Q9NVH2 (INT7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Integrator complex subunit 7
Short name=Int7

Gene names

Name:	INTS7
Synonyms:	C1orf73

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	962 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Plays a role in DNA damage response (DDR) signaling during the S phase. Ref.11
Subunit structure	Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12. Interacts with NABP2. Ref.7 Ref.11
Subcellular location	Nucleus. Chromosome. Note: Localizes to sites of DNA damage in a H2AX-independent manner. Ref.11
Sequence similarities	Belongs to the Integrator subunit 7 family.
Sequence caution	The sequence BAA91650.1 differs from that shown. Reason: Erroneous termination at position 618. Translated as Cys. The sequence BAB14116.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	DNA damage
Cellular component	Chromosome Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA damage checkpoint Inferred from mutant phenotype Ref.11. Source: UniProtKB cellular response to ionizing radiation Inferred from direct assay Ref.11. Source: UniProtKB snRNA processing Inferred from direct assay Ref.7. Source: HGNC
Cellular_component	chromosome Inferred from direct assay Ref.11. Source: UniProtKB integrator complex Inferred from direct assay Ref.7. Source: HGNC
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NVH2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NVH2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     759-772: Missing.

Isoform 3 (identifier: Q9NVH2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     773-792: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q9NVH2-4)

The sequence of this isoform differs from the canonical sequence as follows:
     76-124: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 962	962	Integrator complex subunit 7		PRO_0000259549
Regions
	Compositional bias	937 – 955	19	Gln-rich
Amino acid modifications
	Modified residue	525	1	Phosphothreonine By similarity
	Modified residue	527	1	Phosphotyrosine By similarity
Natural variations
	Alternative sequence	76 – 124	49	Missing in isoform 4.		VSP_043201
	Alternative sequence	759 – 772	14	Missing in isoform 2.		VSP_021463
	Alternative sequence	773 – 792	20	Missing in isoform 3.		VSP_021464
	Natural variant	425	1	H → R. Ref.2 Ref.5 Corresponds to variant rs17851788 [ dbSNP | Ensembl ].		VAR_028963
Experimental info
	Sequence conflict	805	1	K → T in BAB14116. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 45253FE31FD5B96D	FASTA	962	106,834
