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Q9NV31

- IMP3_HUMAN

UniProt

Q9NV31 - IMP3_HUMAN

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Protein
U3 small nucleolar ribonucleoprotein protein IMP3
Gene
IMP3, C15orf12, MRPS4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.1 Publication

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. protein binding Source: HGNC
  3. rRNA binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. rRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Keywords - Ligandi

RNA-binding, rRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar ribonucleoprotein protein IMP3
Short name:
U3 snoRNP protein IMP3
Alternative name(s):
BRMS2
Gene namesi
Name:IMP3
Synonyms:C15orf12, MRPS4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:14497. IMP3.

Subcellular locationi

Nucleusnucleolus 1 Publication

GO - Cellular componenti

  1. nucleolus Source: HGNC
  2. nucleus Source: LIFEdb
  3. ribonucleoprotein complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25517.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 184184U3 small nucleolar ribonucleoprotein protein IMP3
PRO_0000132709Add
BLAST

Proteomic databases

MaxQBiQ9NV31.
PaxDbiQ9NV31.
PeptideAtlasiQ9NV31.
PRIDEiQ9NV31.

PTM databases

PhosphoSiteiQ9NV31.

Expressioni

Gene expression databases

ArrayExpressiQ9NV31.
BgeeiQ9NV31.
CleanExiHS_IMP3.
GenevestigatoriQ9NV31.

Interactioni

Subunit structurei

Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with MPHOSPH10.1 Publication

Protein-protein interaction databases

BioGridi120560. 6 interactions.
IntActiQ9NV31. 3 interactions.
MINTiMINT-1449196.
STRINGi9606.ENSP00000326981.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi111 – 1177
Beta strandi121 – 1233
Helixi124 – 1329
Beta strandi136 – 1383
Beta strandi149 – 1513
Helixi152 – 1554
Beta strandi158 – 1614
Beta strandi164 – 1663

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CQJNMR-A109-166[»]
ProteinModelPortaliQ9NV31.
SMRiQ9NV31. Positions 1-175.

Miscellaneous databases

EvolutionaryTraceiQ9NV31.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini109 – 17567S4 RNA-binding
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi32 – 7443Arg-rich
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0522.
HOGENOMiHOG000213883.
HOVERGENiHBG052121.
InParanoidiQ9NV31.
KOiK14560.
OMAiKKVDFLN.
OrthoDBiEOG7HQN9J.
PhylomeDBiQ9NV31.
TreeFamiTF300149.

Family and domain databases

Gene3Di3.10.290.10. 1 hit.
InterProiIPR022801. Ribosomal_S4/S9.
IPR002942. S4_RNA-bd.
[Graphical view]
PANTHERiPTHR11831. PTHR11831. 1 hit.
PfamiPF01479. S4. 1 hit.
[Graphical view]
SMARTiSM00363. S4. 1 hit.
[Graphical view]
PROSITEiPS50889. S4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NV31-1 [UniParc]FASTAAdd to Basket

« Hide

MVRKLKFHEQ KLLKQVDFLN WEVTDHNLHE LRVLRRYRLQ RREDYTRYNQ    50
LSRAVRELAR RLRDLPERDQ FRVRASAALL DKLYALGLVP TRGSLELCDF 100
VTASSFCRRR LPTVLLKLRM AQHLQAAVAF VEQGHVRVGP DVVTDPAFLV 150
TRSMEDFVTW VDSSKIKRHV LEYNEERDDF DLEA 184
Length:184
Mass (Da):21,850
Last modified:October 1, 2000 - v1
Checksum:iAAE0352DF7C790F1
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 151Q → R in BAD96841. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY050497 mRNA. Translation: AAL06639.1.
AL136913 mRNA. Translation: CAB66847.1.
AK001830 mRNA. Translation: BAA91929.1.
AK057531 mRNA. Translation: BAG51929.1.
AK223121 mRNA. Translation: BAD96841.1.
CH471136 Genomic DNA. Translation: EAW99244.1.
BC006487 mRNA. Translation: AAH06487.1.
BC011745 mRNA. Translation: AAH11745.1.
CCDSiCCDS10282.1.
RefSeqiNP_060755.1. NM_018285.3.
UniGeneiHs.513043.

Genome annotation databases

EnsembliENST00000314852; ENSP00000326981; ENSG00000177971.
ENST00000403490; ENSP00000385217; ENSG00000177971.
GeneIDi55272.
KEGGihsa:55272.
UCSCiuc002bat.2. human.

Polymorphism databases

DMDMi52783099.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY050497 mRNA. Translation: AAL06639.1 .
AL136913 mRNA. Translation: CAB66847.1 .
AK001830 mRNA. Translation: BAA91929.1 .
AK057531 mRNA. Translation: BAG51929.1 .
AK223121 mRNA. Translation: BAD96841.1 .
CH471136 Genomic DNA. Translation: EAW99244.1 .
BC006487 mRNA. Translation: AAH06487.1 .
BC011745 mRNA. Translation: AAH11745.1 .
CCDSi CCDS10282.1.
RefSeqi NP_060755.1. NM_018285.3.
UniGenei Hs.513043.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2CQJ NMR - A 109-166 [» ]
ProteinModelPortali Q9NV31.
SMRi Q9NV31. Positions 1-175.
ModBasei Search...

Protein-protein interaction databases

BioGridi 120560. 6 interactions.
IntActi Q9NV31. 3 interactions.
MINTi MINT-1449196.
STRINGi 9606.ENSP00000326981.

PTM databases

PhosphoSitei Q9NV31.

Polymorphism databases

DMDMi 52783099.

Proteomic databases

MaxQBi Q9NV31.
PaxDbi Q9NV31.
PeptideAtlasi Q9NV31.
PRIDEi Q9NV31.

Protocols and materials databases

DNASUi 55272.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000314852 ; ENSP00000326981 ; ENSG00000177971 .
ENST00000403490 ; ENSP00000385217 ; ENSG00000177971 .
GeneIDi 55272.
KEGGi hsa:55272.
UCSCi uc002bat.2. human.

Organism-specific databases

CTDi 55272.
GeneCardsi GC15M075931.
H-InvDB HIX0172858.
HGNCi HGNC:14497. IMP3.
MIMi 612980. gene.
neXtProti NX_Q9NV31.
PharmGKBi PA25517.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0522.
HOGENOMi HOG000213883.
HOVERGENi HBG052121.
InParanoidi Q9NV31.
KOi K14560.
OMAi KKVDFLN.
OrthoDBi EOG7HQN9J.
PhylomeDBi Q9NV31.
TreeFami TF300149.

Miscellaneous databases

ChiTaRSi IMP3. human.
EvolutionaryTracei Q9NV31.
GeneWikii IMP3.
GenomeRNAii 55272.
NextBioi 59389.
PROi Q9NV31.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9NV31.
Bgeei Q9NV31.
CleanExi HS_IMP3.
Genevestigatori Q9NV31.

Family and domain databases

Gene3Di 3.10.290.10. 1 hit.
InterProi IPR022801. Ribosomal_S4/S9.
IPR002942. S4_RNA-bd.
[Graphical view ]
PANTHERi PTHR11831. PTHR11831. 1 hit.
Pfami PF01479. S4. 1 hit.
[Graphical view ]
SMARTi SM00363. S4. 1 hit.
[Graphical view ]
PROSITEi PS50889. S4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Potential metastasis suppressor gene(s) in chromosome 11 hybrid of MDA MB 435 breast carcinoma cell line."
    Samant R.S., Seraj J., Sakamaki T., Verderame M.F., Welch D.R.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta and Testis.
  4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye and Placenta.
  7. "The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes."
    Granneman S., Gallagher J.E.G., Vogelzangs J., Horstman W., van Venrooij W.J., Baserga S.J., Pruijn G.J.M.
    Nucleic Acids Res. 31:1877-1887(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH MPHOSPH10.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Solution structure of the S4 domain of U3 small nucleolar ribonucleoprotein protein IMP3 homolog."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 109-166.

Entry informationi

Entry nameiIMP3_HUMAN
AccessioniPrimary (citable) accession number: Q9NV31
Secondary accession number(s): B3KQ67, Q53G10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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