Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9NVF9

- EKI2_HUMAN

UniProt

Q9NVF9 - EKI2_HUMAN

Protein

Ethanolamine kinase 2

Gene

ETNK2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity By similarity.By similarity

    Catalytic activityi

    ATP + ethanolamine = ADP + O-phosphoethanolamine.

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ethanolamine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycerophospholipid biosynthetic process Source: Reactome
    2. in utero embryonic development Source: Ensembl
    3. multicellular organism growth Source: Ensembl
    4. phosphatidylethanolamine biosynthetic process Source: Reactome
    5. phospholipid metabolic process Source: Reactome
    6. placenta development Source: Ensembl
    7. post-embryonic development Source: Ensembl
    8. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_120919. Synthesis of PE.
    UniPathwayiUPA00558; UER00741.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ethanolamine kinase 2 (EC:2.7.1.82)
    Short name:
    EKI 2
    Alternative name(s):
    Ethanolamine kinase-like protein
    Gene namesi
    Name:ETNK2
    Synonyms:EKI2
    ORF Names:HMFT1716
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:25575. ETNK2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134888760.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 386386Ethanolamine kinase 2PRO_0000206229Add
    BLAST

    Proteomic databases

    PaxDbiQ9NVF9.
    PRIDEiQ9NVF9.

    Expressioni

    Tissue specificityi

    Expressed in kidney, liver, ovary, testis and prostate.1 Publication

    Gene expression databases

    ArrayExpressiQ9NVF9.
    BgeeiQ9NVF9.
    CleanExiHS_ETNK2.
    GenevestigatoriQ9NVF9.

    Organism-specific databases

    HPAiHPA057167.

    Interactioni

    Protein-protein interaction databases

    BioGridi120519. 2 interactions.
    IntActiQ9NVF9. 3 interactions.
    STRINGi9606.ENSP00000356170.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NVF9.
    SMRiQ9NVF9. Positions 62-381.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the choline/ethanolamine kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0510.
    HOGENOMiHOG000004856.
    HOVERGENiHBG018981.
    InParanoidiQ9NVF9.
    KOiK00894.
    OMAiTASLQCC.
    OrthoDBiEOG72NRQH.
    PhylomeDBiQ9NVF9.
    TreeFamiTF313549.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NVF9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAVPPSAPQP RASFHLRRHT PCPQCSWGME EKAAASASCR EPPGPPRAAA    50
    VAYFGISVDP DDILPGALRL IQELRPHWKP EQVRTKRFTD GITNKLVACY 100
    VEEDMQDCVL VRVYGERTEL LVDRENEVRN FQLLRAHSCA PKLYCTFQNG 150
    LCYEYMQGVA LEPEHIREPR LFRLIALEMA KIHTIHANGS LPKPILWHKM 200
    HNYFTLVKNE INPSLSADVP KVEVLERELA WLKEHLSQLE SPVVFCHNDL 250
    LCKNIIYDSI KGHVRFIDYE YAGYNYQAFD IGNHFNEFAG VNEVDYCLYP 300
    ARETQLQWLH YYLQAQKGMA VTPREVQRLY VQVNKFALAS HFFWALWALI 350
    QNQYSTIDFD FLRYAVIRFN QYFKVKPQAS ALEMPK 386
    Length:386
    Mass (Da):44,781
    Last modified:May 18, 2010 - v3
    Checksum:i341E981AD2B80C15
    GO
    Isoform 2 (identifier: Q9NVF9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         339-386: ASHFFWALWA...PQASALEMPK → GPSCVSSTMT...HPEPVLHHRL

    Show »
    Length:394
    Mass (Da):44,841
    Checksum:i1A334DF65649D885
    GO
    Isoform 3 (identifier: Q9NVF9-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         173-213: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:345
    Mass (Da):40,009
    Checksum:iDF9063552B7E5E2E
    GO

    Sequence cautioni

    The sequence BAH13637.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti10 – 101P → Q in BAA91793. (PubMed:14702039)Curated
    Sequence conflicti148 – 1481Q → R in BAH13637. (PubMed:14702039)Curated
    Sequence conflicti241 – 2411S → F in BAH13637. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti227 – 2271R → Q.1 Publication
    Corresponds to variant rs3737657 [ dbSNP | Ensembl ].
    VAR_022145

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei173 – 21341Missing in isoform 3. 1 PublicationVSP_039558Add
    BLAST
    Alternative sequencei339 – 38648ASHFF…LEMPK → GPSCVSSTMTASLQCCRVGN RHGEIARLTLSGLFPGVSLL LGSLGPHPEPVLHHRL in isoform 2. 1 PublicationVSP_039098Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001623 mRNA. Translation: BAA91793.1.
    AK302145 mRNA. Translation: BAH13637.1. Different initiation.
    AL592146 Genomic DNA. Translation: CAI16602.1.
    AL592146 Genomic DNA. Translation: CAI16603.1.
    CH471067 Genomic DNA. Translation: EAW91501.1.
    CH471067 Genomic DNA. Translation: EAW91502.1.
    BC010082 mRNA. Translation: AAH10082.1.
    AB073608 mRNA. Translation: BAD38645.1.
    CCDSiCCDS1442.2. [Q9NVF9-1]
    RefSeqiNP_060678.2. NM_018208.2. [Q9NVF9-1]
    XP_005245359.1. XM_005245302.1. [Q9NVF9-2]
    XP_005245361.1. XM_005245304.1. [Q9NVF9-3]
    UniGeneiHs.497469.

