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Protein

Transmembrane protein 39A

Gene

TMEM39A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 39A
Gene namesi
Name:TMEM39A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000176142.12
HGNCiHGNC:25600 TMEM39A
neXtProtiNX_Q9NV64

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Transmembranei110 – 130HelicalSequence analysisAdd BLAST21
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Transmembranei287 – 307HelicalSequence analysisAdd BLAST21
Transmembranei319 – 339HelicalSequence analysisAdd BLAST21
Transmembranei420 – 440HelicalSequence analysisAdd BLAST21
Transmembranei446 – 466HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55254
OpenTargetsiENSG00000176142
PharmGKBiPA134956032

Polymorphism and mutation databases

DMDMi74734456

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002792241 – 488Transmembrane protein 39AAdd BLAST488

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi31N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9NV64
MaxQBiQ9NV64
PaxDbiQ9NV64
PeptideAtlasiQ9NV64
PRIDEiQ9NV64
ProteomicsDBi82750
82751 [Q9NV64-2]

PTM databases

iPTMnetiQ9NV64
PhosphoSitePlusiQ9NV64

Expressioni

Gene expression databases

BgeeiENSG00000176142
CleanExiHS_TMEM39A
ExpressionAtlasiQ9NV64 baseline and differential
GenevisibleiQ9NV64 HS

Organism-specific databases

HPAiHPA039140

Interactioni

Protein-protein interaction databases

BioGridi120545, 31 interactors
STRINGi9606.ENSP00000326063

Structurei

3D structure databases

ProteinModelPortaliQ9NV64
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM39 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3828 Eukaryota
ENOG410XQMI LUCA
GeneTreeiENSGT00390000018895
HOGENOMiHOG000230708
HOVERGENiHBG059894
InParanoidiQ9NV64
OMAiPEPVRHC
OrthoDBiEOG091G091E
PhylomeDBiQ9NV64
TreeFamiTF321110

Family and domain databases

InterProiView protein in InterPro
IPR019397 Uncharacterised_TMEM39
PANTHERiPTHR12995 PTHR12995, 1 hit
PfamiView protein in Pfam
PF10271 Tmp39, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NV64-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGGRRGPSR QQLSRSALPS LQTLVGGGCG NGTGLRNRNG SAIGLPVPPI
60 70 80 90 100
TALITPGPVR HCQIPDLPVD GSLLFEFLFF IYLLVALFIQ YINIYKTVWW
110 120 130 140 150
YPYNHPASCT SLNFHLIDYH LAAFITVMLA RRLVWALISE ATKAGAASMI
160 170 180 190 200
HYMVLISARL VLLTLCGWVL CWTLVNLFRS HSVLNLLFLG YPFGVYVPLC
210 220 230 240 250
CFHQDSRAHL LLTDYNYVVQ HEAVEESAST VGGLAKSKDF LSLLLESLKE
260 270 280 290 300
QFNNATPIPT HSCPLSPDLI RNEVECLKAD FNHRIKEVLF NSLFSAYYVA
310 320 330 340 350
FLPLCFVKST QYYDMRWSCE HLIMVWINAF VMLTTQLLPS KYCDLLHKSA
360 370 380 390 400
AHLGKWQKLE HGSYSNAPQH IWSENTIWPQ GVLVRHSRCL YRAMGPYNVA
410 420 430 440 450
VPSDVSHARF YFLFHRPLRL LNLLILIEGS VVFYQLYSLL RSEKWNHTLS
460 470 480
MALILFCNYY VLFKLLRDRI VLGRAYSYPL NSYELKAN
Length:488
Mass (Da):55,667
Last modified:October 1, 2000 - v1
Checksum:iEC3EB5D8B05ED09B
GO
Isoform 2 (identifier: Q9NV64-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     141-146: ATKAGA → VCVCKL
     147-488: Missing.

Show »
Length:146
Mass (Da):16,154
Checksum:i5CB090676E67F358
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti79F → L in BAD96968 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036095247S → L in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_030871487A → T1 PublicationCorresponds to variant dbSNP:rs1132200Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023416141 – 146ATKAGA → VCVCKL in isoform 2. 1 Publication6
Alternative sequenceiVSP_023417147 – 488Missing in isoform 2. 1 PublicationAdd BLAST342

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001764 mRNA Translation: BAA91893.1
AK223248 mRNA Translation: BAD96968.1
AK222950 mRNA Translation: BAD96670.1
CH471052 Genomic DNA Translation: EAW79571.1
CH471052 Genomic DNA Translation: EAW79572.1
BC003192 mRNA Translation: AAH03192.1
BC021277 mRNA Translation: AAH21277.1
CCDSiCCDS2987.1 [Q9NV64-1]
RefSeqiNP_060736.1, NM_018266.2 [Q9NV64-1]
XP_006713750.1, XM_006713687.1 [Q9NV64-1]
UniGeneiHs.594171

Genome annotation databases

EnsembliENST00000319172; ENSP00000326063; ENSG00000176142 [Q9NV64-1]
ENST00000438581; ENSP00000402149; ENSG00000176142 [Q9NV64-2]
GeneIDi55254
KEGGihsa:55254
UCSCiuc003eck.3 human [Q9NV64-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTM39A_HUMAN
AccessioniPrimary (citable) accession number: Q9NV64
Secondary accession number(s): D3DN80
, Q53FN4, Q53GI1, Q6PKB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: October 1, 2000
Last modified: June 20, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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