Q9NUZ1 (ACOXL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acyl-coenzyme A oxidase-like protein
Short name=Acyl-CoA oxidase-like protein
EC=1.3.3.-

Gene names

Name:

ACOXL

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	547 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Cofactor	FAD By similarity.
Sequence similarities	Belongs to the acyl-CoA oxidase family.
Sequence caution	The sequence AAH22268.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame. The sequence BAA91970.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	fatty acid beta-oxidation Inferred from electronic annotation. Source: InterPro
Cellular_component	peroxisome Inferred from electronic annotation. Source: InterPro
Molecular_function	acyl-CoA dehydrogenase activity Inferred from electronic annotation. Source: InterPro acyl-CoA oxidase activity Inferred from electronic annotation. Source: InterPro flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9NUZ1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9NUZ1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     354-383: Missing.

Isoform 3 (identifier: Q9NUZ1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     263-279: SRRQFGPKTKEEVKIIE → RSRIISQNCCSAPAGLY
     280-547: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 547	547	Acyl-coenzyme A oxidase-like protein		PRO_0000305100
Regions
	Nucleotide binding	350 – 355	6	FAD By similarity
Natural variations
	Alternative sequence	263 – 279	17	SRRQF…VKIIE → RSRIISQNCCSAPAGLY in isoform 3.		VSP_028237
	Alternative sequence	280 – 547	268	Missing in isoform 3.		VSP_028238
	Alternative sequence	354 – 383	30	Missing in isoform 2.		VSP_028239
	Natural variant	255	1	T → M. Corresponds to variant rs1554005 [ dbSNP | Ensembl ].		VAR_035164
	Natural variant	535	1	P → L. Corresponds to variant rs17041850 [ dbSNP | Ensembl ].		VAR_035165
Experimental info
	Sequence conflict	219	1	S → L in AAH22268. Ref.3
	Sequence conflict	512	1	C → R in BAA91970. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 2, 2008. Version 3. Checksum: 7F2B9B961AAE2F08	FASTA	547	61,795
	10 20 30 40 50 60 MRALTVQRVK FAMDLPLLKR AGQDLAEKTK NFVSRSLVIG EVLSMADMAT GVKCGIIYWL 70 80 90 100 110 120 FGGAIRNLGS PEHVTKWFQP LQEQKYTGMF AMTERGHGSN ARGIQTEATF DLSAQEFVID 130 140 150 160 170 180 TPCENAEKMY IGNAMYGNYA AVFAQLIIDG RSQGPHCFIV PVRDENGSLY PGVTAIDMMY 190 200 210 220 230 240 KEGLHGVDNG ILIFDKVRIP RENLLDKFGS VAPDGQYHSP IRNKSARFNA MLAALTPSRL 250 260 270 280 290 300 AVAFQAMGAM KLGLTIAIRY SHSRRQFGPK TKEEVKIIEH QTQTLRLMPH LATALALTFV 310 320 330 340 350 360 SRYAGALLDE DVFQGKELVN SRSLQALVAG LKAYSTWENI RCLQDCRECT GGMGYMMENR 370 380 390 400 410 420 ISGLKCDTDV FATFEGDDVV MLQVVGRELL AQYTKQYEEK PLFGLLQNWA ESVGDKLRTS 430 440 450 460 470 480 FLAFNMDTVD DLAFLLKAVK FRERVLQRGL VARIYYKVKT KKEDFFHAWN SCLHHVASLS 490 500 510 520 530 540 LAHTHRVTLE QFSLAVKSCP DQEDQTLLMK FCLLYGTKLV FQERAWYLEH KYLTPMASTR IRNQERC
	Isoform 2 [UniParc]. Checksum: B5754E07F073B6C9	FASTA	517	58,428
	10 20 30 40 50 60 MRALTVQRVK FAMDLPLLKR AGQDLAEKTK NFVSRSLVIG EVLSMADMAT GVKCGIIYWL 70 80 90 100 110 120 FGGAIRNLGS PEHVTKWFQP LQEQKYTGMF AMTERGHGSN ARGIQTEATF DLSAQEFVID 130 140 150 160 170 180 TPCENAEKMY IGNAMYGNYA AVFAQLIIDG RSQGPHCFIV PVRDENGSLY PGVTAIDMMY 190 200 210 220 230 240 KEGLHGVDNG ILIFDKVRIP RENLLDKFGS VAPDGQYHSP IRNKSARFNA MLAALTPSRL 250 260 270 280 290 300 AVAFQAMGAM KLGLTIAIRY SHSRRQFGPK TKEEVKIIEH QTQTLRLMPH LATALALTFV 310 320 330 340 350 360 SRYAGALLDE DVFQGKELVN SRSLQALVAG LKAYSTWENI RCLQDCRECT GGMVVGRELL 370 380 390 400 410 420 AQYTKQYEEK PLFGLLQNWA ESVGDKLRTS FLAFNMDTVD DLAFLLKAVK FRERVLQRGL 430 440 450 460 470 480 VARIYYKVKT KKEDFFHAWN SCLHHVASLS LAHTHRVTLE QFSLAVKSCP DQEDQTLLMK 490 500 510 FCLLYGTKLV FQERAWYLEH KYLTPMASTR IRNQERC
	Isoform 3 [UniParc]. Checksum: B1E0B26AAEA56D45	FASTA	279	30,737
	10 20 30 40 50 60 MRALTVQRVK FAMDLPLLKR AGQDLAEKTK NFVSRSLVIG EVLSMADMAT GVKCGIIYWL 70 80 90 100 110 120 FGGAIRNLGS PEHVTKWFQP LQEQKYTGMF AMTERGHGSN ARGIQTEATF DLSAQEFVID 130 140 150 160 170 180 TPCENAEKMY IGNAMYGNYA AVFAQLIIDG RSQGPHCFIV PVRDENGSLY PGVTAIDMMY 190 200 210 220 230 240 KEGLHGVDNG ILIFDKVRIP RENLLDKFGS VAPDGQYHSP IRNKSARFNA MLAALTPSRL 250 260 270 AVAFQAMGAM KLGLTIAIRY SHRSRIISQN CCSAPAGLY