    Genome annotation databases

    EnsembliENST00000367201; ENSP00000356169; ENSG00000143845. [Q9NVF9-2]
    ENST00000367202; ENSP00000356170; ENSG00000143845. [Q9NVF9-1]
    GeneIDi55224.
    KEGGihsa:55224.
    UCSCiuc001han.4. human. [Q9NVF9-2]
    uc001hao.4. human. [Q9NVF9-1]
    uc010pqs.2. human. [Q9NVF9-3]

    Polymorphism databases

    DMDMi296439366.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001623 mRNA. Translation: BAA91793.1 .
    AK302145 mRNA. Translation: BAH13637.1 . Different initiation.
    AL592146 Genomic DNA. Translation: CAI16602.1 .
    AL592146 Genomic DNA. Translation: CAI16603.1 .
    CH471067 Genomic DNA. Translation: EAW91501.1 .
    CH471067 Genomic DNA. Translation: EAW91502.1 .
    BC010082 mRNA. Translation: AAH10082.1 .
    AB073608 mRNA. Translation: BAD38645.1 .
    CCDSi CCDS1442.2. [Q9NVF9-1 ]
    RefSeqi NP_060678.2. NM_018208.2. [Q9NVF9-1 ]
    XP_005245359.1. XM_005245302.1. [Q9NVF9-2 ]
    XP_005245361.1. XM_005245304.1. [Q9NVF9-3 ]
    UniGenei Hs.497469.

    3D structure databases

    ProteinModelPortali Q9NVF9.
    SMRi Q9NVF9. Positions 62-381.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120519. 2 interactions.
    IntActi Q9NVF9. 3 interactions.
    STRINGi 9606.ENSP00000356170.

    Polymorphism databases

    DMDMi 296439366.

    Proteomic databases

    PaxDbi Q9NVF9.
    PRIDEi Q9NVF9.

    Protocols and materials databases

    DNASUi 55224.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000367201 ; ENSP00000356169 ; ENSG00000143845 . [Q9NVF9-2 ]
    ENST00000367202 ; ENSP00000356170 ; ENSG00000143845 . [Q9NVF9-1 ]
    GeneIDi 55224.
    KEGGi hsa:55224.
    UCSCi uc001han.4. human. [Q9NVF9-2 ]
    uc001hao.4. human. [Q9NVF9-1 ]
    uc010pqs.2. human. [Q9NVF9-3 ]

    Organism-specific databases

    CTDi 55224.
    GeneCardsi GC01M204100.
    H-InvDB HIX0001494.
    HGNCi HGNC:25575. ETNK2.
    HPAi HPA057167.
    MIMi 609859. gene.
    neXtProti NX_Q9NVF9.
    PharmGKBi PA134888760.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0510.
    HOGENOMi HOG000004856.
    HOVERGENi HBG018981.
    InParanoidi Q9NVF9.
    KOi K00894.
    OMAi TASLQCC.
    OrthoDBi EOG72NRQH.
    PhylomeDBi Q9NVF9.
    TreeFami TF313549.

    Enzyme and pathway databases

    UniPathwayi UPA00558 ; UER00741 .
    Reactomei REACT_120919. Synthesis of PE.

    Miscellaneous databases

    ChiTaRSi ETNK2. human.
    GenomeRNAii 55224.
    NextBioi 59212.
    PROi Q9NVF9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NVF9.
    Bgeei Q9NVF9.
    CleanExi HS_ETNK2.
    Genevestigatori Q9NVF9.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 25-386 (ISOFORM 3).
      Tissue: Testis.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Uterus.
    5. "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas."
      Yamada S., Ohira M., Horie H., Ando K., Takayasu H., Suzuki Y., Sugano S., Hirata T., Goto T., Matsunaga T., Hiyama E., Hayashi Y., Ando H., Suita S., Kaneko M., Sasaki F., Hashizume K., Ohnuma N., Nakagawara A.
      Oncogene 23:5901-5911(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 25-386 (ISOFORM 1), VARIANT GLN-227.
      Tissue: Hepatoblastoma.
    6. "Overexpression of a mammalian ethanolamine-specific kinase accelerates the CDP-ethanolamine pathway."
      Lykidis A., Wang J., Karim M.A., Jackowski S.
      J. Biol. Chem. 276:2174-2179(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiEKI2_HUMAN
    AccessioniPrimary (citable) accession number: Q9NVF9
    Secondary accession number(s): B7Z7K1
    , Q5SXX5, Q68CK3, Q96G05
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 109 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3