	10 20 30 40 50 60 MASNSTKSFL ADAGYGEQEL DANSALMELD KGLRSGKLGE QCEAVVRFPR LFQKYPFPIL 70 80 90 100 110 120 INSAFLKLAD VFRVGNNFLR LCVLKVTQQS EKHLEKILNV DEFVKRIFSV IHSNDPVARA 130 140 150 160 170 180 ITLRMLGSLA SIIPERKNAH HSIRQSLDSH DNVEVEAAVF AAANFSAQSK DFAVGICNKI 190 200 210 220 230 240 SEMIQGLATP VDLKLKLIPI LQHMHHDAIL ASSARQLLQQ LVTSYPSTKM VIVSLHTFTL 250 260 270 280 290 300 LAASSLVDTP KQIQLLLQYL KNDPRKAVKR LAIQDLKLLA NKTPHTWSRE NIQALCECAL 310 320 330 340 350 360 QTPYDSLKLG MLSVLSTLSG TIAIKHYFSI VPGNVSSSPR SSDLVKLAQE CCYHNNRGIA 370 380 390 400 410 420 AHGVRVLTNI TVSCQEKDLL ALEQDAVFGL ESLLVLCSQD DSPGAQATLK IALNCMVKLA 430 440 450 460 470 480 KGRPHLSQSV VETLLTQLHS AQDAARILMC HCLAAIAMQL PVLGDGMLGD LMELYKVIGR 490 500 510 520 530 540 SATDKQQELL VSLATVIFVA SQKALSVESK AVIKQQLESV SNGWTVYRIA RQASRMGNHD 550 560 570 580 590 600 MAKELYQSLL TQVASEHFYF WLNSLKEFSH AEQCLTGLQE ENYSSALSCI AESLKFYHKG 610 620 630 640 650 660 IASLTAASTP LNPLSFQCEF VKLRIDLLQA FSQLICTCNS LKTSPPPAIA TTIAMTLGND 670 680 690 700 710 720 LQRCGRISNQ MKQSMEEFRS LASRYGDLYQ ASFDADSATL RNVELQQQSC LLISHAIEAL 730 740 750 760 770 780 ILDPESASFQ EYGSTGTAHA DSEYERRMMS VYNHVLEEVE SLNRKYTPVS YMHTACLCNA 790 800 810 820 830 840 IIALLKVPLS FQRYFFQKLQ STSIKLALSP SPRNPAEPIA VQNNQQLALK VEGVVQHGSK 850 860 870 880 890 900 PGLFRKIQSV CLNVSSTLQS KSGQDYKIPI DNMTNEMEQR VEPHNDYFST QFLLNFAILG 910 920 930 940 950 960 THNITVESSV KDANGIVWKT GPRTTIFVKS LEDPYSQQIR LQQQQAQQPL QQQQQRNAYT RF
	Isoform 2 [UniParc]. Checksum: 1458903417E4B25C	FASTA	948	105,165
	10 20 30 40 50 60 MASNSTKSFL ADAGYGEQEL DANSALMELD KGLRSGKLGE QCEAVVRFPR LFQKYPFPIL 70 80 90 100 110 120 INSAFLKLAD VFRVGNNFLR LCVLKVTQQS EKHLEKILNV DEFVKRIFSV IHSNDPVARA 130 140 150 160 170 180 ITLRMLGSLA SIIPERKNAH HSIRQSLDSH DNVEVEAAVF AAANFSAQSK DFAVGICNKI 190 200 210 220 230 240 SEMIQGLATP VDLKLKLIPI LQHMHHDAIL ASSARQLLQQ LVTSYPSTKM VIVSLHTFTL 250 260 270 280 290 300 LAASSLVDTP KQIQLLLQYL KNDPRKAVKR LAIQDLKLLA NKTPHTWSRE NIQALCECAL 310 320 330 340 350 360 QTPYDSLKLG MLSVLSTLSG TIAIKHYFSI VPGNVSSSPR SSDLVKLAQE CCYHNNRGIA 370 380 390 400 410 420 AHGVRVLTNI TVSCQEKDLL ALEQDAVFGL ESLLVLCSQD DSPGAQATLK IALNCMVKLA 430 440 450 460 470 480 KGRPHLSQSV VETLLTQLHS AQDAARILMC HCLAAIAMQL PVLGDGMLGD LMELYKVIGR 490 500 510 520 530 540 SATDKQQELL VSLATVIFVA SQKALSVESK AVIKQQLESV SNGWTVYRIA RQASRMGNHD 550 560 570 580 590 600 MAKELYQSLL TQVASEHFYF WLNSLKEFSH AEQCLTGLQE ENYSSALSCI AESLKFYHKG 610 620 630 640 650 660 IASLTAASTP LNPLSFQCEF VKLRIDLLQA FSQLICTCNS LKTSPPPAIA TTIAMTLGND 670 680 690 700 710 720 LQRCGRISNQ MKQSMEEFRS LASRYGDLYQ ASFDADSATL RNVELQQQSC LLISHAIEAL 730 740 750 760 770 780 ILDPESASFQ EYGSTGTAHA DSEYERRMMS VYNHVLEEHT ACLCNAIIAL LKVPLSFQRY 790 800 810 820 830 840 FFQKLQSTSI KLALSPSPRN PAEPIAVQNN QQLALKVEGV VQHGSKPGLF RKIQSVCLNV 850 860 870 880 890 900 SSTLQSKSGQ DYKIPIDNMT NEMEQRVEPH NDYFSTQFLL NFAILGTHNI TVESSVKDAN 910 920 930 940 GIVWKTGPRT TIFVKSLEDP YSQQIRLQQQ QAQQPLQQQQ QRNAYTRF
	Isoform 3 [UniParc]. Checksum: 785F91471229C53E	FASTA	942	104,696
