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Protein

Transmembrane protein 140

Gene

TMEM140

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 140
Gene namesi
Name:TMEM140
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21870. TMEM140.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1111CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei12 – 3221HelicalSequence AnalysisAdd
BLAST
Topological domaini33 – 7745ExtracellularSequence AnalysisAdd
BLAST
Transmembranei78 – 9821HelicalSequence AnalysisAdd
BLAST
Topological domaini99 – 11416CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei115 – 13521HelicalSequence AnalysisAdd
BLAST
Topological domaini136 – 15015ExtracellularSequence AnalysisAdd
BLAST
Transmembranei151 – 17121HelicalSequence AnalysisAdd
BLAST
Topological domaini172 – 18514CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596261.

Polymorphism and mutation databases

DMDMi296452934.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Transmembrane protein 140PRO_0000274357Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi38 – 381N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

PTM databases

PhosphoSiteiQ9NV12.

Expressioni

Gene expression databases

BgeeiQ9NV12.
CleanExiHS_TMEM140.
GenevisibleiQ9NV12. HS.

Organism-specific databases

HPAiHPA016871.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SYNE4Q8N2053EBI-2844246,EBI-7131783

Protein-protein interaction databases

BioGridi120569. 1 interaction.
IntActiQ9NV12. 3 interactions.
STRINGi9606.ENSP00000275767.

Structurei

3D structure databases

ProteinModelPortaliQ9NV12.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47402.
GeneTreeiENSGT00390000014089.
HOGENOMiHOG000294193.
HOVERGENiHBG094057.
InParanoidiQ9NV12.
OMAiLLWKAGN.
OrthoDBiEOG7B8S69.
PhylomeDBiQ9NV12.
TreeFamiTF336296.

Family and domain databases

InterProiIPR028038. TM140.
[Graphical view]
PfamiPF14985. TM140. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NV12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPRPRWRD QLLFMSIIVL VIVVICLMFY ALLWEAGNLT DLPNLRIGFY
60 70 80 90 100
NFCLWNEDTS TLQCHQFPEL EALGVPRVGL GLARLGVYGS LVLTLFAPQP
110 120 130 140 150
LLLAQCNSDE RAWRLAVGFL AVSSVLLAGG LGLFLSYVWK WVRLSLPGPG
160 170 180
FLALGSAQAL LILLLIAMAV FPLRAERAES KLESC
Length:185
Mass (Da):20,419
Last modified:May 18, 2010 - v2
Checksum:i6BD0CE084FDBC53A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti6 – 61P → S.
Corresponds to variant rs292500 [ dbSNP | Ensembl ].
VAR_030262
Natural varianti7 – 71R → Q.1 Publication
Corresponds to variant rs3800592 [ dbSNP | Ensembl ].
VAR_030263
Natural varianti11 – 111Q → E.1 Publication
Corresponds to variant rs11558290 [ dbSNP | Ensembl ].
VAR_030264
Natural varianti29 – 291F → L.3 Publications
Corresponds to variant rs292501 [ dbSNP | Ensembl ].
VAR_030265
Natural varianti112 – 1121A → E in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035670

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001862 mRNA. Translation: BAA91948.1.
AC083862 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24065.1.
BC020942 mRNA. Translation: AAH20942.1.
CCDSiCCDS5837.1.
RefSeqiNP_060765.4. NM_018295.4.
UniGeneiHs.521213.

Genome annotation databases

EnsembliENST00000275767; ENSP00000275767; ENSG00000146859.
GeneIDi55281.
KEGGihsa:55281.
UCSCiuc003vsi.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001862 mRNA. Translation: BAA91948.1.
AC083862 Genomic DNA. No translation available.
CH236950 Genomic DNA. Translation: EAL24065.1.
BC020942 mRNA. Translation: AAH20942.1.
CCDSiCCDS5837.1.
RefSeqiNP_060765.4. NM_018295.4.
UniGeneiHs.521213.

3D structure databases

ProteinModelPortaliQ9NV12.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120569. 1 interaction.
IntActiQ9NV12. 3 interactions.
STRINGi9606.ENSP00000275767.

PTM databases

PhosphoSiteiQ9NV12.

Polymorphism and mutation databases

DMDMi296452934.

Protocols and materials databases

DNASUi55281.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275767; ENSP00000275767; ENSG00000146859.
GeneIDi55281.
KEGGihsa:55281.
UCSCiuc003vsi.3. human.

Organism-specific databases

CTDi55281.
GeneCardsiGC07P134832.
HGNCiHGNC:21870. TMEM140.
HPAiHPA016871.
neXtProtiNX_Q9NV12.
PharmGKBiPA144596261.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG47402.
GeneTreeiENSGT00390000014089.
HOGENOMiHOG000294193.
HOVERGENiHBG094057.
InParanoidiQ9NV12.
OMAiLLWKAGN.
OrthoDBiEOG7B8S69.
PhylomeDBiQ9NV12.
TreeFamiTF336296.

Miscellaneous databases

GenomeRNAii55281.
NextBioi59430.
PROiQ9NV12.

Gene expression databases

BgeeiQ9NV12.
CleanExiHS_TMEM140.
GenevisibleiQ9NV12. HS.

Family and domain databases

InterProiIPR028038. TM140.
[Graphical view]
PfamiPF14985. TM140. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-29.
    Tissue: Placenta.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-29.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLN-7; GLU-11 AND LEU-29.
    Tissue: Brain.
  5. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLU-112.

Entry informationi

Entry nameiTM140_HUMAN
AccessioniPrimary (citable) accession number: Q9NV12
Secondary accession number(s): A4D1P9, Q8WUC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: May 18, 2010
Last modified: June 24, 2015
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.