Q9NV31 (IMP3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
U3 small nucleolar ribonucleoprotein protein IMP3
Short name=U3 snoRNP protein IMP3

Alternative name(s):
BRMS2

Gene names

Name:	IMP3
Synonyms:	C15orf12, MRPS4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	184 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing. Ref.7
Subunit structure	Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with MPHOSPH10. Ref.7
Subcellular location	Nucleus › nucleolus Ref.7.
Sequence similarities	Belongs to the ribosomal protein S4P family. Contains 1 S4 RNA-binding domain.

Ontologies

Keywords
Biological process	Ribosome biogenesis rRNA processing
Cellular component	Nucleus
Ligand	RNA-binding rRNA-binding
Molecular function	Ribonucleoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	rRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleolus Inferred from direct assay Ref.7. Source: HGNC ribonucleoprotein complex Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	rRNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 184

184

U3 small nucleolar ribonucleoprotein protein IMP3

PRO_0000132709

Regions

Domain

109 – 175

67

S4 RNA-binding

Compositional bias

32 – 74

43

Arg-rich

Experimental info

Sequence conflict

15

1

Q → R in BAD96841. Ref.4

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

184

Helix Strand Turn

Details...

Helix

111 – 117

7

Beta strand

121 – 123

3

Helix

124 – 132

9

Beta strand

136 – 138

3

Beta strand

149 – 151

3

Helix

152 – 155

4

Beta strand

158 – 161

4

Beta strand

164 – 166

3

Sequences

	Sequence		Length	Mass (Da)
	Q9NV31 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: AAE0352DF7C790F1	FASTA	184	21,850
	10 20 30 40 50 60 MVRKLKFHEQ KLLKQVDFLN WEVTDHNLHE LRVLRRYRLQ RREDYTRYNQ LSRAVRELAR 70 80 90 100 110 120 RLRDLPERDQ FRVRASAALL DKLYALGLVP TRGSLELCDF VTASSFCRRR LPTVLLKLRM 130 140 150 160 170 180 AQHLQAAVAF VEQGHVRVGP DVVTDPAFLV TRSMEDFVTW VDSSKIKRHV LEYNEERDDF DLEA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Potential metastasis suppressor gene(s) in chromosome 11 hybrid of MDA MB 435 breast carcinoma cell line." Samant R.S., Seraj J., Sakamaki T., Verderame M.F., Welch D.R. Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta and Testis.
[4]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye and Placenta.
[7]	"The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes." Granneman S., Gallagher J.E.G., Vogelzangs J., Horstman W., van Venrooij W.J., Baserga S.J., Pruijn G.J.M. Nucleic Acids Res. 31:1877-1887(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH MPHOSPH10.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]	"Solution structure of the S4 domain of U3 small nucleolar ribonucleoprotein protein IMP3 homolog." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2005) to the PDB data bank Cited for: STRUCTURE BY NMR OF 109-166.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AY050497 mRNA. Translation: AAL06639.1.
AL136913 mRNA. Translation: CAB66847.1.
AK001830 mRNA. Translation: BAA91929.1.
AK057531 mRNA. Translation: BAG51929.1.
AK223121 mRNA. Translation: BAD96841.1.
CH471136 Genomic DNA. Translation: EAW99244.1.
BC006487 mRNA. Translation: AAH06487.1.
BC011745 mRNA. Translation: AAH11745.1.

IPI

IPI00019488.

RefSeq

NP_060755.1. NM_018285.3.

UniGene

Hs.513043.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2CQJ	NMR	-	A	109-166	[»]

ProteinModelPortal

Q9NV31.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9NV31. 3 interactions.

MINT

MINT-1449196.

STRING

9606.ENSP00000326981.

PTM databases

PhosphoSite

Q9NV31.

Polymorphism databases

DMDM

52783099.

Proteomic databases

PaxDb

Q9NV31.

PeptideAtlas

Q9NV31.

PRIDE

Q9NV31.

Protocols and materials databases

DNASU

55272.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000314852; ENSP00000326981; ENSG00000177971.
ENST00000403490; ENSP00000385217; ENSG00000177971.

GeneID

55272.

KEGG

hsa:55272.

UCSC

uc002bat.2. human.

Organism-specific databases

CTD

55272.

GeneCards

GC15M075931.

H-InvDB

HIX0172858.

HGNC

HGNC:14497. IMP3.

MIM

612980. gene.

neXtProt

NX_Q9NV31.

PharmGKB

PA25517.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG0522.

HOGENOM

HOG000213883.

HOVERGEN

HBG052121.

InParanoid

Q9NV31.

KO

K14560.

OMA

FIEQGHV.

OrthoDB

EOG4GB779.

PhylomeDB

Q9NV31.

Gene expression databases

ArrayExpress

Q9NV31.

Bgee

Q9NV31.

CleanEx

HS_IMP3.

Genevestigator

Q9NV31.

GermOnline

ENSG00000177971. Homo sapiens.

Family and domain databases

Gene3D

3.10.290.10. 1 hit.

InterPro

IPR022801. Ribosomal_S4/S9.
IPR002942. S4_RNA-bd.
[Graphical view]

PANTHER

PTHR11831. PTHR11831. 1 hit.

Pfam

PF01479. S4. 1 hit.
[Graphical view]

SMART

SM00363. S4. 1 hit.
[Graphical view]

PROSITE

PS00632. RIBOSOMAL_S4. False negative.
PS50889. S4. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

IMP3. human.

EvolutionaryTrace

Q9NV31.

GenomeRNAi

55272.

NextBio

59389.

SOURCE

Search...

Entry information

Entry name

IMP3_HUMAN

Accession

Primary (citable) accession number: Q9NV31
Secondary accession number(s): B3KQ67, Q53G10

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 104 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.