	10 20 30 40 50 60 MASNSTKSFL ADAGYGEQEL DANSALMELD KGLRSGKLGE QCEAVVRFPR LFQKYPFPIL 70 80 90 100 110 120 INSAFLKLAD VFRVGNNFLR LCVLKVTQQS EKHLEKILNV DEFVKRIFSV IHSNDPVARA 130 140 150 160 170 180 ITLRMLGSLA SIIPERKNAH HSIRQSLDSH DNVEVEAAVF AAANFSAQSK DFAVGICNKI 190 200 210 220 230 240 SEMIQGLATP VDLKLKLIPI LQHMHHDAIL ASSARQLLQQ LVTSYPSTKM VIVSLHTFTL 250 260 270 280 290 300 LAASSLVDTP KQIQLLLQYL KNDPRKAVKR LAIQDLKLLA NKTPHTWSRE NIQALCECAL 310 320 330 340 350 360 QTPYDSLKLG MLSVLSTLSG TIAIKHYFSI VPGNVSSSPR SSDLVKLAQE CCYHNNRGIA 370 380 390 400 410 420 AHGVRVLTNI TVSCQEKDLL ALEQDAVFGL ESLLVLCSQD DSPGAQATLK IALNCMVKLA 430 440 450 460 470 480 KGRPHLSQSV VETLLTQLHS AQDAARILMC HCLAAIAMQL PVLGDGMLGD LMELYKVIGR 490 500 510 520 530 540 SATDKQQELL VSLATVIFVA SQKALSVESK AVIKQQLESV SNGWTVYRIA RQASRMGNHD 550 560 570 580 590 600 MAKELYQSLL TQVASEHFYF WLNSLKEFSH AEQCLTGLQE ENYSSALSCI AESLKFYHKG 610 620 630 640 650 660 IASLTAASTP LNPLSFQCEF VKLRIDLLQA FSQLICTCNS LKTSPPPAIA TTIAMTLGND 670 680 690 700 710 720 LQRCGRISNQ MKQSMEEFRS LASRYGDLYQ ASFDADSATL RNVELQQQSC LLISHAIEAL 730 740 750 760 770 780 ILDPESASFQ EYGSTGTAHA DSEYERRMMS VYNHVLEEVE SLNRKYTPVS YMRYFFQKLQ 790 800 810 820 830 840 STSIKLALSP SPRNPAEPIA VQNNQQLALK VEGVVQHGSK PGLFRKIQSV CLNVSSTLQS 850 860 870 880 890 900 KSGQDYKIPI DNMTNEMEQR VEPHNDYFST QFLLNFAILG THNITVESSV KDANGIVWKT 910 920 930 940 GPRTTIFVKS LEDPYSQQIR LQQQQAQQPL QQQQQRNAYT RF
	Isoform 4 [UniParc]. Checksum: 419D8CE78A8CAA74	FASTA	913	101,118
	10 20 30 40 50 60 MASNSTKSFL ADAGYGEQEL DANSALMELD KGLRSGKLGE QCEAVVRFPR LFQKYPFPIL 70 80 90 100 110 120 INSAFLKLAD VFRVGMLGSL ASIIPERKNA HHSIRQSLDS HDNVEVEAAV FAAANFSAQS 130 140 150 160 170 180 KDFAVGICNK ISEMIQGLAT PVDLKLKLIP ILQHMHHDAI LASSARQLLQ QLVTSYPSTK 190 200 210 220 230 240 MVIVSLHTFT LLAASSLVDT PKQIQLLLQY LKNDPRKAVK RLAIQDLKLL ANKTPHTWSR 250 260 270 280 290 300 ENIQALCECA LQTPYDSLKL GMLSVLSTLS GTIAIKHYFS IVPGNVSSSP RSSDLVKLAQ 310 320 330 340 350 360 ECCYHNNRGI AAHGVRVLTN ITVSCQEKDL LALEQDAVFG LESLLVLCSQ DDSPGAQATL 370 380 390 400 410 420 KIALNCMVKL AKGRPHLSQS VVETLLTQLH SAQDAARILM CHCLAAIAMQ LPVLGDGMLG 430 440 450 460 470 480 DLMELYKVIG RSATDKQQEL LVSLATVIFV ASQKALSVES KAVIKQQLES VSNGWTVYRI 490 500 510 520 530 540 ARQASRMGNH DMAKELYQSL LTQVASEHFY FWLNSLKEFS HAEQCLTGLQ EENYSSALSC 550 560 570 580 590 600 IAESLKFYHK GIASLTAAST PLNPLSFQCE FVKLRIDLLQ AFSQLICTCN SLKTSPPPAI 610 620 630 640 650 660 ATTIAMTLGN DLQRCGRISN QMKQSMEEFR SLASRYGDLY QASFDADSAT LRNVELQQQS 670 680 690 700 710 720 CLLISHAIEA LILDPESASF QEYGSTGTAH ADSEYERRMM SVYNHVLEEV ESLNRKYTPV 730 740 750 760 770 780 SYMHTACLCN AIIALLKVPL SFQRYFFQKL QSTSIKLALS PSPRNPAEPI AVQNNQQLAL 790 800 810 820 830 840 KVEGVVQHGS KPGLFRKIQS VCLNVSSTLQ SKSGQDYKIP IDNMTNEMEQ RVEPHNDYFS 850 860 870 880 890 900 TQFLLNFAIL GTHNITVESS VKDANGIVWK TGPRTTIFVK SLEDPYSQQI RLQQQQAQQP 910 LQQQQQRNAY TRF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4). Tissue: Brain.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ARG-425. Tissue: Testis.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ARG-425. Tissue: Skin and Uterus.
[6]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 204-962 (ISOFORM 1). Tissue: Testis.
