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Q9NV56

- MRGBP_HUMAN

UniProt

Q9NV56 - MRGBP_HUMAN

Protein

MRG/MORF4L-binding protein

Gene

MRGBP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.

    GO - Biological processi

    1. chromatin modification Source: UniProtKB-KW
    2. chromatin organization Source: Reactome
    3. regulation of growth Source: UniProtKB-KW
    4. regulation of transcription, DNA-templated Source: UniProtKB-KW
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Chromatin regulator

    Keywords - Biological processi

    Growth regulation, Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_172610. HATs acetylate histones.
    REACT_197820. HATs acetylate histones.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    MRG/MORF4L-binding protein
    Alternative name(s):
    MRG-binding protein
    Up-regulated in colon cancer 4
    Short name:
    Urcc4
    Gene namesi
    Name:MRGBP
    Synonyms:C20orf20
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:15866. MRGBP.

    Subcellular locationi

    GO - Cellular componenti

    1. H4/H2A histone acetyltransferase complex Source: InterPro
    2. nucleoplasm Source: Reactome
    3. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25736.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 204203MRG/MORF4L-binding proteinPRO_0000215876Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylglycine1 Publication
    Modified residuei191 – 1911Phosphoserine3 Publications
    Modified residuei195 – 1951Phosphoserine2 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9NV56.
    PaxDbiQ9NV56.
    PeptideAtlasiQ9NV56.
    PRIDEiQ9NV56.

    PTM databases

    PhosphoSiteiQ9NV56.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NV56.
    BgeeiQ9NV56.
    CleanExiHS_C20orf20.
    GenevestigatoriQ9NV56.

    Organism-specific databases

    HPAiHPA017012.

    Interactioni

    Subunit structurei

    Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. MRGBP may interact directly with MORF4L1/MRG15 and MORF4L2/MRGX.1 Publication

    Protein-protein interaction databases

    BioGridi120548. 43 interactions.
    DIPiDIP-29018N.
    IntActiQ9NV56. 25 interactions.
    STRINGi9606.ENSP00000359518.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NV56.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi7 – 104Poly-Gly

    Sequence similaritiesi

    Belongs to the EAF7 family.Curated

    Phylogenomic databases

    eggNOGiNOG137406.
    HOGENOMiHOG000008169.
    HOVERGENiHBG052509.
    InParanoidiQ9NV56.
    KOiK11343.
    OMAiEEMETHA.
    OrthoDBiEOG7CRTRK.
    PhylomeDBiQ9NV56.
    TreeFamiTF326334.

    Family and domain databases

    InterProiIPR012423. Eaf7/MRGBP.
    [Graphical view]
    PANTHERiPTHR13581. PTHR13581. 1 hit.
    PfamiPF07904. Eaf7. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9NV56-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGEAEVGGGG AAGDKGPGEA ATSPAEETVV WSPEVEVCLF HAMLGHKPVG    50
    VNRHFHMICI RDKFSQNIGR QVPSKVIWDH LSTMYDMQAL HESEILPFPN 100
    PERNFVLPEE IIQEVREGKV MIEEEMKEEM KEDVDPHNGA DDVFSSSGSL 150
    GKASEKSSKD KEKNSSDLGC KEGADKRKRS RVTDKVLTAN SNPSSPSAAK 200
    RRRT 204
    Length:204
    Mass (Da):22,417
    Last modified:October 1, 2000 - v1
    Checksum:iE6B87C2E14A67F9B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB085682 mRNA. Translation: BAF80630.1.
    AK001776 mRNA. Translation: BAA91902.1.
    AL035669 Genomic DNA. Translation: CAC12748.1.
    CH471077 Genomic DNA. Translation: EAW75342.1.
    CH471077 Genomic DNA. Translation: EAW75343.1.
    BC009889 mRNA. Translation: AAH09889.1.
    BC014235 mRNA. Translation: AAH14235.1.
    BC018841 mRNA. Translation: AAH18841.1.
    CCDSiCCDS13503.1.
    RefSeqiNP_060740.1. NM_018270.4.
    UniGeneiHs.590870.

