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Q9NVC3

- S38A7_HUMAN

UniProt

Q9NVC3 - S38A7_HUMAN

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Protein

Putative sodium-coupled neutral amino acid transporter 7

Gene

SLC38A7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Mediates sodium-dependent transport of amino acids, preferentially L-glutamine.By similarity

GO - Molecular functioni

  1. L-alanine transmembrane transporter activity Source: Ensembl
  2. L-amino acid transmembrane transporter activity Source: UniProtKB
  3. L-asparagine transmembrane transporter activity Source: Ensembl
  4. L-aspartate transmembrane transporter activity Source: Ensembl
  5. L-glutamate transmembrane transporter activity Source: Ensembl
  6. L-glutamine transmembrane transporter activity Source: UniProtKB
  7. L-histidine transmembrane transporter activity Source: Ensembl
  8. L-leucine transmembrane transporter activity Source: Ensembl
  9. L-methionine transmembrane transporter activity Source: Ensembl
  10. L-serine transmembrane transporter activity Source: Ensembl

GO - Biological processi

  1. sodium ion transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Protein family/group databases

TCDBi2.A.18.6.13. the amino acid/auxin permease (aaap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative sodium-coupled neutral amino acid transporter 7
Alternative name(s):
Solute carrier family 38 member 7
Gene namesi
Name:SLC38A7
Synonyms:SNAT7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:25582. SLC38A7.

Subcellular locationi

Membrane By similarity; Multi-pass membrane protein By similarity
Note: In neurons, located in soma and axons.By similarity

GO - Cellular componenti

  1. axon Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
  3. neuronal cell body Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162403772.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 462462Putative sodium-coupled neutral amino acid transporter 7PRO_0000319597Add
BLAST

Proteomic databases

MaxQBiQ9NVC3.
PaxDbiQ9NVC3.
PRIDEiQ9NVC3.

PTM databases

PhosphoSiteiQ9NVC3.

Expressioni

Gene expression databases

BgeeiQ9NVC3.
CleanExiHS_SLC38A7.
ExpressionAtlasiQ9NVC3. baseline and differential.
GenevestigatoriQ9NVC3.

Organism-specific databases

HPAiHPA041777.

Interactioni

Protein-protein interaction databases

MINTiMINT-4650882.
STRINGi9606.ENSP00000219320.

Structurei

3D structure databases

ProteinModelPortaliQ9NVC3.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei56 – 7621HelicalSequence AnalysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence AnalysisAdd
BLAST
Transmembranei130 – 15021HelicalSequence AnalysisAdd
BLAST
Transmembranei178 – 19821HelicalSequence AnalysisAdd
BLAST
Transmembranei205 – 22521HelicalSequence AnalysisAdd
BLAST
Transmembranei239 – 25921HelicalSequence AnalysisAdd
BLAST
Transmembranei282 – 30221HelicalSequence AnalysisAdd
BLAST
Transmembranei319 – 33921HelicalSequence AnalysisAdd
BLAST
Transmembranei371 – 39121HelicalSequence AnalysisAdd
BLAST
Transmembranei395 – 41521HelicalSequence AnalysisAdd
BLAST
Transmembranei428 – 44821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0814.
GeneTreeiENSGT00710000106751.
HOGENOMiHOG000008036.
HOVERGENiHBG055999.
InParanoidiQ9NVC3.
KOiK14994.
OMAiTWGGVVT.
OrthoDBiEOG769ZJG.
PhylomeDBiQ9NVC3.
TreeFamiTF328787.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NVC3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQVSINNDY SEWDLSTDAG ERARLLQSPC VDTAPKSEWE ASPGGLDRGT
60 70 80 90 100
TSTLGAIFIV VNACLGAGLL NFPAAFSTAG GVAAGIALQM GMLVFIISGL
110 120 130 140 150
VILAYCSQAS NERTYQEVVW AVCGKLTGVL CEVAIAVYTF GTCIAFLIII
160 170 180 190 200
GDQQDKIIAV MAKEPEGASG PWYTDRKFTI SLTAFLFILP LSIPREIGFQ
210 220 230 240 250
KYASFLSVVG TWYVTAIVII KYIWPDKEMT PGNILTRPAS WMAVFNAMPT
260 270 280 290 300
ICFGFQCHVS SVPVFNSMQQ PEVKTWGGVV TAAMVIALAV YMGTGICGFL
310 320 330 340 350
TFGAAVDPDV LLSYPSEDMA VAVARAFIIL SVLTSYPILH FCGRAVVEGL
360 370 380 390 400
WLRYQGVPVE EDVGRERRRR VLQTLVWFLL TLLLALFIPD IGKVISVIGG
410 420 430 440 450
LAACFIFVFP GLCLIQAKLS EMEEVKPASW WVLVSYGVLL VTLGAFIFGQ
460
TTANAIFVDL LA
Length:462
Mass (Da):49,966
Last modified:October 1, 2000 - v1
Checksum:iB4F46C19D7E6EADB
GO
Isoform 2 (identifier: Q9NVC3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     345-462: Missing.

