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Protein

F-box only protein 28

Gene

FBXO28

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.By similarity

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 28
Gene namesi
Name:FBXO28
Synonyms:CENP-301 Publication, KIAA0483
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:29046. FBXO28.

Subcellular locationi

GO - Cellular componenti

  • condensed chromosome kinetochore Source: UniProtKB-SubCell
  • kinetochore Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134876528.

Polymorphism and mutation databases

BioMutaiFBXO28.
DMDMi59797970.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 368368F-box only protein 28PRO_0000119917Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei235 – 2351PhosphoserineCombined sources
Modified residuei242 – 2421PhosphoserineCombined sources
Modified residuei270 – 2701PhosphothreonineCombined sources
Modified residuei344 – 3441PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NVF7.
MaxQBiQ9NVF7.
PaxDbiQ9NVF7.
PeptideAtlasiQ9NVF7.
PRIDEiQ9NVF7.

PTM databases

iPTMnetiQ9NVF7.
PhosphoSiteiQ9NVF7.

Expressioni

Gene expression databases

BgeeiENSG00000143756.
CleanExiHS_FBXO28.
ExpressionAtlasiQ9NVF7. baseline and differential.
GenevisibleiQ9NVF7. HS.

Organism-specific databases

HPAiHPA003289.

Interactioni

Subunit structurei

Part of a SCF (SKP1-cullin-F-box) protein ligase complex.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
GOLGA2Q083794EBI-740282,EBI-618309
PLEKHF2Q9H8W43EBI-740282,EBI-742388
SDCBP2Q9H1903EBI-740282,EBI-742426
SKP1P632084EBI-740282,EBI-307486
SPAG5Q96R063EBI-740282,EBI-413317

Protein-protein interaction databases

BioGridi116826. 56 interactions.
DIPiDIP-56683N.
IntActiQ9NVF7. 16 interactions.
MINTiMINT-1473642.
STRINGi9606.ENSP00000355827.

Structurei

3D structure databases

ProteinModelPortaliQ9NVF7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini61 – 10949F-boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IJHM. Eukaryota.
ENOG410YPFN. LUCA.
GeneTreeiENSGT00390000002970.
HOGENOMiHOG000048043.
HOVERGENiHBG051573.
InParanoidiQ9NVF7.
KOiK10306.
OMAiPRQSKRL.
OrthoDBiEOG091G0DWO.
PhylomeDBiQ9NVF7.
TreeFamiTF324672.

Family and domain databases

InterProiIPR001810. F-box_dom.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NVF7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAEERMA EEGGGGQGDG GSSLASGSTQ RQPPPPAPQH PQPGSQALPA
60 70 80 90 100
PALAPDQLPQ NNTLVALPIV AIENILSFMS YDEISQLRLV CKRMDLVCQR
110 120 130 140 150
MLNQGFLKVE RYHNLCQKQV KAQLPRRESE RRNHSLARHA DILAAVETRL
160 170 180 190 200
SLLNMTFMKY VDSNLCCFIP GKVIDEIYRV LRYVNSTRAP QRAHEVLQEL
210 220 230 240 250
RDISSMAMEY FDEKIVPILK RKLPGSDVSG RLMGSPPVPG PSAALTTMQL
260 270 280 290 300
FSKQNPSRQE VTKLQQQVKT NGAGVTVLRR EISELRTKVQ EQQKQLQDQD
310 320 330 340 350
QKLLEQTQII GEQNARLAEL ERKLREVMES AVGNSSGSGQ NEESPRKRKK
360
ATEAIDSLRK SKRLRNRK
Length:368
Mass (Da):41,149
Last modified:October 1, 2000 - v1
Checksum:i500A2583AB7315E6
GO
Isoform 2 (identifier: Q9NVF7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     173-179: VIDEIYR → FQDRLQP
     180-368: Missing.

