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Protein

Exonuclease 3'-5' domain-containing protein 2

Gene

EXD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. 3'-5' exonuclease activity Source: GO_Central
  2. nucleic acid binding Source: InterPro

GO - Biological processi

  1. nucleic acid phosphodiester bond hydrolysis Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Exonuclease 3'-5' domain-containing protein 2
Alternative name(s):
Exonuclease 3'-5' domain-like-containing protein 2
Gene namesi
Name:EXD2
Synonyms:C14orf114, EXDL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20217. EXD2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: GO_Central
  2. nucleus Source: GO_Central
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164719421.

Polymorphism and mutation databases

BioMutaiEXD2.
DMDMi410516875.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 621621Exonuclease 3'-5' domain-containing protein 2PRO_0000089924Add
BLAST

Proteomic databases

MaxQBiQ9NVH0.
PaxDbiQ9NVH0.
PRIDEiQ9NVH0.

PTM databases

PhosphoSiteiQ9NVH0.

Expressioni

Gene expression databases

BgeeiQ9NVH0.
CleanExiHS_EXDL2.
ExpressionAtlasiQ9NVH0. baseline and differential.
GenevestigatoriQ9NVH0.

Organism-specific databases

HPAiHPA002906.
HPA005848.

Interactioni

Protein-protein interaction databases

BioGridi120514. 8 interactions.
STRINGi9606.ENSP00000193422.

Structurei

3D structure databases

ProteinModelPortaliQ9NVH0.
SMRiQ9NVH0. Positions 99-257.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini155 – 247933'-5' exonucleaseAdd
BLAST

Sequence similaritiesi

Belongs to the EXD2 family.Curated
Contains 1 3'-5' exonuclease domain.Curated

Phylogenomic databases

eggNOGiNOG68878.
GeneTreeiENSGT00390000014318.
HOGENOMiHOG000046597.
OMAiDIPFRSK.
OrthoDBiEOG773XG0.
PhylomeDBiQ9NVH0.
TreeFamiTF324246.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR002562. 3'-5'_exonuclease_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF01612. DNA_pol_A_exo1. 1 hit.
[Graphical view]
SMARTiSM00474. 35EXOc. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NVH0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRQNLVALT VTTLLGVAVG GFVLWKGIQR RRRSKTSPVT QQPQQKVLGS
60 70 80 90 100
RELPPPEDDQ LHSSAPRSSW KERILKAKVV TVSQEAEWDQ IEPLLRSELE
110 120 130 140 150
DFPVLGIDCE WVNLEGKASP LSLLQMASPS GLCVLVRLPK LICGGKTLPR
160 170 180 190 200
TLLDILADGT ILKVGVGCSE DASKLLQDYG LVVRGCLDLR YLAMRQRNNL
210 220 230 240 250
LCNGLSLKSL AETVLNFPLD KSLLLRCSNW DAETLTEDQV IYAARDAQIS
260 270 280 290 300
VALFLHLLGY PFSRNSPGEK NDDHSSWRKV LEKCQGVVDI PFRSKGMSRL
310 320 330 340 350
GEEVNGEATE SQQKPRNKKS KMDGMVPGNH QGRDPRKHKR KPLGVGYSAR
360 370 380 390 400
KSPLYDNCFL HAPDGQPLCT CDRRKAQWYL DKGIGELVSE EPFVVKLRFE
410 420 430 440 450
PAGRPESPGD YYLMVKENLC VVCGKRDSYI RKNVIPHEYR KHFPIEMKDH
460 470 480 490 500
NSHDVLLLCT SCHAISNYYD NHLKQQLAKE FQAPIGSEEG LRLLEDPERR
510 520 530 540 550
QVRSGARALL NAESLPTQRK EELLQALREF YNTDVVTEEM LQEAASLETR
560 570 580 590 600
ISNENYVPHG LKVVQCHSQG GLRSLMQLES RWRQHFLDSM QPKHLPQQWS
610 620
VDHNHQKLLR KFGEDLPIQL S
Length:621
Mass (Da):70,353
Last modified:October 31, 2012 - v2
Checksum:iCD66A3E68A40C7FF
GO
Isoform 2 (identifier: Q9NVH0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-125: Missing.

Show »
Length:496
Mass (Da):56,346
Checksum:iD07693402FB5BFB6
GO

Sequence cautioni

The sequence CAH10568.1 differs from that shown. Reason: Frameshift at position 269. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti287 – 2871V → G in CAD39094 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti231 – 2311D → N.
Corresponds to variant rs35010854 [ dbSNP | Ensembl ].
VAR_050980
Natural varianti518 – 5181Q → H.2 Publications
Corresponds to variant rs8007859 [ dbSNP | Ensembl ].
VAR_050981

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 125125Missing in isoform 2. 3 PublicationsVSP_044367Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001600 mRNA. Translation: BAA91781.1.
AK295601 mRNA. Translation: BAG58488.1.
AL834434 mRNA. Translation: CAD39094.2.
BX647767 mRNA. Translation: CAH10568.1. Frameshift.
AL359317 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW80985.1.
BC001962 mRNA. Translation: AAH01962.1.
CCDSiCCDS53902.1. [Q9NVH0-1]
CCDS9793.1. [Q9NVH0-2]
RefSeqiNP_001180289.1. NM_001193360.1. [Q9NVH0-1]
NP_001180290.1. NM_001193361.1. [Q9NVH0-1]
NP_001180291.1. NM_001193362.1. [Q9NVH0-1]
NP_001180292.1. NM_001193363.1. [Q9NVH0-1]
NP_060669.1. NM_018199.3. [Q9NVH0-2]
XP_005267874.1. XM_005267817.2. [Q9NVH0-2]
UniGeneiHs.533878.

