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Protein

Transmembrane protein 140

Gene

TMEM140

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000146859-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 140
Gene namesi
Name:TMEM140
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21870. TMEM140.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 77ExtracellularSequence analysisAdd BLAST45
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Topological domaini99 – 114CytoplasmicSequence analysisAdd BLAST16
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Topological domaini136 – 150ExtracellularSequence analysisAdd BLAST15
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Topological domaini172 – 185CytoplasmicSequence analysisAdd BLAST14

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000146859.
PharmGKBiPA144596261.

Polymorphism and mutation databases

DMDMi296452934.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002743571 – 185Transmembrane protein 140Add BLAST185

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NV12.
PeptideAtlasiQ9NV12.
PRIDEiQ9NV12.

PTM databases

iPTMnetiQ9NV12.
PhosphoSitePlusiQ9NV12.

Expressioni

Gene expression databases

BgeeiENSG00000146859.
CleanExiHS_TMEM140.
GenevisibleiQ9NV12. HS.

Organism-specific databases

HPAiHPA016871.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SYNE4Q8N2053EBI-2844246,EBI-7131783

Protein-protein interaction databases

BioGridi120569. 2 interactors.
IntActiQ9NV12. 7 interactors.
STRINGi9606.ENSP00000275767.

Structurei

3D structure databases

ProteinModelPortaliQ9NV12.
SMRiQ9NV12.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWZ5. Eukaryota.
ENOG41119TG. LUCA.
GeneTreeiENSGT00390000014089.
HOGENOMiHOG000294193.
HOVERGENiHBG094057.
InParanoidiQ9NV12.
OMAiLLWKAGN.
OrthoDBiEOG091G0PQH.
PhylomeDBiQ9NV12.
TreeFamiTF336296.

Family and domain databases

InterProiIPR028038. TM140.
[Graphical view]
PfamiPF14985. TM140. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NV12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPRPRWRD QLLFMSIIVL VIVVICLMFY ALLWEAGNLT DLPNLRIGFY
60 70 80 90 100
NFCLWNEDTS TLQCHQFPEL EALGVPRVGL GLARLGVYGS LVLTLFAPQP
110 120 130 140 150
LLLAQCNSDE RAWRLAVGFL AVSSVLLAGG LGLFLSYVWK WVRLSLPGPG
160 170 180
FLALGSAQAL LILLLIAMAV FPLRAERAES KLESC
Length:185
Mass (Da):20,419
Last modified:May 18, 2010 - v2
Checksum:i6BD0CE084FDBC53A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0302626P → S.Corresponds to variant rs292500dbSNPEnsembl.1
Natural variantiVAR_0302637R → Q.1 PublicationCorresponds to variant rs3800592dbSNPEnsembl.1
Natural variantiVAR_03026411Q → E.1 PublicationCorresponds to variant rs11558290dbSNPEnsembl.1
Natural variantiVAR_03026529F → L.3 PublicationsCorresponds to variant rs292501dbSNPEnsembl.1
Natural variantiVAR_035670112A → E in a colorectal cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001862 mRNA. Translation: BAA91948.1.
AC083862 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24065.1.
BC020942 mRNA. Translation: AAH20942.1.
CCDSiCCDS5837.1.
RefSeqiNP_060765.4. NM_018295.4.
UniGeneiHs.521213.

Genome annotation databases

EnsembliENST00000275767; ENSP00000275767; ENSG00000146859.
GeneIDi55281.
KEGGihsa:55281.
UCSCiuc003vsi.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001862 mRNA. Translation: BAA91948.1.
AC083862 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24065.1.
BC020942 mRNA. Translation: AAH20942.1.
CCDSiCCDS5837.1.
RefSeqiNP_060765.4. NM_018295.4.
UniGeneiHs.521213.

3D structure databases

ProteinModelPortaliQ9NV12.
SMRiQ9NV12.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120569. 2 interactors.
IntActiQ9NV12. 7 interactors.
STRINGi9606.ENSP00000275767.

PTM databases

iPTMnetiQ9NV12.
PhosphoSitePlusiQ9NV12.

Polymorphism and mutation databases

DMDMi296452934.

Proteomic databases

PaxDbiQ9NV12.
PeptideAtlasiQ9NV12.
PRIDEiQ9NV12.

Protocols and materials databases

DNASUi55281.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275767; ENSP00000275767; ENSG00000146859.
GeneIDi55281.
KEGGihsa:55281.
UCSCiuc003vsi.4. human.

Organism-specific databases

CTDi55281.
GeneCardsiTMEM140.
HGNCiHGNC:21870. TMEM140.
HPAiHPA016871.
neXtProtiNX_Q9NV12.
OpenTargetsiENSG00000146859.
PharmGKBiPA144596261.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWZ5. Eukaryota.
ENOG41119TG. LUCA.
GeneTreeiENSGT00390000014089.
HOGENOMiHOG000294193.
HOVERGENiHBG094057.
InParanoidiQ9NV12.
OMAiLLWKAGN.
OrthoDBiEOG091G0PQH.
PhylomeDBiQ9NV12.
TreeFamiTF336296.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000146859-MONOMER.

Miscellaneous databases

GenomeRNAii55281.
PROiQ9NV12.

Gene expression databases

BgeeiENSG00000146859.
CleanExiHS_TMEM140.
GenevisibleiQ9NV12. HS.

Family and domain databases

InterProiIPR028038. TM140.
[Graphical view]
PfamiPF14985. TM140. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM140_HUMAN
AccessioniPrimary (citable) accession number: Q9NV12
Secondary accession number(s): A4D1P9, Q8WUC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.