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Protein

Transmembrane protein 184C

Gene

TMEM184C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Possible tumor suppressor which may play a role in cell growth.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 184C
Alternative name(s):
Transmembrane protein 34
Gene namesi
Name:TMEM184C
Synonyms:TMEM34
ORF Names:PRO1355
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:25587. TMEM184C.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721HelicalSequence analysisAdd
BLAST
Transmembranei48 – 6821HelicalSequence analysisAdd
BLAST
Transmembranei86 – 10621HelicalSequence analysisAdd
BLAST
Transmembranei179 – 19921HelicalSequence analysisAdd
BLAST
Transmembranei212 – 23221HelicalSequence analysisAdd
BLAST
Transmembranei254 – 27421HelicalSequence analysisAdd
BLAST
Transmembranei287 – 30721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162406163.

Polymorphism and mutation databases

BioMutaiTMEM184C.
DMDMi296452918.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 438438Transmembrane protein 184CPRO_0000287567Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei422 – 4221PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NVA4.
MaxQBiQ9NVA4.
PaxDbiQ9NVA4.
PeptideAtlasiQ9NVA4.
PRIDEiQ9NVA4.

PTM databases

iPTMnetiQ9NVA4.
PhosphoSiteiQ9NVA4.
SwissPalmiQ9NVA4.

Expressioni

Tissue specificityi

Widely expressed with higher expression in lung, kidney, spleen, pancreas, thymus, prostate, testis, ovary, small intestine and thyroid.1 Publication

Gene expression databases

BgeeiENSG00000164168.
CleanExiHS_TMEM184C.
ExpressionAtlasiQ9NVA4. baseline and differential.
GenevisibleiQ9NVA4. HS.

Organism-specific databases

HPAiHPA054013.

Interactioni

Protein-protein interaction databases

BioGridi120869. 2 interactions.
IntActiQ9NVA4. 5 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9NVA4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM184 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2641. Eukaryota.
ENOG410XQ3V. LUCA.
GeneTreeiENSGT00530000063204.
HOGENOMiHOG000245596.
HOVERGENiHBG106836.
InParanoidiQ9NVA4.
OMAiPSWAMGE.
OrthoDBiEOG091G08U8.
PhylomeDBiQ9NVA4.
TreeFamiTF324245.

Family and domain databases

InterProiIPR005178. Ostalpha/TMEM184C.
[Graphical view]
PANTHERiPTHR23423. PTHR23423. 1 hit.
PfamiPF03619. Solute_trans_a. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NVA4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPCTCTWRNW RQWIRPLVAV IYLVSIVVAV PLCVWELQKL EVGIHTKAWF
60 70 80 90 100
IAGIFLLLTI PISLWVILQH LVHYTQPELQ KPIIRILWMV PIYSLDSWIA
110 120 130 140 150
LKYPGIAIYV DTCRECYEAY VIYNFMGFLT NYLTNRYPNL VLILEAKDQQ
160 170 180 190 200
KHFPPLCCCP PWAMGEVLLF RCKLGVLQYT VVRPFTTIVA LICELLGIYD
210 220 230 240 250
EGNFSFSNAW TYLVIINNMS QLFAMYCLLL FYKVLKEELS PIQPVGKFLC
260 270 280 290 300
VKLVVFVSFW QAVVIALLVK VGVISEKHTW EWQTVEAVAT GLQDFIICIE
310 320 330 340 350
MFLAAIAHHY TFSYKPYVQE AEEGSCFDSF LAMWDVSDIR DDISEQVRHV
360 370 380 390 400
GRTVRGHPRK KLFPEDQDQN EHTSLLSSSS QDAISIASSM PPSPMGHYQG
410 420 430
FGHTVTPQTT PTTAKISDEI LSDTIGEKKE PSDKSVDS
Length:438
Mass (Da):50,142
Last modified:May 18, 2010 - v2
Checksum:i60EF5C2B0C6FD296
GO
Isoform 2 (identifier: Q9NVA4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     262-438: Missing.

Note: No experimental confirmation available.
Show »
Length:261
Mass (Da):30,522
Checksum:iD4610159ECFA363D
GO

Sequence cautioni

The sequence AAK55526 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA90988 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti230 – 2301L → P in BAA90988 (PubMed:14702039).Curated
Sequence conflicti252 – 2521K → R in BAA91851 (PubMed:14702039).Curated
Sequence conflicti261 – 2611Q → P in AAH46128 (PubMed:15489334).Curated
Sequence conflicti355 – 3551R → G in BAA91851 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei262 – 438177Missing in isoform 2. 1 PublicationVSP_025566Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000169 mRNA. Translation: BAA90988.1. Different initiation.
AK001708 mRNA. Translation: BAA91851.1.
BC008120 mRNA. Translation: AAH08120.1.
BC046128 mRNA. Translation: AAH46128.1.
AC093835 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX05015.1.
CH471056 Genomic DNA. Translation: EAX05016.1.
AF305823 mRNA. Translation: AAK55526.1. Different initiation.
CCDSiCCDS3770.1. [Q9NVA4-1]
RefSeqiNP_060711.2. NM_018241.2. [Q9NVA4-1]
UniGeneiHs.203896.

Genome annotation databases

EnsembliENST00000296582; ENSP00000296582; ENSG00000164168. [Q9NVA4-1]
GeneIDi55751.
KEGGihsa:55751.
UCSCiuc003ila.5. human. [Q9NVA4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000169 mRNA. Translation: BAA90988.1. Different initiation.
AK001708 mRNA. Translation: BAA91851.1.
BC008120 mRNA. Translation: AAH08120.1.
BC046128 mRNA. Translation: AAH46128.1.
AC093835 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX05015.1.
CH471056 Genomic DNA. Translation: EAX05016.1.
AF305823 mRNA. Translation: AAK55526.1. Different initiation.
CCDSiCCDS3770.1. [Q9NVA4-1]
RefSeqiNP_060711.2. NM_018241.2. [Q9NVA4-1]
UniGeneiHs.203896.

3D structure databases

ProteinModelPortaliQ9NVA4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120869. 2 interactions.
IntActiQ9NVA4. 5 interactions.

PTM databases

iPTMnetiQ9NVA4.
PhosphoSiteiQ9NVA4.
SwissPalmiQ9NVA4.

Polymorphism and mutation databases

BioMutaiTMEM184C.
DMDMi296452918.

Proteomic databases

EPDiQ9NVA4.
MaxQBiQ9NVA4.
PaxDbiQ9NVA4.
PeptideAtlasiQ9NVA4.
PRIDEiQ9NVA4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296582; ENSP00000296582; ENSG00000164168. [Q9NVA4-1]
GeneIDi55751.
KEGGihsa:55751.
UCSCiuc003ila.5. human. [Q9NVA4-1]

Organism-specific databases

CTDi55751.
GeneCardsiTMEM184C.
H-InvDBHIX0004554.
HGNCiHGNC:25587. TMEM184C.
HPAiHPA054013.
MIMi613937. gene.
neXtProtiNX_Q9NVA4.
PharmGKBiPA162406163.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2641. Eukaryota.
ENOG410XQ3V. LUCA.
GeneTreeiENSGT00530000063204.
HOGENOMiHOG000245596.
HOVERGENiHBG106836.
InParanoidiQ9NVA4.
OMAiPSWAMGE.
OrthoDBiEOG091G08U8.
PhylomeDBiQ9NVA4.
TreeFamiTF324245.

Miscellaneous databases

ChiTaRSiTMEM184C. human.
GenomeRNAii55751.
PROiQ9NVA4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164168.
CleanExiHS_TMEM184C.
ExpressionAtlasiQ9NVA4. baseline and differential.
GenevisibleiQ9NVA4. HS.

Family and domain databases

InterProiIPR005178. Ostalpha/TMEM184C.
[Graphical view]
PANTHERiPTHR23423. PTHR23423. 1 hit.
PfamiPF03619. Solute_trans_a. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiT184C_HUMAN
AccessioniPrimary (citable) accession number: Q9NVA4
Secondary accession number(s): D3DP04
, Q86X84, Q969I7, Q9NXM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 18, 2010
Last modified: September 7, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.