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Q9NV31 (IMP3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
U3 small nucleolar ribonucleoprotein protein IMP3

Short name=U3 snoRNP protein IMP3
Alternative name(s):
BRMS2
Gene names
Name:IMP3
Synonyms:C15orf12, MRPS4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length184 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing. Ref.7

Subunit structure

Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with MPHOSPH10. Ref.7

Subcellular location

Nucleusnucleolus Ref.7.

Sequence similarities

Belongs to the ribosomal protein S4P family.

Contains 1 S4 RNA-binding domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 184184U3 small nucleolar ribonucleoprotein protein IMP3
PRO_0000132709

Regions

Domain109 – 17567S4 RNA-binding
Compositional bias32 – 7443Arg-rich

Experimental info

Sequence conflict151Q → R in BAD96841. Ref.4

Secondary structure

............... 184
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9NV31 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: AAE0352DF7C790F1

FASTA18421,850
        10         20         30         40         50         60 
MVRKLKFHEQ KLLKQVDFLN WEVTDHNLHE LRVLRRYRLQ RREDYTRYNQ LSRAVRELAR 

        70         80         90        100        110        120 
RLRDLPERDQ FRVRASAALL DKLYALGLVP TRGSLELCDF VTASSFCRRR LPTVLLKLRM 

       130        140        150        160        170        180 
AQHLQAAVAF VEQGHVRVGP DVVTDPAFLV TRSMEDFVTW VDSSKIKRHV LEYNEERDDF 


DLEA 

« Hide

References

« Hide 'large scale' references
[1]"Potential metastasis suppressor gene(s) in chromosome 11 hybrid of MDA MB 435 breast carcinoma cell line."
Samant R.S., Seraj J., Sakamaki T., Verderame M.F., Welch D.R.
Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Uterus.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta and Testis.
[4]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye and Placenta.
[7]"The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes."
Granneman S., Gallagher J.E.G., Vogelzangs J., Horstman W., van Venrooij W.J., Baserga S.J., Pruijn G.J.M.
Nucleic Acids Res. 31:1877-1887(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH MPHOSPH10.
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Solution structure of the S4 domain of U3 small nucleolar ribonucleoprotein protein IMP3 homolog."
RIKEN structural genomics initiative (RSGI)
Submitted (NOV-2005) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 109-166.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY050497 mRNA. Translation: AAL06639.1.
AL136913 mRNA. Translation: CAB66847.1.
AK001830 mRNA. Translation: BAA91929.1.
AK057531 mRNA. Translation: BAG51929.1.
AK223121 mRNA. Translation: BAD96841.1.
CH471136 Genomic DNA. Translation: EAW99244.1.
BC006487 mRNA. Translation: AAH06487.1.
BC011745 mRNA. Translation: AAH11745.1.
CCDSCCDS10282.1.
RefSeqNP_060755.1. NM_018285.3.
UniGeneHs.513043.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2CQJNMR-A109-166[»]
ProteinModelPortalQ9NV31.
SMRQ9NV31. Positions 1-175.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120560. 6 interactions.
IntActQ9NV31. 3 interactions.
MINTMINT-1449196.
STRING9606.ENSP00000326981.

PTM databases

PhosphoSiteQ9NV31.

Polymorphism databases

DMDM52783099.

Proteomic databases

MaxQBQ9NV31.
PaxDbQ9NV31.
PeptideAtlasQ9NV31.
PRIDEQ9NV31.

Protocols and materials databases

DNASU55272.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000314852; ENSP00000326981; ENSG00000177971.
ENST00000403490; ENSP00000385217; ENSG00000177971.
GeneID55272.
KEGGhsa:55272.
UCSCuc002bat.2. human.

Organism-specific databases

CTD55272.
GeneCardsGC15M075931.
H-InvDBHIX0172858.
HGNCHGNC:14497. IMP3.
MIM612980. gene.
neXtProtNX_Q9NV31.
PharmGKBPA25517.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0522.
HOGENOMHOG000213883.
HOVERGENHBG052121.
InParanoidQ9NV31.
KOK14560.
OMAKKVDFLN.
OrthoDBEOG7HQN9J.
PhylomeDBQ9NV31.
TreeFamTF300149.

Gene expression databases

ArrayExpressQ9NV31.
BgeeQ9NV31.
CleanExHS_IMP3.
GenevestigatorQ9NV31.

Family and domain databases

Gene3D3.10.290.10. 1 hit.
InterProIPR022801. Ribosomal_S4/S9.
IPR002942. S4_RNA-bd.
[Graphical view]
PANTHERPTHR11831. PTHR11831. 1 hit.
PfamPF01479. S4. 1 hit.
[Graphical view]
SMARTSM00363. S4. 1 hit.
[Graphical view]
PROSITEPS50889. S4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSIMP3. human.
EvolutionaryTraceQ9NV31.
GeneWikiIMP3.
GenomeRNAi55272.
NextBio59389.
PROQ9NV31.
SOURCESearch...

Entry information

Entry nameIMP3_HUMAN
AccessionPrimary (citable) accession number: Q9NV31
Secondary accession number(s): B3KQ67, Q53G10
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM