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Q9NVC3

- S38A7_HUMAN

UniProt

Q9NVC3 - S38A7_HUMAN

Protein

Putative sodium-coupled neutral amino acid transporter 7

Gene

SLC38A7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Mediates sodium-dependent transport of amino acids, preferentially L-glutamine.By similarity

    GO - Molecular functioni

    1. L-alanine transmembrane transporter activity Source: Ensembl
    2. L-amino acid transmembrane transporter activity Source: UniProtKB
    3. L-asparagine transmembrane transporter activity Source: Ensembl
    4. L-aspartate transmembrane transporter activity Source: Ensembl
    5. L-glutamate transmembrane transporter activity Source: Ensembl
    6. L-glutamine transmembrane transporter activity Source: UniProtKB
    7. L-histidine transmembrane transporter activity Source: Ensembl
    8. L-leucine transmembrane transporter activity Source: Ensembl
    9. L-methionine transmembrane transporter activity Source: Ensembl
    10. L-serine transmembrane transporter activity Source: Ensembl

    GO - Biological processi

    1. L-alpha-amino acid transmembrane transport Source: GOC
    2. sodium ion transport Source: UniProtKB

    Keywords - Biological processi

    Amino-acid transport, Ion transport, Sodium transport, Transport

    Keywords - Ligandi

    Sodium

    Protein family/group databases

    TCDBi2.A.18.6.13. the amino acid/auxin permease (aaap) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative sodium-coupled neutral amino acid transporter 7
    Alternative name(s):
    Solute carrier family 38 member 7
    Gene namesi
    Name:SLC38A7
    Synonyms:SNAT7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:25582. SLC38A7.

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity
    Note: In neurons, located in soma and axons.By similarity

    GO - Cellular componenti

    1. axon Source: UniProtKB
    2. integral component of membrane Source: UniProtKB-KW
    3. neuronal cell body Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162403772.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 462462Putative sodium-coupled neutral amino acid transporter 7PRO_0000319597Add
    BLAST

    Proteomic databases

    MaxQBiQ9NVC3.
    PaxDbiQ9NVC3.
    PRIDEiQ9NVC3.

    PTM databases

    PhosphoSiteiQ9NVC3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NVC3.
    BgeeiQ9NVC3.
    CleanExiHS_SLC38A7.
    GenevestigatoriQ9NVC3.

    Organism-specific databases

    HPAiHPA041777.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4650882.
    STRINGi9606.ENSP00000219320.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NVC3.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei56 – 7621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei82 – 10221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei130 – 15021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei178 – 19821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei205 – 22521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei239 – 25921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei282 – 30221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei319 – 33921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei371 – 39121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei395 – 41521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei428 – 44821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0814.
    HOGENOMiHOG000008036.
    HOVERGENiHBG055999.
    InParanoidiQ9NVC3.
    KOiK14994.
    OMAiTWGGVVT.
    OrthoDBiEOG769ZJG.
    PhylomeDBiQ9NVC3.
    TreeFamiTF328787.

    Family and domain databases

    InterProiIPR013057. AA_transpt_TM.
    [Graphical view]
    PfamiPF01490. Aa_trans. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NVC3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAQVSINNDY SEWDLSTDAG ERARLLQSPC VDTAPKSEWE ASPGGLDRGT    50
    TSTLGAIFIV VNACLGAGLL NFPAAFSTAG GVAAGIALQM GMLVFIISGL 100
    VILAYCSQAS NERTYQEVVW AVCGKLTGVL CEVAIAVYTF GTCIAFLIII 150
    GDQQDKIIAV MAKEPEGASG PWYTDRKFTI SLTAFLFILP LSIPREIGFQ 200
    KYASFLSVVG TWYVTAIVII KYIWPDKEMT PGNILTRPAS WMAVFNAMPT 250
    ICFGFQCHVS SVPVFNSMQQ PEVKTWGGVV TAAMVIALAV YMGTGICGFL 300
    TFGAAVDPDV LLSYPSEDMA VAVARAFIIL SVLTSYPILH FCGRAVVEGL 350
    WLRYQGVPVE EDVGRERRRR VLQTLVWFLL TLLLALFIPD IGKVISVIGG 400
    LAACFIFVFP GLCLIQAKLS EMEEVKPASW WVLVSYGVLL VTLGAFIFGQ 450
    TTANAIFVDL LA 462
    Length:462
    Mass (Da):49,966
    Last modified:October 1, 2000 - v1
    Checksum:iB4F46C19D7E6EADB
    GO
    Isoform 2 (identifier: Q9NVC3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         345-462: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:344
    Mass (Da):36,904
    Checksum:iF48CBD890B7E928B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti145 – 1451A → T in BAB14244. (PubMed:14702039)Curated
    Sequence conflicti208 – 2081V → A in BAD96652. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti46 – 461L → P.
    Corresponds to variant rs7193572 [ dbSNP | Ensembl ].
    VAR_039015
    Natural varianti78 – 781T → I.
    Corresponds to variant rs7191331 [ dbSNP | Ensembl ].
    VAR_039016

