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Q9NV88

- INT9_HUMAN

UniProt

Q9NV88 - INT9_HUMAN

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Protein

Integrator complex subunit 9

Gene

INTS9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.

GO - Biological processi

  1. snRNA processing Source: HGNC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Integrator complex subunit 9
Short name:
Int9
Alternative name(s):
Protein related to CPSF subunits of 74 kDa
Short name:
RC-74
Gene namesi
Name:INTS9
Synonyms:RC74
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:25592. INTS9.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. integrator complex Source: HGNC
  3. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162392192.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 658658Integrator complex subunit 9PRO_0000259557Add
BLAST

Proteomic databases

MaxQBiQ9NV88.
PaxDbiQ9NV88.
PRIDEiQ9NV88.

PTM databases

PhosphoSiteiQ9NV88.

Expressioni

Gene expression databases

BgeeiQ9NV88.
CleanExiHS_INTS9.
ExpressionAtlasiQ9NV88. baseline and differential.
GenevestigatoriQ9NV88.

Organism-specific databases

HPAiHPA051615.

Interactioni

Subunit structurei

Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.1 Publication

Protein-protein interaction databases

BioGridi120874. 14 interactions.
IntActiQ9NV88. 1 interaction.
STRINGi9606.ENSP00000398208.

Structurei

3D structure databases

ProteinModelPortaliQ9NV88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1236.
GeneTreeiENSGT00390000001445.
HOGENOMiHOG000045359.
HOVERGENiHBG081802.
InParanoidiQ9NV88.
KOiK13146.
OMAiPLAMKCV.
OrthoDBiEOG7W41BH.
PhylomeDBiQ9NV88.
TreeFamiTF314100.

Family and domain databases

Gene3Di3.60.15.10. 3 hits.
InterProiIPR001279. Beta-lactamas-like.
IPR022712. Beta_Casp.
IPR027074. Integrator_9su.
[Graphical view]
PANTHERiPTHR11203:SF2. PTHR11203:SF2. 1 hit.
PfamiPF10996. Beta-Casp. 1 hit.
[Graphical view]
SMARTiSM01027. Beta-Casp. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 3 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NV88-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKLYCLSGHP TLPCNVLKFK STTIMLDCGL DMTSTLNFLP LPLVQSPRLS
60 70 80 90 100
NLPGWSLKDG NAFLDKELKE CSGHVFVDSV PEFCLPETEL IDLSTVDVIL
110 120 130 140 150
ISNYHCMMAL PYITEHTGFT GTVYATEPTV QIGRLLMEEL VNFIERVPKA
160 170 180 190 200
QSASLWKNKD IQRLLPSPLK DAVEVSTWRR CYTMQEVNSA LSKIQLVGYS
210 220 230 240 250
QKIELFGAVQ VTPLSSGYAL GSSNWIIQSH YEKVSYVSGS SLLTTHPQPM
260 270 280 290 300
DQASLKNSDV LVLTGLTQIP TANPDGMVGE FCSNLALTVR NGGNVLVPCY
310 320 330 340 350
PSGVIYDLLE CLYQYIDSAG LSSVPLYFIS PVANSSLEFS QIFAEWLCHN
360 370 380 390 400
KQSKVYLPEP PFPHAELIQT NKLKHYPSIH GDFSNDFRQP CVVFTGHPSL
410 420 430 440 450
RFGDVVHFME LWGKSSLNTV IFTEPDFSYL EALAPYQPLA MKCIYCPIDT
460 470 480 490 500
RLNFIQVSKL LKEVQPLHVV CPEQYTQPPP AQSHRMDLMI DCQPPAMSYR
510 520 530 540 550
RAEVLALPFK RRYEKIEIMP ELADSLVPME IKPGISLATV SAVLHTKDNK
560 570 580 590 600
HLLQPPPRPA QPTSGKKRKR VSDDVPDCKV LKPLLSGSIP VEQFVQTLEK
610 620 630 640 650
HGFSDIKVED TAKGHIVLLQ EAETLIQIEE DSTHIICDND EMLRVRLRDL

VLKFLQKF
Length:658
Mass (Da):73,814
Last modified:October 31, 2006 - v2
Checksum:i81F1A24B99704684
GO
Isoform 2 (identifier: Q9NV88-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-87: Missing.

Note: No experimental confirmation available.

Show »
Length:637
Mass (Da):71,468
Checksum:iDF93CBBDE1A6061E
GO
Isoform 3 (identifier: Q9NV88-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: Missing.

Show »
Length:634
Mass (Da):71,137
Checksum:i327CFB70D6AB0649
GO

Sequence cautioni

The sequence AAB67601.1 differs from that shown. Reason: Erroneous gene model prediction.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti324 – 3241V → A in BAA91867. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2424Missing in isoform 3. 1 PublicationVSP_044306Add
BLAST
Alternative sequencei67 – 8721Missing in isoform 2. 1 PublicationVSP_043011Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK001733 mRNA. Translation: BAA91867.1.
AK298468 mRNA. Translation: BAH12796.1.
AK300593 mRNA. Translation: BAH13311.1.
AC040975 Genomic DNA. No translation available.
AC131969 Genomic DNA. No translation available.
BC025267 mRNA. Translation: AAH25267.1.
U96629 Genomic DNA. Translation: AAB67601.1. Sequence problems.
BK005726 mRNA. Translation: DAA05726.1.
BK005674 mRNA. Translation: DAA05670.1.
CCDSiCCDS34873.1. [Q9NV88-1]
CCDS55215.1. [Q9NV88-3]
CCDS55216.1. [Q9NV88-2]
RefSeqiNP_001138631.1. NM_001145159.2. [Q9NV88-2]
NP_001166033.1. NM_001172562.1. [Q9NV88-3]
NP_060720.2. NM_018250.3. [Q9NV88-1]
UniGeneiHs.162397.

