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Q9NVH1

- DJC11_HUMAN

UniProt

Q9NVH1 - DJC11_HUMAN

Protein

DnaJ homolog subfamily C member 11

Gene

DNAJC11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (25 Jul 2006)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Keywords - Molecular functioni

    Chaperone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DnaJ homolog subfamily C member 11
    Gene namesi
    Name:DNAJC11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:25570. DNAJC11.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. mitochondrial inner membrane Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134893823.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 559558DnaJ homolog subfamily C member 11PRO_0000247157Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9NVH1.
    PaxDbiQ9NVH1.
    PRIDEiQ9NVH1.

    PTM databases

    PhosphoSiteiQ9NVH1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NVH1.
    BgeeiQ9NVH1.
    CleanExiHS_DNAJC11.
    GenevestigatoriQ9NVH1.

    Organism-specific databases

    HPAiHPA028705.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HTTP428583EBI-1055336,EBI-466029

    Protein-protein interaction databases

    BioGridi120854. 6 interactions.
    IntActiQ9NVH1. 6 interactions.
    MINTiMINT-2819458.
    STRINGi9606.ENSP00000366800.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NVH1.
    SMRiQ9NVH1. Positions 14-82.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini14 – 8269JPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili417 – 45741Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the DNAJC11 family.Curated
    Contains 1 J domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG0484.
    HOGENOMiHOG000231113.
    HOVERGENiHBG080125.
    InParanoidiQ9NVH1.
    KOiK09531.
    OMAiFYLAIQR.
    OrthoDBiEOG70GMFJ.
    PhylomeDBiQ9NVH1.
    TreeFamiTF105170.

    Family and domain databases

    Gene3Di1.10.287.110. 1 hit.
    InterProiIPR024586. DnaJ-like_C11_C.
    IPR001623. DnaJ_domain.
    IPR018253. DnaJ_domain_CS.
    [Graphical view]
    PfamiPF00226. DnaJ. 1 hit.
    PF11875. DUF3395. 1 hit.
    [Graphical view]
    PRINTSiPR00625. JDOMAIN.
    SMARTiSM00271. DnaJ. 1 hit.
    [Graphical view]
    SUPFAMiSSF46565. SSF46565. 1 hit.
    PROSITEiPS00636. DNAJ_1. 1 hit.
    PS50076. DNAJ_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NVH1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MATALSEEEL DNEDYYSLLN VRREASSEEL KAAYRRLCML YHPDKHRDPE    50
    LKSQAERLFN LVHQAYEVLS DPQTRAIYDI YGKRGLEMEG WEVVERRRTP 100
    AEIREEFERL QREREERRLQ QRTNPKGTIS VGVDATDLFD RYDEEYEDVS 150
    GSSFPQIEIN KMHISQSIEA PLTATDTAIL SGSLSTQNGN GGGSINFALR 200
    RVTSAKGWGE LEFGAGDLQG PLFGLKLFRN LTPRCFVTTN CALQFSSRGI 250
    RPGLTTVLAR NLDKNTVGYL QWRWGIQSAM NTSIVRDTKT SHFTVALQLG 300
    IPHSFALISY QHKFQDDDQT RVKGSLKAGF FGTVVEYGAE RKISRHSVLG 350
    AAVSVGVPQG VSLKVKLNRA SQTYFFPIHL TDQLLPSAMF YATVGPLVVY 400
    FAMHRLIIKP YLRAQKEKEL EKQRESAATD VLQKKQEAES AVRLMQESVR 450
    RIIEAEESRM GLIIVNAWYG KFVNDKSRKS EKVKVIDVTV PLQCLVKDSK 500
    LILTEASKAG LPGFYDPCVG EEKNLKVLYQ FRGVLHQVMV LDSEALRIPK 550
    QSHRIDTDG 559
    Length:559
    Mass (Da):63,278
    Last modified:July 25, 2006 - v2
    Checksum:iB16D49B296362800
    GO
    Isoform 2 (identifier: Q9NVH1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         465-502: Missing.

    Show »
    Length:521
    Mass (Da):58,947
    Checksum:iADEAB1206D3FF982
    GO
    Isoform 3 (identifier: Q9NVH1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         367-418: Missing.

    Show »
    Length:507
    Mass (Da):57,197
    Checksum:i72BD808620B5512A
    GO

    Sequence cautioni

    The sequence AAH08772.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti309 – 3091S → I in BAA91780. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti267 – 2671V → M.1 Publication
    Corresponds to variant rs12137794 [ dbSNP | Ensembl ].
    VAR_027078
    Natural varianti290 – 2901T → A.
    Corresponds to variant rs200454 [ dbSNP | Ensembl ].
    VAR_027079
    Natural varianti290 – 2901T → S.1 Publication
    Corresponds to variant rs200454 [ dbSNP | Ensembl ].
    VAR_055703

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei367 – 41852Missing in isoform 3. 1 PublicationVSP_019932Add
    BLAST
    Alternative sequencei465 – 50238Missing in isoform 2. 1 PublicationVSP_019933Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY336749 mRNA. Translation: AAR02411.1.
    AK001599 mRNA. Translation: BAA91780.1.
    AL159177, AL031447 Genomic DNA. Translation: CAH71592.1.
    AL159177, AL031447 Genomic DNA. Translation: CAH71593.1.
    AL031447, AL159177 Genomic DNA. Translation: CAI19465.1.
    AL031447, AL159177 Genomic DNA. Translation: CAI19466.1.
    BC006086 mRNA. Translation: AAH06086.1.
    BC008772 mRNA. Translation: AAH08772.1. Different initiation.
    BC014145 mRNA. Translation: AAH14145.1.
    AL833841 mRNA. Translation: CAD38701.1.
    CCDSiCCDS87.1. [Q9NVH1-1]
    RefSeqiNP_060668.2. NM_018198.3. [Q9NVH1-1]
    UniGeneiHs.462640.

    Genome annotation databases

    EnsembliENST00000294401; ENSP00000294401; ENSG00000007923. [Q9NVH1-3]
    ENST00000377577; ENSP00000366800; ENSG00000007923. [Q9NVH1-1]
    GeneIDi55735.
    KEGGihsa:55735.
    UCSCiuc001aof.2. human. [Q9NVH1-1]
    uc001aog.2. human. [Q9NVH1-3]

    Polymorphism databases

    DMDMi110808199.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY336749 mRNA. Translation: AAR02411.1 .
    AK001599 mRNA. Translation: BAA91780.1 .
    AL159177 , AL031447 Genomic DNA. Translation: CAH71592.1 .
    AL159177 , AL031447 Genomic DNA. Translation: CAH71593.1 .
    AL031447 , AL159177 Genomic DNA. Translation: CAI19465.1 .
    AL031447 , AL159177 Genomic DNA. Translation: CAI19466.1 .
    BC006086 mRNA. Translation: AAH06086.1 .
    BC008772 mRNA. Translation: AAH08772.1 . Different initiation.
    BC014145 mRNA. Translation: AAH14145.1 .
    AL833841 mRNA. Translation: CAD38701.1 .
    CCDSi CCDS87.1. [Q9NVH1-1 ]
    RefSeqi NP_060668.2. NM_018198.3. [Q9NVH1-1 ]
    UniGenei Hs.462640.

    3D structure databases

    ProteinModelPortali Q9NVH1.
    SMRi Q9NVH1. Positions 14-82.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120854. 6 interactions.
    IntActi Q9NVH1. 6 interactions.
    MINTi MINT-2819458.
    STRINGi 9606.ENSP00000366800.

    PTM databases

    PhosphoSitei Q9NVH1.

    Polymorphism databases

    DMDMi 110808199.

    Proteomic databases

    MaxQBi Q9NVH1.
    PaxDbi Q9NVH1.
    PRIDEi Q9NVH1.

    Protocols and materials databases

    DNASUi 55735.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000294401 ; ENSP00000294401 ; ENSG00000007923 . [Q9NVH1-3 ]
    ENST00000377577 ; ENSP00000366800 ; ENSG00000007923 . [Q9NVH1-1 ]
    GeneIDi 55735.
    KEGGi hsa:55735.
    UCSCi uc001aof.2. human. [Q9NVH1-1 ]
    uc001aog.2. human. [Q9NVH1-3 ]

    Organism-specific databases

    CTDi 55735.
    GeneCardsi GC01M006694.
    HGNCi HGNC:25570. DNAJC11.
    HPAi HPA028705.
    MIMi 614827. gene.
    neXtProti NX_Q9NVH1.
    PharmGKBi PA134893823.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0484.
    HOGENOMi HOG000231113.
    HOVERGENi HBG080125.
    InParanoidi Q9NVH1.
    KOi K09531.
    OMAi FYLAIQR.
    OrthoDBi EOG70GMFJ.
    PhylomeDBi Q9NVH1.
    TreeFami TF105170.

    Miscellaneous databases

    ChiTaRSi DNAJC11. human.
    GeneWikii DNAJC11.
    GenomeRNAii 55735.
    NextBioi 60676.
    PROi Q9NVH1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NVH1.
    Bgeei Q9NVH1.
    CleanExi HS_DNAJC11.
    Genevestigatori Q9NVH1.

    Family and domain databases

    Gene3Di 1.10.287.110. 1 hit.
    InterProi IPR024586. DnaJ-like_C11_C.
    IPR001623. DnaJ_domain.
    IPR018253. DnaJ_domain_CS.
    [Graphical view ]
    Pfami PF00226. DnaJ. 1 hit.
    PF11875. DUF3395. 1 hit.
    [Graphical view ]
    PRINTSi PR00625. JDOMAIN.
    SMARTi SM00271. DnaJ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46565. SSF46565. 1 hit.
    PROSITEi PS00636. DNAJ_1. 1 hit.
    PS50076. DNAJ_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel human DNAJ domain-containing protein."
      Xu J., Xie Y., Mao Y.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT MET-267.
      Tissue: Teratocarcinoma.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT SER-290.
      Tissue: Brain, Lung and Placenta.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-559 (ISOFORM 1).
      Tissue: Mammary cancer.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDJC11_HUMAN
    AccessioniPrimary (citable) accession number: Q9NVH1
    Secondary accession number(s): Q4VWF5
    , Q5VZN0, Q6PK20, Q6PK70, Q8NDM2, Q96CL7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: July 25, 2006
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3