Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein-L-isoaspartate O-methyltransferase domain-containing protein 2

Gene

PCMTD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei64 – 641By similarity

GO - Molecular functioni

  1. protein-L-isoaspartate (D-aspartate) O-methyltransferase activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-L-isoaspartate O-methyltransferase domain-containing protein 2
Gene namesi
Name:PCMTD2
Synonyms:C20orf36
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20, UP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:15882. PCMTD2.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25750.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedSequence Analysis
Chaini2 – 361360Protein-L-isoaspartate O-methyltransferase domain-containing protein 2PRO_0000111927Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineSequence Analysis

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

MaxQBiQ9NV79.
PaxDbiQ9NV79.
PRIDEiQ9NV79.

PTM databases

PhosphoSiteiQ9NV79.

Expressioni

Gene expression databases

BgeeiQ9NV79.
CleanExiHS_PCMTD2.
ExpressionAtlasiQ9NV79. baseline and differential.
GenevestigatoriQ9NV79.

Organism-specific databases

HPAiHPA057849.

Interactioni

Protein-protein interaction databases

BioGridi120542. 11 interactions.
IntActiQ9NV79. 2 interactions.
MINTiMINT-8330024.
STRINGi9606.ENSP00000307854.

Structurei

3D structure databases

ProteinModelPortaliQ9NV79.
SMRiQ9NV79. Positions 9-220.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi279 – 2868Poly-Arg

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2518.
GeneTreeiENSGT00510000046651.
HOGENOMiHOG000038039.
HOVERGENiHBG013478.
InParanoidiQ9NV79.
OrthoDBiEOG7J9VQJ.
PhylomeDBiQ9NV79.
TreeFamiTF329329.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR000682. PCMT.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11579. PTHR11579. 1 hit.
PfamiPF01135. PCMT. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NV79-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGGAVSAGED NDELIDNLKE AQYIRTELVE QAFRAIDRAD YYLEEFKENA
60 70 80 90 100
YKDLAWKHGN IHLSAPCIYS EVMEALDLQP GLSFLNLGSG TGYLSSMVGL
110 120 130 140 150
ILGPFGVNHG VELHSDVIEY AKQKLDFFIR TSDSFDKFDF CEPSFVTGNC
160 170 180 190 200
LEISPDCSQY DRVYCGAGVQ KEHEEYMKNL LKVGGILVMP LEEKLTKITR
210 220 230 240 250
TGPSAWETKK ILAVSFAPLI QPCHSESGKS RLVQLPPVAV RSLQDLARIA
260 270 280 290 300
IRGTIKKIIH QETVSKNGNG LKNTPRFKRR RVRRRRMETI VFLDKEVFAS
310 320 330 340 350
RISNPSDDNS CEDLEEERRE EEEKTPPETK PDPPVNFLRQ KVLSLPLPDP
360
LKYYLLYYRE K
Length:361
Mass (Da):41,072
Last modified:October 10, 2003 - v2
Checksum:iCC239150135E0A1B
GO
Isoform 2 (identifier: Q9NV79-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     195-221: Missing.

Note: No experimental confirmation available.

Show »
Length:334
Mass (Da):38,119
Checksum:i22C856548611940C
GO
Isoform 3 (identifier: Q9NV79-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-224: Missing.
     225-236: SESGKSRLVQLP → MLRFCAGLSDFA

Note: No experimental confirmation available.

Show »
Length:137
Mass (Da):16,089
Checksum:i7897444B539D1764
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121D → E in BAA91877. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 224224Missing in isoform 3. 1 PublicationVSP_008546Add
BLAST
Alternative sequencei195 – 22127Missing in isoform 2. 1 PublicationVSP_008547Add
BLAST
Alternative sequencei225 – 23612SESGK…LVQLP → MLRFCAGLSDFA in isoform 3. 1 PublicationVSP_008548Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001745 mRNA. Translation: BAA91877.1.
AK126700 mRNA. Translation: BAC86648.1.
AL121581 Genomic DNA. Translation: CAC17006.1.
CH471077 Genomic DNA. Translation: EAW75152.1.
CH471077 Genomic DNA. Translation: EAW75153.1.
BC033665 mRNA. Translation: AAH33665.1.
BC040945 mRNA. Translation: AAH40945.1.
CCDSiCCDS13559.1. [Q9NV79-1]
CCDS46631.1. [Q9NV79-2]
RefSeqiNP_001098395.1. NM_001104925.1. [Q9NV79-2]
NP_060727.2. NM_018257.2. [Q9NV79-1]
UniGeneiHs.744845.

Genome annotation databases

EnsembliENST00000308824; ENSP00000307854; ENSG00000203880. [Q9NV79-1]
ENST00000369758; ENSP00000358773; ENSG00000203880. [Q9NV79-2]
ENST00000615818; ENSP00000482166; ENSG00000275018. [Q9NV79-1]
GeneIDi55251.
KEGGihsa:55251.
UCSCiuc002yil.4. human. [Q9NV79-1]
uc002yim.4. human. [Q9NV79-2]

Polymorphism databases

DMDMi41688812.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001745 mRNA. Translation: BAA91877.1.
AK126700 mRNA. Translation: BAC86648.1.
AL121581 Genomic DNA. Translation: CAC17006.1.
CH471077 Genomic DNA. Translation: EAW75152.1.
CH471077 Genomic DNA. Translation: EAW75153.1.
BC033665 mRNA. Translation: AAH33665.1.
BC040945 mRNA. Translation: AAH40945.1.
CCDSiCCDS13559.1. [Q9NV79-1]
CCDS46631.1. [Q9NV79-2]
RefSeqiNP_001098395.1. NM_001104925.1. [Q9NV79-2]
NP_060727.2. NM_018257.2. [Q9NV79-1]
UniGeneiHs.744845.

3D structure databases

ProteinModelPortaliQ9NV79.
SMRiQ9NV79. Positions 9-220.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120542. 11 interactions.
IntActiQ9NV79. 2 interactions.
MINTiMINT-8330024.
STRINGi9606.ENSP00000307854.

PTM databases

PhosphoSiteiQ9NV79.

Polymorphism databases

DMDMi41688812.

Proteomic databases

MaxQBiQ9NV79.
PaxDbiQ9NV79.
PRIDEiQ9NV79.

Protocols and materials databases

DNASUi55251.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308824; ENSP00000307854; ENSG00000203880. [Q9NV79-1]
ENST00000369758; ENSP00000358773; ENSG00000203880. [Q9NV79-2]
ENST00000615818; ENSP00000482166; ENSG00000275018. [Q9NV79-1]
GeneIDi55251.
KEGGihsa:55251.
UCSCiuc002yil.4. human. [Q9NV79-1]
uc002yim.4. human. [Q9NV79-2]

Organism-specific databases

CTDi55251.
GeneCardsiGC20P062887.
HGNCiHGNC:15882. PCMTD2.
HPAiHPA057849.
neXtProtiNX_Q9NV79.
PharmGKBiPA25750.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG2518.
GeneTreeiENSGT00510000046651.
HOGENOMiHOG000038039.
HOVERGENiHBG013478.
InParanoidiQ9NV79.
OrthoDBiEOG7J9VQJ.
PhylomeDBiQ9NV79.
TreeFamiTF329329.

Miscellaneous databases

GenomeRNAii55251.
NextBioi59314.
PROiQ9NV79.

Gene expression databases

BgeeiQ9NV79.
CleanExiHS_PCMTD2.
ExpressionAtlasiQ9NV79. baseline and differential.
GenevestigatoriQ9NV79.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR000682. PCMT.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11579. PTHR11579. 1 hit.
PfamiPF01135. PCMT. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Placenta.

Entry informationi

Entry nameiPCMD2_HUMAN
AccessioniPrimary (citable) accession number: Q9NV79
Secondary accession number(s): E1P5H3, Q8IW60, Q9H4K2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: February 4, 2015
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.