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei345 – 462118Missing in isoform 2. 1 PublicationVSP_031511Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001677 mRNA. Translation: BAA91830.1.
    AK022786 mRNA. Translation: BAB14244.1.
    CR457236 mRNA. Translation: CAG33517.1.
    AK222932 mRNA. Translation: BAD96652.1.
    CH471092 Genomic DNA. Translation: EAW82985.1.
    BC001961 mRNA. Translation: AAH01961.1.
    CCDSiCCDS10800.1. [Q9NVC3-1]
    RefSeqiNP_060701.1. NM_018231.1. [Q9NVC3-1]
    UniGeneiHs.10499.

    Genome annotation databases

    EnsembliENST00000219320; ENSP00000219320; ENSG00000103042. [Q9NVC3-1]
    ENST00000570101; ENSP00000454646; ENSG00000103042. [Q9NVC3-1]
    GeneIDi55238.
    KEGGihsa:55238.
    UCSCiuc002eod.1. human. [Q9NVC3-1]

    Polymorphism databases

    DMDMi74734488.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001677 mRNA. Translation: BAA91830.1 .
    AK022786 mRNA. Translation: BAB14244.1 .
    CR457236 mRNA. Translation: CAG33517.1 .
    AK222932 mRNA. Translation: BAD96652.1 .
    CH471092 Genomic DNA. Translation: EAW82985.1 .
    BC001961 mRNA. Translation: AAH01961.1 .
    CCDSi CCDS10800.1. [Q9NVC3-1 ]
    RefSeqi NP_060701.1. NM_018231.1. [Q9NVC3-1 ]
    UniGenei Hs.10499.

    3D structure databases

    ProteinModelPortali Q9NVC3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4650882.
    STRINGi 9606.ENSP00000219320.

    Protein family/group databases

    TCDBi 2.A.18.6.13. the amino acid/auxin permease (aaap) family.

    PTM databases

    PhosphoSitei Q9NVC3.

    Polymorphism databases

    DMDMi 74734488.

    Proteomic databases

    MaxQBi Q9NVC3.
    PaxDbi Q9NVC3.
    PRIDEi Q9NVC3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000219320 ; ENSP00000219320 ; ENSG00000103042 . [Q9NVC3-1 ]
    ENST00000570101 ; ENSP00000454646 ; ENSG00000103042 . [Q9NVC3-1 ]
    GeneIDi 55238.
    KEGGi hsa:55238.
    UCSCi uc002eod.1. human. [Q9NVC3-1 ]

    Organism-specific databases

    CTDi 55238.
    GeneCardsi GC16M058699.
    HGNCi HGNC:25582. SLC38A7.
    HPAi HPA041777.
    MIMi 614236. gene.
    neXtProti NX_Q9NVC3.
    PharmGKBi PA162403772.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0814.
    HOGENOMi HOG000008036.
    HOVERGENi HBG055999.
    InParanoidi Q9NVC3.
    KOi K14994.
    OMAi TWGGVVT.
    OrthoDBi EOG769ZJG.
    PhylomeDBi Q9NVC3.
    TreeFami TF328787.

    Miscellaneous databases

    ChiTaRSi SLC38A7. human.
    GenomeRNAii 55238.
    NextBioi 59263.
    PROi Q9NVC3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NVC3.
    Bgeei Q9NVC3.
    CleanExi HS_SLC38A7.
    Genevestigatori Q9NVC3.

    Family and domain databases

    InterProi IPR013057. AA_transpt_TM.
    [Graphical view ]
    Pfami PF01490. Aa_trans. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Teratocarcinoma.
    2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Kidney.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.

    Entry informationi

    Entry nameiS38A7_HUMAN
    AccessioniPrimary (citable) accession number: Q9NVC3
    Secondary accession number(s): Q53GJ9, Q9H9I5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3