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Protein

Acyl-coenzyme A oxidase-like protein

Gene

ACOXL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

FADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi350 – 3556FADBy similarity

GO - Molecular functioni

  1. acyl-CoA dehydrogenase activity Source: InterPro
  2. acyl-CoA oxidase activity Source: InterPro

GO - Biological processi

  1. fatty acid beta-oxidation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-coenzyme A oxidase-like protein (EC:1.3.3.-)
Short name:
Acyl-CoA oxidase-like protein
Gene namesi
Name:ACOXL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:25621. ACOXL.

Subcellular locationi

GO - Cellular componenti

  1. peroxisome Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134932567.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 547547Acyl-coenzyme A oxidase-like proteinPRO_0000305100Add
BLAST

Proteomic databases

PaxDbiQ9NUZ1.
PRIDEiQ9NUZ1.

PTM databases

PhosphoSiteiQ9NUZ1.

Expressioni

Gene expression databases

BgeeiQ9NUZ1.
CleanExiHS_ACOXL.
ExpressionAtlasiQ9NUZ1. baseline and differential.
GenevestigatoriQ9NUZ1.

Organism-specific databases

HPAiHPA035392.
HPA035393.

Interactioni

Protein-protein interaction databases

BioGridi120577. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9NUZ1.
SMRiQ9NUZ1. Positions 11-534.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acyl-CoA oxidase family.Curated

Phylogenomic databases

eggNOGiCOG1960.
GeneTreeiENSGT00530000062919.
HOVERGENiHBG105796.
InParanoidiQ9NUZ1.
OMAiDPAKYFA.
OrthoDBiEOG7NSB1S.
PhylomeDBiQ9NUZ1.
TreeFamiTF354292.

Family and domain databases

Gene3Di2.40.110.10. 1 hit.
InterProiIPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR002655. Acyl-CoA_oxidase_C.
IPR009075. AcylCo_DH/oxidase_C.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF01756. ACOX. 1 hit.
PF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
[Graphical view]
SUPFAMiSSF47203. SSF47203. 2 hits.
SSF56645. SSF56645. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NUZ1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRALTVQRVK FAMDLPLLKR AGQDLAEKTK NFVSRSLVIG EVLSMADMAT
60 70 80 90 100
GVKCGIIYWL FGGAIRNLGS PEHVTKWFQP LQEQKYTGMF AMTERGHGSN
110 120 130 140 150
ARGIQTEATF DLSAQEFVID TPCENAEKMY IGNAMYGNYA AVFAQLIIDG
160 170 180 190 200
RSQGPHCFIV PVRDENGSLY PGVTAIDMMY KEGLHGVDNG ILIFDKVRIP
210 220 230 240 250
RENLLDKFGS VAPDGQYHSP IRNKSARFNA MLAALTPSRL AVAFQAMGAM
260 270 280 290 300
KLGLTIAIRY SHSRRQFGPK TKEEVKIIEH QTQTLRLMPH LATALALTFV
310 320 330 340 350
SRYAGALLDE DVFQGKELVN SRSLQALVAG LKAYSTWENI RCLQDCRECT
360 370 380 390 400
GGMGYMMENR ISGLKCDTDV FATFEGDDVV MLQVVGRELL AQYTKQYEEK
410 420 430 440 450
PLFGLLQNWA ESVGDKLRTS FLAFNMDTVD DLAFLLKAVK FRERVLQRGL
460 470 480 490 500
VARIYYKVKT KKEDFFHAWN SCLHHVASLS LAHTHRVTLE QFSLAVKSCP
510 520 530 540
DQEDQTLLMK FCLLYGTKLV FQERAWYLEH KYLTPMASTR IRNQERC
Length:547
Mass (Da):61,795
Last modified:September 2, 2008 - v3
Checksum:i7F2B9B961AAE2F08
GO
Isoform 2 (identifier: Q9NUZ1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     354-383: Missing.

Show »
Length:517
Mass (Da):58,428
Checksum:iB5754E07F073B6C9
GO
Isoform 3 (identifier: Q9NUZ1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     263-279: SRRQFGPKTKEEVKIIE → RSRIISQNCCSAPAGLY
     280-547: Missing.

Show »
Length:279
Mass (Da):30,737
Checksum:iB1E0B26AAEA56D45
GO
Isoform 4 (identifier: Q9NUZ1-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     354-383: Missing.
     544-547: QERC → QLLDLCDSVKDDARRVISTFNIPHTYLHAPIAGISNPRAAWAFYPAPLQPRPREEARSRRPKLGAKL

Show »
Length:580
Mass (Da):65,457
Checksum:i9DE724781D7ED1AA
GO

Sequence cautioni

The sequence BAA91970.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti219 – 2191S → L in AAH22268. (PubMed:15489334)Curated
Sequence conflicti512 – 5121C → R in BAA91970. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti255 – 2551T → M.
Corresponds to variant rs1554005 [ dbSNP | Ensembl ].
VAR_035164
Natural varianti535 – 5351P → L.
Corresponds to variant rs17041850 [ dbSNP | Ensembl ].
VAR_035165

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei263 – 27917SRRQF…VKIIE → RSRIISQNCCSAPAGLY in isoform 3. 1 PublicationVSP_028237Add
BLAST
Alternative sequencei280 – 547268Missing in isoform 3. 1 PublicationVSP_028238Add
BLAST
Alternative sequencei354 – 38330Missing in isoform 2 and isoform 4. 1 PublicationVSP_028239Add
BLAST
Alternative sequencei544 – 5474QERC → QLLDLCDSVKDDARRVISTF NIPHTYLHAPIAGISNPRAA WAFYPAPLQPRPREEARSRR PKLGAKL in isoform 4. CuratedVSP_046900

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC096670 Genomic DNA. Translation: AAY14796.1.
AC023131 Genomic DNA. Translation: AAY14838.1.
AC096591 Genomic DNA. Translation: AAY24074.1.
AC114776 Genomic DNA. No translation available.
CH471237 Genomic DNA. Translation: EAW50357.1.
BC022268 mRNA. Translation: AAH22268.1. Sequence problems.
BC131514 mRNA. Translation: AAI31515.2.
AK001904 mRNA. Translation: BAA91970.1. Different initiation.
CCDSiCCDS46389.1. [Q9NUZ1-4]
RefSeqiNP_001136279.1. NM_001142807.1. [Q9NUZ1-4]
UniGeneiHs.253320.

Genome annotation databases

EnsembliENST00000340561; ENSP00000343717; ENSG00000153093. [Q9NUZ1-3]
ENST00000389811; ENSP00000374461; ENSG00000153093. [Q9NUZ1-1]
ENST00000417074; ENSP00000387832; ENSG00000153093.
ENST00000439055; ENSP00000407761; ENSG00000153093. [Q9NUZ1-4]
GeneIDi55289.
KEGGihsa:55289.
UCSCiuc021vmm.1. human. [Q9NUZ1-1]
uc021vmn.1. human. [Q9NUZ1-2]

Polymorphism databases

DMDMi205371797.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC096670 Genomic DNA. Translation: AAY14796.1.
AC023131 Genomic DNA. Translation: AAY14838.1.
AC096591 Genomic DNA. Translation: AAY24074.1.
AC114776 Genomic DNA. No translation available.
CH471237 Genomic DNA. Translation: EAW50357.1.
BC022268 mRNA. Translation: AAH22268.1. Sequence problems.
BC131514 mRNA. Translation: AAI31515.2.
AK001904 mRNA. Translation: BAA91970.1. Different initiation.
CCDSiCCDS46389.1. [Q9NUZ1-4]
RefSeqiNP_001136279.1. NM_001142807.1. [Q9NUZ1-4]
UniGeneiHs.253320.

3D structure databases

ProteinModelPortaliQ9NUZ1.
SMRiQ9NUZ1. Positions 11-534.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120577. 1 interaction.

PTM databases

PhosphoSiteiQ9NUZ1.

Polymorphism databases

DMDMi205371797.

Proteomic databases

PaxDbiQ9NUZ1.
PRIDEiQ9NUZ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340561; ENSP00000343717; ENSG00000153093. [Q9NUZ1-3]
ENST00000389811; ENSP00000374461; ENSG00000153093. [Q9NUZ1-1]
ENST00000417074; ENSP00000387832; ENSG00000153093.
ENST00000439055; ENSP00000407761; ENSG00000153093. [Q9NUZ1-4]
GeneIDi55289.
KEGGihsa:55289.
UCSCiuc021vmm.1. human. [Q9NUZ1-1]
uc021vmn.1. human. [Q9NUZ1-2]

Organism-specific databases

CTDi55289.
GeneCardsiGC02P112536.
HGNCiHGNC:25621. ACOXL.
HPAiHPA035392.
HPA035393.
neXtProtiNX_Q9NUZ1.
PharmGKBiPA134932567.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1960.
GeneTreeiENSGT00530000062919.
HOVERGENiHBG105796.
InParanoidiQ9NUZ1.
OMAiDPAKYFA.
OrthoDBiEOG7NSB1S.
PhylomeDBiQ9NUZ1.
TreeFamiTF354292.

Miscellaneous databases

ChiTaRSiACOXL. human.
GenomeRNAii55289.
NextBioi59470.
PROiQ9NUZ1.

Gene expression databases

BgeeiQ9NUZ1.
CleanExiHS_ACOXL.
ExpressionAtlasiQ9NUZ1. baseline and differential.
GenevestigatoriQ9NUZ1.

Family and domain databases

Gene3Di2.40.110.10. 1 hit.
InterProiIPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR002655. Acyl-CoA_oxidase_C.
IPR009075. AcylCo_DH/oxidase_C.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PfamiPF01756. ACOX. 1 hit.
PF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
[Graphical view]
SUPFAMiSSF47203. SSF47203. 2 hits.
SSF56645. SSF56645. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 163-547 (ISOFORM 2).
    Tissue: Placenta.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 162-547 (ISOFORM 1).
    Tissue: Placenta.

Entry informationi

Entry nameiACOXL_HUMAN
AccessioniPrimary (citable) accession number: Q9NUZ1
Secondary accession number(s): A2RRB7
, B7WPB3, B7WPP7, E9PB20, Q53R27, Q53R31, Q53SC6, Q8TCE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: September 2, 2008
Last modified: January 7, 2015
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.