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Q9NV31

- IMP3_HUMAN

UniProt

Q9NV31 - IMP3_HUMAN

Protein

U3 small nucleolar ribonucleoprotein protein IMP3

Gene

IMP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.1 Publication

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. protein binding Source: HGNC
    3. rRNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. rRNA processing Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Biological processi

    Ribosome biogenesis, rRNA processing

    Keywords - Ligandi

    RNA-binding, rRNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    U3 small nucleolar ribonucleoprotein protein IMP3
    Short name:
    U3 snoRNP protein IMP3
    Alternative name(s):
    BRMS2
    Gene namesi
    Name:IMP3
    Synonyms:C15orf12, MRPS4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:14497. IMP3.

    Subcellular locationi

    Nucleusnucleolus 1 Publication

    GO - Cellular componenti

    1. nucleolus Source: HGNC
    2. nucleus Source: LIFEdb
    3. ribonucleoprotein complex Source: UniProtKB-KW

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25517.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 184184U3 small nucleolar ribonucleoprotein protein IMP3PRO_0000132709Add
    BLAST

    Proteomic databases

    MaxQBiQ9NV31.
    PaxDbiQ9NV31.
    PeptideAtlasiQ9NV31.
    PRIDEiQ9NV31.

    PTM databases

    PhosphoSiteiQ9NV31.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NV31.
    BgeeiQ9NV31.
    CleanExiHS_IMP3.
    GenevestigatoriQ9NV31.

    Interactioni

    Subunit structurei

    Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with MPHOSPH10.1 Publication

    Protein-protein interaction databases

    BioGridi120560. 6 interactions.
    IntActiQ9NV31. 3 interactions.
    MINTiMINT-1449196.
    STRINGi9606.ENSP00000326981.

    Structurei

    Secondary structure

    1
    184
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi111 – 1177
    Beta strandi121 – 1233
    Helixi124 – 1329
    Beta strandi136 – 1383
    Beta strandi149 – 1513
    Helixi152 – 1554
    Beta strandi158 – 1614
    Beta strandi164 – 1663

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2CQJNMR-A109-166[»]
    ProteinModelPortaliQ9NV31.
    SMRiQ9NV31. Positions 1-175.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9NV31.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini109 – 17567S4 RNA-bindingPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi32 – 7443Arg-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ribosomal protein S4P family.Curated
    Contains 1 S4 RNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0522.
    HOGENOMiHOG000213883.
    HOVERGENiHBG052121.
    InParanoidiQ9NV31.
    KOiK14560.
    OMAiKKVDFLN.
    OrthoDBiEOG7HQN9J.
    PhylomeDBiQ9NV31.
    TreeFamiTF300149.

    Family and domain databases

    Gene3Di3.10.290.10. 1 hit.
    InterProiIPR022801. Ribosomal_S4/S9.
    IPR002942. S4_RNA-bd.
    [Graphical view]
    PANTHERiPTHR11831. PTHR11831. 1 hit.
    PfamiPF01479. S4. 1 hit.
    [Graphical view]
    SMARTiSM00363. S4. 1 hit.
    [Graphical view]
    PROSITEiPS50889. S4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NV31-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVRKLKFHEQ KLLKQVDFLN WEVTDHNLHE LRVLRRYRLQ RREDYTRYNQ    50
    LSRAVRELAR RLRDLPERDQ FRVRASAALL DKLYALGLVP TRGSLELCDF 100
    VTASSFCRRR LPTVLLKLRM AQHLQAAVAF VEQGHVRVGP DVVTDPAFLV 150
    TRSMEDFVTW VDSSKIKRHV LEYNEERDDF DLEA 184
    Length:184
    Mass (Da):21,850
    Last modified:October 1, 2000 - v1
    Checksum:iAAE0352DF7C790F1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti15 – 151Q → R in BAD96841. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY050497 mRNA. Translation: AAL06639.1.
    AL136913 mRNA. Translation: CAB66847.1.
    AK001830 mRNA. Translation: BAA91929.1.
    AK057531 mRNA. Translation: BAG51929.1.
    AK223121 mRNA. Translation: BAD96841.1.
    CH471136 Genomic DNA. Translation: EAW99244.1.
    BC006487 mRNA. Translation: AAH06487.1.
    BC011745 mRNA. Translation: AAH11745.1.
    CCDSiCCDS10282.1.
    RefSeqiNP_060755.1. NM_018285.3.
    UniGeneiHs.513043.

    Genome annotation databases

    EnsembliENST00000314852; ENSP00000326981; ENSG00000177971.
    ENST00000403490; ENSP00000385217; ENSG00000177971.
    GeneIDi55272.
    KEGGihsa:55272.
    UCSCiuc002bat.2. human.

    Polymorphism databases

    DMDMi52783099.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY050497 mRNA. Translation: AAL06639.1 .
    AL136913 mRNA. Translation: CAB66847.1 .
    AK001830 mRNA. Translation: BAA91929.1 .
    AK057531 mRNA. Translation: BAG51929.1 .
    AK223121 mRNA. Translation: BAD96841.1 .
    CH471136 Genomic DNA. Translation: EAW99244.1 .
    BC006487 mRNA. Translation: AAH06487.1 .
    BC011745 mRNA. Translation: AAH11745.1 .
    CCDSi CCDS10282.1.
    RefSeqi NP_060755.1. NM_018285.3.
    UniGenei Hs.513043.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2CQJ NMR - A 109-166 [» ]
    ProteinModelPortali Q9NV31.
    SMRi Q9NV31. Positions 1-175.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120560. 6 interactions.
    IntActi Q9NV31. 3 interactions.
    MINTi MINT-1449196.
    STRINGi 9606.ENSP00000326981.

    PTM databases

    PhosphoSitei Q9NV31.

    Polymorphism databases

    DMDMi 52783099.

    Proteomic databases

    MaxQBi Q9NV31.
    PaxDbi Q9NV31.
    PeptideAtlasi Q9NV31.
    PRIDEi Q9NV31.

    Protocols and materials databases

    DNASUi 55272.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000314852 ; ENSP00000326981 ; ENSG00000177971 .
    ENST00000403490 ; ENSP00000385217 ; ENSG00000177971 .
    GeneIDi 55272.
    KEGGi hsa:55272.
    UCSCi uc002bat.2. human.

    Organism-specific databases

    CTDi 55272.
    GeneCardsi GC15M075931.
    H-InvDB HIX0172858.
    HGNCi HGNC:14497. IMP3.
    MIMi 612980. gene.
    neXtProti NX_Q9NV31.
    PharmGKBi PA25517.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0522.
    HOGENOMi HOG000213883.
    HOVERGENi HBG052121.
    InParanoidi Q9NV31.
    KOi K14560.
    OMAi KKVDFLN.
    OrthoDBi EOG7HQN9J.
    PhylomeDBi Q9NV31.
    TreeFami TF300149.

    Miscellaneous databases

    ChiTaRSi IMP3. human.
    EvolutionaryTracei Q9NV31.
    GeneWikii IMP3.
    GenomeRNAii 55272.
    NextBioi 59389.
    PROi Q9NV31.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NV31.
    Bgeei Q9NV31.
    CleanExi HS_IMP3.
    Genevestigatori Q9NV31.

    Family and domain databases

    Gene3Di 3.10.290.10. 1 hit.
    InterProi IPR022801. Ribosomal_S4/S9.
    IPR002942. S4_RNA-bd.
    [Graphical view ]
    PANTHERi PTHR11831. PTHR11831. 1 hit.
    Pfami PF01479. S4. 1 hit.
    [Graphical view ]
    SMARTi SM00363. S4. 1 hit.
    [Graphical view ]
    PROSITEi PS50889. S4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Potential metastasis suppressor gene(s) in chromosome 11 hybrid of MDA MB 435 breast carcinoma cell line."
      Samant R.S., Seraj J., Sakamaki T., Verderame M.F., Welch D.R.
      Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta and Testis.
    4. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye and Placenta.
    7. "The human Imp3 and Imp4 proteins form a ternary complex with hMpp10, which only interacts with the U3 snoRNA in 60-80S ribonucleoprotein complexes."
      Granneman S., Gallagher J.E.G., Vogelzangs J., Horstman W., van Venrooij W.J., Baserga S.J., Pruijn G.J.M.
      Nucleic Acids Res. 31:1877-1887(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH MPHOSPH10.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Solution structure of the S4 domain of U3 small nucleolar ribonucleoprotein protein IMP3 homolog."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2005) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 109-166.

    Entry informationi

    Entry nameiIMP3_HUMAN
    AccessioniPrimary (citable) accession number: Q9NV31
    Secondary accession number(s): B3KQ67, Q53G10
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. Ribosomal proteins
      Ribosomal proteins families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3