Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9NVF9 (EKI2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ethanolamine kinase 2

Short name=EKI 2
EC=2.7.1.82
Alternative name(s):
Ethanolamine kinase-like protein
Gene names
Name:ETNK2
Synonyms:EKI2
ORF Names:HMFT1716
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length386 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity By similarity.

Catalytic activity

ATP + ethanolamine = ADP + O-phosphoethanolamine.

Pathway

Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.

Tissue specificity

Expressed in kidney, liver, ovary, testis and prostate. Ref.6

Sequence similarities

Belongs to the choline/ethanolamine kinase family.

Sequence caution

The sequence BAH13637.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NVF9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NVF9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     339-386: ASHFFWALWA...PQASALEMPK → GPSCVSSTMT...HPEPVLHHRL
Isoform 3 (identifier: Q9NVF9-3)

The sequence of this isoform differs from the canonical sequence as follows:
     173-213: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 386386Ethanolamine kinase 2
PRO_0000206229

Natural variations

Alternative sequence173 – 21341Missing in isoform 3.
VSP_039558
Alternative sequence339 – 38648ASHFF…LEMPK → GPSCVSSTMTASLQCCRVGN RHGEIARLTLSGLFPGVSLL LGSLGPHPEPVLHHRL in isoform 2.
VSP_039098
Natural variant2271R → Q. Ref.5
Corresponds to variant rs3737657 [ dbSNP | Ensembl ].
VAR_022145

Experimental info

Sequence conflict101P → Q in BAA91793. Ref.1
Sequence conflict1481Q → R in BAH13637. Ref.1
Sequence conflict2411S → F in BAH13637. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 18, 2010. Version 3.
Checksum: 341E981AD2B80C15

FASTA38644,781
        10         20         30         40         50         60 
MAVPPSAPQP RASFHLRRHT PCPQCSWGME EKAAASASCR EPPGPPRAAA VAYFGISVDP 

        70         80         90        100        110        120 
DDILPGALRL IQELRPHWKP EQVRTKRFTD GITNKLVACY VEEDMQDCVL VRVYGERTEL 

       130        140        150        160        170        180 
LVDRENEVRN FQLLRAHSCA PKLYCTFQNG LCYEYMQGVA LEPEHIREPR LFRLIALEMA 

       190        200        210        220        230        240 
KIHTIHANGS LPKPILWHKM HNYFTLVKNE INPSLSADVP KVEVLERELA WLKEHLSQLE 

       250        260        270        280        290        300 
SPVVFCHNDL LCKNIIYDSI KGHVRFIDYE YAGYNYQAFD IGNHFNEFAG VNEVDYCLYP 

       310        320        330        340        350        360 
ARETQLQWLH YYLQAQKGMA VTPREVQRLY VQVNKFALAS HFFWALWALI QNQYSTIDFD 

       370        380 
FLRYAVIRFN QYFKVKPQAS ALEMPK 

« Hide

Isoform 2 [UniParc].

Checksum: 1A334DF65649D885
Show »

FASTA39444,841
Isoform 3 [UniParc].

Checksum: DF9063552B7E5E2E
Show »

FASTA34540,009

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 25-386 (ISOFORM 3).
Tissue: Testis.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Uterus.
[5]"Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas."
Yamada S., Ohira M., Horie H., Ando K., Takayasu H., Suzuki Y., Sugano S., Hirata T., Goto T., Matsunaga T., Hiyama E., Hayashi Y., Ando H., Suita S., Kaneko M., Sasaki F., Hashizume K., Ohnuma N., Nakagawara A.
Oncogene 23:5901-5911(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 25-386 (ISOFORM 1), VARIANT GLN-227.
Tissue: Hepatoblastoma.
[6]"Overexpression of a mammalian ethanolamine-specific kinase accelerates the CDP-ethanolamine pathway."
Lykidis A., Wang J., Karim M.A., Jackowski S.
J. Biol. Chem. 276:2174-2179(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK001623 mRNA. Translation: BAA91793.1.
AK302145 mRNA. Translation: BAH13637.1. Different initiation.
AL592146 Genomic DNA. Translation: CAI16602.1.
AL592146 Genomic DNA. Translation: CAI16603.1.
CH471067 Genomic DNA. Translation: EAW91501.1.
CH471067 Genomic DNA. Translation: EAW91502.1.
BC010082 mRNA. Translation: AAH10082.1.
AB073608 mRNA. Translation: BAD38645.1.
RefSeqNP_060678.2. NM_018208.2.
XP_005245359.1. XM_005245302.1.
XP_005245361.1. XM_005245304.1.
UniGeneHs.497469.

3D structure databases

ProteinModelPortalQ9NVF9.
SMRQ9NVF9. Positions 62-381.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120519. 2 interactions.
IntActQ9NVF9. 3 interactions.
STRING9606.ENSP00000356170.

Polymorphism databases

DMDM296439366.

Proteomic databases

PaxDbQ9NVF9.
PRIDEQ9NVF9.

Protocols and materials databases

DNASU55224.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000367201; ENSP00000356169; ENSG00000143845. [Q9NVF9-2]
ENST00000367202; ENSP00000356170; ENSG00000143845. [Q9NVF9-1]
GeneID55224.
KEGGhsa:55224.
UCSCuc001han.4. human. [Q9NVF9-2]
uc001hao.4. human. [Q9NVF9-1]
uc010pqs.2. human. [Q9NVF9-3]

Organism-specific databases

CTD55224.
GeneCardsGC01M204100.
H-InvDBHIX0001494.
HGNCHGNC:25575. ETNK2.
HPAHPA057167.
MIM609859. gene.
neXtProtNX_Q9NVF9.
PharmGKBPA134888760.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0510.
HOGENOMHOG000004856.
HOVERGENHBG018981.
InParanoidQ9NVF9.
KOK00894.
OMASLGPHPE.
OrthoDBEOG72NRQH.
PhylomeDBQ9NVF9.
TreeFamTF313549.

Enzyme and pathway databases

ReactomeREACT_111217. Metabolism.
UniPathwayUPA00558; UER00741.

Gene expression databases

ArrayExpressQ9NVF9.
BgeeQ9NVF9.
CleanExHS_ETNK2.
GenevestigatorQ9NVF9.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
ProtoNetSearch...

Other

ChiTaRSETNK2. human.
GenomeRNAi55224.
NextBio59212.
PROQ9NVF9.
SOURCESearch...

Entry information

Entry nameEKI2_HUMAN
AccessionPrimary (citable) accession number: Q9NVF9
Secondary accession number(s): B7Z7K1 expand/collapse secondary AC list , Q5SXX5, Q68CK3, Q96G05
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 18, 2010
Last modified: April 16, 2014
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM