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Protein

TBC1 domain family member 13

Gene

TBC1D13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a GTPase-activating protein for RAB35. Together with RAB35 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-8854214 TBC/RABGAPs

Names & Taxonomyi

Protein namesi
Recommended name:
TBC1 domain family member 13
Gene namesi
Name:TBC1D13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000107021.15
HGNCiHGNC:25571 TBC1D13
MIMi616218 gene
neXtProtiNX_Q9NVG8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000107021
PharmGKBiPA134898118

Polymorphism and mutation databases

BioMutaiTBC1D13
DMDMi308153549

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002080381 – 400TBC1 domain family member 13Add BLAST400

Proteomic databases

EPDiQ9NVG8
MaxQBiQ9NVG8
PaxDbiQ9NVG8
PeptideAtlasiQ9NVG8
PRIDEiQ9NVG8

PTM databases

iPTMnetiQ9NVG8
PhosphoSitePlusiQ9NVG8

Expressioni

Gene expression databases

BgeeiENSG00000107021
CleanExiHS_TBC1D13
ExpressionAtlasiQ9NVG8 baseline and differential
GenevisibleiQ9NVG8 HS

Organism-specific databases

HPAiHPA045865

Interactioni

Subunit structurei

Interacts with RAB1A and RAB10; in a GTP-dependent manner.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ARHGEF5Q127744EBI-12264956,EBI-602199

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120091, 2 interactors
IntActiQ9NVG8, 3 interactors
STRINGi9606.ENSP00000361731

Structurei

3D structure databases

ProteinModelPortaliQ9NVG8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 345Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST311

Phylogenomic databases

eggNOGiKOG4567 Eukaryota
COG5210 LUCA
GeneTreeiENSGT00860000133795
HOGENOMiHOG000006332
HOVERGENiHBG058240
InParanoidiQ9NVG8
OMAiHWEVVQR
OrthoDBiEOG091G07A5
PhylomeDBiQ9NVG8
TreeFamiTF105911

Family and domain databases

InterProiView protein in InterPro
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
PfamiView protein in Pfam
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00164 TBC, 1 hit
SUPFAMiSSF47923 SSF47923, 4 hits
PROSITEiView protein in PROSITE
PS50086 TBC_RABGAP, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NVG8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSLHKSRIA DFQDVLKEPS IALEKLRELS FSGIPCEGGL RCLCWKILLN
60 70 80 90 100
YLPLERASWT SILAKQRELY AQFLREMIIQ PGIAKANMGV SREDVTFEDH
110 120 130 140 150
PLNPNPDSRW NTYFKDNEVL LQIDKDVRRL CPDISFFQRA TDYPCLLILD
160 170 180 190 200
PQNEFETLRK RVEQTTLKSQ TVARNRSGVT NMSSPHKNSV PSSLNEYEVL
210 220 230 240 250
PNGCEAHWEV VERILFIYAK LNPGIAYVQG MNEIVGPLYY TFATDPNSEW
260 270 280 290 300
KEHAEADTFF CFTNLMAEIR DNFIKSLDDS QCGITYKMEK VYSTLKDKDV
310 320 330 340 350
ELYLKLQEQN IKPQFFAFRW LTLLLSQEFL LPDVIRIWDS LFADDNRFDF
360 370 380 390 400
LLLVCCAMLM LIREQLLEGD FTVNMRLLQD YPITDVCQIL QKAKELQDSK
Length:400
Mass (Da):46,554
Last modified:October 5, 2010 - v3
Checksum:i9FD10CC4035ACC7F
GO
Isoform 2 (identifier: Q9NVG8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     182-306: Missing.

Show »
Length:275
Mass (Da):32,171
Checksum:i38AF7B7C367EAB75
GO
Isoform 3 (identifier: Q9NVG8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-181: Missing.

Note: No experimental confirmation available.
Show »
Length:219
Mass (Da):25,596
Checksum:i4D6EEB0F98BE741D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti101P → T in AAI50312 (PubMed:15489334).Curated1
Sequence conflicti223P → H in AAI50312 (PubMed:15489334).Curated1
Sequence conflicti335I → T in BAA91784 (PubMed:19077034).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070804190V → A1 PublicationCorresponds to variant dbSNP:rs1572912Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0539941 – 181Missing in isoform 3. 1 PublicationAdd BLAST181
Alternative sequenceiVSP_039845182 – 306Missing in isoform 2. 1 PublicationAdd BLAST125

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB449899 mRNA Translation: BAH16642.1
AK001605 mRNA Translation: BAA91784.1
AK123828 mRNA Translation: BAG53966.1
AK289777 mRNA Translation: BAF82466.1
AL441992 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87832.1
CH471090 Genomic DNA Translation: EAW87833.1
CH471090 Genomic DNA Translation: EAW87835.1
BC132817 mRNA Translation: AAI32818.1
BC136509 mRNA Translation: AAI36510.1
BC150311 mRNA Translation: AAI50312.1
CCDSiCCDS6911.1 [Q9NVG8-1]
CCDS69677.1 [Q9NVG8-2]
RefSeqiNP_001273701.1, NM_001286772.1 [Q9NVG8-2]
NP_060671.3, NM_018201.4 [Q9NVG8-1]
UniGeneiHs.3376

Genome annotation databases

EnsembliENST00000223865; ENSP00000223865; ENSG00000107021 [Q9NVG8-2]
ENST00000372648; ENSP00000361731; ENSG00000107021 [Q9NVG8-1]
GeneIDi54662
KEGGihsa:54662
UCSCiuc010myj.5 human [Q9NVG8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTBC13_HUMAN
AccessioniPrimary (citable) accession number: Q9NVG8
Secondary accession number(s): A7E2E7
, B3KW04, B9EGJ8, Q5T270, Q5T271
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: October 5, 2010
Last modified: April 25, 2018
This is version 123 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health