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Protein

DnaJ homolog subfamily C member 11

Gene

DNAJC11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 11
Gene namesi
Name:DNAJC11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:25570. DNAJC11.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. mitochondrial inner membrane Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134893823.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 559558DnaJ homolog subfamily C member 11PRO_0000247157Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9NVH1.
PaxDbiQ9NVH1.
PRIDEiQ9NVH1.

PTM databases

PhosphoSiteiQ9NVH1.

Expressioni

Gene expression databases

BgeeiQ9NVH1.
CleanExiHS_DNAJC11.
ExpressionAtlasiQ9NVH1. baseline and differential.
GenevestigatoriQ9NVH1.

Organism-specific databases

HPAiHPA028705.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HTTP428583EBI-1055336,EBI-466029

Protein-protein interaction databases

BioGridi120854. 13 interactions.
IntActiQ9NVH1. 6 interactions.
MINTiMINT-2819458.
STRINGi9606.ENSP00000366800.

Structurei

3D structure databases

ProteinModelPortaliQ9NVH1.
SMRiQ9NVH1. Positions 14-82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 8269JPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili417 – 45741Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the DNAJC11 family.Curated
Contains 1 J domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG0484.
GeneTreeiENSGT00780000122011.
HOGENOMiHOG000231113.
HOVERGENiHBG080125.
InParanoidiQ9NVH1.
KOiK09531.
OMAiFYLAIQR.
OrthoDBiEOG70GMFJ.
PhylomeDBiQ9NVH1.
TreeFamiTF105170.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR024586. DnaJ-like_C11_C.
IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF11875. DUF3395. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NVH1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATALSEEEL DNEDYYSLLN VRREASSEEL KAAYRRLCML YHPDKHRDPE
60 70 80 90 100
LKSQAERLFN LVHQAYEVLS DPQTRAIYDI YGKRGLEMEG WEVVERRRTP
110 120 130 140 150
AEIREEFERL QREREERRLQ QRTNPKGTIS VGVDATDLFD RYDEEYEDVS
160 170 180 190 200
GSSFPQIEIN KMHISQSIEA PLTATDTAIL SGSLSTQNGN GGGSINFALR
210 220 230 240 250
RVTSAKGWGE LEFGAGDLQG PLFGLKLFRN LTPRCFVTTN CALQFSSRGI
260 270 280 290 300
RPGLTTVLAR NLDKNTVGYL QWRWGIQSAM NTSIVRDTKT SHFTVALQLG
310 320 330 340 350
IPHSFALISY QHKFQDDDQT RVKGSLKAGF FGTVVEYGAE RKISRHSVLG
360 370 380 390 400
AAVSVGVPQG VSLKVKLNRA SQTYFFPIHL TDQLLPSAMF YATVGPLVVY
410 420 430 440 450
FAMHRLIIKP YLRAQKEKEL EKQRESAATD VLQKKQEAES AVRLMQESVR
460 470 480 490 500
RIIEAEESRM GLIIVNAWYG KFVNDKSRKS EKVKVIDVTV PLQCLVKDSK
510 520 530 540 550
LILTEASKAG LPGFYDPCVG EEKNLKVLYQ FRGVLHQVMV LDSEALRIPK

QSHRIDTDG
Length:559
Mass (Da):63,278
Last modified:July 25, 2006 - v2
Checksum:iB16D49B296362800
GO
Isoform 2 (identifier: Q9NVH1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     465-502: Missing.

Show »
Length:521
Mass (Da):58,947
Checksum:iADEAB1206D3FF982
GO
Isoform 3 (identifier: Q9NVH1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     367-418: Missing.

Show »
Length:507
Mass (Da):57,197
Checksum:i72BD808620B5512A
GO

Sequence cautioni

The sequence AAH08772.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti309 – 3091S → I in BAA91780 (Ref. 1) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti267 – 2671V → M.1 Publication
Corresponds to variant rs12137794 [ dbSNP | Ensembl ].
VAR_027078
Natural varianti290 – 2901T → A.
Corresponds to variant rs200454 [ dbSNP | Ensembl ].
VAR_027079
Natural varianti290 – 2901T → S.1 Publication
Corresponds to variant rs200454 [ dbSNP | Ensembl ].
VAR_055703

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei367 – 41852Missing in isoform 3. 1 PublicationVSP_019932Add
BLAST
Alternative sequencei465 – 50238Missing in isoform 2. 1 PublicationVSP_019933Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY336749 mRNA. Translation: AAR02411.1.
AK001599 mRNA. Translation: BAA91780.1.
AL159177, AL031447 Genomic DNA. Translation: CAH71592.1.
AL159177, AL031447 Genomic DNA. Translation: CAH71593.1.
AL031447, AL159177 Genomic DNA. Translation: CAI19465.1.
AL031447, AL159177 Genomic DNA. Translation: CAI19466.1.
BC006086 mRNA. Translation: AAH06086.1.
BC008772 mRNA. Translation: AAH08772.1. Different initiation.
BC014145 mRNA. Translation: AAH14145.1.
AL833841 mRNA. Translation: CAD38701.1.
CCDSiCCDS87.1. [Q9NVH1-1]
RefSeqiNP_060668.2. NM_018198.3. [Q9NVH1-1]
UniGeneiHs.462640.

Genome annotation databases

EnsembliENST00000294401; ENSP00000294401; ENSG00000007923. [Q9NVH1-3]
ENST00000377577; ENSP00000366800; ENSG00000007923. [Q9NVH1-1]
GeneIDi55735.
KEGGihsa:55735.
UCSCiuc001aof.2. human. [Q9NVH1-1]
uc001aog.2. human. [Q9NVH1-3]

Polymorphism databases

DMDMi110808199.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY336749 mRNA. Translation: AAR02411.1.
AK001599 mRNA. Translation: BAA91780.1.
AL159177, AL031447 Genomic DNA. Translation: CAH71592.1.
AL159177, AL031447 Genomic DNA. Translation: CAH71593.1.
AL031447, AL159177 Genomic DNA. Translation: CAI19465.1.
AL031447, AL159177 Genomic DNA. Translation: CAI19466.1.
BC006086 mRNA. Translation: AAH06086.1.
BC008772 mRNA. Translation: AAH08772.1. Different initiation.
BC014145 mRNA. Translation: AAH14145.1.
AL833841 mRNA. Translation: CAD38701.1.
CCDSiCCDS87.1. [Q9NVH1-1]
RefSeqiNP_060668.2. NM_018198.3. [Q9NVH1-1]
UniGeneiHs.462640.

3D structure databases

ProteinModelPortaliQ9NVH1.
SMRiQ9NVH1. Positions 14-82.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120854. 13 interactions.
IntActiQ9NVH1. 6 interactions.
MINTiMINT-2819458.
STRINGi9606.ENSP00000366800.

PTM databases

PhosphoSiteiQ9NVH1.

Polymorphism databases

DMDMi110808199.

Proteomic databases

MaxQBiQ9NVH1.
PaxDbiQ9NVH1.
PRIDEiQ9NVH1.

Protocols and materials databases

DNASUi55735.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294401; ENSP00000294401; ENSG00000007923. [Q9NVH1-3]
ENST00000377577; ENSP00000366800; ENSG00000007923. [Q9NVH1-1]
GeneIDi55735.
KEGGihsa:55735.
UCSCiuc001aof.2. human. [Q9NVH1-1]
uc001aog.2. human. [Q9NVH1-3]

Organism-specific databases

CTDi55735.
GeneCardsiGC01M006694.
HGNCiHGNC:25570. DNAJC11.
HPAiHPA028705.
MIMi614827. gene.
neXtProtiNX_Q9NVH1.
PharmGKBiPA134893823.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0484.
GeneTreeiENSGT00780000122011.
HOGENOMiHOG000231113.
HOVERGENiHBG080125.
InParanoidiQ9NVH1.
KOiK09531.
OMAiFYLAIQR.
OrthoDBiEOG70GMFJ.
PhylomeDBiQ9NVH1.
TreeFamiTF105170.

Miscellaneous databases

ChiTaRSiDNAJC11. human.
GeneWikiiDNAJC11.
GenomeRNAii55735.
NextBioi60676.
PROiQ9NVH1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NVH1.
CleanExiHS_DNAJC11.
ExpressionAtlasiQ9NVH1. baseline and differential.
GenevestigatoriQ9NVH1.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR024586. DnaJ-like_C11_C.
IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF11875. DUF3395. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel human DNAJ domain-containing protein."
    Xu J., Xie Y., Mao Y.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-267.
    Tissue: Teratocarcinoma.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT SER-290.
    Tissue: Brain, Lung and Placenta.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-559 (ISOFORM 1).
    Tissue: Mammary cancer.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDJC11_HUMAN
AccessioniPrimary (citable) accession number: Q9NVH1
Secondary accession number(s): Q4VWF5
, Q5VZN0, Q6PK20, Q6PK70, Q8NDM2, Q96CL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: February 4, 2015
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.