Reviewed, UniProtKB/Swiss-Prot Q9NVH1 (DJC11_HUMAN)

Names and origin

Protein names

Recommended name:
DnaJ homolog subfamily C member 11

Gene names

Name:

DNAJC11

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	559 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Belongs to the DNAJC11 family. Contains 1 J domain.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Molecular function	Chaperone
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	heat shock protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NVH1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NVH1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     465-502: Missing.

Isoform 3 (identifier: Q9NVH1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     367-418: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 559	559	DnaJ homolog subfamily C member 11		PRO_0000247157
Regions
	Domain	14 – 82	69	J
	Coiled coil	417 – 457	41	Potential
Natural variations
	Alternative sequence	367 – 418	52	Missing in isoform 3.		VSP_019932
	Alternative sequence	465 – 502	38	Missing in isoform 2.		VSP_019933
	Natural variant	267	1	V → M: dbSNP rs12137794. Ref.2		VAR_027078
	Natural variant	290	1	T → A: dbSNP rs200454.		VAR_027079
	Natural variant	290	1	T → S: dbSNP rs200454. Ref.4		VAR_055703
Experimental info
	Sequence conflict	309	1	S → I in BAA91780. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 25, 2006. Version 2. Checksum: B16D49B296362800	FASTA	559	63,278
	10 20 30 40 50 60 MATALSEEEL DNEDYYSLLN VRREASSEEL KAAYRRLCML YHPDKHRDPE LKSQAERLFN 70 80 90 100 110 120 LVHQAYEVLS DPQTRAIYDI YGKRGLEMEG WEVVERRRTP AEIREEFERL QREREERRLQ 130 140 150 160 170 180 QRTNPKGTIS VGVDATDLFD RYDEEYEDVS GSSFPQIEIN KMHISQSIEA PLTATDTAIL 190 200 210 220 230 240 SGSLSTQNGN GGGSINFALR RVTSAKGWGE LEFGAGDLQG PLFGLKLFRN LTPRCFVTTN 250 260 270 280 290 300 CALQFSSRGI RPGLTTVLAR NLDKNTVGYL QWRWGIQSAM NTSIVRDTKT SHFTVALQLG 310 320 330 340 350 360 IPHSFALISY QHKFQDDDQT RVKGSLKAGF FGTVVEYGAE RKISRHSVLG AAVSVGVPQG 370 380 390 400 410 420 VSLKVKLNRA SQTYFFPIHL TDQLLPSAMF YATVGPLVVY FAMHRLIIKP YLRAQKEKEL 430 440 450 460 470 480 EKQRESAATD VLQKKQEAES AVRLMQESVR RIIEAEESRM GLIIVNAWYG KFVNDKSRKS 490 500 510 520 530 540 EKVKVIDVTV PLQCLVKDSK LILTEASKAG LPGFYDPCVG EEKNLKVLYQ FRGVLHQVMV 550 LDSEALRIPK QSHRIDTDG
	Isoform 2. Checksum: ADEAB1206D3FF982	FASTA	521	58,947
	10 20 30 40 50 60 MATALSEEEL DNEDYYSLLN VRREASSEEL KAAYRRLCML YHPDKHRDPE LKSQAERLFN 70 80 90 100 110 120 LVHQAYEVLS DPQTRAIYDI YGKRGLEMEG WEVVERRRTP AEIREEFERL QREREERRLQ 130 140 150 160 170 180 QRTNPKGTIS VGVDATDLFD RYDEEYEDVS GSSFPQIEIN KMHISQSIEA PLTATDTAIL 190 200 210 220 230 240 SGSLSTQNGN GGGSINFALR RVTSAKGWGE LEFGAGDLQG PLFGLKLFRN LTPRCFVTTN 250 260 270 280 290 300 CALQFSSRGI RPGLTTVLAR NLDKNTVGYL QWRWGIQSAM NTSIVRDTKT SHFTVALQLG 310 320 330 340 350 360 IPHSFALISY QHKFQDDDQT RVKGSLKAGF FGTVVEYGAE RKISRHSVLG AAVSVGVPQG 370 380 390 400 410 420 VSLKVKLNRA SQTYFFPIHL TDQLLPSAMF YATVGPLVVY FAMHRLIIKP YLRAQKEKEL 430 440 450 460 470 480 EKQRESAATD VLQKKQEAES AVRLMQESVR RIIEAEESRM GLIILTEASK AGLPGFYDPC 490 500 510 520 VGEEKNLKVL YQFRGVLHQV MVLDSEALRI PKQSHRIDTD G
	Isoform 3. Checksum: 72BD808620B5512A	FASTA	507	57,197
