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Q9NV96

- CC50A_HUMAN

UniProt

Q9NV96 - CC50A_HUMAN

Protein

Cell cycle control protein 50A

Gene

TMEM30A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth, and, reconstituted to liposomes, predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). The ATP8A1:TMEM30A flippase complex seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Required for the formation of the ATP8A2, ATP8B1 and ATP8B2 P-type ATPAse intermediate phosphoenzymes. Involved in uptake of platelet-activating factor (PAF), synthetic drug alkylphospholipid edelfosine, and, probably in association with ATP8B1, of perifosine. Also mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2, ATP8B4, ATP10A, ATP10B, ATP10D, ATP11A, ATP11B and ATP11C from the ER to other membrane localizations.4 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. drug transmembrane transport Source: UniProtKB
    2. phospholipid translocation Source: UniProtKB
    3. positive regulation of protein exit from endoplasmic reticulum Source: UniProtKB
    4. protein localization to endosome Source: UniProtKB

    Keywords - Biological processi

    Lipid transport, Transport

    Protein family/group databases

    TCDBi8.A.27.1.5. the cdc50 p-type atpase lipid flippase subunit (cdc50) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cell cycle control protein 50A
    Alternative name(s):
    P4-ATPase flippase complex beta subunit TMEM30A
    Transmembrane protein 30A
    Gene namesi
    Name:TMEM30A
    Synonyms:C6orf67, CDC50A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:16667. TMEM30A.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: UniProtKB-SubCell
    2. endoplasmic reticulum Source: UniProtKB
    3. Golgi apparatus Source: UniProtKB-SubCell
    4. integral component of membrane Source: UniProtKB-KW
    5. membrane Source: UniProtKB
    6. transport vesicle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasmic vesicle, Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134936902.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 361360Cell cycle control protein 50APRO_0000244469Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi190 – 1901N-linked (GlcNAc...)1 Publication
    Glycosylationi294 – 2941N-linked (GlcNAc...)1 Publication

    Post-translational modificationi

    N-glycosylated. Contains high mannose-type oligosaccharides By similarity.By similarity

    Keywords - PTMi

    Acetylation, Glycoprotein

    Proteomic databases

    MaxQBiQ9NV96.
    PaxDbiQ9NV96.
    PeptideAtlasiQ9NV96.
    PRIDEiQ9NV96.

    PTM databases

    PhosphoSiteiQ9NV96.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NV96.
    BgeeiQ9NV96.
    CleanExiHS_TMEM30A.
    GenevestigatoriQ9NV96.

    Organism-specific databases

    HPAiHPA014561.

    Interactioni

    Subunit structurei

    Component of various P4-ATPase flippase complexes which consists of a catalytic alpha subunit and an accessory beta subunit. The ATP8A2:TMEM30A flippase complex has been purified, and ATP8B1:TMEM30A and ATP8B2:TMEM30A flippase complexes have been shown to form intermediate phosphoenzymes in vitro. Interacts with alpha subunits ATP8A1, ATP8B1, ATP8B2, ATP8B4, ATP11A, ATP11B and ATP11C.4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ATP8B1O435203EBI-2836942,EBI-9524729

    Protein-protein interaction databases

    BioGridi120872. 8 interactions.
    IntActiQ9NV96. 7 interactions.
    MINTiMINT-5006648.
    STRINGi9606.ENSP00000359067.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NV96.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 4948CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini71 – 325255Exoplasmic loopSequence AnalysisAdd
    BLAST
    Topological domaini347 – 36115CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei50 – 7021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei326 – 34621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domaini

    The N-terminal domain seems to play a role in the reaction cycle of the catalytic subunit such as ATP8A2.By similarity

    Sequence similaritiesi

    Belongs to the CDC50/LEM3 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5035.
    HOGENOMiHOG000209057.
    HOVERGENiHBG055537.
    InParanoidiQ9NV96.
    OMAiDACKPED.
    OrthoDBiEOG7C5M8D.
    PhylomeDBiQ9NV96.
    TreeFamiTF300873.

    Family and domain databases

    InterProiIPR005045. DUF284_TM_euk.
    [Graphical view]
    PANTHERiPTHR10926. PTHR10926. 1 hit.
    PfamiPF03381. CDC50. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015840. DUF284_TM_euk. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NV96-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAMNYNAKDE VDGGPPCAPG GTAKTRRPDN TAFKQQRLPA WQPILTAGTV    50
    LPIFFIIGLI FIPIGIGIFV TSNNIREIEI DYTGTEPSSP CNKCLSPDVT 100
    PCFCTINFTL EKSFEGNVFM YYGLSNFYQN HRRYVKSRDD SQLNGDSSAL 150
    LNPSKECEPY RRNEDKPIAP CGAIANSMFN DTLELFLIGN DSYPIPIALK 200
    KKGIAWWTDK NVKFRNPPGG DNLEERFKGT TKPVNWLKPV YMLDSDPDNN 250
    GFINEDFIVW MRTAALPTFR KLYRLIERKS DLHPTLPAGR YSLNVTYNYP 300
    VHYFDGRKRM ILSTISWMGG KNPFLGIAYI AVGSISFLLG VVLLVINHKY 350
    RNSSNTADIT I 361
    Length:361
    Mass (Da):40,684
    Last modified:October 1, 2000 - v1
    Checksum:i64B3F28C3EB7801B
    GO
    Isoform 2 (identifier: Q9NV96-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         79-114: Missing.

    Show »
    Length:325
    Mass (Da):36,713
    Checksum:i40D7000253A6787F
    GO
    Isoform 3 (identifier: Q9NV96-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-119: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:242
    Mass (Da):27,729
    Checksum:i262B426C680712B5
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 119119Missing in isoform 3. 1 PublicationVSP_019567Add
    BLAST
    Alternative sequencei79 – 11436Missing in isoform 2. 2 PublicationsVSP_019568Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001718 mRNA. Translation: BAA91859.1.
    AK292823 mRNA. Translation: BAF85512.1.
    AL832815 mRNA. Translation: CAH56262.1.
    AL832490 mRNA. Translation: CAH56205.1.
    AL162046 mRNA. Translation: CAB82389.1.
    AL080250 Genomic DNA. Translation: CAI19900.1.
    CH471051 Genomic DNA. Translation: EAW48743.1.
    CH471051 Genomic DNA. Translation: EAW48744.1.
    CH471051 Genomic DNA. Translation: EAW48745.1.
    BC009006 mRNA. Translation: AAH09006.1.
    CCDSiCCDS47453.1. [Q9NV96-2]
    CCDS4983.1. [Q9NV96-1]
    PIRiT47140.
    RefSeqiNP_001137430.1. NM_001143958.1. [Q9NV96-2]
    NP_060717.1. NM_018247.3. [Q9NV96-1]
    UniGeneiHs.108530.

    Genome annotation databases

    EnsembliENST00000230461; ENSP00000230461; ENSG00000112697. [Q9NV96-1]
    ENST00000370050; ENSP00000359067; ENSG00000112697. [Q9NV96-3]
    ENST00000475111; ENSP00000431007; ENSG00000112697. [Q9NV96-2]
    GeneIDi55754.
    KEGGihsa:55754.
    UCSCiuc003phw.2. human. [Q9NV96-1]
    uc003phx.2. human. [Q9NV96-2]

    Polymorphism databases

    DMDMi74752991.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001718 mRNA. Translation: BAA91859.1 .
    AK292823 mRNA. Translation: BAF85512.1 .
    AL832815 mRNA. Translation: CAH56262.1 .
    AL832490 mRNA. Translation: CAH56205.1 .
    AL162046 mRNA. Translation: CAB82389.1 .
    AL080250 Genomic DNA. Translation: CAI19900.1 .
    CH471051 Genomic DNA. Translation: EAW48743.1 .
    CH471051 Genomic DNA. Translation: EAW48744.1 .
    CH471051 Genomic DNA. Translation: EAW48745.1 .
    BC009006 mRNA. Translation: AAH09006.1 .
    CCDSi CCDS47453.1. [Q9NV96-2 ]
    CCDS4983.1. [Q9NV96-1 ]
    PIRi T47140.
    RefSeqi NP_001137430.1. NM_001143958.1. [Q9NV96-2 ]
    NP_060717.1. NM_018247.3. [Q9NV96-1 ]
    UniGenei Hs.108530.

    3D structure databases

    ProteinModelPortali Q9NV96.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120872. 8 interactions.
    IntActi Q9NV96. 7 interactions.
    MINTi MINT-5006648.
    STRINGi 9606.ENSP00000359067.

