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Protein

Alpha-parvin

Gene

PARVA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishement of cell polarity, cell adhesion, cell spreading, and directed cell migration.By similarity4 Publications

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Angiogenesis, Cell adhesion, Cell shape, Chemotaxis, Cilium biogenesis/degradation

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

BioCyciZFISH:G66-33590-MONOMER.
ReactomeiR-HSA-446343. Localization of the PINCH-ILK-PARVIN complex to focal adhesions.
R-HSA-446353. Cell-extracellular matrix interactions.
R-HSA-446388. Regulation of cytoskeletal remodeling and cell spreading by IPP complex components.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-parvin
Alternative name(s):
Actopaxin
CH-ILKBP
Calponin-like integrin-linked kinase-binding protein
Matrix-remodeling-associated protein 2
Gene namesi
Name:PARVA
Synonyms:MXRA2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:14652. PARVA.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • cytoskeleton Source: UniProtKB-SubCell
  • cytosol Source: Reactome
  • focal adhesion Source: UniProtKB
  • plasma membrane Source: UniProtKB-SubCell
  • Z disc Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55742.
PharmGKBiPA32950.

Polymorphism and mutation databases

BioMutaiPARVA.
DMDMi20139236.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001215802 – 372Alpha-parvinAdd BLAST371

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei8PhosphoserineCombined sources1
Modified residuei14PhosphoserineCombined sources1
Modified residuei19PhosphoserineCombined sources1
Modified residuei28PhosphoserineCombined sources1
Modified residuei62PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NVD7.
MaxQBiQ9NVD7.
PaxDbiQ9NVD7.
PeptideAtlasiQ9NVD7.
PRIDEiQ9NVD7.

PTM databases

iPTMnetiQ9NVD7.
PhosphoSitePlusiQ9NVD7.

Expressioni

Tissue specificityi

Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver.3 Publications

Gene expression databases

BgeeiENSG00000197702.
CleanExiHS_PARVA.

Organism-specific databases

HPAiHPA005964.

Interactioni

Subunit structurei

Interacts with TGFB1I1 (By similarity). Interacts with ILK, LIMS1 and PXN (via LD motifs). Interacts with ARHGAP31. Interacts with the actin cytoskeleton.By similarity6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ILKQ1341814EBI-747655,EBI-747644
MOCOSQ96EN84EBI-747655,EBI-1220583

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

Protein-protein interaction databases

BioGridi120860. 36 interactors.
IntActiQ9NVD7. 12 interactors.
MINTiMINT-1465264.
STRINGi9606.ENSP00000334008.

Structurei

Secondary structure

1372
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi249 – 256Combined sources8
Helixi258 – 276Combined sources19
Helixi277 – 279Combined sources3
Turni286 – 292Combined sources7
Helixi294 – 303Combined sources10
Helixi310 – 312Combined sources3
Helixi320 – 336Combined sources17
Helixi346 – 350Combined sources5
Helixi354 – 368Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K2RNMR-A244-372[»]
2VZCX-ray1.05A/B242-372[»]
2VZDX-ray2.10A/B242-372[»]
2VZGX-ray1.80B242-372[»]
2VZIX-ray2.20B242-372[»]
3KMUX-ray1.80B248-372[»]
3KMWX-ray2.00B248-372[»]
3REPX-ray1.80B248-372[»]
ProteinModelPortaliQ9NVD7.
SMRiQ9NVD7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NVD7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini95 – 201CH 1PROSITE-ProRule annotationAdd BLAST107
Domaini262 – 369CH 2PROSITE-ProRule annotationAdd BLAST108

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 25Interaction with ARHGAP311 Publication5

Sequence similaritiesi

Belongs to the parvin family.Curated
Contains 2 CH (calponin-homology) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3631. Eukaryota.
ENOG410XQWH. LUCA.
HOGENOMiHOG000247027.
HOVERGENiHBG053517.
InParanoidiQ9NVD7.
KOiK06275.
PhylomeDBiQ9NVD7.

Family and domain databases

Gene3Di1.10.418.10. 2 hits.
InterProiIPR001715. CH-domain.
IPR028433. Parvin.
[Graphical view]
PANTHERiPTHR12114. PTHR12114. 1 hit.
PfamiPF00307. CH. 2 hits.
[Graphical view]
PIRSFiPIRSF039131. Parvin. 1 hit.
SMARTiSM00033. CH. 2 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 2 hits.
PROSITEiPS50021. CH. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NVD7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATSPQKSPS VPKSPTPKSP PSRKKDDSFL GKLGGTLARR KKAKEVSELQ
60 70 80 90 100
EEGMNAINLP LSPIPFELDP EDTMLEENEV RTMVDPNSRS DPKLQELMKV
110 120 130 140 150
LIDWINDVLV GERIIVKDLA EDLYDGQVLQ KLFEKLESEK LNVAEVTQSE
160 170 180 190 200
IAQKQKLQTV LEKINETLKL PPRSIKWNVD SVHAKSLVAI LHLLVALSQY
210 220 230 240 250
FRAPIRLPDH VSIQVVVVQK REGILQSRQI QEEITGNTEA LSGRHERDAF
260 270 280 290 300
DTLFDHAPDK LNVVKKTLIT FVNKHLNKLN LEVTELETQF ADGVYLVLLM
310 320 330 340 350
GLLEGYFVPL HSFFLTPDSF EQKVLNVSFA FELMQDGGLE KPKPRPEDIV
360 370
NCDLKSTLRV LYNLFTKYRN VE
Length:372
Mass (Da):42,244
Last modified:October 1, 2000 - v1
Checksum:iF48BB5B1E83F8CEF
GO
Isoform 2 (identifier: Q9NVD7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     134-182: EKLESEKLNV...RSIKWNVDSV → GRRVECCNGC...KCVEHGITAQ
     183-372: Missing.

