Q9NVC3 (S38A7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative sodium-coupled neutral amino acid transporter 7

Gene names

Name:	SLC38A7
Synonyms:	SNAT7

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	462 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Mediates sodium-dependent transport of amino acids, preferentially L-glutamine By similarity.
Subcellular location	Membrane; Multi-pass membrane protein By similarity. Note: In neurons, located in soma and axons By similarity.
Sequence similarities	Belongs to the amino acid/polyamine transporter 2 family.

Ontologies

Keywords
Biological process	Amino-acid transport Ion transport Sodium transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Sodium
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	sodium ion transport Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	axon Inferred from sequence or structural similarity. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW neuronal cell body Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	L-alanine transmembrane transporter activity Inferred from electronic annotation. Source: Compara L-asparagine transmembrane transporter activity Inferred from electronic annotation. Source: Compara L-aspartate transmembrane transporter activity Inferred from electronic annotation. Source: Compara L-glutamate transmembrane transporter activity Inferred from electronic annotation. Source: Compara L-glutamine transmembrane transporter activity Inferred from sequence or structural similarity. Source: UniProtKB L-histidine transmembrane transporter activity Inferred from electronic annotation. Source: Compara L-leucine transmembrane transporter activity Inferred from electronic annotation. Source: Compara L-methionine transmembrane transporter activity Inferred from electronic annotation. Source: Compara L-serine transmembrane transporter activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NVC3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NVC3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     345-462: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 462	462	Putative sodium-coupled neutral amino acid transporter 7		PRO_0000319597
Regions
	Transmembrane	56 – 76	21	Helical; Potential
	Transmembrane	82 – 102	21	Helical; Potential
	Transmembrane	130 – 150	21	Helical; Potential
	Transmembrane	178 – 198	21	Helical; Potential
	Transmembrane	205 – 225	21	Helical; Potential
	Transmembrane	239 – 259	21	Helical; Potential
	Transmembrane	282 – 302	21	Helical; Potential
	Transmembrane	319 – 339	21	Helical; Potential
	Transmembrane	371 – 391	21	Helical; Potential
	Transmembrane	395 – 415	21	Helical; Potential
	Transmembrane	428 – 448	21	Helical; Potential
Amino acid modifications
	Modified residue	28	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	345 – 462	118	Missing in isoform 2.		VSP_031511
	Natural variant	46	1	L → P. Corresponds to variant rs7193572 [ dbSNP | Ensembl ].		VAR_039015
	Natural variant	78	1	T → I. Corresponds to variant rs7191331 [ dbSNP | Ensembl ].		VAR_039016
Experimental info
	Sequence conflict	145	1	A → T in BAB14244. Ref.1
	Sequence conflict	208	1	V → A in BAD96652. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: B4F46C19D7E6EADB	FASTA	462	49,966
	10 20 30 40 50 60 MAQVSINNDY SEWDLSTDAG ERARLLQSPC VDTAPKSEWE ASPGGLDRGT TSTLGAIFIV 70 80 90 100 110 120 VNACLGAGLL NFPAAFSTAG GVAAGIALQM GMLVFIISGL VILAYCSQAS NERTYQEVVW 130 140 150 160 170 180 AVCGKLTGVL CEVAIAVYTF GTCIAFLIII GDQQDKIIAV MAKEPEGASG PWYTDRKFTI 190 200 210 220 230 240 SLTAFLFILP LSIPREIGFQ KYASFLSVVG TWYVTAIVII KYIWPDKEMT PGNILTRPAS 250 260 270 280 290 300 WMAVFNAMPT ICFGFQCHVS SVPVFNSMQQ PEVKTWGGVV TAAMVIALAV YMGTGICGFL 310 320 330 340 350 360 TFGAAVDPDV LLSYPSEDMA VAVARAFIIL SVLTSYPILH FCGRAVVEGL WLRYQGVPVE 370 380 390 400 410 420 EDVGRERRRR VLQTLVWFLL TLLLALFIPD IGKVISVIGG LAACFIFVFP GLCLIQAKLS 430 440 450 460 EMEEVKPASW WVLVSYGVLL VTLGAFIFGQ TTANAIFVDL LA
	Isoform 2 [UniParc]. Checksum: F48CBD890B7E928B	FASTA	344	36,904
	10 20 30 40 50 60 MAQVSINNDY SEWDLSTDAG ERARLLQSPC VDTAPKSEWE ASPGGLDRGT TSTLGAIFIV 70 80 90 100 110 120 VNACLGAGLL NFPAAFSTAG GVAAGIALQM GMLVFIISGL VILAYCSQAS NERTYQEVVW 130 140 150 160 170 180 AVCGKLTGVL CEVAIAVYTF GTCIAFLIII GDQQDKIIAV MAKEPEGASG PWYTDRKFTI 190 200 210 220 230 240 SLTAFLFILP LSIPREIGFQ KYASFLSVVG TWYVTAIVII KYIWPDKEMT PGNILTRPAS 250 260 270 280 290 300 WMAVFNAMPT ICFGFQCHVS SVPVFNSMQQ PEVKTWGGVV TAAMVIALAV YMGTGICGFL 310 320 330 340 TFGAAVDPDV LLSYPSEDMA VAVARAFIIL SVLTSYPILH FCGR

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Teratocarcinoma.
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Kidney.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK001677 mRNA. Translation: BAA91830.1. AK022786 mRNA. Translation: BAB14244.1. CR457236 mRNA. Translation: CAG33517.1. AK222932 mRNA. Translation: BAD96652.1. CH471092 Genomic DNA. Translation: EAW82985.1. BC001961 mRNA. Translation: AAH01961.1.
IPI	IPI00019349. IPI00885114.
RefSeq	NP_060701.1. NM_018231.1.
UniGene	Hs.10499.
3D structure databases
ProteinModelPortal	Q9NVC3.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000219320.
PTM databases
PhosphoSite	Q9NVC3.
Polymorphism databases
DMDM	74734488.
Proteomic databases
PaxDb	Q9NVC3.
PRIDE	Q9NVC3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000219320; ENSP00000219320; ENSG00000103042. ENST00000570101; ENSP00000454646; ENSG00000103042.
GeneID	55238.
KEGG	hsa:55238.
UCSC	uc002eoc.1. human.
Organism-specific databases
CTD	55238.
GeneCards	GC16M058699.
HGNC	HGNC:25582. SLC38A7.
HPA	HPA041777.
MIM	614236. gene.
neXtProt	NX_Q9NVC3.
PharmGKB	PA162403772.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0814.
HOGENOM	HOG000008036.
HOVERGEN	HBG055999.
InParanoid	Q9NVC3.
KO	K14994.
OMA	TWGGVVT.
OrthoDB	EOG46143X.
PhylomeDB	Q9NVC3.
Gene expression databases
ArrayExpress	Q9NVC3.
Bgee	Q9NVC3.
CleanEx	HS_SLC38A7.
Genevestigator	Q9NVC3.
Family and domain databases
InterPro	IPR013057. AA_transpt_TM. [Graphical view]
Pfam	PF01490. Aa_trans. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SLC38A7. human.
GenomeRNAi	55238.
NextBio	59263.
SOURCE	Search...

Entry information

Entry name

S38A7_HUMAN

Accession

Primary (citable) accession number: Q9NVC3
Secondary accession number(s): Q53GJ9, Q9H9I5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	October 1, 2000
Last modified:	April 3, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.