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Protein

Septin-11

Gene

SEPT11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity). During Listeria monocytogenes infection, not required for the bacterial entry process, but restricts its efficacy.By similarityCurated2 Publications

Caution

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei103GTP; via amide nitrogenBy similarity1
Binding sitei238GTP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei253GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi48 – 55GTPBy similarity8
Nucleotide bindingi184 – 192GTPBy similarity9

GO - Molecular functioni

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • protein heterooligomerization Source: UniProtKB

Keywordsi

Biological processCell cycle, Cell division
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Septin-11
Gene namesi
Name:SEPT11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000138758.11
HGNCiHGNC:25589 SEPT11
MIMi612887 gene
neXtProtiNX_Q9NVA2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoskeleton, Synapse

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving SEPT11 may be a cause of chronic neutrophilic leukemia. Translocation t(4;11)(q21;q23) with KMT2A/MLL1.

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi48G → A: High reduction in GTPase activity. No effect on GTP-binding. Loss of filament formation. 1 Publication1

Organism-specific databases

DisGeNETi55752
OpenTargetsiENSG00000138758
PharmGKBiPA128394688

Polymorphism and mutation databases

BioMutaiSEPT11
DMDMi50401687

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001735422 – 429Septin-11Add BLAST428

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei9PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9NVA2
MaxQBiQ9NVA2
PaxDbiQ9NVA2
PeptideAtlasiQ9NVA2
PRIDEiQ9NVA2

2D gel databases

OGPiQ9NVA2
UCD-2DPAGEiQ9NVA2

PTM databases

iPTMnetiQ9NVA2
PhosphoSitePlusiQ9NVA2
SwissPalmiQ9NVA2

Expressioni

Tissue specificityi

Widely expressed, except in leukocytes.2 Publications

Gene expression databases

BgeeiENSG00000138758
CleanExiHS_SEPT11
ExpressionAtlasiQ9NVA2 baseline and differential
GenevisibleiQ9NVA2 HS

Organism-specific databases

HPAiHPA003459
HPA005665

Interactioni

Subunit structurei

Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Interacts with SEPT7, SEPT9 and SEPT12. Forms homooligomers.3 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi12087053 interactors.
CORUMiQ9NVA2
DIPiDIP-36161N
IntActiQ9NVA2 12 interactors.
STRINGi9606.ENSP00000264893

Structurei

3D structure databases

ProteinModelPortaliQ9NVA2
SMRiQ9NVA2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 304Septin-type GAdd BLAST267

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili320 – 415Sequence analysisAdd BLAST96

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2655 Eukaryota
COG5019 LUCA
GeneTreeiENSGT00910000144070
HOGENOMiHOG000233586
HOVERGENiHBG065093
InParanoidiQ9NVA2
KOiK16939
OMAiRSRQYPW
OrthoDBiEOG091G0IKM
PhylomeDBiQ9NVA2
TreeFamiTF101080

Family and domain databases

CDDicd01850 CDC_Septin, 1 hit
InterProiView protein in InterPro
IPR030379 G_SEPTIN_dom
IPR027417 P-loop_NTPase
IPR016491 Septin
PfamiView protein in Pfam
PF00735 Septin, 1 hit
PIRSFiPIRSF006698 Septin, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51719 G_SEPTIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NVA2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVAVGRPSN EELRNLSLSG HVGFDSLPDQ LVNKSTSQGF CFNILCVGET
60 70 80 90 100
GIGKSTLMDT LFNTKFESDP ATHNEPGVRL KARSYELQES NVRLKLTIVD
110 120 130 140 150
TVGFGDQINK DDSYKPIVEY IDAQFEAYLQ EELKIKRSLF NYHDTRIHAC
160 170 180 190 200
LYFIAPTGHS LKSLDLVTMK KLDSKVNIIP IIAKADTIAK NELHKFKSKI
210 220 230 240 250
MSELVSNGVQ IYQFPTDEET VAEINATMSV HLPFAVVGST EEVKIGNKMA
260 270 280 290 300
KARQYPWGVV QVENENHCDF VKLREMLIRV NMEDLREQTH TRHYELYRRC
310 320 330 340 350
KLEEMGFKDT DPDSKPFSLQ ETYEAKRNEF LGELQKKEEE MRQMFVMRVK
360 370 380 390 400
EKEAELKEAE KELHEKFDLL KRTHQEEKKK VEDKKKELEE EVNNFQKKKA
410 420
AAQLLQSQAQ QSGAQQTKKD KDKKNASFT
Length:429
Mass (Da):49,398
Last modified:January 23, 2007 - v3
Checksum:iD467F1F315FFD028
GO
Isoform 2 (identifier: Q9NVA2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MAVAVGRPS → MEERKPAHVLRSFKYAAFM

Note: No experimental confirmation available.
Show »
Length:439
Mass (Da):50,823
Checksum:iC8E82F016C56A392
GO

Sequence cautioni

The sequence BAB55250 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB53741 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti142Y → H in CAB53741 (PubMed:15489334).Curated1
Sequence conflicti298R → H in CAB53741 (PubMed:15489334).Curated1
Sequence conflicti321E → G in CAB53741 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0383201 – 9MAVAVGRPS → MEERKPAHVLRSFKYAAFM in isoform 2. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU727629 mRNA Translation: ADU87631.1
AK001711 mRNA Translation: BAA91853.1
AK027633 mRNA Translation: BAB55250.1 Different initiation.
AK302700 mRNA Translation: BAH13782.1
AC104687 Genomic DNA Translation: AAY40922.1
AC111196 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05805.1
BC008083 mRNA Translation: AAH08083.3
BC063615 mRNA Translation: AAH63615.1
AL110300 mRNA Translation: CAB53741.2 Sequence problems.
CCDSiCCDS34018.1 [Q9NVA2-1]
CCDS77931.1 [Q9NVA2-2]
RefSeqiNP_001293076.1, NM_001306147.1 [Q9NVA2-2]
NP_060713.1, NM_018243.3 [Q9NVA2-1]
XP_016863889.1, XM_017008400.1 [Q9NVA2-2]
UniGeneiHs.128199

Genome annotation databases

EnsembliENST00000264893; ENSP00000264893; ENSG00000138758 [Q9NVA2-1]
ENST00000510515; ENSP00000422896; ENSG00000138758 [Q9NVA2-2]
GeneIDi55752
KEGGihsa:55752
UCSCiuc003hkj.4 human [Q9NVA2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Similar proteinsi

Entry informationi

Entry nameiSEP11_HUMAN
AccessioniPrimary (citable) accession number: Q9NVA2
Secondary accession number(s): B7Z7Z6
, E9KL32, Q4W5G1, Q7L4N1, Q96SP1, Q9UFY9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 149 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome