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Protein

Pantothenate kinase 4

Gene

PANK4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the physiological regulation of the intracellular CoA concentration.By similarity

Catalytic activityi

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.

Enzyme regulationi

Regulated by feedback inhibition by CoA and its thioesters.By similarity

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Pantothenate kinase 4 (PANK4), Pantothenate kinase 3 (PANK3), Pantothenate kinase 4, Pantothenate kinase 1 (PANK1), Pantothenate kinase 2, mitochondrial (PANK2), Pantothenate kinase 4 (PANK4), Pantothenate kinase 4
  2. Phosphopantothenate--cysteine ligase (PPCS)
  3. Phosphopantothenoylcysteine decarboxylase (PPCDC)
  4. Bifunctional coenzyme A synthase (COASY)
  5. Bifunctional coenzyme A synthase (COASY)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei196Acetyl-CoABy similarity1
Binding sitei199Acetyl-CoABy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processCoenzyme A biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS08249-MONOMER
ReactomeiR-HSA-196783 Coenzyme A biosynthesis
UniPathwayiUPA00241; UER00352

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate kinase 4 (EC:2.7.1.33)
Short name:
hPanK4
Alternative name(s):
Pantothenic acid kinase 4
Gene namesi
Name:PANK4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000157881.13
HGNCiHGNC:19366 PANK4
MIMi606162 gene
neXtProtiNX_Q9NVE7

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi55229
PharmGKBiPA134887214

Polymorphism and mutation databases

BioMutaiPANK4
DMDMi27805669

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001618062 – 773Pantothenate kinase 4Add BLAST772

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei320Nitrated tyrosineBy similarity1
Modified residuei393PhosphoserineCombined sources1
Modified residuei404PhosphoserineCombined sources1
Modified residuei406PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Nitration, Phosphoprotein

Proteomic databases

EPDiQ9NVE7
MaxQBiQ9NVE7
PaxDbiQ9NVE7
PeptideAtlasiQ9NVE7
PRIDEiQ9NVE7

PTM databases

iPTMnetiQ9NVE7
PhosphoSitePlusiQ9NVE7
SwissPalmiQ9NVE7

Expressioni

Tissue specificityi

Ubiquitously expressed with higher expression in the muscle.1 Publication

Gene expression databases

BgeeiENSG00000157881
CleanExiHS_PANK4
ExpressionAtlasiQ9NVE7 baseline and differential
GenevisibleiQ9NVE7 HS

Organism-specific databases

HPAiHPA011723
HPA012036
HPA027961

Interactioni

Subunit structurei

Homodimer. Interacts with PKM (By similarity).By similarity

Protein-protein interaction databases

BioGridi120524, 23 interactors
IntActiQ9NVE7, 5 interactors
MINTiQ9NVE7
STRINGi9606.ENSP00000367727

Structurei

3D structure databases

ProteinModelPortaliQ9NVE7
SMRiQ9NVE7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type II pantothenate kinase family.Curated

Phylogenomic databases

eggNOGiKOG2201 Eukaryota
KOG4584 Eukaryota
COG5146 LUCA
HOGENOMiHOG000194691
HOVERGENiHBG053496
InParanoidiQ9NVE7
KOiK09680
OrthoDBiEOG091G0D6C
PhylomeDBiQ9NVE7
TreeFamiTF342917

Family and domain databases

Gene3Di1.20.1700.10, 1 hit
InterProiView protein in InterPro
IPR036075 AF1104-like_sf
IPR035073 At2g17340_3_helix_bundle
IPR002791 DUF89
IPR015844 PanK_long
IPR004567 Type_II_PanK
PfamiView protein in Pfam
PF01937 DUF89, 1 hit
PF03630 Fumble, 1 hit
PIRSFiPIRSF036939 PanK_long, 1 hit
SUPFAMiSSF111321 SSF111321, 1 hit
TIGRFAMsiTIGR00555 panK_eukar, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NVE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAECGASGSG SSGDSLDKSI TLPPDEIFRN LENAKRFAID IGGSLTKLAY
60 70 80 90 100
YSTVQHKVAK VRSFDHSGKD TEREHEPPYE ISVQEEITAR LHFIKFENTY
110 120 130 140 150
IEACLDFIKD HLVNTETKVI QATGGGAYKF KDLIEEKLRL KVDKEDVMTC
160 170 180 190 200
LIKGCNFVLK NIPHEAFVYQ KDSDPEFRFQ TNHPHIFPYL LVNIGSGVSI
210 220 230 240 250
VKVETEDRFE WVGGSSIGGG TFWGLGALLT KTKKFDELLH LASRGQHSNV
260 270 280 290 300
DMLVRDVYGG AHQTLGLSGN LIASSFGKSA TADQEFSKED MAKSLLHMIS
310 320 330 340 350
NDIGQLACLH ARLHSLDRVY FGGFFIRGHP VTMRTITYSI NFFSKGEVQA
360 370 380 390 400
LFLRHEGYLG AIGAFLKGAE QDNPNQYSWG ENYAGSSGLM SASPELGPAQ
410 420 430 440 450
RARSGTFDLL EMDRLERPLV DLPLLLDPPS YVPDTVDLTD DALARKYWLT
460 470 480 490 500
CFEEALDGVV KRAVASQPDS VDAAERAEKF RQKYWNKLQT LRQQPFAYGT
510 520 530 540 550
LTVRSLLDTR EHCLNEFNFP DPYSKVKQRE NGVALRCFPG VVRSLDALGW
560 570 580 590 600
EERQLALVKG LLAGNVFDWG AKAVSAVLES DPYFGFEEAK RKLQERPWLV
610 620 630 640 650
DSYSEWLQRL KGPPHKCALI FADNSGIDII LGVFPFVREL LLRGTEVILA
660 670 680 690 700
CNSGPALNDV THSESLIVAE RIAGMDPVVH SALQEERLLL VQTGSSSPCL
710 720 730 740 750
DLSRLDKGLA ALVRERGADL VVIEGMGRAV HTNYHAALRC ESLKLAVIKN
760 770
AWLAERLGGR LFSVIFKYEV PAE
Length:773
Mass (Da):85,991
Last modified:October 1, 2000 - v1
Checksum:iD55027171A85E8B6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035470475E → K in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs966358882Ensembl.1
Natural variantiVAR_027409547A → V1 PublicationCorresponds to variant dbSNP:rs7535528Ensembl.1
Natural variantiVAR_015170684Q → R1 PublicationCorresponds to variant dbSNP:rs2494620Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001644 mRNA Translation: BAA91805.1
AK223546 mRNA Translation: BAD97266.1
AL139246 Genomic DNA No translation available.
CH471183 Genomic DNA Translation: EAW56097.1
BC043496 mRNA Translation: AAH43496.1
AL442072 mRNA Translation: CAC09438.1
BK000012 Genomic DNA Translation: DAA00006.1
RefSeqiNP_060686.2, NM_018216.2
UniGeneiHs.26156

Genome annotation databases

EnsembliENST00000378466; ENSP00000367727; ENSG00000157881
ENST00000615291; ENSP00000478189; ENSG00000273494
GeneIDi55229
KEGGihsa:55229
UCSCiuc001ajm.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPANK4_HUMAN
AccessioniPrimary (citable) accession number: Q9NVE7
Secondary accession number(s): B9DI84
, Q53EU3, Q5TA84, Q7RTX3, Q9H3X5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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