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Protein

Transmembrane protein 140

Gene

TMEM140

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 140
Gene namesi
Name:TMEM140
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000146859.6
HGNCiHGNC:21870 TMEM140
neXtProtiNX_Q9NV12

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 77ExtracellularSequence analysisAdd BLAST45
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Topological domaini99 – 114CytoplasmicSequence analysisAdd BLAST16
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Topological domaini136 – 150ExtracellularSequence analysisAdd BLAST15
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Topological domaini172 – 185CytoplasmicSequence analysisAdd BLAST14

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55281
OpenTargetsiENSG00000146859
PharmGKBiPA144596261

Polymorphism and mutation databases

DMDMi296452934

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002743571 – 185Transmembrane protein 140Add BLAST185

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9NV12
PeptideAtlasiQ9NV12
PRIDEiQ9NV12

PTM databases

iPTMnetiQ9NV12
PhosphoSitePlusiQ9NV12

Expressioni

Gene expression databases

BgeeiENSG00000146859
CleanExiHS_TMEM140
GenevisibleiQ9NV12 HS

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120569, 4 interactors
IntActiQ9NV12, 11 interactors
MINTiQ9NV12

Structurei

3D structure databases

ProteinModelPortaliQ9NV12
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWZ5 Eukaryota
ENOG41119TG LUCA
GeneTreeiENSGT00390000014089
HOGENOMiHOG000294193
HOVERGENiHBG094057
InParanoidiQ9NV12
OMAiLLWKAGN
OrthoDBiEOG091G0PQH
PhylomeDBiQ9NV12
TreeFamiTF336296

Family and domain databases

InterProiView protein in InterPro
IPR028038 TM140
PANTHERiPTHR16103 PTHR16103, 1 hit
PfamiView protein in Pfam
PF14985 TM140, 1 hit

Sequencei

Sequence statusi: Complete.

Q9NV12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPRPRWRD QLLFMSIIVL VIVVICLMFY ALLWEAGNLT DLPNLRIGFY
60 70 80 90 100
NFCLWNEDTS TLQCHQFPEL EALGVPRVGL GLARLGVYGS LVLTLFAPQP
110 120 130 140 150
LLLAQCNSDE RAWRLAVGFL AVSSVLLAGG LGLFLSYVWK WVRLSLPGPG
160 170 180
FLALGSAQAL LILLLIAMAV FPLRAERAES KLESC
Length:185
Mass (Da):20,419
Last modified:May 18, 2010 - v2
Checksum:i6BD0CE084FDBC53A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0302626P → S. Corresponds to variant dbSNP:rs292500Ensembl.1
Natural variantiVAR_0302637R → Q1 PublicationCorresponds to variant dbSNP:rs3800592Ensembl.1
Natural variantiVAR_03026411Q → E1 PublicationCorresponds to variant dbSNP:rs11558290Ensembl.1
Natural variantiVAR_03026529F → L3 PublicationsCorresponds to variant dbSNP:rs292501Ensembl.1
Natural variantiVAR_035670112A → E in a colorectal cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001862 mRNA Translation: BAA91948.1
AC083862 Genomic DNA No translation available.
CH236950 Genomic DNA Translation: EAL24065.1
BC020942 mRNA Translation: AAH20942.1
CCDSiCCDS5837.1
RefSeqiNP_060765.4, NM_018295.4
UniGeneiHs.521213

Genome annotation databases

EnsembliENST00000275767; ENSP00000275767; ENSG00000146859
GeneIDi55281
KEGGihsa:55281
UCSCiuc003vsi.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTM140_HUMAN
AccessioniPrimary (citable) accession number: Q9NV12
Secondary accession number(s): A4D1P9, Q8WUC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 18, 2010
Last modified: April 25, 2018
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health