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Protein

Transmembrane protein 100

Gene

TMEM100

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex.By similarity

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation

Enzyme and pathway databases

SignaLinkiQ9NV29.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 100
Gene namesi
Name:TMEM100
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:25607. TMEM100.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • perikaryon Source: UniProtKB
  • perinuclear region of cytoplasm Source: UniProtKB
  • plasma membrane Source: UniProtKB

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55273.
OpenTargetsiENSG00000166292.
PharmGKBiPA142670749.

Polymorphism and mutation databases

BioMutaiTMEM100.
DMDMi109895209.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002408461 – 134Transmembrane protein 100Add BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei121PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9NV29.
PeptideAtlasiQ9NV29.
PRIDEiQ9NV29.

PTM databases

iPTMnetiQ9NV29.
PhosphoSitePlusiQ9NV29.

Expressioni

Tissue specificityi

Expressed in neurons of the myenteric and submucosal plexuses in the gastric body, jejunum and proximal colon. Expressed in arterial endothelial cells and neurons of the central nervous system and peripheral nervous system. Expressed in umbilical artery endothelial cells (at protein level).2 Publications

Inductioni

Up-regulated by GDF2/BMP9 and BMP10 (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000166292.
CleanExiHS_TMEM100.
ExpressionAtlasiQ9NV29. baseline and differential.
GenevisibleiQ9NV29. HS.

Organism-specific databases

HPAiHPA055936.

Interactioni

Subunit structurei

Interacts (via C-terminus) with TRPA1 and TRPV1.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120561. 4 interactors.
IntActiQ9NV29. 6 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ9NV29.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IY9U. Eukaryota.
ENOG410YJ77. LUCA.
GeneTreeiENSGT00390000018520.
HOGENOMiHOG000154600.
HOVERGENiHBG054506.
InParanoidiQ9NV29.
OMAiPLVSECQ.
OrthoDBiEOG091G0X1R.
PhylomeDBiQ9NV29.
TreeFamiTF332068.

Family and domain databases

InterProiView protein in InterPro
IPR032536. TMEM100.
PANTHERiPTHR16100:SF7. PTHR16100:SF7. 1 hit.
PfamiView protein in Pfam
PF16311. TMEM100. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NV29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEEPIKEIL GAPKAHMAAT MEKSPKSEVV ITTVPLVSEI QLMAATGGTE
60 70 80 90 100
LSCYRCIIPF AVVVFIAGIV VTAVAYSFNS HGSIISIFGL VVLSSGLFLL
110 120 130
ASSALCWKVR QRSKKAKRRE SQTALVANQR SLFA
Length:134
Mass (Da):14,386
Last modified:June 27, 2006 - v2
Checksum:i7F80C71D1D065245
GO

Sequence cautioni

The sequence AC009837 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti133F → S in BAA91931 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001832 mRNA. Translation: BAA91931.1.
AC009837 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94537.1.
CH471109 Genomic DNA. Translation: EAW94538.1.
CH471109 Genomic DNA. Translation: EAW94539.1.
BC010128 mRNA. Translation: AAH10128.1.
CCDSiCCDS11587.1.
RefSeqiNP_001093110.1. NM_001099640.1.
NP_060756.2. NM_018286.2.
XP_016880303.1. XM_017024814.1.
XP_016880304.1. XM_017024815.1.
XP_016880305.1. XM_017024816.1.
UniGeneiHs.173233.

Genome annotation databases

EnsembliENST00000424486; ENSP00000395328; ENSG00000166292.
ENST00000575734; ENSP00000465638; ENSG00000166292.
GeneIDi55273.
KEGGihsa:55273.
UCSCiuc002iuj.5. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTM100_HUMAN
AccessioniPrimary (citable) accession number: Q9NV29
Secondary accession number(s): D3DTY7, I3L214, Q96FZ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: July 5, 2017
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot