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Protein

Coiled-coil domain-containing protein 87

Gene

CCDC87

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 87
Gene namesi
Name:CCDC87
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:25579. CCDC87.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596455.

Polymorphism and mutation databases

BioMutaiCCDC87.
DMDMi296434428.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 849849Coiled-coil domain-containing protein 87PRO_0000295145Add
BLAST

Proteomic databases

PaxDbiQ9NVE4.
PeptideAtlasiQ9NVE4.
PRIDEiQ9NVE4.

PTM databases

iPTMnetiQ9NVE4.
PhosphoSiteiQ9NVE4.

Expressioni

Gene expression databases

BgeeiENSG00000182791.
CleanExiHS_CCDC87.
GenevisibleiQ9NVE4. HS.

Organism-specific databases

HPAiHPA053514.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GOLGA2Q083793EBI-749261,EBI-618309
KRT15P190123EBI-749261,EBI-739566
TRIM27P143733EBI-749261,EBI-719493
TRIM54Q9BYV23EBI-749261,EBI-2130429
USHBP1Q8N6Y03EBI-749261,EBI-739895

Protein-protein interaction databases

BioGridi120526. 13 interactions.
IntActiQ9NVE4. 9 interactions.
MINTiMINT-1472868.
STRINGi9606.ENSP00000328487.

Structurei

3D structure databases

ProteinModelPortaliQ9NVE4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili387 – 41529Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFC5. Eukaryota.
ENOG410XQT4. LUCA.
GeneTreeiENSGT00390000018647.
HOGENOMiHOG000290635.
HOVERGENiHBG070861.
InParanoidiQ9NVE4.
OMAiWEKWSNK.
OrthoDBiEOG091G046A.
PhylomeDBiQ9NVE4.
TreeFamiTF353429.

Sequencei

Sequence statusi: Complete.

Q9NVE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMEPPKPEPE LQRFYHRLLR PLSLFPTRTT SPEPQKRPPQ EGRILQSFPL
60 70 80 90 100
AKLTVASLCS QVAKLLAGSG IAAGVPPEAR LRLIKVILDE LKCSWREPPA
110 120 130 140 150
ELSLSHKNNQ KLRKRLEAYV LLSSEQLFLR YLHLLVTMST PRGVFTESAT
160 170 180 190 200
LTRLAASLAR DCTLFLTSPN VYRGLLADFQ ALLRAEQASG DVDKLHPVCP
210 220 230 240 250
AGTFKLCPIP WPHSTGFAQV QCSNLNLNYL IQLSRPPEFL NEPGRMDPVK
260 270 280 290 300
ELKSIPRLKR KKPFHWLPSI GKKREIDISS SQMVSLPSYP VAPTSRASPS
310 320 330 340 350
PFCPELRRGQ SMPSLREGWR LADELGLPPL PSRPLTPLVL ATESKPELTG
360 370 380 390 400
LIVAEDLKQL IKKMKLEGTR YPPLDSGLPP LLGVVTRHPA AGHRLEELEK
410 420 430 440 450
MLRNLQEEEA SGQWDPQPPK SFPLHPQPVT ITLKLRNEVV VQAAAVRVSD
460 470 480 490 500
RNFLDSFHIE GAGALYNHLA GELDPKAIEK MDIDNFVGST TREVYKELMS
510 520 530 540 550
HVSSDHLHFD QGPLVEPAAD KDWSTFLSSA FLRQEKQPQI INPELVGLYS
560 570 580 590 600
QRANTLQSNT KKMPSLPSLQ ATKSWEKWSN KASLMNSWKT TLSVDDYFKY
610 620 630 640 650
LTNHETDFLH VIFQMHEEEV PVEIVAPARE SLEIQHPPPL LEDEEPDFVP
660 670 680 690 700
GEWDWNTVLE HRLGAGKTPH LGEPHKILSL QKHLEQLWSV LEVPDKDQVD
710 720 730 740 750
MTIKYSSKAR LRQLPSLVNA WERALKPIQL REALLARLEW FEGQASNPNR
760 770 780 790 800
FFKKTNLSSS HFLEENQVRS HLHRKLNLME SSLVSLLEEI ELIFGEPVIF
810 820 830 840
KGRPYLDKMK SDKVEMLYWL QQQRRVRHLV SALKDPHQST LFRSSAASL
Length:849
Mass (Da):96,402
Last modified:May 18, 2010 - v2
Checksum:i6FFEAD6E56B6BCD8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti738 – 7381L → R in BAA91808 (PubMed:14702039).Curated
Sequence conflicti834 – 8341K → R in BAA91808 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti156 – 1561A → T.
Corresponds to variant rs1110707 [ dbSNP | Ensembl ].
VAR_056782
Natural varianti217 – 2171F → L.1 Publication
Corresponds to variant rs17853294 [ dbSNP | Ensembl ].
VAR_033224

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001648 mRNA. Translation: BAA91808.1.
AP001157 Genomic DNA. No translation available.
BC034469 mRNA. Translation: AAH34469.1.
CCDSiCCDS8145.1.
RefSeqiNP_060689.2. NM_018219.2.
UniGeneiHs.121072.

Genome annotation databases

EnsembliENST00000333861; ENSP00000328487; ENSG00000182791.
GeneIDi55231.
KEGGihsa:55231.
UCSCiuc001oiq.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001648 mRNA. Translation: BAA91808.1.
AP001157 Genomic DNA. No translation available.
BC034469 mRNA. Translation: AAH34469.1.
CCDSiCCDS8145.1.
RefSeqiNP_060689.2. NM_018219.2.
UniGeneiHs.121072.

3D structure databases

ProteinModelPortaliQ9NVE4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120526. 13 interactions.
IntActiQ9NVE4. 9 interactions.
MINTiMINT-1472868.
STRINGi9606.ENSP00000328487.

PTM databases

iPTMnetiQ9NVE4.
PhosphoSiteiQ9NVE4.

Polymorphism and mutation databases

BioMutaiCCDC87.
DMDMi296434428.

Proteomic databases

PaxDbiQ9NVE4.
PeptideAtlasiQ9NVE4.
PRIDEiQ9NVE4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333861; ENSP00000328487; ENSG00000182791.
GeneIDi55231.
KEGGihsa:55231.
UCSCiuc001oiq.5. human.

Organism-specific databases

CTDi55231.
GeneCardsiCCDC87.
HGNCiHGNC:25579. CCDC87.
HPAiHPA053514.
neXtProtiNX_Q9NVE4.
PharmGKBiPA144596455.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFC5. Eukaryota.
ENOG410XQT4. LUCA.
GeneTreeiENSGT00390000018647.
HOGENOMiHOG000290635.
HOVERGENiHBG070861.
InParanoidiQ9NVE4.
OMAiWEKWSNK.
OrthoDBiEOG091G046A.
PhylomeDBiQ9NVE4.
TreeFamiTF353429.

Miscellaneous databases

GenomeRNAii55231.
PROiQ9NVE4.

Gene expression databases

BgeeiENSG00000182791.
CleanExiHS_CCDC87.
GenevisibleiQ9NVE4. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCCD87_HUMAN
AccessioniPrimary (citable) accession number: Q9NVE4
Secondary accession number(s): Q8NE76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: May 18, 2010
Last modified: September 7, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.