[7]	"Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II." Baillat D., Hakimi M.-A., Naeaer A.M., Shilatifard A., Cooch N., Shiekhattar R. Cell 123:265-276(2005) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE INTEGRATOR COMPLEX.
[8]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[9]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[10]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]	"A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling." Cotta-Ramusino C., McDonald E.R. III, Hurov K., Sowa M.E., Harper J.W., Elledge S.J. Science 332:1313-1317(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH NABP2, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK001363 mRNA. Translation: BAA91650.1. Sequence problems. AK001598 mRNA. Translation: BAA91779.1. AK022509 mRNA. Translation: BAB14067.1. AK022589 mRNA. Translation: BAB14116.1. Different initiation. AK297225 mRNA. Translation: BAG59708.1. AL117576 mRNA. Translation: CAB56000.1. AM392654 mRNA. Translation: CAL37532.1. AC092814 Genomic DNA. No translation available. CH471100 Genomic DNA. Translation: EAW93406.1. BC020523 mRNA. Translation: AAH20523.1. BC030716 mRNA. Translation: AAH30716.1. BC033918 mRNA. Translation: AAH33918.1. AL133049 mRNA. Translation: CAB61376.1. BK005725 mRNA. Translation: DAA05725.1.
IPI	IPI00645022. IPI00645488. IPI00743871. IPI00909591.
PIR	T17310. T42652.
RefSeq	NP_001186738.1. NM_001199809.1. NP_001186740.1. NM_001199811.1. NP_001186741.1. NM_001199812.1. NP_056249.1. NM_015434.3.
UniGene	Hs.369285.
3D structure databases
ProteinModelPortal	Q9NVH2.
SMR	Q9NVH2. Positions 103-136, 251-286.
ModBase	Search...
PTM databases
PhosphoSite	Q9NVH2.
Polymorphism databases
DMDM	74752993.
Proteomic databases
PaxDb	Q9NVH2.
PRIDE	Q9NVH2.
Protocols and materials databases
DNASU	25896.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000366992; ENSP00000355959; ENSG00000143493. ENST00000366993; ENSP00000355960; ENSG00000143493. ENST00000366994; ENSP00000355961; ENSG00000143493. ENST00000440600; ENSP00000388908; ENSG00000143493.
GeneID	25896.
KEGG	hsa:25896.
UCSC	uc001hiw.2. human. uc001hiy.2. human. uc009xdb.2. human.
Organism-specific databases
CTD	25896.
GeneCards	GC01M212113.
HGNC	HGNC:24484. INTS7.
MIM	611350. gene.
neXtProt	NX_Q9NVH2.
PharmGKB	PA142672522.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG286030.
HOGENOM	HOG000063719.
HOVERGEN	HBG079489.
InParanoid	Q9NVH2.
KO	K13144.
OMA	HMHHDAS.
OrthoDB	EOG46DM23.
PhylomeDB	Q9NVH2.
Gene expression databases
Bgee	Q9NVH2.
CleanEx	HS_INTS7.
Genevestigator	Q9NVH2.
GermOnline	ENSG00000143493. Homo sapiens.
Family and domain databases
Gene3D	1.25.10.10. 2 hits.
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	INTS7. human.
GenomeRNAi	25896.
NextBio	47341.
SOURCE	Search...

Entry information

Entry name

INT7_HUMAN

Accession

Primary (citable) accession number: Q9NVH2
Secondary accession number(s): B4DLZ6 , B7WNP6, B7WPB6, Q8N4K7, Q8WUH5, Q9H9V3, Q9NVU5, Q9UFC6, Q9UFM3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.