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Protein

DDB1- and CUL4-associated factor 13

Gene

DCAF13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Possible role in ribosomal RNA processing (By similarity). May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.By similarity1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis, rRNA processing, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-6790901. rRNA modification in the nucleus.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.
SignaLinkiQ9NV06.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
DDB1- and CUL4-associated factor 13
Alternative name(s):
WD repeat and SOF domain-containing protein 1
Gene namesi
Name:DCAF13
Synonyms:WDSOF1
ORF Names:HSPC064
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:24535. DCAF13.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165585440.

Polymorphism and mutation databases

BioMutaiDCAF13.
DMDMi160358731.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445DDB1- and CUL4-associated factor 13PRO_0000310428Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei49 – 491N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9NV06.
MaxQBiQ9NV06.
PaxDbiQ9NV06.
PeptideAtlasiQ9NV06.
PRIDEiQ9NV06.

PTM databases

iPTMnetiQ9NV06.
PhosphoSiteiQ9NV06.

Expressioni

Gene expression databases

BgeeiENSG00000164934.
CleanExiHS_WDSOF1.
ExpressionAtlasiQ9NV06. baseline and differential.
GenevisibleiQ9NV06. HS.

Organism-specific databases

HPAiHPA044504.

Interactioni

Subunit structurei

Interacts with DDB1.1 Publication

Protein-protein interaction databases

BioGridi117393. 33 interactions.
IntActiQ9NV06. 10 interactions.
MINTiMINT-4994304.
STRINGi9606.ENSP00000297579.

Structurei

3D structure databases

ProteinModelPortaliQ9NV06.
SMRiQ9NV06. Positions 17-354.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati64 – 10441WD 1Add
BLAST
Repeati107 – 14640WD 2Add
BLAST
Repeati149 – 19143WD 3Add
BLAST
Repeati194 – 23441WD 4Add
BLAST
Repeati236 – 27641WD 5Add
BLAST
Repeati280 – 31940WD 6Add
BLAST
Repeati323 – 36240WD 7Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat DCAF13/WDSOF1 family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0268. Eukaryota.
ENOG410XNX6. LUCA.
GeneTreeiENSGT00390000005711.
HOGENOMiHOG000210082.
HOVERGENiHBG056998.
InParanoidiQ9NV06.
KOiK11806.
PhylomeDBiQ9NV06.
TreeFamiTF300844.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR007287. Sof1.
IPR013979. TIF_beta_prop-like.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08662. eIF2A. 1 hit.
PF04158. Sof1. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NV06-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKVKMLSRNP DNYVRETKLD LQRVPRNYDP ALHPFEVPRE YIRALNATKL
60 70 80 90 100
ERVFAKPFLA SLDGHRDGVN CLAKHPEKLA TVLSGACDGE VRIWNLTQRN
110 120 130 140 150
CIRTIQAHEG FVRGICTRFC GTSFFTVGDD KTVKQWKMDG PGYGDEEEPL
160 170 180 190 200
HTILGKTVYT GIDHHWKEAV FATCGQQVDI WDEQRTNPIC SMTWGFDSIS
210 220 230 240 250
SVKFNPIETF LLGSCASDRN IVLYDMRQAT PLKKVILDMR TNTICWNPME
260 270 280 290 300
AFIFTAANED YNLYTFDMRA LDTPVMVHMD HVSAVLDVDY SPTGKEFVSA
310 320 330 340 350
SFDKSIRIFP VDKSRSREVY HTKRMQHVIC VKWTSDSKYI MCGSDEMNIR
360 370 380 390 400
LWKANASEKL GVLTSREKAA KDYNQKLKEK FQHYPHIKRI ARHRHLPKSI
410 420 430 440
YSQIQEQRIM KEARRRKEVN RIKHSKPGSV PLVSEKKKHV VAVVK
Length:445
Mass (Da):51,402
Last modified:November 13, 2007 - v2
Checksum:i33F6079364A0F0A3
GO
Isoform 2 (identifier: Q9NV06-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     91-96: VRIWNL → LVMTKL
     97-445: Missing.

Note: No experimental confirmation available.
Show »
Length:96
Mass (Da):10,919
Checksum:i5E6BC46DEA1832DF
GO

Sequence cautioni

The sequence AAH26067 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAI01811 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAI12043 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB55377 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC11163 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 381P → S in BAC11163 (PubMed:14702039).Curated
Sequence conflicti86 – 861A → S in AAH26067 (PubMed:15489334).Curated
Sequence conflicti304 – 3041K → E in BAC11163 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti42 – 421I → V.2 Publications
Corresponds to variant rs3134253 [ dbSNP | Ensembl ].
VAR_037035
Natural varianti70 – 701N → S.
Corresponds to variant rs13272825 [ dbSNP | Ensembl ].
VAR_037036

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei91 – 966VRIWNL → LVMTKL in isoform 2. 1 PublicationVSP_029283
Alternative sequencei97 – 445349Missing in isoform 2. 1 PublicationVSP_029284Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161549 mRNA. Translation: AAF29036.1.
AK001874 mRNA. Translation: BAA91955.1.
AK027799 mRNA. Translation: BAB55377.1. Different initiation.
AK074725 mRNA. Translation: BAC11163.1. Different initiation.
BC026067 mRNA. Translation: AAH26067.2. Different initiation.
BC101810 mRNA. Translation: AAI01811.1. Different initiation.
BC112042 mRNA. Translation: AAI12043.1. Different initiation.
RefSeqiNP_056235.4. NM_015420.6.
UniGeneiHs.532265.

Genome annotation databases

EnsembliENST00000612750; ENSP00000484962; ENSG00000164934. [Q9NV06-1]
ENST00000618975; ENSP00000480810; ENSG00000164934. [Q9NV06-2]
GeneIDi25879.
KEGGihsa:25879.
UCSCiuc064pix.1. human. [Q9NV06-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161549 mRNA. Translation: AAF29036.1.
AK001874 mRNA. Translation: BAA91955.1.
AK027799 mRNA. Translation: BAB55377.1. Different initiation.
AK074725 mRNA. Translation: BAC11163.1. Different initiation.
BC026067 mRNA. Translation: AAH26067.2. Different initiation.
BC101810 mRNA. Translation: AAI01811.1. Different initiation.
BC112042 mRNA. Translation: AAI12043.1. Different initiation.
RefSeqiNP_056235.4. NM_015420.6.
UniGeneiHs.532265.

3D structure databases

ProteinModelPortaliQ9NV06.
SMRiQ9NV06. Positions 17-354.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117393. 33 interactions.
IntActiQ9NV06. 10 interactions.
MINTiMINT-4994304.
STRINGi9606.ENSP00000297579.

PTM databases

iPTMnetiQ9NV06.
PhosphoSiteiQ9NV06.

Polymorphism and mutation databases

BioMutaiDCAF13.
DMDMi160358731.

Proteomic databases

EPDiQ9NV06.
MaxQBiQ9NV06.
PaxDbiQ9NV06.
PeptideAtlasiQ9NV06.
PRIDEiQ9NV06.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000612750; ENSP00000484962; ENSG00000164934. [Q9NV06-1]
ENST00000618975; ENSP00000480810; ENSG00000164934. [Q9NV06-2]
GeneIDi25879.
KEGGihsa:25879.
UCSCiuc064pix.1. human. [Q9NV06-1]

Organism-specific databases

CTDi25879.
GeneCardsiDCAF13.
H-InvDBHIX0201273.
HGNCiHGNC:24535. DCAF13.
HPAiHPA044504.
MIMi616196. gene.
neXtProtiNX_Q9NV06.
PharmGKBiPA165585440.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0268. Eukaryota.
ENOG410XNX6. LUCA.
GeneTreeiENSGT00390000005711.
HOGENOMiHOG000210082.
HOVERGENiHBG056998.
InParanoidiQ9NV06.
KOiK11806.
PhylomeDBiQ9NV06.
TreeFamiTF300844.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-HSA-6790901. rRNA modification in the nucleus.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.
SignaLinkiQ9NV06.

Miscellaneous databases

ChiTaRSiDCAF13. human.
GenomeRNAii25879.
PROiQ9NV06.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164934.
CleanExiHS_WDSOF1.
ExpressionAtlasiQ9NV06. baseline and differential.
GenevisibleiQ9NV06. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR007287. Sof1.
IPR013979. TIF_beta_prop-like.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08662. eIF2A. 1 hit.
PF04158. Sof1. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCA13_HUMAN
AccessioniPrimary (citable) accession number: Q9NV06
Secondary accession number(s): Q3MII9
, Q8NCH8, Q8TC51, Q96JY7, Q9NZX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: September 7, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.