Note: No experimental confirmation available.

Show »
Length:344
Mass (Da):36,904
Checksum:iF48CBD890B7E928B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti145 – 1451A → T in BAB14244. (PubMed:14702039)Curated
Sequence conflicti208 – 2081V → A in BAD96652. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti46 – 461L → P.
Corresponds to variant rs7193572 [ dbSNP | Ensembl ].
VAR_039015
Natural varianti78 – 781T → I.
Corresponds to variant rs7191331 [ dbSNP | Ensembl ].
VAR_039016

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei345 – 462118Missing in isoform 2. 1 PublicationVSP_031511Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK001677 mRNA. Translation: BAA91830.1.
AK022786 mRNA. Translation: BAB14244.1.
CR457236 mRNA. Translation: CAG33517.1.
AK222932 mRNA. Translation: BAD96652.1.
CH471092 Genomic DNA. Translation: EAW82985.1.
BC001961 mRNA. Translation: AAH01961.1.
CCDSiCCDS10800.1. [Q9NVC3-1]
RefSeqiNP_060701.1. NM_018231.1. [Q9NVC3-1]
UniGeneiHs.10499.

Genome annotation databases

EnsembliENST00000219320; ENSP00000219320; ENSG00000103042. [Q9NVC3-1]
ENST00000570101; ENSP00000454646; ENSG00000103042. [Q9NVC3-1]
GeneIDi55238.
KEGGihsa:55238.
UCSCiuc002eod.1. human. [Q9NVC3-1]

Polymorphism databases

DMDMi74734488.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK001677 mRNA. Translation: BAA91830.1 .
AK022786 mRNA. Translation: BAB14244.1 .
CR457236 mRNA. Translation: CAG33517.1 .
AK222932 mRNA. Translation: BAD96652.1 .
CH471092 Genomic DNA. Translation: EAW82985.1 .
BC001961 mRNA. Translation: AAH01961.1 .
CCDSi CCDS10800.1. [Q9NVC3-1 ]
RefSeqi NP_060701.1. NM_018231.1. [Q9NVC3-1 ]
UniGenei Hs.10499.

3D structure databases

ProteinModelPortali Q9NVC3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4650882.
STRINGi 9606.ENSP00000219320.

Protein family/group databases

TCDBi 2.A.18.6.13. the amino acid/auxin permease (aaap) family.

PTM databases

PhosphoSitei Q9NVC3.

Polymorphism databases

DMDMi 74734488.

Proteomic databases

MaxQBi Q9NVC3.
PaxDbi Q9NVC3.
PRIDEi Q9NVC3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000219320 ; ENSP00000219320 ; ENSG00000103042 . [Q9NVC3-1 ]
ENST00000570101 ; ENSP00000454646 ; ENSG00000103042 . [Q9NVC3-1 ]
GeneIDi 55238.
KEGGi hsa:55238.
UCSCi uc002eod.1. human. [Q9NVC3-1 ]

Organism-specific databases

CTDi 55238.
GeneCardsi GC16M058699.
HGNCi HGNC:25582. SLC38A7.
HPAi HPA041777.
MIMi 614236. gene.
neXtProti NX_Q9NVC3.
PharmGKBi PA162403772.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0814.
GeneTreei ENSGT00710000106751.
HOGENOMi HOG000008036.
HOVERGENi HBG055999.
InParanoidi Q9NVC3.
KOi K14994.
OMAi TWGGVVT.
OrthoDBi EOG769ZJG.
PhylomeDBi Q9NVC3.
TreeFami TF328787.

Miscellaneous databases

ChiTaRSi SLC38A7. human.
GenomeRNAii 55238.
NextBioi 59263.
PROi Q9NVC3.
SOURCEi Search...

Gene expression databases

Bgeei Q9NVC3.
CleanExi HS_SLC38A7.
ExpressionAtlasi Q9NVC3. baseline and differential.
Genevestigatori Q9NVC3.

Family and domain databases

InterProi IPR013057. AA_transpt_TM.
[Graphical view ]
Pfami PF01490. Aa_trans. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Teratocarcinoma.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.

Entry informationi

Entry nameiS38A7_HUMAN
AccessioniPrimary (citable) accession number: Q9NVC3
Secondary accession number(s): Q53GJ9, Q9H9I5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3