Note: No experimental confirmation available.
Show »
Length:182
Mass (Da):20,625
Checksum:iB7D6685D209E628F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11V → A in AAH14535 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008884134 – 182EKLES…NVDSV → GRRVECCNGCVFNCRWLDHL LVARRSYSQFTVAYLEMDYK CVEHGITAQ in isoform 2. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_008885183 – 372Missing in isoform 2. 1 PublicationAdd BLAST190

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237771 mRNA. Translation: AAG27173.1.
AF325830 mRNA. Translation: AAK49911.1.
AK001655 mRNA. Translation: BAA91815.1.
AK022316 mRNA. Translation: BAB14009.1.
BC016713 mRNA. Translation: AAH16713.1.
BC014535 mRNA. Translation: AAH14535.1.
RefSeqiNP_060692.2. NM_018222.4.
UniGeneiHs.432914.

Genome annotation databases

EnsembliENST00000550549; ENSP00000447198; ENSG00000197702.
GeneIDi55742.
KEGGihsa:55742.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237771 mRNA. Translation: AAG27173.1.
AF325830 mRNA. Translation: AAK49911.1.
AK001655 mRNA. Translation: BAA91815.1.
AK022316 mRNA. Translation: BAB14009.1.
BC016713 mRNA. Translation: AAH16713.1.
BC014535 mRNA. Translation: AAH14535.1.
RefSeqiNP_060692.2. NM_018222.4.
UniGeneiHs.432914.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K2RNMR-A244-372[»]
2VZCX-ray1.05A/B242-372[»]
2VZDX-ray2.10A/B242-372[»]
2VZGX-ray1.80B242-372[»]
2VZIX-ray2.20B242-372[»]
3KMUX-ray1.80B248-372[»]
3KMWX-ray2.00B248-372[»]
3REPX-ray1.80B248-372[»]
ProteinModelPortaliQ9NVD7.
SMRiQ9NVD7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120860. 36 interactors.
IntActiQ9NVD7. 12 interactors.
MINTiMINT-1465264.
STRINGi9606.ENSP00000334008.

PTM databases

iPTMnetiQ9NVD7.
PhosphoSitePlusiQ9NVD7.

Polymorphism and mutation databases

BioMutaiPARVA.
DMDMi20139236.

Proteomic databases

EPDiQ9NVD7.
MaxQBiQ9NVD7.
PaxDbiQ9NVD7.
PeptideAtlasiQ9NVD7.
PRIDEiQ9NVD7.

Protocols and materials databases

DNASUi55742.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000550549; ENSP00000447198; ENSG00000197702.
GeneIDi55742.
KEGGihsa:55742.

Organism-specific databases

CTDi55742.
DisGeNETi55742.
GeneCardsiPARVA.
HGNCiHGNC:14652. PARVA.
HPAiHPA005964.
MIMi608120. gene.
neXtProtiNX_Q9NVD7.
PharmGKBiPA32950.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3631. Eukaryota.
ENOG410XQWH. LUCA.
HOGENOMiHOG000247027.
HOVERGENiHBG053517.
InParanoidiQ9NVD7.
KOiK06275.
PhylomeDBiQ9NVD7.

Enzyme and pathway databases

BioCyciZFISH:G66-33590-MONOMER.
ReactomeiR-HSA-446343. Localization of the PINCH-ILK-PARVIN complex to focal adhesions.
R-HSA-446353. Cell-extracellular matrix interactions.
R-HSA-446388. Regulation of cytoskeletal remodeling and cell spreading by IPP complex components.

Miscellaneous databases

ChiTaRSiPARVA. human.
EvolutionaryTraceiQ9NVD7.
GeneWikiiPARVA.
GenomeRNAii55742.
PROiQ9NVD7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197702.
CleanExiHS_PARVA.

Family and domain databases

Gene3Di1.10.418.10. 2 hits.
InterProiIPR001715. CH-domain.
IPR028433. Parvin.
[Graphical view]
PANTHERiPTHR12114. PTHR12114. 1 hit.
PfamiPF00307. CH. 2 hits.
[Graphical view]
PIRSFiPIRSF039131. Parvin. 1 hit.
SMARTiSM00033. CH. 2 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 2 hits.
PROSITEiPS50021. CH. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPARVA_HUMAN
AccessioniPrimary (citable) accession number: Q9NVD7
Secondary accession number(s): Q96C85, Q9HA48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 151 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.