Note: Gene prediction based on EST data.
Show »
Length:179
Mass (Da):19,747
Checksum:i31F64A57FD990AD5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti345 – 3451P → H Found in a renal cell carcinoma case; somatic mutation. 1 Publication
VAR_064713

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei173 – 1797VIDEIYR → FQDRLQP in isoform 2. CuratedVSP_047265
Alternative sequencei180 – 368189Missing in isoform 2. CuratedVSP_047266Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001628 mRNA. Translation: BAA91795.1.
AL390122 Genomic DNA. Translation: CAH70934.1.
BC031576 mRNA. Translation: AAH31576.1.
AB007952 mRNA. Translation: BAA32327.1.
CCDSiCCDS1539.1. [Q9NVF7-1]
CCDS44320.1. [Q9NVF7-2]
RefSeqiNP_001129587.1. NM_001136115.2. [Q9NVF7-2]
NP_055991.1. NM_015176.3. [Q9NVF7-1]
UniGeneiHs.64691.
Hs.713992.

Genome annotation databases

EnsembliENST00000366862; ENSP00000355827; ENSG00000143756. [Q9NVF7-1]
ENST00000424254; ENSP00000416888; ENSG00000143756. [Q9NVF7-2]
GeneIDi23219.
KEGGihsa:23219.
UCSCiuc001hoh.3. human. [Q9NVF7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001628 mRNA. Translation: BAA91795.1.
AL390122 Genomic DNA. Translation: CAH70934.1.
BC031576 mRNA. Translation: AAH31576.1.
AB007952 mRNA. Translation: BAA32327.1.
CCDSiCCDS1539.1. [Q9NVF7-1]
CCDS44320.1. [Q9NVF7-2]
RefSeqiNP_001129587.1. NM_001136115.2. [Q9NVF7-2]
NP_055991.1. NM_015176.3. [Q9NVF7-1]
UniGeneiHs.64691.
Hs.713992.

3D structure databases

ProteinModelPortaliQ9NVF7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116826. 56 interactions.
DIPiDIP-56683N.
IntActiQ9NVF7. 16 interactions.
MINTiMINT-1473642.
STRINGi9606.ENSP00000355827.

PTM databases

iPTMnetiQ9NVF7.
PhosphoSiteiQ9NVF7.

Polymorphism and mutation databases

BioMutaiFBXO28.
DMDMi59797970.

Proteomic databases

EPDiQ9NVF7.
MaxQBiQ9NVF7.
PaxDbiQ9NVF7.
PeptideAtlasiQ9NVF7.
PRIDEiQ9NVF7.

Protocols and materials databases

DNASUi23219.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366862; ENSP00000355827; ENSG00000143756. [Q9NVF7-1]
ENST00000424254; ENSP00000416888; ENSG00000143756. [Q9NVF7-2]
GeneIDi23219.
KEGGihsa:23219.
UCSCiuc001hoh.3. human. [Q9NVF7-1]

Organism-specific databases

CTDi23219.
GeneCardsiFBXO28.
HGNCiHGNC:29046. FBXO28.
HPAiHPA003289.
MIMi609100. gene.
neXtProtiNX_Q9NVF7.
PharmGKBiPA134876528.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJHM. Eukaryota.
ENOG410YPFN. LUCA.
GeneTreeiENSGT00390000002970.
HOGENOMiHOG000048043.
HOVERGENiHBG051573.
InParanoidiQ9NVF7.
KOiK10306.
OMAiPRQSKRL.
OrthoDBiEOG091G0DWO.
PhylomeDBiQ9NVF7.
TreeFamiTF324672.

Miscellaneous databases

GeneWikiiFBXO28.
GenomeRNAii23219.
PROiQ9NVF7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143756.
CleanExiHS_FBXO28.
ExpressionAtlasiQ9NVF7. baseline and differential.
GenevisibleiQ9NVF7. HS.

Family and domain databases

InterProiIPR001810. F-box_dom.
[Graphical view]
PfamiPF00646. F-box. 1 hit.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFBX28_HUMAN
AccessioniPrimary (citable) accession number: Q9NVF7
Secondary accession number(s): E9PEM8, O75070
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.