ID TM140_HUMAN Reviewed; 185 AA. AC Q9NV12; A4D1P9; Q8WUC3; DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot. DT 18-MAY-2010, sequence version 2. DT 27-MAR-2024, entry version 137. DE RecName: Full=Transmembrane protein 140; GN Name=TMEM140; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-29. RC TISSUE=Placenta; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12853948; DOI=10.1038/nature01782; RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H., RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., RA Wilson R.K.; RT "The DNA sequence of human chromosome 7."; RL Nature 424:157-164(2003). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT LEU-29. RX PubMed=12690205; DOI=10.1126/science.1083423; RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D., RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., RA Adams M.D., Tsui L.-C.; RT "Human chromosome 7: DNA sequence and biology."; RL Science 300:767-772(2003). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS GLN-7; GLU-11 AND RP LEU-29. RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [5] RP VARIANT [LARGE SCALE ANALYSIS] GLU-112. RX PubMed=16959974; DOI=10.1126/science.1133427; RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V., RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., RA Velculescu V.E.; RT "The consensus coding sequences of human breast and colorectal cancers."; RL Science 314:268-274(2006). RN [6] RP TISSUE SPECIFICITY. RX PubMed=26198430; DOI=10.1186/s13045-015-0187-4; RA Li B., Huang M.Z., Wang X.Q., Tao B.B., Zhong J., Wang X.H., Zhang W.C., RA Li S.T.; RT "TMEM140 is associated with the prognosis of glioma by promoting cell RT viability and invasion."; RL J. Hematol. Oncol. 8:89-89(2015). CC -!- INTERACTION: CC Q9NV12; Q96BI3: APH1A; NbExp=3; IntAct=EBI-2844246, EBI-2606935; CC Q9NV12; Q13520: AQP6; NbExp=3; IntAct=EBI-2844246, EBI-13059134; CC Q9NV12; P07307-3: ASGR2; NbExp=3; IntAct=EBI-2844246, EBI-12808270; CC Q9NV12; P20273-5: CD22; NbExp=3; IntAct=EBI-2844246, EBI-13320645; CC Q9NV12; P19397: CD53; NbExp=3; IntAct=EBI-2844246, EBI-6657396; CC Q9NV12; P11912: CD79A; NbExp=3; IntAct=EBI-2844246, EBI-7797864; CC Q9NV12; Q99675: CGRRF1; NbExp=3; IntAct=EBI-2844246, EBI-2130213; CC Q9NV12; O00501: CLDN5; NbExp=3; IntAct=EBI-2844246, EBI-18400628; CC Q9NV12; O95471: CLDN7; NbExp=3; IntAct=EBI-2844246, EBI-740744; CC Q9NV12; Q6ZS10: CLEC17A; NbExp=3; IntAct=EBI-2844246, EBI-11977093; CC Q9NV12; P58418: CLRN1; NbExp=3; IntAct=EBI-2844246, EBI-17274839; CC Q9NV12; Q15125: EBP; NbExp=3; IntAct=EBI-2844246, EBI-3915253; CC Q9NV12; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-2844246, EBI-18304435; CC Q9NV12; Q96KR6: FAM210B; NbExp=3; IntAct=EBI-2844246, EBI-18938272; CC Q9NV12; Q8TBE3: FNDC9; NbExp=3; IntAct=EBI-2844246, EBI-12142257; CC Q9NV12; Q8NBJ4: GOLM1; NbExp=3; IntAct=EBI-2844246, EBI-712073; CC Q9NV12; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-2844246, EBI-13345167; CC Q9NV12; O15529: GPR42; NbExp=3; IntAct=EBI-2844246, EBI-18076404; CC Q9NV12; Q9UM44: HHLA2; NbExp=3; IntAct=EBI-2844246, EBI-2867874; CC Q9NV12; Q7Z5P4: HSD17B13; NbExp=3; IntAct=EBI-2844246, EBI-18053395; CC Q9NV12; P38484: IFNGR2; NbExp=3; IntAct=EBI-2844246, EBI-3905457; CC Q9NV12; Q15842: KCNJ8; NbExp=3; IntAct=EBI-2844246, EBI-17440235; CC Q9NV12; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-2844246, EBI-10171774; CC Q9NV12; Q16553: LY6E; NbExp=3; IntAct=EBI-2844246, EBI-18234679; CC Q9NV12; Q9GZY8-5: MFF; NbExp=3; IntAct=EBI-2844246, EBI-11956541; CC Q9NV12; O14880: MGST3; NbExp=3; IntAct=EBI-2844246, EBI-724754; CC Q9NV12; Q7Z6M3: MILR1; NbExp=3; IntAct=EBI-2844246, EBI-18391669; CC Q9NV12; Q96HJ5: MS4A3; NbExp=3; IntAct=EBI-2844246, EBI-12806656; CC Q9NV12; Q15800: MSMO1; NbExp=3; IntAct=EBI-2844246, EBI-949102; CC Q9NV12; Q13113: PDZK1IP1; NbExp=3; IntAct=EBI-2844246, EBI-716063; CC Q9NV12; Q96TC7: RMDN3; NbExp=3; IntAct=EBI-2844246, EBI-1056589; CC Q9NV12; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-2844246, EBI-17247926; CC Q9NV12; Q3SXP7: SHISAL1; NbExp=3; IntAct=EBI-2844246, EBI-18037857; CC Q9NV12; Q9Y3P8: SIT1; NbExp=3; IntAct=EBI-2844246, EBI-6977215; CC Q9NV12; Q9NUM3: SLC39A9; NbExp=3; IntAct=EBI-2844246, EBI-2823239; CC Q9NV12; Q9HBV2: SPACA1; NbExp=3; IntAct=EBI-2844246, EBI-17498703; CC Q9NV12; P27105: STOM; NbExp=3; IntAct=EBI-2844246, EBI-1211440; CC Q9NV12; Q8N205: SYNE4; NbExp=3; IntAct=EBI-2844246, EBI-7131783; CC Q9NV12; Q8N6K0: TEX29; NbExp=3; IntAct=EBI-2844246, EBI-19027521; CC Q9NV12; Q6ZP80: TMEM182; NbExp=3; IntAct=EBI-2844246, EBI-10255122; CC Q9NV12; Q6UW68: TMEM205; NbExp=3; IntAct=EBI-2844246, EBI-6269551; CC Q9NV12; Q6UWW9: TMEM207; NbExp=3; IntAct=EBI-2844246, EBI-13301303; CC Q9NV12; Q9P0T7: TMEM9; NbExp=3; IntAct=EBI-2844246, EBI-723976; CC Q9NV12; Q9Y320: TMX2; NbExp=3; IntAct=EBI-2844246, EBI-6447886; CC Q9NV12; O95859: TSPAN12; NbExp=3; IntAct=EBI-2844246, EBI-2466403; CC Q9NV12; Q5TGU0: TSPO2; NbExp=3; IntAct=EBI-2844246, EBI-12195249; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane CC protein {ECO:0000305}. CC -!- TISSUE SPECIFICITY: Expression significantly higher in gliomas than in CC normal brain tissues. {ECO:0000269|PubMed:26198430}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK001862; BAA91948.1; -; mRNA. DR EMBL; AC083862; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH236950; EAL24065.1; -; Genomic_DNA. DR EMBL; BC020942; AAH20942.1; -; mRNA. DR CCDS; CCDS5837.1; -. DR RefSeq; NP_060765.4; NM_018295.4. DR AlphaFoldDB; Q9NV12; -. DR BioGRID; 120569; 57. DR IntAct; Q9NV12; 49. DR MINT; Q9NV12; -. DR STRING; 9606.ENSP00000275767; -. DR GlyCosmos; Q9NV12; 1 site, No reported glycans. DR GlyGen; Q9NV12; 1 site. DR iPTMnet; Q9NV12; -. DR PhosphoSitePlus; Q9NV12; -. DR BioMuta; TMEM140; -. DR DMDM; 296452934; -. DR PaxDb; 9606-ENSP00000275767; -. DR PeptideAtlas; Q9NV12; -. DR Antibodypedia; 18112; 32 antibodies from 7 providers. DR DNASU; 55281; -. DR Ensembl; ENST00000275767.3; ENSP00000275767.2; ENSG00000146859.6. DR GeneID; 