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Protein

Zinc finger protein 701

Gene

ZNF701

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri281 – 30323C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri309 – 33022C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri336 – 35823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri364 – 38623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri392 – 41423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri420 – 44223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri448 – 47023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri476 – 49823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri504 – 52623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 701
Gene namesi
Name:ZNF701
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25597. ZNF701.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670498.

Polymorphism and mutation databases

BioMutaiZNF701.
DMDMi296453055.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 531531Zinc finger protein 701PRO_0000233281Add
BLAST

Proteomic databases

EPDiQ9NV72.
MaxQBiQ9NV72.
PaxDbiQ9NV72.
PRIDEiQ9NV72.
TopDownProteomicsiQ9NV72-2. [Q9NV72-2]

PTM databases

iPTMnetiQ9NV72.
PhosphoSiteiQ9NV72.

Expressioni

Gene expression databases

BgeeiQ9NV72.
CleanExiHS_ZNF701.
ExpressionAtlasiQ9NV72. baseline and differential.
GenevisibleiQ9NV72. HS.

Organism-specific databases

HPAiHPA005532.

Interactioni

Protein-protein interaction databases

BioGridi120880. 2 interactions.
STRINGi9606.ENSP00000301093.

Structurei

3D structure databases

ProteinModelPortaliQ9NV72.
SMRiQ9NV72. Positions 232-531.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini74 – 14673KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 9 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri281 – 30323C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri309 – 33022C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri336 – 35823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri364 – 38623C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri392 – 41423C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri420 – 44223C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri448 – 47023C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri476 – 49823C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri504 – 52623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00690000102079.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9NV72.
KOiK09228.
OMAiTCFQEIE.
PhylomeDBiQ9NV72.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NV72-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGFLHVGQDG LELPTSGDPP ASASQSAGIT GVSHRTQPPC FEGLTSKDLV
60 70 80 90 100
REEKTRKRKR KAKESGMALL QGLLTFRDVA IEFSQEEWKC LDPAQRTLYR
110 120 130 140 150
DVMLENYRNL VSLDTSSKCM MKMFSSTGQG NTEVVHTGTL QIHASHHIGD
160 170 180 190 200
TCFQEIEKDI HDFVFQWQEN ETNGHEALMT KTKKLMSSTE RHDQRHAGNK
210 220 230 240 250
PIKNELGSSF HSHLPEVHIF HPEGKIGNQV EKAINDAFSV SASQRISCRP
260 270 280 290 300
KTRISNKYRN NFLQSSLLTQ KREVHTREKS FQRNESGKAF NGSSLLKKHQ
310 320 330 340 350
IIHLGDKQYK CDVCGKDFHQ KRYLACHRCH TGENPYTCNE CGKTFSHNSA
360 370 380 390 400
LLVHKAIHTG EKPYKCNECG KVFNQQSNLA RHHRVHTGEK PYKCEECDKV
410 420 430 440 450
FSRKSHLERH RRIHTGEKPY KCKVCDKAFR RDSHLAQHTV IHTGEKPYKC
460 470 480 490 500
NECGKTFVQN SSLVMHKVIH TGEKRYKCNE CGKVFNHKSN LACHRRLHTG
510 520 530
EKPYKCNECG KVFNRKSNLE RHHRLHTGKK S
Length:531
Mass (Da):60,903
Last modified:October 1, 2014 - v3
Checksum:i0C93D18DC4B2BEBE
GO
Isoform 2 (identifier: Q9NV72-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-66: Missing.

Note: No experimental confirmation available.
Show »
Length:465
Mass (Da):53,857
Checksum:i1D021303772C87E5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti70 – 701L → P.2 Publications
Corresponds to variant rs162832 [ dbSNP | Ensembl ].
VAR_033592
Natural varianti182 – 1821T → I.2 Publications
Corresponds to variant rs366793 [ dbSNP | Ensembl ].
VAR_033593
Natural varianti185 – 1851L → V.
Corresponds to variant rs12462687 [ dbSNP | Ensembl ].
VAR_060432
Natural varianti306 – 3061D → E.
Corresponds to variant rs427127 [ dbSNP | Ensembl ].
VAR_061964
Natural varianti337 – 3371T → K.2 Publications
Corresponds to variant rs373554 [ dbSNP | Ensembl ].
VAR_052898
Natural varianti495 – 4951R → H.1 Publication
Corresponds to variant rs67702454 [ dbSNP | Ensembl ].
VAR_060433
Natural varianti521 – 5211R → C.
Corresponds to variant rs444172 [ dbSNP | Ensembl ].
VAR_033594

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6666Missing in isoform 2. 2 PublicationsVSP_055969Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001753 mRNA. Translation: BAA91884.1.
AC022150 Genomic DNA. No translation available.
BC080612 mRNA. Translation: AAH80612.2.
BC131719 mRNA. Translation: AAI31720.1.
BC136425 mRNA. Translation: AAI36426.1.
BC136426 mRNA. Translation: AAI36427.1.
CCDSiCCDS33092.1. [Q9NV72-2]
CCDS54311.1. [Q9NV72-1]
RefSeqiNP_001166126.1. NM_001172655.1. [Q9NV72-1]
NP_060730.2. NM_018260.2. [Q9NV72-2]
XP_011525394.1. XM_011527092.1. [Q9NV72-1]
UniGeneiHs.235167.

Genome annotation databases

EnsembliENST00000301093; ENSP00000301093; ENSG00000167562. [Q9NV72-1]
ENST00000391785; ENSP00000375662; ENSG00000167562. [Q9NV72-2]
ENST00000540331; ENSP00000444339; ENSG00000167562. [Q9NV72-1]
GeneIDi55762.
KEGGihsa:55762.
UCSCiuc002pzs.3. human. [Q9NV72-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001753 mRNA. Translation: BAA91884.1.
AC022150 Genomic DNA. No translation available.
BC080612 mRNA. Translation: AAH80612.2.
BC131719 mRNA. Translation: AAI31720.1.
BC136425 mRNA. Translation: AAI36426.1.
BC136426 mRNA. Translation: AAI36427.1.
CCDSiCCDS33092.1. [Q9NV72-2]
CCDS54311.1. [Q9NV72-1]
RefSeqiNP_001166126.1. NM_001172655.1. [Q9NV72-1]
NP_060730.2. NM_018260.2. [Q9NV72-2]
XP_011525394.1. XM_011527092.1. [Q9NV72-1]
UniGeneiHs.235167.

3D structure databases

ProteinModelPortaliQ9NV72.
SMRiQ9NV72. Positions 232-531.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120880. 2 interactions.
STRINGi9606.ENSP00000301093.

PTM databases

iPTMnetiQ9NV72.
PhosphoSiteiQ9NV72.

Polymorphism and mutation databases

BioMutaiZNF701.
DMDMi296453055.

Proteomic databases

EPDiQ9NV72.
MaxQBiQ9NV72.
PaxDbiQ9NV72.
PRIDEiQ9NV72.
TopDownProteomicsiQ9NV72-2. [Q9NV72-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301093; ENSP00000301093; ENSG00000167562. [Q9NV72-1]
ENST00000391785; ENSP00000375662; ENSG00000167562. [Q9NV72-2]
ENST00000540331; ENSP00000444339; ENSG00000167562. [Q9NV72-1]
GeneIDi55762.
KEGGihsa:55762.
UCSCiuc002pzs.3. human. [Q9NV72-1]

Organism-specific databases

CTDi55762.
GeneCardsiZNF701.
HGNCiHGNC:25597. ZNF701.
HPAiHPA005532.
neXtProtiNX_Q9NV72.
PharmGKBiPA142670498.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00690000102079.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9NV72.
KOiK09228.
OMAiTCFQEIE.
PhylomeDBiQ9NV72.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii55762.
PROiQ9NV72.

Gene expression databases

BgeeiQ9NV72.
CleanExiHS_ZNF701.
ExpressionAtlasiQ9NV72. baseline and differential.
GenevisibleiQ9NV72. HS.

Family and domain databases

Gene3Di3.30.160.60. 9 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS PRO-70; ILE-182; LYS-337 AND HIS-495.
    Tissue: Teratocarcinoma.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS PRO-70; ILE-182 AND LYS-337.
    Tissue: Lymphoma and Testis.

Entry informationi

Entry nameiZN701_HUMAN
AccessioniPrimary (citable) accession number: Q9NV72
Secondary accession number(s): A2RRM8
, B9EGF2, F5GZM6, Q66K42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 1, 2014
Last modified: June 8, 2016
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.