    Genome annotation databases

    EnsembliENST00000370487; ENSP00000359518; ENSG00000101189.
    GeneIDi55257.
    KEGGihsa:55257.
    UCSCiuc002ydi.3. human.

    Polymorphism databases

    DMDMi28201787.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB085682 mRNA. Translation: BAF80630.1 .
    AK001776 mRNA. Translation: BAA91902.1 .
    AL035669 Genomic DNA. Translation: CAC12748.1 .
    CH471077 Genomic DNA. Translation: EAW75342.1 .
    CH471077 Genomic DNA. Translation: EAW75343.1 .
    BC009889 mRNA. Translation: AAH09889.1 .
    BC014235 mRNA. Translation: AAH14235.1 .
    BC018841 mRNA. Translation: AAH18841.1 .
    CCDSi CCDS13503.1.
    RefSeqi NP_060740.1. NM_018270.4.
    UniGenei Hs.590870.

    3D structure databases

    ProteinModelPortali Q9NV56.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120548. 43 interactions.
    DIPi DIP-29018N.
    IntActi Q9NV56. 25 interactions.
    STRINGi 9606.ENSP00000359518.

    PTM databases

    PhosphoSitei Q9NV56.

    Polymorphism databases

    DMDMi 28201787.

    Proteomic databases

    MaxQBi Q9NV56.
    PaxDbi Q9NV56.
    PeptideAtlasi Q9NV56.
    PRIDEi Q9NV56.

    Protocols and materials databases

    DNASUi 55257.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370487 ; ENSP00000359518 ; ENSG00000101189 .
    GeneIDi 55257.
    KEGGi hsa:55257.
    UCSCi uc002ydi.3. human.

    Organism-specific databases

    CTDi 55257.
    GeneCardsi GC20P061428.
    HGNCi HGNC:15866. MRGBP.
    HPAi HPA017012.
    MIMi 611157. gene.
    neXtProti NX_Q9NV56.
    PharmGKBi PA25736.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG137406.
    HOGENOMi HOG000008169.
    HOVERGENi HBG052509.
    InParanoidi Q9NV56.
    KOi K11343.
    OMAi EEMETHA.
    OrthoDBi EOG7CRTRK.
    PhylomeDBi Q9NV56.
    TreeFami TF326334.

    Enzyme and pathway databases

    Reactomei REACT_172610. HATs acetylate histones.
    REACT_197820. HATs acetylate histones.

    Miscellaneous databases

    GenomeRNAii 55257.
    NextBioi 59340.
    PROi Q9NV56.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NV56.
    Bgeei Q9NV56.
    CleanExi HS_C20orf20.
    Genevestigatori Q9NV56.

    Family and domain databases

    InterProi IPR012423. Eaf7/MRGBP.
    [Graphical view ]
    PANTHERi PTHR13581. PTHR13581. 1 hit.
    Pfami PF07904. Eaf7. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of Urcc4, a novel gene up-regulated in colon cancer."
      Shimokawa T., Furukawa Y., Nakamura Y.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.
    3. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin and Uterus.
    6. "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex."
      Cai Y., Jin J., Tomomori-Sato C., Sato S., Sorokina I., Parmely T.J., Conaway R.C., Conaway J.W.
      J. Biol. Chem. 278:42733-42736(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 104-116; 132-152 AND 186-200, IDENTIFICATION IN NUA4 COMPLEX, INTERACTION WITH MORF4L1 AND MORF4L2, IDENTIFICATION BY MASS SPECTROMETRY.
    7. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-191, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-191 AND SER-195, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT GLY-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-191 AND SER-195, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMRGBP_HUMAN
    AccessioniPrimary (citable) accession number: Q9NV56
    Secondary accession number(s): A8C4L5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2003
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3