	10 20 30 40 50 60 MATALSEEEL DNEDYYSLLN VRREASSEEL KAAYRRLCML YHPDKHRDPE LKSQAERLFN 70 80 90 100 110 120 LVHQAYEVLS DPQTRAIYDI YGKRGLEMEG WEVVERRRTP AEIREEFERL QREREERRLQ 130 140 150 160 170 180 QRTNPKGTIS VGVDATDLFD RYDEEYEDVS GSSFPQIEIN KMHISQSIEA PLTATDTAIL 190 200 210 220 230 240 SGSLSTQNGN GGGSINFALR RVTSAKGWGE LEFGAGDLQG PLFGLKLFRN LTPRCFVTTN 250 260 270 280 290 300 CALQFSSRGI RPGLTTVLAR NLDKNTVGYL QWRWGIQSAM NTSIVRDTKT SHFTVALQLG 310 320 330 340 350 360 IPHSFALISY QHKFQDDDQT RVKGSLKAGF FGTVVEYGAE RKISRHSVLG AAVSVGVPQG 370 380 390 400 410 420 VSLKVKELEK QRESAATDVL QKKQEAESAV RLMQESVRRI IEAEESRMGL IIVNAWYGKF 430 440 450 460 470 480 VNDKSRKSEK VKVIDVTVPL QCLVKDSKLI LTEASKAGLP GFYDPCVGEE KNLKVLYQFR 490 500 GVLHQVMVLD SEALRIPKQS HRIDTDG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a novel human DNAJ domain-containing protein." Xu J., Xie Y., Mao Y. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-267. Tissue: Teratocarcinoma.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT SER-290. Tissue: Brain, Lung and Placenta.
[5]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-559 (ISOFORM 1). Tissue: Mammary cancer.
[6]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY336749 mRNA. Translation: AAR02411.1. AK001599 mRNA. Translation: BAA91780.1. AL159177, AL031447 Genomic DNA. Translation: CAH71592.1. AL159177, AL031447 Genomic DNA. Translation: CAH71593.1. AL031447, AL159177 Genomic DNA. Translation: CAI19465.1. AL031447, AL159177 Genomic DNA. Translation: CAI19466.1. BC006086 mRNA. Translation: AAH06086.1. BC008772 mRNA. Translation: AAH08772.1. Different initiation. BC014145 mRNA. Translation: AAH14145.1. AL833841 mRNA. Translation: CAD38701.1.
IPI	IPI00333016. IPI00465290. IPI00607744.
RefSeq	NP_060668.2.
UniGene	Hs.462640
3D structure databases
SMR	Q9NVH1. Positions 11-89.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NVH1. 2 interactions.
STRING	Q9NVH1.
Proteomic databases
PRIDE	Q9NVH1.
Genome annotation databases
Ensembl	ENST00000377577; ENSP00000366800; ENSG00000007923; Homo sapiens. [Genome view]
GeneID	55735.
KEGG	hsa:55735.
UCSC	uc001aof.1. human. uc001aog.1. human.
Organism-specific databases
CTD	55735.
GeneCards	GC01M006628.
HGNC	HGNC:25570. DNAJC11.
PharmGKB	PA134893823.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG080125.
InParanoid	Q9NVH1.
OMA	QVMVLDS.
OrthoDB	EOG983GQC.
PhylomeDB	Q9NVH1.
Gene expression databases
ArrayExpress	Q9NVH1.
Bgee	Q9NVH1.
CleanEx	HS_DNAJC11.
Genevestigator	Q9NVH1.
GermOnline	ENSG00000007923. Homo sapiens.
Family and domain databases
InterPro	IPR001623. DnaJ_N. IPR018253. Heat_shock_DnaJ_CS. IPR015609. Hsp40/DnaJ_Rel. [Graphical view]
Gene3D	G3DSA:1.10.287.110. DnaJ_N. 1 hit.
PANTHER	PTHR11821. Hsp40/DnaJ_Rel. 1 hit.
Pfam	PF00226. DnaJ. 1 hit. [Graphical view]
SMART	SM00271. DnaJ. 1 hit. [Graphical view]
SUPFAM	SSF46565. DnaJ_N. 1 hit.
PROSITE	PS00636. DNAJ_1. 1 hit. PS50076. DNAJ_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	60676.

Entry information

Entry name

DJC11_HUMAN

Accession

Primary (citable) accession number: Q9NVH1
Secondary accession number(s): Q4VWF5 , Q5VZN0, Q6PK20, Q6PK70, Q8NDM2, Q96CL7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2006
Last sequence update:	July 25, 2006
Last modified:	March 2, 2010
This is version 62 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.