Genome annotation databases

EnsembliENST00000416984; ENSP00000398208; ENSG00000104299. [Q9NV88-2]
ENST00000521022; ENSP00000429065; ENSG00000104299. [Q9NV88-1]
ENST00000521777; ENSP00000430943; ENSG00000104299. [Q9NV88-3]
GeneIDi55756.
KEGGihsa:55756.
UCSCiuc003xha.3. human. [Q9NV88-1]
uc011law.2. human. [Q9NV88-2]

Polymorphism databases

DMDMi119371246.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK001733 mRNA. Translation: BAA91867.1 .
AK298468 mRNA. Translation: BAH12796.1 .
AK300593 mRNA. Translation: BAH13311.1 .
AC040975 Genomic DNA. No translation available.
AC131969 Genomic DNA. No translation available.
BC025267 mRNA. Translation: AAH25267.1 .
U96629 Genomic DNA. Translation: AAB67601.1 . Sequence problems.
BK005726 mRNA. Translation: DAA05726.1 .
BK005674 mRNA. Translation: DAA05670.1 .
CCDSi CCDS34873.1. [Q9NV88-1 ]
CCDS55215.1. [Q9NV88-3 ]
CCDS55216.1. [Q9NV88-2 ]
RefSeqi NP_001138631.1. NM_001145159.2. [Q9NV88-2 ]
NP_001166033.1. NM_001172562.1. [Q9NV88-3 ]
NP_060720.2. NM_018250.3. [Q9NV88-1 ]
UniGenei Hs.162397.

3D structure databases

ProteinModelPortali Q9NV88.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120874. 14 interactions.
IntActi Q9NV88. 1 interaction.
STRINGi 9606.ENSP00000398208.

PTM databases

PhosphoSitei Q9NV88.

Polymorphism databases

DMDMi 119371246.

Proteomic databases

MaxQBi Q9NV88.
PaxDbi Q9NV88.
PRIDEi Q9NV88.

Protocols and materials databases

DNASUi 55756.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000416984 ; ENSP00000398208 ; ENSG00000104299 . [Q9NV88-2 ]
ENST00000521022 ; ENSP00000429065 ; ENSG00000104299 . [Q9NV88-1 ]
ENST00000521777 ; ENSP00000430943 ; ENSG00000104299 . [Q9NV88-3 ]
GeneIDi 55756.
KEGGi hsa:55756.
UCSCi uc003xha.3. human. [Q9NV88-1 ]
uc011law.2. human. [Q9NV88-2 ]

Organism-specific databases

CTDi 55756.
GeneCardsi GC08M028625.
HGNCi HGNC:25592. INTS9.
HPAi HPA051615.
MIMi 611352. gene.
neXtProti NX_Q9NV88.
PharmGKBi PA162392192.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1236.
GeneTreei ENSGT00390000001445.
HOGENOMi HOG000045359.
HOVERGENi HBG081802.
InParanoidi Q9NV88.
KOi K13146.
OMAi PLAMKCV.
OrthoDBi EOG7W41BH.
PhylomeDBi Q9NV88.
TreeFami TF314100.

Miscellaneous databases

ChiTaRSi INTS9. human.
GeneWikii INTS9.
GenomeRNAii 55756.
NextBioi 60763.
PROi Q9NV88.
SOURCEi Search...

Gene expression databases

Bgeei Q9NV88.
CleanExi HS_INTS9.
ExpressionAtlasi Q9NV88. baseline and differential.
Genevestigatori Q9NV88.

Family and domain databases

Gene3Di 3.60.15.10. 3 hits.
InterProi IPR001279. Beta-lactamas-like.
IPR022712. Beta_Casp.
IPR027074. Integrator_9su.
[Graphical view ]
PANTHERi PTHR11203:SF2. PTHR11203:SF2. 1 hit.
Pfami PF10996. Beta-Casp. 1 hit.
[Graphical view ]
SMARTi SM01027. Beta-Casp. 1 hit.
[Graphical view ]
SUPFAMi SSF56281. SSF56281. 3 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
  2. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. "Human chromosome 8 BAC clone CIT987SK-2A8 complete sequence."
    Adams M.D.
    Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 163-658.
  5. "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II."
    Baillat D., Hakimi M.-A., Naeaer A.M., Shilatifard A., Cooch N., Shiekhattar R.
    Cell 123:265-276(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE INTEGRATOR COMPLEX.
  6. "A CPSF-73 homologue is required for cell cycle progression but not cell growth and interacts with a protein having features of CPSF-100."
    Dominski Z., Yang X.-C., Purdy M., Wagner E.J., Marzluff W.F.
    Mol. Cell. Biol. 25:1489-1500(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, SUBCELLULAR LOCATION, INTERACTION WITH CPSF3L.

Entry informationi

Entry nameiINT9_HUMAN
AccessioniPrimary (citable) accession number: Q9NV88
Secondary accession number(s): B7Z560
, B7Z6M5, O00224, Q8TB16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: October 29, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Although strongly related to RNA-specific endonuclease proteins, it lacks the HXHXDH motif that binds zinc and participates in the catalytic center. Its function as endonuclease is therefore unsure.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3