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Q9NV79

- PCMD2_HUMAN

UniProt

Q9NV79 - PCMD2_HUMAN

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Protein

Protein-L-isoaspartate O-methyltransferase domain-containing protein 2

Gene
PCMTD2, C20orf36
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei64 – 641 By similarity

GO - Molecular functioni

  1. protein-L-isoaspartate (D-aspartate) O-methyltransferase activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-L-isoaspartate O-methyltransferase domain-containing protein 2
Gene namesi
Name:PCMTD2
Synonyms:C20orf36
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:15882. PCMTD2.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25750.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed Reviewed prediction
Chaini2 – 361360Protein-L-isoaspartate O-methyltransferase domain-containing protein 2PRO_0000111927Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine Reviewed prediction

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

MaxQBiQ9NV79.
PaxDbiQ9NV79.
PRIDEiQ9NV79.

PTM databases

PhosphoSiteiQ9NV79.

Expressioni

Gene expression databases

ArrayExpressiQ9NV79.
BgeeiQ9NV79.
CleanExiHS_PCMTD2.
GenevestigatoriQ9NV79.

Organism-specific databases

HPAiHPA057849.

Interactioni

Protein-protein interaction databases

BioGridi120542. 7 interactions.
IntActiQ9NV79. 2 interactions.
MINTiMINT-8330024.
STRINGi9606.ENSP00000307854.

Structurei

3D structure databases

ProteinModelPortaliQ9NV79.
SMRiQ9NV79. Positions 9-220.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi279 – 2868Poly-Arg

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2518.
HOGENOMiHOG000038039.
HOVERGENiHBG013478.
InParanoidiQ9NV79.
OMAiLAHNIRI.
OrthoDBiEOG7J9VQJ.
PhylomeDBiQ9NV79.
TreeFamiTF329329.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR000682. PCMT.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR11579. PTHR11579. 1 hit.
PfamiPF01135. PCMT. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NV79-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGGAVSAGED NDELIDNLKE AQYIRTELVE QAFRAIDRAD YYLEEFKENA    50
YKDLAWKHGN IHLSAPCIYS EVMEALDLQP GLSFLNLGSG TGYLSSMVGL 100
ILGPFGVNHG VELHSDVIEY AKQKLDFFIR TSDSFDKFDF CEPSFVTGNC 150
LEISPDCSQY DRVYCGAGVQ KEHEEYMKNL LKVGGILVMP LEEKLTKITR 200
TGPSAWETKK ILAVSFAPLI QPCHSESGKS RLVQLPPVAV RSLQDLARIA 250
IRGTIKKIIH QETVSKNGNG LKNTPRFKRR RVRRRRMETI VFLDKEVFAS 300
RISNPSDDNS CEDLEEERRE EEEKTPPETK PDPPVNFLRQ KVLSLPLPDP 350
LKYYLLYYRE K 361
Length:361
Mass (Da):41,072
Last modified:October 10, 2003 - v2
Checksum:iCC239150135E0A1B
GO
Isoform 2 (identifier: Q9NV79-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     195-221: Missing.

Note: No experimental confirmation available.

Show »
Length:334
Mass (Da):38,119
Checksum:i22C856548611940C
GO
Isoform 3 (identifier: Q9NV79-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-224: Missing.
     225-236: SESGKSRLVQLP → MLRFCAGLSDFA

Note: No experimental confirmation available.

Show »
Length:137
Mass (Da):16,089
Checksum:i7897444B539D1764
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 224224Missing in isoform 3. VSP_008546Add
BLAST
Alternative sequencei195 – 22127Missing in isoform 2. VSP_008547Add
BLAST
Alternative sequencei225 – 23612SESGK…LVQLP → MLRFCAGLSDFA in isoform 3. VSP_008548Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121D → E in BAA91877. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK001745 mRNA. Translation: BAA91877.1.
AK126700 mRNA. Translation: BAC86648.1.
AL121581 Genomic DNA. Translation: CAC17006.1.
CH471077 Genomic DNA. Translation: EAW75152.1.
CH471077 Genomic DNA. Translation: EAW75153.1.
BC033665 mRNA. Translation: AAH33665.1.
BC040945 mRNA. Translation: AAH40945.1.
CCDSiCCDS13559.1. [Q9NV79-1]
CCDS46631.1. [Q9NV79-2]
RefSeqiNP_001098395.1. NM_001104925.1. [Q9NV79-2]
NP_060727.2. NM_018257.2. [Q9NV79-1]
UniGeneiHs.744845.

Genome annotation databases

EnsembliENST00000308824; ENSP00000307854; ENSG00000203880. [Q9NV79-1]
ENST00000369758; ENSP00000358773; ENSG00000203880. [Q9NV79-2]
GeneIDi55251.
KEGGihsa:55251.
UCSCiuc002yil.4. human. [Q9NV79-1]
uc002yim.4. human. [Q9NV79-2]

Polymorphism databases

DMDMi41688812.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK001745 mRNA. Translation: BAA91877.1 .
AK126700 mRNA. Translation: BAC86648.1 .
AL121581 Genomic DNA. Translation: CAC17006.1 .
CH471077 Genomic DNA. Translation: EAW75152.1 .
CH471077 Genomic DNA. Translation: EAW75153.1 .
BC033665 mRNA. Translation: AAH33665.1 .
BC040945 mRNA. Translation: AAH40945.1 .
CCDSi CCDS13559.1. [Q9NV79-1 ]
CCDS46631.1. [Q9NV79-2 ]
RefSeqi NP_001098395.1. NM_001104925.1. [Q9NV79-2 ]
NP_060727.2. NM_018257.2. [Q9NV79-1 ]
UniGenei Hs.744845.

3D structure databases

ProteinModelPortali Q9NV79.
SMRi Q9NV79. Positions 9-220.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120542. 7 interactions.
IntActi Q9NV79. 2 interactions.
MINTi MINT-8330024.
STRINGi 9606.ENSP00000307854.

PTM databases

PhosphoSitei Q9NV79.

Polymorphism databases

DMDMi 41688812.

Proteomic databases

MaxQBi Q9NV79.
PaxDbi Q9NV79.
PRIDEi Q9NV79.

Protocols and materials databases

DNASUi 55251.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000308824 ; ENSP00000307854 ; ENSG00000203880 . [Q9NV79-1 ]
ENST00000369758 ; ENSP00000358773 ; ENSG00000203880 . [Q9NV79-2 ]
GeneIDi 55251.
KEGGi hsa:55251.
UCSCi uc002yil.4. human. [Q9NV79-1 ]
uc002yim.4. human. [Q9NV79-2 ]

Organism-specific databases

CTDi 55251.
GeneCardsi GC20P062887.
HGNCi HGNC:15882. PCMTD2.
HPAi HPA057849.
neXtProti NX_Q9NV79.
PharmGKBi PA25750.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2518.
HOGENOMi HOG000038039.
HOVERGENi HBG013478.
InParanoidi Q9NV79.
OMAi LAHNIRI.
OrthoDBi EOG7J9VQJ.
PhylomeDBi Q9NV79.
TreeFami TF329329.

Miscellaneous databases

GenomeRNAii 55251.
NextBioi 59314.
PROi Q9NV79.

Gene expression databases

ArrayExpressi Q9NV79.
Bgeei Q9NV79.
CleanExi HS_PCMTD2.
Genevestigatori Q9NV79.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR000682. PCMT.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR11579. PTHR11579. 1 hit.
Pfami PF01135. PCMT. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Placenta.

Entry informationi

Entry nameiPCMD2_HUMAN
AccessioniPrimary (citable) accession number: Q9NV79
Secondary accession number(s): E1P5H3, Q8IW60, Q9H4K2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: July 9, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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