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Q9NV12

- TM140_HUMAN

UniProt

Q9NV12 - TM140_HUMAN

Protein

Transmembrane protein 140

Gene

TMEM140

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane protein 140
    Gene namesi
    Name:TMEM140
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:21870. TMEM140.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA144596261.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 185185Transmembrane protein 140PRO_0000274357Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi38 – 381N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    PTM databases

    PhosphoSiteiQ9NV12.

    Expressioni

    Gene expression databases

    BgeeiQ9NV12.
    CleanExiHS_TMEM140.
    GenevestigatoriQ9NV12.

    Organism-specific databases

    HPAiHPA016871.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9NV12. 2 interactions.
    STRINGi9606.ENSP00000275767.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NV12.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1111CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini33 – 7745ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini99 – 11416CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini136 – 15015ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini172 – 18514CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei12 – 3221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei78 – 9821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei115 – 13521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei151 – 17121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG47402.
    HOGENOMiHOG000294193.
    HOVERGENiHBG094057.
    InParanoidiQ9NV12.
    OMAiLLWKAGN.
    OrthoDBiEOG7B8S69.
    PhylomeDBiQ9NV12.
    TreeFamiTF336296.

    Family and domain databases

    InterProiIPR028038. TM140.
    [Graphical view]
    PfamiPF14985. TM140. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NV12-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGPRPRWRD QLLFMSIIVL VIVVICLMFY ALLWEAGNLT DLPNLRIGFY    50
    NFCLWNEDTS TLQCHQFPEL EALGVPRVGL GLARLGVYGS LVLTLFAPQP 100
    LLLAQCNSDE RAWRLAVGFL AVSSVLLAGG LGLFLSYVWK WVRLSLPGPG 150
    FLALGSAQAL LILLLIAMAV FPLRAERAES KLESC 185
    Length:185
    Mass (Da):20,419
    Last modified:May 18, 2010 - v2
    Checksum:i6BD0CE084FDBC53A
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti6 – 61P → S.
    Corresponds to variant rs292500 [ dbSNP | Ensembl ].
    VAR_030262
    Natural varianti7 – 71R → Q.1 Publication
    Corresponds to variant rs3800592 [ dbSNP | Ensembl ].
    VAR_030263
    Natural varianti11 – 111Q → E.1 Publication
    Corresponds to variant rs11558290 [ dbSNP | Ensembl ].
    VAR_030264
    Natural varianti29 – 291F → L.3 Publications
    Corresponds to variant rs292501 [ dbSNP | Ensembl ].
    VAR_030265
    Natural varianti112 – 1121A → E in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035670

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001862 mRNA. Translation: BAA91948.1.
    AC083862 Genomic DNA. No translation available.
    CH236950 Genomic DNA. Translation: EAL24065.1.
    BC020942 mRNA. Translation: AAH20942.1.
    CCDSiCCDS5837.1.
    RefSeqiNP_060765.4. NM_018295.4.
    UniGeneiHs.521213.

    Genome annotation databases

    EnsembliENST00000275767; ENSP00000275767; ENSG00000146859.
    GeneIDi55281.
    KEGGihsa:55281.
    UCSCiuc003vsi.3. human.

    Polymorphism databases

    DMDMi296452934.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001862 mRNA. Translation: BAA91948.1 .
    AC083862 Genomic DNA. No translation available.
    CH236950 Genomic DNA. Translation: EAL24065.1 .
    BC020942 mRNA. Translation: AAH20942.1 .
    CCDSi CCDS5837.1.
    RefSeqi NP_060765.4. NM_018295.4.
    UniGenei Hs.521213.

    3D structure databases

    ProteinModelPortali Q9NV12.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9NV12. 2 interactions.
    STRINGi 9606.ENSP00000275767.

    PTM databases

    PhosphoSitei Q9NV12.

    Polymorphism databases

    DMDMi 296452934.

    Protocols and materials databases

    DNASUi 55281.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000275767 ; ENSP00000275767 ; ENSG00000146859 .
    GeneIDi 55281.
    KEGGi hsa:55281.
    UCSCi uc003vsi.3. human.

    Organism-specific databases

    CTDi 55281.
    GeneCardsi GC07P134832.
    HGNCi HGNC:21870. TMEM140.
    HPAi HPA016871.
    neXtProti NX_Q9NV12.
    PharmGKBi PA144596261.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47402.
    HOGENOMi HOG000294193.
    HOVERGENi HBG094057.
    InParanoidi Q9NV12.
    OMAi LLWKAGN.
    OrthoDBi EOG7B8S69.
    PhylomeDBi Q9NV12.
    TreeFami TF336296.

    Miscellaneous databases

    GenomeRNAii 55281.
    NextBioi 59430.
    PROi Q9NV12.

    Gene expression databases

    Bgeei Q9NV12.
    CleanExi HS_TMEM140.
    Genevestigatori Q9NV12.

    Family and domain databases

    InterProi IPR028038. TM140.
    [Graphical view ]
    Pfami PF14985. TM140. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-29.
      Tissue: Placenta.
    2. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-29.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLN-7; GLU-11 AND LEU-29.
      Tissue: Brain.
    5. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLU-112.

    Entry informationi

    Entry nameiTM140_HUMAN
    AccessioniPrimary (citable) accession number: Q9NV12
    Secondary accession number(s): A4D1P9, Q8WUC3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 79 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3