    Protein family/group databases

    TCDBi 8.A.27.1.5. the cdc50 p-type atpase lipid flippase subunit (cdc50) family.

    PTM databases

    PhosphoSitei Q9NV96.

    Polymorphism databases

    DMDMi 74752991.

    Proteomic databases

    MaxQBi Q9NV96.
    PaxDbi Q9NV96.
    PeptideAtlasi Q9NV96.
    PRIDEi Q9NV96.

    Protocols and materials databases

    DNASUi 55754.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000230461 ; ENSP00000230461 ; ENSG00000112697 . [Q9NV96-1 ]
    ENST00000370050 ; ENSP00000359067 ; ENSG00000112697 . [Q9NV96-3 ]
    ENST00000475111 ; ENSP00000431007 ; ENSG00000112697 . [Q9NV96-2 ]
    GeneIDi 55754.
    KEGGi hsa:55754.
    UCSCi uc003phw.2. human. [Q9NV96-1 ]
    uc003phx.2. human. [Q9NV96-2 ]

    Organism-specific databases

    CTDi 55754.
    GeneCardsi GC06M075962.
    HGNCi HGNC:16667. TMEM30A.
    HPAi HPA014561.
    MIMi 611028. gene.
    neXtProti NX_Q9NV96.
    PharmGKBi PA134936902.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5035.
    HOGENOMi HOG000209057.
    HOVERGENi HBG055537.
    InParanoidi Q9NV96.
    OMAi DACKPED.
    OrthoDBi EOG7C5M8D.
    PhylomeDBi Q9NV96.
    TreeFami TF300873.

    Miscellaneous databases

    ChiTaRSi TMEM30A. human.
    GenomeRNAii 55754.
    NextBioi 60753.
    PROi Q9NV96.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NV96.
    Bgeei Q9NV96.
    CleanExi HS_TMEM30A.
    Genevestigatori Q9NV96.

    Family and domain databases

    InterProi IPR005045. DUF284_TM_euk.
    [Graphical view ]
    PANTHERi PTHR10926. PTHR10926. 1 hit.
    Pfami PF03381. CDC50. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015840. DUF284_TM_euk. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Trachea.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: Amygdala, Lymph node and Testis.
    3. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    6. "Identification and characterization of CDC50A, CDC50B and CDC50C genes in silico."
      Katoh Y., Katoh M.
      Oncol. Rep. 12:939-943(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    8. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-294.
      Tissue: Liver.
    9. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-190.
      Tissue: Leukemic T-cell.
    10. "CDC50A plays a key role in the uptake of the anticancer drug perifosine in human carcinoma cells."
      Munoz-Martinez F., Torres C., Castanys S., Gamarro F.
      Biochem. Pharmacol. 80:793-800(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    11. "Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4-ATPases."
      van der Velden L.M., Wichers C.G., van Breevoort A.E., Coleman J.A., Molday R.S., Berger R., Klomp L.W., van de Graaf S.F.
      J. Biol. Chem. 285:40088-40096(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH ATP8A1; ATP8A2; ATP8B1; ATP8B2 AND ATP8B4.
    12. "CDC50 proteins are critical components of the human class-1 P4-ATPase transport machinery."
      Bryde S., Hennrich H., Verhulst P.M., Devaux P.F., Lenoir G., Holthuis J.C.
      J. Biol. Chem. 285:40562-40572(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH ATP8A1; ATP8B1; ATP8B2 AND ATP8B4.
    13. "Critical role of the beta-subunit CDC50A in the stable expression, assembly, subcellular localization, and lipid transport activity of the P4-ATPase ATP8A2."
      Coleman J.A., Molday R.S.
      J. Biol. Chem. 286:17205-17216(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ATP8A2.
    14. "ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner."
      Takatsu H., Baba K., Shima T., Umino H., Kato U., Umeda M., Nakayama K., Shin H.W.
      J. Biol. Chem. 286:38159-38167(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ATP11A; ATP11B AND ATP11C, SUBCELLULAR LOCATION.
    15. "Human TMEM30a promotes uptake of antitumor and bioactive choline phospholipids into mammalian cells."
      Chen R., Brady E., McIntyre T.M.
      J. Immunol. 186:3215-3225(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiCC50A_HUMAN
    AccessioniPrimary (citable) accession number: Q9NV96
    Secondary accession number(s): A8K9V8
    , E1P539, Q658Z3, Q96H09, Q9NSL9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

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