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Q9NVC3 (S38A7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative sodium-coupled neutral amino acid transporter 7
Alternative name(s):
Solute carrier family 38 member 7
Gene names
Name:SLC38A7
Synonyms:SNAT7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length462 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mediates sodium-dependent transport of amino acids, preferentially L-glutamine By similarity.

Subcellular location

Membrane; Multi-pass membrane protein By similarity. Note: In neurons, located in soma and axons By similarity.

Sequence similarities

Belongs to the amino acid/polyamine transporter 2 family.

Ontologies

Keywords
   Biological processAmino-acid transport
Ion transport
Sodium transport
Transport
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainTransmembrane
Transmembrane helix
   LigandSodium
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processL-alpha-amino acid transmembrane transport

Inferred from sequence or structural similarity. Source: GOC

sodium ion transport

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentaxon

Inferred from sequence or structural similarity. Source: UniProtKB

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

neuronal cell body

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionL-alanine transmembrane transporter activity

Inferred from electronic annotation. Source: Ensembl

L-amino acid transmembrane transporter activity

Inferred from sequence or structural similarity. Source: UniProtKB

L-asparagine transmembrane transporter activity

Inferred from electronic annotation. Source: Ensembl

L-aspartate transmembrane transporter activity

Inferred from electronic annotation. Source: Ensembl

L-glutamate transmembrane transporter activity

Inferred from electronic annotation. Source: Ensembl

L-glutamine transmembrane transporter activity

Inferred from sequence or structural similarity. Source: UniProtKB

L-histidine transmembrane transporter activity

Inferred from electronic annotation. Source: Ensembl

L-leucine transmembrane transporter activity

Inferred from electronic annotation. Source: Ensembl

L-methionine transmembrane transporter activity

Inferred from electronic annotation. Source: Ensembl

L-serine transmembrane transporter activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NVC3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NVC3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     345-462: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 462462Putative sodium-coupled neutral amino acid transporter 7
PRO_0000319597

Regions

Transmembrane56 – 7621Helical; Potential
Transmembrane82 – 10221Helical; Potential
Transmembrane130 – 15021Helical; Potential
Transmembrane178 – 19821Helical; Potential
Transmembrane205 – 22521Helical; Potential
Transmembrane239 – 25921Helical; Potential
Transmembrane282 – 30221Helical; Potential
Transmembrane319 – 33921Helical; Potential
Transmembrane371 – 39121Helical; Potential
Transmembrane395 – 41521Helical; Potential
Transmembrane428 – 44821Helical; Potential

Natural variations

Alternative sequence345 – 462118Missing in isoform 2.
VSP_031511
Natural variant461L → P.
Corresponds to variant rs7193572 [ dbSNP | Ensembl ].
VAR_039015
Natural variant781T → I.
Corresponds to variant rs7191331 [ dbSNP | Ensembl ].
VAR_039016

Experimental info

Sequence conflict1451A → T in BAB14244. Ref.1
Sequence conflict2081V → A in BAD96652. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: B4F46C19D7E6EADB

FASTA46249,966
        10         20         30         40         50         60 
MAQVSINNDY SEWDLSTDAG ERARLLQSPC VDTAPKSEWE ASPGGLDRGT TSTLGAIFIV 

        70         80         90        100        110        120 
VNACLGAGLL NFPAAFSTAG GVAAGIALQM GMLVFIISGL VILAYCSQAS NERTYQEVVW 

       130        140        150        160        170        180 
AVCGKLTGVL CEVAIAVYTF GTCIAFLIII GDQQDKIIAV MAKEPEGASG PWYTDRKFTI 

       190        200        210        220        230        240 
SLTAFLFILP LSIPREIGFQ KYASFLSVVG TWYVTAIVII KYIWPDKEMT PGNILTRPAS 

       250        260        270        280        290        300 
WMAVFNAMPT ICFGFQCHVS SVPVFNSMQQ PEVKTWGGVV TAAMVIALAV YMGTGICGFL 

       310        320        330        340        350        360 
TFGAAVDPDV LLSYPSEDMA VAVARAFIIL SVLTSYPILH FCGRAVVEGL WLRYQGVPVE 

       370        380        390        400        410        420 
EDVGRERRRR VLQTLVWFLL TLLLALFIPD IGKVISVIGG LAACFIFVFP GLCLIQAKLS 

       430        440        450        460 
EMEEVKPASW WVLVSYGVLL VTLGAFIFGQ TTANAIFVDL LA 

« Hide

Isoform 2 [UniParc].

Checksum: F48CBD890B7E928B
Show »

FASTA34436,904

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Teratocarcinoma.
[2]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[3]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Kidney.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK001677 mRNA. Translation: BAA91830.1.
AK022786 mRNA. Translation: BAB14244.1.
CR457236 mRNA. Translation: CAG33517.1.
AK222932 mRNA. Translation: BAD96652.1.
CH471092 Genomic DNA. Translation: EAW82985.1.
BC001961 mRNA. Translation: AAH01961.1.
CCDSCCDS10800.1. [Q9NVC3-1]
RefSeqNP_060701.1. NM_018231.1. [Q9NVC3-1]
UniGeneHs.10499.

3D structure databases

ProteinModelPortalQ9NVC3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4650882.
STRING9606.ENSP00000219320.

Protein family/group databases

TCDB2.A.18.6.13. the amino acid/auxin permease (aaap) family.

PTM databases

PhosphoSiteQ9NVC3.

Polymorphism databases

DMDM74734488.

Proteomic databases

MaxQBQ9NVC3.
PaxDbQ9NVC3.
PRIDEQ9NVC3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000219320; ENSP00000219320; ENSG00000103042. [Q9NVC3-1]
ENST00000570101; ENSP00000454646; ENSG00000103042. [Q9NVC3-1]
GeneID55238.
KEGGhsa:55238.
UCSCuc002eod.1. human. [Q9NVC3-1]

Organism-specific databases

CTD55238.
GeneCardsGC16M058699.
HGNCHGNC:25582. SLC38A7.
HPAHPA041777.
MIM614236. gene.
neXtProtNX_Q9NVC3.
PharmGKBPA162403772.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0814.
HOGENOMHOG000008036.
HOVERGENHBG055999.
InParanoidQ9NVC3.
KOK14994.
OMATWGGVVT.
OrthoDBEOG769ZJG.
PhylomeDBQ9NVC3.
TreeFamTF328787.

Gene expression databases

ArrayExpressQ9NVC3.
BgeeQ9NVC3.
CleanExHS_SLC38A7.
GenevestigatorQ9NVC3.

Family and domain databases

InterProIPR013057. AA_transpt_TM.
[Graphical view]
PfamPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLC38A7. human.
GenomeRNAi55238.
NextBio59263.
PROQ9NVC3.
SOURCESearch...

Entry information

Entry nameS38A7_HUMAN
AccessionPrimary (citable) accession number: Q9NVC3
Secondary accession number(s): Q53GJ9, Q9H9I5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM