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Protein

U3 small nucleolar ribonucleoprotein protein IMP3

Gene

IMP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.1 Publication

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. snoRNA binding Source: GO_Central

GO - Biological processi

  1. rRNA processing Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Keywords - Ligandi

RNA-binding, rRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar ribonucleoprotein protein IMP3
Short name:
U3 snoRNP protein IMP3
Alternative name(s):
BRMS2
Gene namesi
Name:IMP3
Synonyms:C15orf12, MRPS4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:14497. IMP3.

Subcellular locationi

  1. Nucleusnucleolus 1 Publication

GO - Cellular componenti

  1. Mpp10 complex Source: GO_Central
  2. nucleolus Source: HGNC
  3. nucleus Source: LIFEdb
  4. small-subunit processome Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25517.

Polymorphism and mutation databases

BioMutaiIMP3.
DMDMi52783099.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 184184U3 small nucleolar ribonucleoprotein protein IMP3PRO_0000132709Add
BLAST

Proteomic databases

MaxQBiQ9NV31.
PaxDbiQ9NV31.
PeptideAtlasiQ9NV31.
PRIDEiQ9NV31.

PTM databases

PhosphoSiteiQ9NV31.

Expressioni

Gene expression databases

BgeeiQ9NV31.
CleanExiHS_IMP3.
ExpressionAtlasiQ9NV31. baseline and differential.
GenevestigatoriQ9NV31.

Interactioni

Subunit structurei

Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with MPHOSPH10.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNDBP1O952735EBI-747481,EBI-748961
KLC3Q6P5973EBI-747481,EBI-1643885
TFIP11Q9UBB93EBI-747481,EBI-1105213
USHBP1Q8N6Y03EBI-747481,EBI-739895
ZYXQ159423EBI-747481,EBI-444225

Protein-protein interaction databases

BioGridi120560. 16 interactions.
IntActiQ9NV31. 7 interactions.
MINTiMINT-1449196.
STRINGi9606.ENSP00000326981.

Structurei

Secondary structure

1
184
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi111 – 1177Combined sources
Beta strandi121 – 1233Combined sources
Helixi124 – 1329Combined sources
Beta strandi136 – 1383Combined sources
Beta strandi149 – 1513Combined sources
Helixi152 – 1554Combined sources
Beta strandi158 – 1614Combined sources
Beta strandi164 – 1663Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CQJNMR-A109-166[»]
ProteinModelPortaliQ9NV31.
SMRiQ9NV31. Positions 29-179.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NV31.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini109 – 17567S4 RNA-bindingPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi32 – 7443Arg-richAdd
BLAST

Sequence similaritiesi

Belongs to the ribosomal protein S4P family.Curated
Contains 1 S4 RNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0522.
GeneTreeiENSGT00550000075090.
HOGENOMiHOG000213883.
HOVERGENiHBG052121.
InParanoidiQ9NV31.
KOiK14560.
OMAiVDFLNWK.
OrthoDBiEOG7HQN9J.
PhylomeDBiQ9NV31.
TreeFamiTF300149.

Family and domain databases

Gene3Di3.10.290.10. 1 hit.
InterProiIPR022801. Ribosomal_S4/S9.
IPR002942. S4_RNA-bd.
[Graphical view]
PANTHERiPTHR11831. PTHR11831. 1 hit.
PfamiPF01479. S4. 1 hit.
[Graphical view]
SMARTiSM00363. S4. 1 hit.
[Graphical view]
PROSITEiPS50889. S4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NV31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRKLKFHEQ KLLKQVDFLN WEVTDHNLHE LRVLRRYRLQ RREDYTRYNQ
60 70 80 90 100
LSRAVRELAR RLRDLPERDQ FRVRASAALL DKLYALGLVP TRGSLELCDF
110 120 130 140 150
VTASSFCRRR LPTVLLKLRM AQHLQAAVAF VEQGHVRVGP DVVTDPAFLV
160 170 180
TRSMEDFVTW VDSSKIKRHV LEYNEERDDF DLEA
Length:184
Mass (Da):21,850
Last modified:October 1, 2000 - v1
Checksum:iAAE0352DF7C790F1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 151Q → R in BAD96841 (Ref. 4) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY050497 mRNA. Translation: AAL06639.1.
AL136913 mRNA. Translation: CAB66847.1.
AK001830 mRNA. Translation: BAA91929.1.
AK057531 mRNA. Translation: BAG51929.1.
AK223121 mRNA. Translation: BAD96841.1.
CH471136 Genomic DNA. Translation: EAW99244.1.
BC006487 mRNA. Translation: AAH06487.1.
BC011745 mRNA. Translation: AAH11745.1.
CCDSiCCDS10282.1.
RefSeqiNP_060755.1. NM_018285.3.
UniGeneiHs.513043.

