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Protein

Transmembrane protein 39A

Gene

TMEM39A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176142-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 39A
Gene namesi
Name:TMEM39A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:25600. TMEM39A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei72 – 92HelicalSequence analysisAdd BLAST21
Transmembranei110 – 130HelicalSequence analysisAdd BLAST21
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Transmembranei182 – 202HelicalSequence analysisAdd BLAST21
Transmembranei287 – 307HelicalSequence analysisAdd BLAST21
Transmembranei319 – 339HelicalSequence analysisAdd BLAST21
Transmembranei420 – 440HelicalSequence analysisAdd BLAST21
Transmembranei446 – 466HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55254.
OpenTargetsiENSG00000176142.
PharmGKBiPA134956032.

Polymorphism and mutation databases

DMDMi74734456.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002792241 – 488Transmembrane protein 39AAdd BLAST488

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi31N-linked (GlcNAc...)Sequence analysis1
Glycosylationi39N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9NV64.
MaxQBiQ9NV64.
PaxDbiQ9NV64.
PeptideAtlasiQ9NV64.
PRIDEiQ9NV64.

PTM databases

iPTMnetiQ9NV64.
PhosphoSitePlusiQ9NV64.

Expressioni

Gene expression databases

BgeeiENSG00000176142.
CleanExiHS_TMEM39A.
ExpressionAtlasiQ9NV64. baseline and differential.
GenevisibleiQ9NV64. HS.

Organism-specific databases

HPAiHPA039140.

Interactioni

Protein-protein interaction databases

BioGridi120545. 26 interactors.
STRINGi9606.ENSP00000326063.

Structurei

3D structure databases

ProteinModelPortaliQ9NV64.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM39 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3828. Eukaryota.
ENOG410XQMI. LUCA.
GeneTreeiENSGT00390000018895.
HOGENOMiHOG000230708.
HOVERGENiHBG059894.
InParanoidiQ9NV64.
OMAiRMRDAFM.
OrthoDBiEOG091G091E.
PhylomeDBiQ9NV64.
TreeFamiTF321110.

Family and domain databases

InterProiIPR019397. Uncharacterised_TMEM39.
[Graphical view]
PANTHERiPTHR12995. PTHR12995. 1 hit.
PfamiPF10271. Tmp39. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NV64-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGGRRGPSR QQLSRSALPS LQTLVGGGCG NGTGLRNRNG SAIGLPVPPI
60 70 80 90 100
TALITPGPVR HCQIPDLPVD GSLLFEFLFF IYLLVALFIQ YINIYKTVWW
110 120 130 140 150
YPYNHPASCT SLNFHLIDYH LAAFITVMLA RRLVWALISE ATKAGAASMI
160 170 180 190 200
HYMVLISARL VLLTLCGWVL CWTLVNLFRS HSVLNLLFLG YPFGVYVPLC
210 220 230 240 250
CFHQDSRAHL LLTDYNYVVQ HEAVEESAST VGGLAKSKDF LSLLLESLKE
260 270 280 290 300
QFNNATPIPT HSCPLSPDLI RNEVECLKAD FNHRIKEVLF NSLFSAYYVA
310 320 330 340 350
FLPLCFVKST QYYDMRWSCE HLIMVWINAF VMLTTQLLPS KYCDLLHKSA
360 370 380 390 400
AHLGKWQKLE HGSYSNAPQH IWSENTIWPQ GVLVRHSRCL YRAMGPYNVA
410 420 430 440 450
VPSDVSHARF YFLFHRPLRL LNLLILIEGS VVFYQLYSLL RSEKWNHTLS
460 470 480
MALILFCNYY VLFKLLRDRI VLGRAYSYPL NSYELKAN
Length:488
Mass (Da):55,667
Last modified:October 1, 2000 - v1
Checksum:iEC3EB5D8B05ED09B
GO
Isoform 2 (identifier: Q9NV64-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     141-146: ATKAGA → VCVCKL
     147-488: Missing.

Show »
Length:146
Mass (Da):16,154
Checksum:i5CB090676E67F358
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti79F → L in BAD96968 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036095247S → L in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_030871487A → T.1 PublicationCorresponds to variant rs1132200dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023416141 – 146ATKAGA → VCVCKL in isoform 2. 1 Publication6
Alternative sequenceiVSP_023417147 – 488Missing in isoform 2. 1 PublicationAdd BLAST342

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001764 mRNA. Translation: BAA91893.1.
AK223248 mRNA. Translation: BAD96968.1.
AK222950 mRNA. Translation: BAD96670.1.
CH471052 Genomic DNA. Translation: EAW79571.1.
CH471052 Genomic DNA. Translation: EAW79572.1.
BC003192 mRNA. Translation: AAH03192.1.
BC021277 mRNA. Translation: AAH21277.1.
CCDSiCCDS2987.1. [Q9NV64-1]
RefSeqiNP_060736.1. NM_018266.2. [Q9NV64-1]
XP_006713750.1. XM_006713687.1. [Q9NV64-1]
UniGeneiHs.594171.

Genome annotation databases

EnsembliENST00000319172; ENSP00000326063; ENSG00000176142. [Q9NV64-1]
ENST00000438581; ENSP00000402149; ENSG00000176142. [Q9NV64-2]
GeneIDi55254.
KEGGihsa:55254.
UCSCiuc003eck.3. human. [Q9NV64-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001764 mRNA. Translation: BAA91893.1.
AK223248 mRNA. Translation: BAD96968.1.
AK222950 mRNA. Translation: BAD96670.1.
CH471052 Genomic DNA. Translation: EAW79571.1.
CH471052 Genomic DNA. Translation: EAW79572.1.
BC003192 mRNA. Translation: AAH03192.1.
BC021277 mRNA. Translation: AAH21277.1.
CCDSiCCDS2987.1. [Q9NV64-1]
RefSeqiNP_060736.1. NM_018266.2. [Q9NV64-1]
XP_006713750.1. XM_006713687.1. [Q9NV64-1]
UniGeneiHs.594171.

3D structure databases

ProteinModelPortaliQ9NV64.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120545. 26 interactors.
STRINGi9606.ENSP00000326063.

PTM databases

iPTMnetiQ9NV64.
PhosphoSitePlusiQ9NV64.

Polymorphism and mutation databases

DMDMi74734456.

Proteomic databases

EPDiQ9NV64.
MaxQBiQ9NV64.
PaxDbiQ9NV64.
PeptideAtlasiQ9NV64.
PRIDEiQ9NV64.

Protocols and materials databases

DNASUi55254.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319172; ENSP00000326063; ENSG00000176142. [Q9NV64-1]
ENST00000438581; ENSP00000402149; ENSG00000176142. [Q9NV64-2]
GeneIDi55254.
KEGGihsa:55254.
UCSCiuc003eck.3. human. [Q9NV64-1]

Organism-specific databases

CTDi55254.
DisGeNETi55254.
GeneCardsiTMEM39A.
HGNCiHGNC:25600. TMEM39A.
HPAiHPA039140.
neXtProtiNX_Q9NV64.
OpenTargetsiENSG00000176142.
PharmGKBiPA134956032.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3828. Eukaryota.
ENOG410XQMI. LUCA.
GeneTreeiENSGT00390000018895.
HOGENOMiHOG000230708.
HOVERGENiHBG059894.
InParanoidiQ9NV64.
OMAiRMRDAFM.
OrthoDBiEOG091G091E.
PhylomeDBiQ9NV64.
TreeFamiTF321110.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176142-MONOMER.

Miscellaneous databases

GenomeRNAii55254.
PROiQ9NV64.

Gene expression databases

BgeeiENSG00000176142.
CleanExiHS_TMEM39A.
ExpressionAtlasiQ9NV64. baseline and differential.
GenevisibleiQ9NV64. HS.

Family and domain databases

InterProiIPR019397. Uncharacterised_TMEM39.
[Graphical view]
PANTHERiPTHR12995. PTHR12995. 1 hit.
PfamiPF10271. Tmp39. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM39A_HUMAN
AccessioniPrimary (citable) accession number: Q9NV64
Secondary accession number(s): D3DN80
, Q53FN4, Q53GI1, Q6PKB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.