Reviewed,
UniProtKB/Swiss-Prot Q9NV23 (SAST_HUMAN)
Last modified
October 13, 2009.
Version 56.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: S-acyl fatty acid synthase thioesterase, medium chain EC=3.1.2.14 Alternative name(s): Oleoyl-ACP hydrolase Thioesterase II Thioesterase domain-containing protein 1 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 265 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | In fatty acid biosynthesis chain termination and release of the free fatty acid product is achieved by hydrolysis of the thio ester by a thioesterase I, a component of the fatty acid synthetase complex. The chain length of the released fatty acid is usually C16. However, in the mammary glands of non-ruminant mammals, and in the uropygial gland of certain waterfowl there exists a second thioesterase which releases medium-chain length fatty acids (C8 to C2) By similarity. |
| Catalytic activity | Oleoyl-[acyl-carrier-protein] + H2O = [acyl-carrier-protein] + oleate. |
| Sequence similarities | Belongs to the thioesterase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Fatty acid biosynthesis Lipid synthesis |
| Molecular function | Hydrolase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | oleoyl-[acyl-carrier-protein] hydrolase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
Cross-references
Sequence databases | |
|---|---|
| AK001844 mRNA. Translation: BAA91937.1. BC050372 mRNA. Translation: AAH50372.1. | |
| IPI | IPI00030167. |
| RefSeq | NP_001034791.1. |
| UniGene | Hs.24309 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9NV23. |
Genome annotation databases | |
| Ensembl | ENST00000378217; ENSP00000367462; ENSG00000152463; Homo sapiens. [Genome view] ENST00000378225; ENSP00000367470; ENSG00000152463; Homo sapiens. [Genome view] ENST00000378228; ENSP00000367473; ENSG00000152463; Homo sapiens. [Genome view] ENST00000413672; ENSP00000399449; ENSG00000152463; Homo sapiens. [Genome view] ENST00000416462; ENSP00000413732; ENSG00000152463; Homo sapiens. [Genome view] ENST00000428897; ENSP00000399290; ENSG00000152463; Homo sapiens. [Genome view] ENST00000429028; ENSP00000399663; ENSG00000152463; Homo sapiens. [Genome view] |
| GeneID | 55301. |
| KEGG | hsa:55301. |
| UCSC | uc001inu.1. human. |
Organism-specific databases | |
| CTD | 55301. |
| GeneCards | GC10P015126. |
| HGNC | HGNC:25625. OLAH. |
| HPA | CAB015417. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q9NV23. |
Enzyme and pathway databases | |
| BRENDA | 3.1.2.14. 247. |
Gene expression databases | |
| ArrayExpress | Q9NV23. |
| Bgee | Q9NV23. |
| CleanEx | HS_OLAH. |
| Genevestigator | Q9NV23. |
| GermOnline | ENSG00000152463. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR012223. TEII. IPR001031. Thioesterase. [Graphical view] |
| PANTHER | PTHR11487. TEII. 1 hit. |
| Pfam | PF00975. Thioesterase. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 59524. |
Entry information
| Entry name | SAST_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9NV23 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 10 Human chromosome 10: entries, gene names and cross-references to MIM |
| SIMILARITY comments Index of protein domains and families |

Clusters with


