELYKVIGR 

       490        500        510        520        530        540 
SATDKQQELL VSLATVIFVA SQKALSVESK AVIKQQLESV SNGWTVYRIA RQASRMGNHD 

       550        560        570        580        590        600 
MAKELYQSLL TQVASEHFYF WLNSLKEFSH AEQCLTGLQE ENYSSALSCI AESLKFYHKG 

       610        620        630        640        650        660 
IASLTAASTP LNPLSFQCEF VKLRIDLLQA FSQLICTCNS LKTSPPPAIA TTIAMTLGND 

       670        680        690        700        710        720 
LQRCGRISNQ MKQSMEEFRS LASRYGDLYQ ASFDADSATL RNVELQQQSC LLISHAIEAL 

       730        740        750        760        770        780 
ILDPESASFQ EYGSTGTAHA DSEYERRMMS VYNHVLEEVE SLNRKYTPVS YMHTACLCNA 

       790        800        810        820        830        840 
IIALLKVPLS FQRYFFQKLQ STSIKLALSP SPRNPAEPIA VQNNQQLALK VEGVVQHGSK 

       850        860        870        880        890        900 
PGLFRKIQSV CLNVSSTLQS KSGQDYKIPI DNMTNEMEQR VEPHNDYFST QFLLNFAILG 

       910        920        930        940        950        960 
THNITVESSV KDANGIVWKT GPRTTIFVKS LEDPYSQQIR LQQQQAQQPL QQQQQRNAYT 


RF 

« Hide

Isoform 2 [UniParc].

Checksum: 1458903417E4B25C
Show »

FASTA948105,165
Isoform 3 [UniParc].

Checksum: 785F91471229C53E
Show »

FASTA942104,696
Isoform 4 [UniParc].

Checksum: 419D8CE78A8CAA74
Show »

FASTA913101,118

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
Tissue: Brain.
[2]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ARG-425.
Tissue: Testis.
[3]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ARG-425.
Tissue: Skin and Uterus.
[6]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 204-962 (ISOFORM 1).
Tissue: Testis.
[7]"Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II."
Baillat D., Hakimi M.-A., Naeaer A.M., Shilatifard A., Cooch N., Shiekhattar R.
Cell 123:265-276(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE INTEGRATOR COMPLEX.
[8]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]"A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling."
Cotta-Ramusino C., McDonald E.R. III, Hurov K., Sowa M.E., Harper J.W., Elledge S.J.
Science 332:1313-1317(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH NABP2, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK001363 mRNA. Translation: BAA91650.1. Sequence problems.
AK001598 mRNA. Translation: BAA91779.1.
AK022509 mRNA. Translation: BAB14067.1.
AK022589 mRNA. Translation: BAB14116.1. Different initiation.
AK297225 mRNA. Translation: BAG59708.1.
AL117576 mRNA. Translation: CAB56000.1.
AM392654 mRNA. Translation: CAL37532.1.
AC092814 Genomic DNA. No translation available.
CH471100 Genomic DNA. Translation: EAW93406.1.
BC020523 mRNA. Translation: AAH20523.1.
BC030716 mRNA. Translation: AAH30716.1.
BC033918 mRNA. Translation: AAH33918.1.
AL133049 mRNA. Translation: CAB61376.1.
BK005725 mRNA. Translation: DAA05725.1.
CCDSCCDS1501.1. [Q9NVH2-1]
CCDS55683.1. [Q9NVH2-4]
CCDS55684.1. [Q9NVH2-3]
CCDS55685.1. [Q9NVH2-2]
PIRT17310.
T42652.
RefSeqNP_001186738.1. NM_001199809.1. [Q9NVH2-4]
NP_001186740.1. NM_001199811.1. [Q9NVH2-2]
NP_001186741.1. NM_001199812.1. [Q9NVH2-3]
NP_056249.1. NM_015434.3. [Q9NVH2-1]
UniGeneHs.369285.

3D structure databases

ProteinModelPortalQ9NVH2.
SMRQ9NVH2. Positions 412-438.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117404. 14 interactions.
MINTMINT-4540227.

PTM databases

PhosphoSiteQ9NVH2.

Polymorphism databases

DMDM74752993.

Proteomic databases

MaxQBQ9NVH2.
PaxDbQ9NVH2.
PRIDEQ9NVH2.

Protocols and materials databases

DNASU25896.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000366992; ENSP00000355959; ENSG00000143493. [Q9NVH2-3]
ENST00000366993; ENSP00000355960; ENSG00000143493. [Q9NVH2-2]
ENST00000366994; ENSP00000355961; ENSG00000143493. [Q9NVH2-1]
ENST00000440600; ENSP00000388908; ENSG00000143493. [Q9NVH2-4]
GeneID25896.
KEGGhsa:25896.
UCSCuc001hiw.2. human. [Q9NVH2-1]
uc001hiy.2. human. [Q9NVH2-2]
uc009xdb.2. human. [Q9NVH2-3]
uc010pta.2. human. [Q9NVH2-4]

Organism-specific databases

CTD25896.
GeneCardsGC01M212113.
HGNCHGNC:24484. INTS7.
MIM611350. gene.
neXtProtNX_Q9NVH2.
PharmGKBPA142672522.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG286030.
HOGENOMHOG000063719.
HOVERGENHBG079489.
InParanoidQ9NVH2.
KOK13144.
OMAHMHHDAS.
OrthoDBEOG78SQKT.
PhylomeDBQ9NVH2.
TreeFamTF106105.

Gene expression databases

BgeeQ9NVH2.
CleanExHS_INTS7.
GenevestigatorQ9NVH2.

Family and domain databases

Gene3D1.25.10.10. 2 hits.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
[Graphical view]
SUPFAMSSF48371. SSF48371. 1 hit.
ProtoNetSearch...

Other

ChiTaRSINTS7. human.
GeneWikiINTS7.
GenomeRNAi25896.
NextBio47341.
PROQ9NVH2.
SOURCESearch...

Entry information

Entry nameINT7_HUMAN
AccessionPrimary (citable) accession number: Q9NVH2
Secondary accession number(s): B4DLZ6 expand/collapse secondary AC list , B7WNP6, B7WPB6, Q8N4K7, Q8WUH5, Q9H9V3, Q9NVU5, Q9UFC6, Q9UFM3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM