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Protein

Pantothenate kinase 4

Gene

PANK4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the physiological regulation of the intracellular CoA concentration.By similarity

Catalytic activityi

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.

Enzyme regulationi

Regulated by feedback inhibition by CoA and its thioesters.By similarity

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Pantothenate kinase 4 (PANK4), Pantothenate kinase 3 (PANK3), Pantothenate kinase 1 (PANK1), Pantothenate kinase 2, mitochondrial (PANK2)
  2. Phosphopantothenate--cysteine ligase (PPCS)
  3. Phosphopantothenoylcysteine decarboxylase (PPCDC)
  4. Bifunctional coenzyme A synthase (COASY)
  5. Bifunctional coenzyme A synthase (COASY)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei196Acetyl-CoABy similarity1
Binding sitei199Acetyl-CoABy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS08249-MONOMER.
ZFISH:HS08249-MONOMER.
ReactomeiR-HSA-196783. Coenzyme A biosynthesis.
UniPathwayiUPA00241; UER00352.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate kinase 4 (EC:2.7.1.33)
Short name:
hPanK4
Alternative name(s):
Pantothenic acid kinase 4
Gene namesi
Name:PANK4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:19366. PANK4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi55229.
OpenTargetsiENSG00000273494.
PharmGKBiPA134887214.

Polymorphism and mutation databases

BioMutaiPANK4.
DMDMi27805669.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001618062 – 773Pantothenate kinase 4Add BLAST772

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei320Nitrated tyrosineBy similarity1
Modified residuei393PhosphoserineCombined sources1
Modified residuei404PhosphoserineCombined sources1
Modified residuei406PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Nitration, Phosphoprotein

Proteomic databases

EPDiQ9NVE7.
MaxQBiQ9NVE7.
PaxDbiQ9NVE7.
PeptideAtlasiQ9NVE7.
PRIDEiQ9NVE7.

PTM databases

iPTMnetiQ9NVE7.
PhosphoSitePlusiQ9NVE7.
SwissPalmiQ9NVE7.

Expressioni

Tissue specificityi

Ubiquitously expressed with higher expression in the muscle.1 Publication

Gene expression databases

BgeeiENSG00000157881.
CleanExiHS_PANK4.
ExpressionAtlasiQ9NVE7. baseline and differential.
GenevisibleiQ9NVE7. HS.

Organism-specific databases

HPAiHPA012036.
HPA027961.

Interactioni

Subunit structurei

Homodimer. Interacts with PKM (By similarity).By similarity

Protein-protein interaction databases

BioGridi120524. 21 interactors.
IntActiQ9NVE7. 2 interactors.
MINTiMINT-1369914.
STRINGi9606.ENSP00000367727.

Structurei

3D structure databases

ProteinModelPortaliQ9NVE7.
SMRiQ9NVE7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type II pantothenate kinase family.Curated

Phylogenomic databases

eggNOGiKOG2201. Eukaryota.
KOG4584. Eukaryota.
COG5146. LUCA.
HOGENOMiHOG000194691.
HOVERGENiHBG053496.
InParanoidiQ9NVE7.
KOiK09680.
OMAiPPYEISV.
OrthoDBiEOG091G0D6C.
PhylomeDBiQ9NVE7.
TreeFamiTF342917.

Family and domain databases

InterProiIPR002791. DUF89.
IPR015844. PanK_long.
IPR004567. Type_II_PanK.
[Graphical view]
PfamiPF01937. DUF89. 1 hit.
PF03630. Fumble. 1 hit.
[Graphical view]
PIRSFiPIRSF036939. PanK_long. 1 hit.
SUPFAMiSSF111321. SSF111321. 1 hit.
TIGRFAMsiTIGR00555. panK_eukar. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9NVE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAECGASGSG SSGDSLDKSI TLPPDEIFRN LENAKRFAID IGGSLTKLAY
60 70 80 90 100
YSTVQHKVAK VRSFDHSGKD TEREHEPPYE ISVQEEITAR LHFIKFENTY
110 120 130 140 150
IEACLDFIKD HLVNTETKVI QATGGGAYKF KDLIEEKLRL KVDKEDVMTC
160 170 180 190 200
LIKGCNFVLK NIPHEAFVYQ KDSDPEFRFQ TNHPHIFPYL LVNIGSGVSI
210 220 230 240 250
VKVETEDRFE WVGGSSIGGG TFWGLGALLT KTKKFDELLH LASRGQHSNV
260 270 280 290 300
DMLVRDVYGG AHQTLGLSGN LIASSFGKSA TADQEFSKED MAKSLLHMIS
310 320 330 340 350
NDIGQLACLH ARLHSLDRVY FGGFFIRGHP VTMRTITYSI NFFSKGEVQA
360 370 380 390 400
LFLRHEGYLG AIGAFLKGAE QDNPNQYSWG ENYAGSSGLM SASPELGPAQ
410 420 430 440 450
RARSGTFDLL EMDRLERPLV DLPLLLDPPS YVPDTVDLTD DALARKYWLT
460 470 480 490 500
CFEEALDGVV KRAVASQPDS VDAAERAEKF RQKYWNKLQT LRQQPFAYGT
510 520 530 540 550
LTVRSLLDTR EHCLNEFNFP DPYSKVKQRE NGVALRCFPG VVRSLDALGW
560 570 580 590 600
EERQLALVKG LLAGNVFDWG AKAVSAVLES DPYFGFEEAK RKLQERPWLV
610 620 630 640 650
DSYSEWLQRL KGPPHKCALI FADNSGIDII LGVFPFVREL LLRGTEVILA
660 670 680 690 700
CNSGPALNDV THSESLIVAE RIAGMDPVVH SALQEERLLL VQTGSSSPCL
710 720 730 740 750
DLSRLDKGLA ALVRERGADL VVIEGMGRAV HTNYHAALRC ESLKLAVIKN
760 770
AWLAERLGGR LFSVIFKYEV PAE
Length:773
Mass (Da):85,991
Last modified:October 1, 2000 - v1
Checksum:iD55027171A85E8B6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035470475E → K in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_027409547A → V.1 PublicationCorresponds to variant rs7535528dbSNPEnsembl.1
Natural variantiVAR_015170684Q → R.1 PublicationCorresponds to variant rs2494620dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001644 mRNA. Translation: BAA91805.1.
AK223546 mRNA. Translation: BAD97266.1.
AL139246 Genomic DNA. Translation: CAX30819.1.
CH471183 Genomic DNA. Translation: EAW56097.1.
BC043496 mRNA. Translation: AAH43496.1.
AL442072 mRNA. Translation: CAC09438.1.
BK000012 Genomic DNA. Translation: DAA00006.1.
RefSeqiNP_060686.2. NM_018216.2.
UniGeneiHs.26156.

