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Protein

Integrator complex subunit 7

Gene

INTS7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Plays a role in DNA damage response (DDR) signaling during the S phase.1 Publication

GO - Biological processi

  • cellular response to ionizing radiation Source: UniProtKB
  • DNA damage checkpoint Source: UniProtKB
  • snRNA 3'-end processing Source: GO_Central
  • snRNA processing Source: HGNC
  • snRNA transcription from RNA polymerase II promoter Source: Reactome
Complete GO annotation...

Keywords - Biological processi

DNA damage

Enzyme and pathway databases

ReactomeiR-HSA-6807505. RNA polymerase II transcribes snRNA genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrator complex subunit 7
Short name:
Int7
Gene namesi
Name:INTS7
Synonyms:C1orf73
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:24484. INTS7.

Subcellular locationi

GO - Cellular componenti

  • chromosome Source: UniProtKB
  • integrator complex Source: HGNC
  • nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi25896.
OpenTargetsiENSG00000143493.
PharmGKBiPA142672522.

Polymorphism and mutation databases

BioMutaiINTS7.
DMDMi74752993.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002595491 – 962Integrator complex subunit 7Add BLAST962

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei338PhosphoserineCombined sources1
Modified residuei809PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NVH2.
MaxQBiQ9NVH2.
PaxDbiQ9NVH2.
PeptideAtlasiQ9NVH2.
PRIDEiQ9NVH2.

PTM databases

iPTMnetiQ9NVH2.
PhosphoSitePlusiQ9NVH2.

Expressioni

Gene expression databases

BgeeiENSG00000143493.
CleanExiHS_INTS7.
ExpressionAtlasiQ9NVH2. baseline and differential.
GenevisibleiQ9NVH2. HS.

Interactioni

Subunit structurei

Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12. Interacts with NABP2.2 Publications

Protein-protein interaction databases

BioGridi117404. 57 interactors.
IntActiQ9NVH2. 19 interactors.
MINTiMINT-4540227.
STRINGi9606.ENSP00000355961.

Structurei

3D structure databases

ProteinModelPortaliQ9NVH2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi937 – 955Gln-richAdd BLAST19

Sequence similaritiesi

Belongs to the Integrator subunit 7 family.Curated

Phylogenomic databases

eggNOGiKOG1988. Eukaryota.
ENOG410XSMR. LUCA.
GeneTreeiENSGT00390000011724.
HOGENOMiHOG000063719.
HOVERGENiHBG079489.
InParanoidiQ9NVH2.
KOiK13144.
OMAiHMHHDAS.
OrthoDBiEOG091G01BS.
PhylomeDBiQ9NVH2.
TreeFamiTF106105.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR033060. INTS7.
[Graphical view]
PANTHERiPTHR13322:SF2. PTHR13322:SF2. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NVH2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASNSTKSFL ADAGYGEQEL DANSALMELD KGLRSGKLGE QCEAVVRFPR
60 70 80 90 100
LFQKYPFPIL INSAFLKLAD VFRVGNNFLR LCVLKVTQQS EKHLEKILNV
110 120 130 140 150
DEFVKRIFSV IHSNDPVARA ITLRMLGSLA SIIPERKNAH HSIRQSLDSH
160 170 180 190 200
DNVEVEAAVF AAANFSAQSK DFAVGICNKI SEMIQGLATP VDLKLKLIPI
210 220 230 240 250
LQHMHHDAIL ASSARQLLQQ LVTSYPSTKM VIVSLHTFTL LAASSLVDTP
260 270 280 290 300
KQIQLLLQYL KNDPRKAVKR LAIQDLKLLA NKTPHTWSRE NIQALCECAL
310 320 330 340 350
QTPYDSLKLG MLSVLSTLSG TIAIKHYFSI VPGNVSSSPR SSDLVKLAQE
360 370 380 390 400
CCYHNNRGIA AHGVRVLTNI TVSCQEKDLL ALEQDAVFGL ESLLVLCSQD
410 420 430 440 450
DSPGAQATLK IALNCMVKLA KGRPHLSQSV VETLLTQLHS AQDAARILMC
460 470 480 490 500
HCLAAIAMQL PVLGDGMLGD LMELYKVIGR SATDKQQELL VSLATVIFVA
510 520 530 540 550
SQKALSVESK AVIKQQLESV SNGWTVYRIA RQASRMGNHD MAKELYQSLL
560 570 580 590 600
TQVASEHFYF WLNSLKEFSH AEQCLTGLQE ENYSSALSCI AESLKFYHKG
610 620 630 640 650
IASLTAASTP LNPLSFQCEF VKLRIDLLQA FSQLICTCNS LKTSPPPAIA
660 670 680 690 700
TTIAMTLGND LQRCGRISNQ MKQSMEEFRS LASRYGDLYQ ASFDADSATL
710 720 730 740 750
RNVELQQQSC LLISHAIEAL ILDPESASFQ EYGSTGTAHA DSEYERRMMS
760 770 780 790 800
VYNHVLEEVE SLNRKYTPVS YMHTACLCNA IIALLKVPLS FQRYFFQKLQ
810 820 830 840 850
STSIKLALSP SPRNPAEPIA VQNNQQLALK VEGVVQHGSK PGLFRKIQSV
860 870 880 890 900
CLNVSSTLQS KSGQDYKIPI DNMTNEMEQR VEPHNDYFST QFLLNFAILG
910 920 930 940 950
THNITVESSV KDANGIVWKT GPRTTIFVKS LEDPYSQQIR LQQQQAQQPL
960
QQQQQRNAYT RF
Length:962
Mass (Da):106,834
Last modified:October 1, 2000 - v1
Checksum:i45253FE31FD5B96D
GO
Isoform 2 (identifier: Q9NVH2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     759-772: Missing.