Genome annotation databases

EnsembliENST00000314852; ENSP00000326981; ENSG00000177971.
ENST00000403490; ENSP00000385217; ENSG00000177971.
GeneIDi55272.
KEGGihsa:55272.
UCSCiuc002bat.2. human.

Polymorphism and mutation databases

BioMutaiIMP3.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY050497 mRNA. Translation: AAL06639.1.
AL136913 mRNA. Translation: CAB66847.1.
AK001830 mRNA. Translation: BAA91929.1.
AK057531 mRNA. Translation: BAG51929.1.
AK223121 mRNA. Translation: BAD96841.1.
CH471136 Genomic DNA. Translation: EAW99244.1.
BC006487 mRNA. Translation: AAH06487.1.
BC011745 mRNA. Translation: AAH11745.1.
CCDSiCCDS10282.1.
RefSeqiNP_060755.1. NM_018285.3.
UniGeneiHs.513043.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CQJNMR-A109-166[»]
ProteinModelPortaliQ9NV31.
SMRiQ9NV31. Positions 29-179.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120560. 16 interactions.
IntActiQ9NV31. 7 interactions.
MINTiMINT-1449196.
STRINGi9606.ENSP00000326981.

PTM databases

PhosphoSiteiQ9NV31.

Polymorphism and mutation databases

BioMutaiIMP3.
DMDMi52783099.

Proteomic databases

MaxQBiQ9NV31.
PaxDbiQ9NV31.
PeptideAtlasiQ9NV31.
PRIDEiQ9NV31.

Protocols and materials databases

DNASUi55272.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314852; ENSP00000326981; ENSG00000177971.
ENST00000403490; ENSP00000385217; ENSG00000177971.
GeneIDi55272.
KEGGihsa:55272.
UCSCiuc002bat.2. human.

Organism-specific databases

CTDi55272.
GeneCardsiGC15M075931.
H-InvDBHIX0172858.
HGNCiHGNC:14497. IMP3.
MIMi612980. gene.
neXtProtiNX_Q9NV31.
PharmGKBiPA25517.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0522.
GeneTreeiENSGT00550000075090.
HOGENOMiHOG000213883.
HOVERGENiHBG052121.
InParanoidiQ9NV31.
KOiK14560.
OMAiVDFLNWK.
OrthoDBiEOG7HQN9J.
PhylomeDBiQ9NV31.
TreeFamiTF300149.

Miscellaneous databases

ChiTaRSiIMP3. human.
EvolutionaryTraceiQ9NV31.
GeneWikiiIMP3.
GenomeRNAii55272.
NextBioi59389.
PROiQ9NV31.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NV31.
CleanExiHS_IMP3.
ExpressionAtlasiQ9NV31. baseline and differential.
GenevestigatoriQ9NV31.

Family and domain databases

Gene3Di3.10.290.10. 1 hit.
InterProiIPR022801. Ribosomal_S4/S9.
IPR002942. S4_RNA-bd.
[Graphical view]
PANTHERiPTHR11831. PTHR11831. 1 hit.
PfamiPF01479. S4. 1 hit.
[Graphical view]
SMARTiSM00363. S4. 1 hit.
[Graphical view]
PROSITEiPS50889. S4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Potential metastasis suppressor gene(s) in chromosome 11 hybrid of MDA MB 435 breast carcinoma cell line."
    Samant R.S., Seraj J., Sakamaki T., Verderame M.F., Welch D.R.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta and Testis.
  4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye and Placenta.
  7. "The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes."
    Granneman S., Gallagher J.E.G., Vogelzangs J., Horstman W., van Venrooij W.J., Baserga S.J., Pruijn G.J.M.
    Nucleic Acids Res. 31:1877-1887(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH MPHOSPH10.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Solution structure of the S4 domain of U3 small nucleolar ribonucleoprotein protein IMP3 homolog."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 109-166.

Entry informationi

Entry nameiIMP3_HUMAN
AccessioniPrimary (citable) accession number: Q9NV31
Secondary accession number(s): B3KQ67, Q53G10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: October 1, 2000
Last modified: April 29, 2015
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.