Q9NV79 (PCMD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein-L-isoaspartate O-methyltransferase domain-containing protein 2

Gene names

Name:	PCMTD2
Synonyms:	C20orf36

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
PTM	Lipoprotein Myristate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NV79-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NV79-2)

The sequence of this isoform differs from the canonical sequence as follows:
     195-221: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9NV79-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-224: Missing.
     225-236: SESGKSRLVQLP → MLRFCAGLSDFA

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Potential
	Chain	2 – 361	360	Protein-L-isoaspartate O-methyltransferase domain-containing protein 2		PRO_0000111927
Regions
	Compositional bias	279 – 286	8	Poly-Arg
Sites
	Active site	64	1	By similarity
Amino acid modifications
	Lipidation	2	1	N-myristoyl glycine Potential
Natural variations
	Alternative sequence	1 – 224	224	Missing in isoform 3.		VSP_008546
	Alternative sequence	195 – 221	27	Missing in isoform 2.		VSP_008547
	Alternative sequence	225 – 236	12	SESGK…LVQLP → MLRFCAGLSDFA in isoform 3.		VSP_008548
Experimental info
	Sequence conflict	12	1	D → E in BAA91877. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 10, 2003. Version 2. Checksum: CC239150135E0A1B	FASTA	361	41,072
	10 20 30 40 50 60 MGGAVSAGED NDELIDNLKE AQYIRTELVE QAFRAIDRAD YYLEEFKENA YKDLAWKHGN 70 80 90 100 110 120 IHLSAPCIYS EVMEALDLQP GLSFLNLGSG TGYLSSMVGL ILGPFGVNHG VELHSDVIEY 130 140 150 160 170 180 AKQKLDFFIR TSDSFDKFDF CEPSFVTGNC LEISPDCSQY DRVYCGAGVQ KEHEEYMKNL 190 200 210 220 230 240 LKVGGILVMP LEEKLTKITR TGPSAWETKK ILAVSFAPLI QPCHSESGKS RLVQLPPVAV 250 260 270 280 290 300 RSLQDLARIA IRGTIKKIIH QETVSKNGNG LKNTPRFKRR RVRRRRMETI VFLDKEVFAS 310 320 330 340 350 360 RISNPSDDNS CEDLEEERRE EEEKTPPETK PDPPVNFLRQ KVLSLPLPDP LKYYLLYYRE K
	Isoform 2 [UniParc]. Checksum: 22C856548611940C	FASTA	334	38,119
	10 20 30 40 50 60 MGGAVSAGED NDELIDNLKE AQYIRTELVE QAFRAIDRAD YYLEEFKENA YKDLAWKHGN 70 80 90 100 110 120 IHLSAPCIYS EVMEALDLQP GLSFLNLGSG TGYLSSMVGL ILGPFGVNHG VELHSDVIEY 130 140 150 160 170 180 AKQKLDFFIR TSDSFDKFDF CEPSFVTGNC LEISPDCSQY DRVYCGAGVQ KEHEEYMKNL 190 200 210 220 230 240 LKVGGILVMP LEEKPCHSES GKSRLVQLPP VAVRSLQDLA RIAIRGTIKK IIHQETVSKN 250 260 270 280 290 300 GNGLKNTPRF KRRRVRRRRM ETIVFLDKEV FASRISNPSD DNSCEDLEEE RREEEEKTPP 310 320 330 ETKPDPPVNF LRQKVLSLPL PDPLKYYLLY YREK
	Isoform 3 [UniParc]. Checksum: 7897444B539D1764	FASTA	137	16,089
	10 20 30 40 50 60 MLRFCAGLSD FAPVAVRSLQ DLARIAIRGT IKKIIHQETV SKNGNGLKNT PRFKRRRVRR 70 80 90 100 110 120 RRMETIVFLD KEVFASRISN PSDDNSCEDL EEERREEEEK TPPETKPDPP VNFLRQKVLS 130 LPLPDPLKYY LLYYREK

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
[2]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain and Placenta.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK001745 mRNA. Translation: BAA91877.1. AK126700 mRNA. Translation: BAC86648.1. AL121581 Genomic DNA. Translation: CAC17006.1. CH471077 Genomic DNA. Translation: EAW75152.1. CH471077 Genomic DNA. Translation: EAW75153.1. BC033665 mRNA. Translation: AAH33665.1. BC040945 mRNA. Translation: AAH40945.1.
IPI	IPI00217155. IPI00374720. IPI00884185.
RefSeq	NP_001098395.1. NM_001104925.1. NP_060727.2. NM_018257.2.
UniGene	Hs.741158.
3D structure databases
ProteinModelPortal	Q9NV79.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9NV79. 1 interaction.
STRING	9606.ENSP00000307854.
PTM databases
PhosphoSite	Q9NV79.
Polymorphism databases
DMDM	41688812.
Proteomic databases
PaxDb	Q9NV79.
PRIDE	Q9NV79.
Protocols and materials databases
DNASU	55251.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000266078; ENSP00000266078; ENSG00000203880. ENST00000308824; ENSP00000307854; ENSG00000203880. ENST00000369758; ENSP00000358773; ENSG00000203880.
GeneID	55251.
KEGG	hsa:55251.
UCSC	uc002yil.4. human. uc002yim.4. human.
Organism-specific databases
CTD	55251.
GeneCards	GC20P062887.
HGNC	HGNC:15882. PCMTD2.
neXtProt	NX_Q9NV79.
PharmGKB	PA25750.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2518.
HOGENOM	HOG000038039.
HOVERGEN	HBG013478.
InParanoid	Q9NV79.
OrthoDB	EOG40GCRC.
Gene expression databases
ArrayExpress	Q9NV79.
Bgee	Q9NV79.
CleanEx	HS_PCMTD2.
Genevestigator	Q9NV79.
GermOnline	ENSG00000203880. Homo sapiens.
Family and domain databases
InterPro	IPR000682. PCMT. [Graphical view]
PANTHER	PTHR11579. PTHR11579. 1 hit.
Pfam	PF01135. PCMT. 1 hit. [Graphical view]
PROSITE	PS01279. PCMT. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	55251.
NextBio	59314.

Entry information

Entry name

PCMD2_HUMAN

Accession

Primary (citable) accession number: Q9NV79
Secondary accession number(s): E1P5H3, Q8IW60, Q9H4K2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	October 10, 2003
Last modified:	May 1, 2013
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.