Show »
Length:948
Mass (Da):105,165
Checksum:i1458903417E4B25C
GO
Isoform 3 (identifier: Q9NVH2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     773-792: Missing.

Note: No experimental confirmation available.
Show »
Length:942
Mass (Da):104,696
Checksum:i785F91471229C53E
GO
Isoform 4 (identifier: Q9NVH2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-124: Missing.

Note: No experimental confirmation available.
Show »
Length:913
Mass (Da):101,118
Checksum:i419D8CE78A8CAA74
GO

Sequence cautioni

The sequence BAA91650 differs from that shown. Reason: Erroneous termination at position 618. Translated as Cys.Curated
The sequence BAB14116 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti805K → T in BAB14116 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028963425H → R.2 PublicationsCorresponds to variant rs17851788dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04320176 – 124Missing in isoform 4. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_021463759 – 772Missing in isoform 2. 2 PublicationsAdd BLAST14
Alternative sequenceiVSP_021464773 – 792Missing in isoform 3. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001363 mRNA. Translation: BAA91650.1. Sequence problems.
AK001598 mRNA. Translation: BAA91779.1.
AK022509 mRNA. Translation: BAB14067.1.
AK022589 mRNA. Translation: BAB14116.1. Different initiation.
AK297225 mRNA. Translation: BAG59708.1.
AL117576 mRNA. Translation: CAB56000.1.
AM392654 mRNA. Translation: CAL37532.1.
AC092814 Genomic DNA. No translation available.
CH471100 Genomic DNA. Translation: EAW93406.1.
BC020523 mRNA. Translation: AAH20523.1.
BC030716 mRNA. Translation: AAH30716.1.
BC033918 mRNA. Translation: AAH33918.1.
AL133049 mRNA. Translation: CAB61376.1.
BK005725 mRNA. Translation: DAA05725.1.
CCDSiCCDS1501.1. [Q9NVH2-1]
CCDS55683.1. [Q9NVH2-4]
CCDS55684.1. [Q9NVH2-3]
CCDS55685.1. [Q9NVH2-2]
PIRiT17310.
T42652.
RefSeqiNP_001186738.1. NM_001199809.1. [Q9NVH2-4]
NP_001186740.1. NM_001199811.1. [Q9NVH2-2]
NP_001186741.1. NM_001199812.1. [Q9NVH2-3]
NP_056249.1. NM_015434.3. [Q9NVH2-1]
UniGeneiHs.369285.

