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Q9NV79

- PCMD2_HUMAN

UniProt

Q9NV79 - PCMD2_HUMAN

Protein

Protein-L-isoaspartate O-methyltransferase domain-containing protein 2

Gene

PCMTD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (10 Oct 2003)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei64 – 641By similarity

    GO - Molecular functioni

    1. protein-L-isoaspartate (D-aspartate) O-methyltransferase activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein-L-isoaspartate O-methyltransferase domain-containing protein 2
    Gene namesi
    Name:PCMTD2
    Synonyms:C20orf36
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:15882. PCMTD2.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25750.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedSequence Analysis
    Chaini2 – 361360Protein-L-isoaspartate O-methyltransferase domain-containing protein 2PRO_0000111927Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycineSequence Analysis

    Keywords - PTMi

    Lipoprotein, Myristate

    Proteomic databases

    MaxQBiQ9NV79.
    PaxDbiQ9NV79.
    PRIDEiQ9NV79.

    PTM databases

    PhosphoSiteiQ9NV79.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NV79.
    BgeeiQ9NV79.
    CleanExiHS_PCMTD2.
    GenevestigatoriQ9NV79.

    Organism-specific databases

    HPAiHPA057849.

    Interactioni

    Protein-protein interaction databases

    BioGridi120542. 7 interactions.
    IntActiQ9NV79. 2 interactions.
    MINTiMINT-8330024.
    STRINGi9606.ENSP00000307854.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NV79.
    SMRiQ9NV79. Positions 9-220.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi279 – 2868Poly-Arg

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2518.
    HOGENOMiHOG000038039.
    HOVERGENiHBG013478.
    InParanoidiQ9NV79.
    OMAiLAHNIRI.
    OrthoDBiEOG7J9VQJ.
    PhylomeDBiQ9NV79.
    TreeFamiTF329329.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR000682. PCMT.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PANTHERiPTHR11579. PTHR11579. 1 hit.
    PfamiPF01135. PCMT. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NV79-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGGAVSAGED NDELIDNLKE AQYIRTELVE QAFRAIDRAD YYLEEFKENA    50
    YKDLAWKHGN IHLSAPCIYS EVMEALDLQP GLSFLNLGSG TGYLSSMVGL 100
    ILGPFGVNHG VELHSDVIEY AKQKLDFFIR TSDSFDKFDF CEPSFVTGNC 150
    LEISPDCSQY DRVYCGAGVQ KEHEEYMKNL LKVGGILVMP LEEKLTKITR 200
    TGPSAWETKK ILAVSFAPLI QPCHSESGKS RLVQLPPVAV RSLQDLARIA 250
    IRGTIKKIIH QETVSKNGNG LKNTPRFKRR RVRRRRMETI VFLDKEVFAS 300
    RISNPSDDNS CEDLEEERRE EEEKTPPETK PDPPVNFLRQ KVLSLPLPDP 350
    LKYYLLYYRE K 361
    Length:361
    Mass (Da):41,072
    Last modified:October 10, 2003 - v2
    Checksum:iCC239150135E0A1B
    GO
    Isoform 2 (identifier: Q9NV79-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         195-221: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:334
    Mass (Da):38,119
    Checksum:i22C856548611940C
    GO
    Isoform 3 (identifier: Q9NV79-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-224: Missing.
         225-236: SESGKSRLVQLP → MLRFCAGLSDFA

    Note: No experimental confirmation available.

    Show »
    Length:137
    Mass (Da):16,089
    Checksum:i7897444B539D1764
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti12 – 121D → E in BAA91877. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 224224Missing in isoform 3. 1 PublicationVSP_008546Add
    BLAST
    Alternative sequencei195 – 22127Missing in isoform 2. 1 PublicationVSP_008547Add
    BLAST
    Alternative sequencei225 – 23612SESGK…LVQLP → MLRFCAGLSDFA in isoform 3. 1 PublicationVSP_008548Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001745 mRNA. Translation: BAA91877.1.
    AK126700 mRNA. Translation: BAC86648.1.
    AL121581 Genomic DNA. Translation: CAC17006.1.
    CH471077 Genomic DNA. Translation: EAW75152.1.
    CH471077 Genomic DNA. Translation: EAW75153.1.
    BC033665 mRNA. Translation: AAH33665.1.
    BC040945 mRNA. Translation: AAH40945.1.
    CCDSiCCDS13559.1. [Q9NV79-1]
    CCDS46631.1. [Q9NV79-2]
    RefSeqiNP_001098395.1. NM_001104925.1. [Q9NV79-2]
    NP_060727.2. NM_018257.2. [Q9NV79-1]
    UniGeneiHs.744845.

    Genome annotation databases

    EnsembliENST00000308824; ENSP00000307854; ENSG00000203880. [Q9NV79-1]
    ENST00000369758; ENSP00000358773; ENSG00000203880. [Q9NV79-2]
    GeneIDi55251.
    KEGGihsa:55251.
    UCSCiuc002yil.4. human. [Q9NV79-1]
    uc002yim.4. human. [Q9NV79-2]

    Polymorphism databases

    DMDMi41688812.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001745 mRNA. Translation: BAA91877.1 .
    AK126700 mRNA. Translation: BAC86648.1 .
    AL121581 Genomic DNA. Translation: CAC17006.1 .
    CH471077 Genomic DNA. Translation: EAW75152.1 .
    CH471077 Genomic DNA. Translation: EAW75153.1 .
    BC033665 mRNA. Translation: AAH33665.1 .
    BC040945 mRNA. Translation: AAH40945.1 .
    CCDSi CCDS13559.1. [Q9NV79-1 ]
    CCDS46631.1. [Q9NV79-2 ]
    RefSeqi NP_001098395.1. NM_001104925.1. [Q9NV79-2 ]
    NP_060727.2. NM_018257.2. [Q9NV79-1 ]
    UniGenei Hs.744845.

    3D structure databases

    ProteinModelPortali Q9NV79.
    SMRi Q9NV79. Positions 9-220.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120542. 7 interactions.
    IntActi Q9NV79. 2 interactions.
    MINTi MINT-8330024.
    STRINGi 9606.ENSP00000307854.

    PTM databases

    PhosphoSitei Q9NV79.

    Polymorphism databases

    DMDMi 41688812.

    Proteomic databases

    MaxQBi Q9NV79.
    PaxDbi Q9NV79.
    PRIDEi Q9NV79.

    Protocols and materials databases

    DNASUi 55251.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000308824 ; ENSP00000307854 ; ENSG00000203880 . [Q9NV79-1 ]
    ENST00000369758 ; ENSP00000358773 ; ENSG00000203880 . [Q9NV79-2 ]
    GeneIDi 55251.
    KEGGi hsa:55251.
    UCSCi uc002yil.4. human. [Q9NV79-1 ]
    uc002yim.4. human. [Q9NV79-2 ]

    Organism-specific databases

    CTDi 55251.
    GeneCardsi GC20P062887.
    HGNCi HGNC:15882. PCMTD2.
    HPAi HPA057849.
    neXtProti NX_Q9NV79.
    PharmGKBi PA25750.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2518.
    HOGENOMi HOG000038039.
    HOVERGENi HBG013478.
    InParanoidi Q9NV79.
    OMAi LAHNIRI.
    OrthoDBi EOG7J9VQJ.
    PhylomeDBi Q9NV79.
    TreeFami TF329329.

    Miscellaneous databases

    GenomeRNAii 55251.
    NextBioi 59314.
    PROi Q9NV79.

    Gene expression databases

    ArrayExpressi Q9NV79.
    Bgeei Q9NV79.
    CleanExi HS_PCMTD2.
    Genevestigatori Q9NV79.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR000682. PCMT.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PANTHERi PTHR11579. PTHR11579. 1 hit.
    Pfami PF01135. PCMT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    2. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain and Placenta.

    Entry informationi

    Entry nameiPCMD2_HUMAN
    AccessioniPrimary (citable) accession number: Q9NV79
    Secondary accession number(s): E1P5H3, Q8IW60, Q9H4K2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 10, 2003
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3