55281; -. DR KEGG; hsa:55281; -. DR MANE-Select; ENST00000275767.3; ENSP00000275767.2; NM_018295.5; NP_060765.4. DR UCSC; uc003vsi.4; human. DR AGR; HGNC:21870; -. DR CTD; 55281; -. DR DisGeNET; 55281; -. DR GeneCards; TMEM140; -. DR HGNC; HGNC:21870; TMEM140. DR HPA; ENSG00000146859; Tissue enhanced (skeletal). DR neXtProt; NX_Q9NV12; -. DR OpenTargets; ENSG00000146859; -. DR PharmGKB; PA144596261; -. DR VEuPathDB; HostDB:ENSG00000146859; -. DR eggNOG; ENOG502S6FP; Eukaryota. DR GeneTree; ENSGT00390000014089; -. DR HOGENOM; CLU_125527_0_0_1; -. DR InParanoid; Q9NV12; -. DR OMA; NFCLWNQ; -. DR OrthoDB; 4640484at2759; -. DR PhylomeDB; Q9NV12; -. DR TreeFam; TF336296; -. DR PathwayCommons; Q9NV12; -. DR SignaLink; Q9NV12; -. DR BioGRID-ORCS; 55281; 12 hits in 1159 CRISPR screens. DR ChiTaRS; TMEM140; human. DR GenomeRNAi; 55281; -. DR Pharos; Q9NV12; Tdark. DR PRO; PR:Q9NV12; -. DR Proteomes; UP000005640; Chromosome 7. DR RNAct; Q9NV12; Protein. DR Bgee; ENSG00000146859; Expressed in blood and 160 other cell types or tissues. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR InterPro; IPR028038; TM140. DR PANTHER; PTHR16103; TRANSMEMBRANE PROTEIN 140; 1. DR PANTHER; PTHR16103:SF0; TRANSMEMBRANE PROTEIN 140; 1. DR Pfam; PF14985; TM140; 1. DR Genevisible; Q9NV12; HS. PE 1: Evidence at protein level; KW Glycoprotein; Membrane; Reference proteome; Transmembrane; KW Transmembrane helix. FT CHAIN 1..185 FT /note="Transmembrane protein 140" FT /id="PRO_0000274357" FT TOPO_DOM 1..11 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 12..32 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 33..77 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 78..98 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 99..114 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 115..135 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 136..150 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 151..171 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 172..185 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT CARBOHYD 38 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT VARIANT 6 FT /note="P -> S (in dbSNP:rs292500)" FT /id="VAR_030262" FT VARIANT 7 FT /note="R -> Q (in dbSNP:rs3800592)" FT /evidence="ECO:0000269|PubMed:15489334" FT /id="VAR_030263" FT VARIANT 11 FT /note="Q -> E (in dbSNP:rs11558290)" FT /evidence="ECO:0000269|PubMed:15489334" FT /id="VAR_030264" FT VARIANT 29 FT /note="F -> L (in dbSNP:rs292501)" FT /evidence="ECO:0000269|PubMed:12690205, FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334" FT /id="VAR_030265" FT VARIANT 112 FT /note="A -> E (in a colorectal cancer sample; somatic FT mutation; dbSNP:rs292502)" FT /evidence="ECO:0000269|PubMed:16959974" FT /id="VAR_035670" SQ SEQUENCE 185 AA; 20419 MW; 6BD0CE084FDBC53A CRC64; MAGPRPRWRD QLLFMSIIVL VIVVICLMFY ALLWEAGNLT DLPNLRIGFY NFCLWNEDTS TLQCHQFPEL EALGVPRVGL GLARLGVYGS LVLTLFAPQP LLLAQCNSDE RAWRLAVGFL AVSSVLLAGG LGLFLSYVWK WVRLSLPGPG FLALGSAQAL LILLLIAMAV FPLRAERAES KLESC //