Genome annotation databases

EnsembliENST00000366992; ENSP00000355959; ENSG00000143493. [Q9NVH2-3]
ENST00000366993; ENSP00000355960; ENSG00000143493. [Q9NVH2-2]
ENST00000366994; ENSP00000355961; ENSG00000143493. [Q9NVH2-1]
ENST00000440600; ENSP00000388908; ENSG00000143493. [Q9NVH2-4]
GeneIDi25896.
KEGGihsa:25896.
UCSCiuc001hiw.3. human. [Q9NVH2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001363 mRNA. Translation: BAA91650.1. Sequence problems.
AK001598 mRNA. Translation: BAA91779.1.
AK022509 mRNA. Translation: BAB14067.1.
AK022589 mRNA. Translation: BAB14116.1. Different initiation.
AK297225 mRNA. Translation: BAG59708.1.
AL117576 mRNA. Translation: CAB56000.1.
AM392654 mRNA. Translation: CAL37532.1.
AC092814 Genomic DNA. No translation available.
CH471100 Genomic DNA. Translation: EAW93406.1.
BC020523 mRNA. Translation: AAH20523.1.
BC030716 mRNA. Translation: AAH30716.1.
BC033918 mRNA. Translation: AAH33918.1.
AL133049 mRNA. Translation: CAB61376.1.
BK005725 mRNA. Translation: DAA05725.1.
CCDSiCCDS1501.1. [Q9NVH2-1]
CCDS55683.1. [Q9NVH2-4]
CCDS55684.1. [Q9NVH2-3]
CCDS55685.1. [Q9NVH2-2]
PIRiT17310.
T42652.
RefSeqiNP_001186738.1. NM_001199809.1. [Q9NVH2-4]
NP_001186740.1. NM_001199811.1. [Q9NVH2-2]
NP_001186741.1. NM_001199812.1. [Q9NVH2-3]
NP_056249.1. NM_015434.3. [Q9NVH2-1]
UniGeneiHs.369285.

3D structure databases

ProteinModelPortaliQ9NVH2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117404. 57 interactors.
IntActiQ9NVH2. 19 interactors.
MINTiMINT-4540227.
STRINGi9606.ENSP00000355961.

PTM databases

iPTMnetiQ9NVH2.
PhosphoSitePlusiQ9NVH2.

Polymorphism and mutation databases

BioMutaiINTS7.
DMDMi74752993.

Proteomic databases

EPDiQ9NVH2.
MaxQBiQ9NVH2.
PaxDbiQ9NVH2.
PeptideAtlasiQ9NVH2.
PRIDEiQ9NVH2.

Protocols and materials databases

DNASUi25896.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366992; ENSP00000355959; ENSG00000143493. [Q9NVH2-3]
ENST00000366993; ENSP00000355960; ENSG00000143493. [Q9NVH2-2]
ENST00000366994; ENSP00000355961; ENSG00000143493. [Q9NVH2-1]
ENST00000440600; ENSP00000388908; ENSG00000143493. [Q9NVH2-4]
GeneIDi25896.
KEGGihsa:25896.
UCSCiuc001hiw.3. human. [Q9NVH2-1]

Organism-specific databases

CTDi25896.
DisGeNETi25896.
GeneCardsiINTS7.
HGNCiHGNC:24484. INTS7.
MIMi611350. gene.
neXtProtiNX_Q9NVH2.
OpenTargetsiENSG00000143493.
PharmGKBiPA142672522.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1988. Eukaryota.
ENOG410XSMR. LUCA.
GeneTreeiENSGT00390000011724.
HOGENOMiHOG000063719.
HOVERGENiHBG079489.
InParanoidiQ9NVH2.
KOiK13144.
OMAiHMHHDAS.
OrthoDBiEOG091G01BS.
PhylomeDBiQ9NVH2.
TreeFamiTF106105.

Enzyme and pathway databases

ReactomeiR-HSA-6807505. RNA polymerase II transcribes snRNA genes.

Miscellaneous databases

ChiTaRSiINTS7. human.
GeneWikiiINTS7.
GenomeRNAii25896.
PROiQ9NVH2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143493.
CleanExiHS_INTS7.
ExpressionAtlasiQ9NVH2. baseline and differential.
GenevisibleiQ9NVH2. HS.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR033060. INTS7.
[Graphical view]
PANTHERiPTHR13322:SF2. PTHR13322:SF2. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiINT7_HUMAN
AccessioniPrimary (citable) accession number: Q9NVH2
Secondary accession number(s): B4DLZ6
, B7WNP6, B7WPB6, Q8N4K7, Q8WUH5, Q9H9V3, Q9NVU5, Q9UFC6, Q9UFM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.