References

[1]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 163-547 (ISOFORM 2). Tissue: Placenta.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 162-547 (ISOFORM 1). Tissue: Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC096670 Genomic DNA. Translation: AAY14796.1. AC023131 Genomic DNA. Translation: AAY14838.1. AC096591 Genomic DNA. Translation: AAY24074.1. AC114776 Genomic DNA. No translation available. CH471237 Genomic DNA. Translation: EAW50357.1. BC022268 mRNA. Translation: AAH22268.1. Sequence problems. BC131514 mRNA. Translation: AAI31515.2. AK001904 mRNA. Translation: BAA91970.1. Different initiation.
IPI	IPI00019534. IPI00412291. IPI01013599.
RefSeq	NP_001136279.1. NM_001142807.1.
UniGene	Hs.253320.
3D structure databases
HSSP	HSSP built from PDB template 1IS2 based on UniProtKB P07872.
ProteinModelPortal	Q9NUZ1.
ModBase	Search...
PTM databases
PhosphoSite	Q9NUZ1.
Polymorphism databases
DMDM	205371797.
Proteomic databases
PaxDb	Q9NUZ1.
PRIDE	Q9NUZ1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000340561; ENSP00000343717; ENSG00000153093. ENST00000389811; ENSP00000374461; ENSG00000153093. ENST00000417074; ENSP00000387832; ENSG00000153093.
GeneID	55289.
KEGG	hsa:55289.
UCSC	uc021vmm.1. human. uc021vmn.1. human.
Organism-specific databases
CTD	55289.
GeneCards	GC02P111729.
HGNC	HGNC:25621. ACOXL.
neXtProt	NX_Q9NUZ1.
PharmGKB	PA134932567.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1960.
HOVERGEN	HBG105796.
InParanoid	Q9NUZ1.
OrthoDB	EOG4Q84X4.
Gene expression databases
ArrayExpress	Q9NUZ1.
Bgee	Q9NUZ1.
CleanEx	HS_ACOXL.
Genevestigator	Q9NUZ1.
Family and domain databases
Gene3D	2.40.110.10. 1 hit.
InterPro	IPR006090. Acyl-CoA_Oxase/DH_1. IPR006091. Acyl-CoA_Oxase/DH_cen-dom. IPR012258. Acyl-CoA_oxidase. IPR002655. Acyl-CoA_oxidase_C. IPR009075. AcylCo_DH/oxidase_C. IPR009100. AcylCoA_DH/oxidase. [Graphical view]
PANTHER	PTHR10909:SF11. PTHR10909:SF11. 1 hit.
Pfam	PF01756. ACOX. 1 hit. PF00441. Acyl-CoA_dh_1. 1 hit. PF02770. Acyl-CoA_dh_M. 1 hit. [Graphical view]
SUPFAM	SSF56645. AcylCoA_dehyd_NM. 1 hit. SSF47203. AcylCoADH_C_like. 2 hits.
ProtoNet	Search...
Other
ChiTaRS	ACOXL. human.
GenomeRNAi	55289.
NextBio	59470.

Entry information

Entry name

ACOXL_HUMAN

Accession

Primary (citable) accession number: Q9NUZ1
Secondary accession number(s): A2RRB7 , B7WPB3, B7WPP7, Q53R27, Q53R31, Q53SC6, Q8TCE7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	September 2, 2008
Last modified:	May 1, 2013
This is version 94 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.