Genome annotation databases

EnsembliENST00000378466; ENSP00000367727; ENSG00000157881.
ENST00000615291; ENSP00000478189; ENSG00000273494.
GeneIDi55229.
KEGGihsa:55229.
UCSCiuc001ajm.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001644 mRNA. Translation: BAA91805.1.
AK223546 mRNA. Translation: BAD97266.1.
AL139246 Genomic DNA. Translation: CAX30819.1.
CH471183 Genomic DNA. Translation: EAW56097.1.
BC043496 mRNA. Translation: AAH43496.1.
AL442072 mRNA. Translation: CAC09438.1.
BK000012 Genomic DNA. Translation: DAA00006.1.
RefSeqiNP_060686.2. NM_018216.2.
UniGeneiHs.26156.

3D structure databases

ProteinModelPortaliQ9NVE7.
SMRiQ9NVE7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120524. 21 interactors.
IntActiQ9NVE7. 2 interactors.
MINTiMINT-1369914.
STRINGi9606.ENSP00000367727.

PTM databases

iPTMnetiQ9NVE7.
PhosphoSitePlusiQ9NVE7.
SwissPalmiQ9NVE7.

Polymorphism and mutation databases

BioMutaiPANK4.
DMDMi27805669.

Proteomic databases

EPDiQ9NVE7.
MaxQBiQ9NVE7.
PaxDbiQ9NVE7.
PeptideAtlasiQ9NVE7.
PRIDEiQ9NVE7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378466; ENSP00000367727; ENSG00000157881.
ENST00000615291; ENSP00000478189; ENSG00000273494.
GeneIDi55229.
KEGGihsa:55229.
UCSCiuc001ajm.2. human.

Organism-specific databases

CTDi55229.
DisGeNETi55229.
GeneCardsiPANK4.
HGNCiHGNC:19366. PANK4.
HPAiHPA012036.
HPA027961.
MIMi606162. gene.
neXtProtiNX_Q9NVE7.
OpenTargetsiENSG00000273494.
PharmGKBiPA134887214.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2201. Eukaryota.
KOG4584. Eukaryota.
COG5146. LUCA.
HOGENOMiHOG000194691.
HOVERGENiHBG053496.
InParanoidiQ9NVE7.
KOiK09680.
OMAiPPYEISV.
OrthoDBiEOG091G0D6C.
PhylomeDBiQ9NVE7.
TreeFamiTF342917.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00352.
BioCyciMetaCyc:HS08249-MONOMER.
ZFISH:HS08249-MONOMER.
ReactomeiR-HSA-196783. Coenzyme A biosynthesis.

Miscellaneous databases

ChiTaRSiPANK4. human.
GeneWikiiPANK4.
GenomeRNAii55229.
PROiQ9NVE7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000157881.
CleanExiHS_PANK4.
ExpressionAtlasiQ9NVE7. baseline and differential.
GenevisibleiQ9NVE7. HS.

Family and domain databases

InterProiIPR002791. DUF89.
IPR015844. PanK_long.
IPR004567. Type_II_PanK.
[Graphical view]
PfamiPF01937. DUF89. 1 hit.
PF03630. Fumble. 1 hit.
[Graphical view]
PIRSFiPIRSF036939. PanK_long. 1 hit.
SUPFAMiSSF111321. SSF111321. 1 hit.
TIGRFAMsiTIGR00555. panK_eukar. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPANK4_HUMAN
AccessioniPrimary (citable) accession number: Q9NVE7
Secondary accession number(s): B9DI84
, Q53EU3, Q5TA84, Q7RTX3, Q9H3X5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.