Genome annotation databases

EnsembliENST00000312994; ENSP00000313140; ENSG00000081177. [Q9NVH0-1]
ENST00000409014; ENSP00000386915; ENSG00000081177. [Q9NVH0-2]
ENST00000409018; ENSP00000387331; ENSG00000081177. [Q9NVH0-1]
ENST00000409242; ENSP00000386839; ENSG00000081177. [Q9NVH0-2]
ENST00000409675; ENSP00000386762; ENSG00000081177. [Q9NVH0-2]
ENST00000409949; ENSP00000386632; ENSG00000081177. [Q9NVH0-2]
GeneIDi55218.
KEGGihsa:55218.
UCSCiuc001xkt.3. human. [Q9NVH0-1]

Polymorphism and mutation databases

BioMutaiEXD2.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001600 mRNA. Translation: BAA91781.1.
AK295601 mRNA. Translation: BAG58488.1.
AL834434 mRNA. Translation: CAD39094.2.
BX647767 mRNA. Translation: CAH10568.1. Frameshift.
AL359317 Genomic DNA. No translation available.
CH471061 Genomic DNA. Translation: EAW80985.1.
BC001962 mRNA. Translation: AAH01962.1.
CCDSiCCDS53902.1. [Q9NVH0-1]
CCDS9793.1. [Q9NVH0-2]
RefSeqiNP_001180289.1. NM_001193360.1. [Q9NVH0-1]
NP_001180290.1. NM_001193361.1. [Q9NVH0-1]
NP_001180291.1. NM_001193362.1. [Q9NVH0-1]
NP_001180292.1. NM_001193363.1. [Q9NVH0-1]
NP_060669.1. NM_018199.3. [Q9NVH0-2]
XP_005267874.1. XM_005267817.2. [Q9NVH0-2]
UniGeneiHs.533878.

3D structure databases

ProteinModelPortaliQ9NVH0.
SMRiQ9NVH0. Positions 99-257.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120514. 8 interactions.
STRINGi9606.ENSP00000193422.

PTM databases

PhosphoSiteiQ9NVH0.

Polymorphism and mutation databases

BioMutaiEXD2.
DMDMi410516875.

Proteomic databases

MaxQBiQ9NVH0.
PaxDbiQ9NVH0.
PRIDEiQ9NVH0.

Protocols and materials databases

DNASUi55218.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312994; ENSP00000313140; ENSG00000081177. [Q9NVH0-1]
ENST00000409014; ENSP00000386915; ENSG00000081177. [Q9NVH0-2]
ENST00000409018; ENSP00000387331; ENSG00000081177. [Q9NVH0-1]
ENST00000409242; ENSP00000386839; ENSG00000081177. [Q9NVH0-2]
ENST00000409675; ENSP00000386762; ENSG00000081177. [Q9NVH0-2]
ENST00000409949; ENSP00000386632; ENSG00000081177. [Q9NVH0-2]
GeneIDi55218.
KEGGihsa:55218.
UCSCiuc001xkt.3. human. [Q9NVH0-1]

Organism-specific databases

CTDi55218.
GeneCardsiGC14P069658.
HGNCiHGNC:20217. EXD2.
HPAiHPA002906.
HPA005848.
neXtProtiNX_Q9NVH0.
PharmGKBiPA164719421.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG68878.
GeneTreeiENSGT00390000014318.
HOGENOMiHOG000046597.
OMAiDIPFRSK.
OrthoDBiEOG773XG0.
PhylomeDBiQ9NVH0.
TreeFamiTF324246.

Miscellaneous databases

ChiTaRSiEXD2. human.
GenomeRNAii55218.
NextBioi59188.
PROiQ9NVH0.

Gene expression databases

BgeeiQ9NVH0.
CleanExiHS_EXDL2.
ExpressionAtlasiQ9NVH0. baseline and differential.
GenevestigatoriQ9NVH0.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR002562. 3'-5'_exonuclease_dom.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF01612. DNA_pol_A_exo1. 1 hit.
[Graphical view]
SMARTiSM00474. 35EXOc. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT HIS-518.
    Tissue: Hippocampus and Teratocarcinoma.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT HIS-518.
    Tissue: Endometrium and Melanoma.
  3. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Lung.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiEXD2_HUMAN
AccessioniPrimary (citable) accession number: Q9NVH0
Secondary accession number(s): B4DIH6
, G5E947, Q6AWB6, Q8N3D3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: October 31, 2012
Last modified: April 29, 2015
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.