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Q9NUZ1

- ACOXL_HUMAN

UniProt

Q9NUZ1 - ACOXL_HUMAN

Protein

Acyl-coenzyme A oxidase-like protein

Gene

ACOXL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 3 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    Cofactori

    FAD.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi350 – 3556FADBy similarity

    GO - Molecular functioni

    1. acyl-CoA dehydrogenase activity Source: InterPro
    2. acyl-CoA oxidase activity Source: InterPro

    GO - Biological processi

    1. fatty acid beta-oxidation Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acyl-coenzyme A oxidase-like protein (EC:1.3.3.-)
    Short name:
    Acyl-CoA oxidase-like protein
    Gene namesi
    Name:ACOXL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:25621. ACOXL.

    Subcellular locationi

    GO - Cellular componenti

    1. peroxisome Source: InterPro

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134932567.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 547547Acyl-coenzyme A oxidase-like proteinPRO_0000305100Add
    BLAST

    Proteomic databases

    PaxDbiQ9NUZ1.
    PRIDEiQ9NUZ1.

    PTM databases

    PhosphoSiteiQ9NUZ1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9NUZ1.
    BgeeiQ9NUZ1.
    CleanExiHS_ACOXL.
    GenevestigatoriQ9NUZ1.

    Organism-specific databases

    HPAiHPA035392.
    HPA035393.

    Interactioni

    Protein-protein interaction databases

    BioGridi120577. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NUZ1.
    SMRiQ9NUZ1. Positions 11-534.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acyl-CoA oxidase family.Curated

    Phylogenomic databases

    eggNOGiCOG1960.
    HOVERGENiHBG105796.
    InParanoidiQ9NUZ1.
    OMAiHKYLTPM.
    OrthoDBiEOG7NSB1S.
    PhylomeDBiQ9NUZ1.
    TreeFamiTF354292.

    Family and domain databases

    Gene3Di2.40.110.10. 1 hit.
    InterProiIPR006091. Acyl-CoA_Oxase/DH_cen-dom.
    IPR002655. Acyl-CoA_oxidase_C.
    IPR009075. AcylCo_DH/oxidase_C.
    IPR009100. AcylCoA_DH/oxidase_NM_dom.
    [Graphical view]
    PfamiPF01756. ACOX. 1 hit.
    PF00441. Acyl-CoA_dh_1. 1 hit.
    PF02770. Acyl-CoA_dh_M. 1 hit.
    [Graphical view]
    SUPFAMiSSF47203. SSF47203. 2 hits.
    SSF56645. SSF56645. 1 hit.

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NUZ1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRALTVQRVK FAMDLPLLKR AGQDLAEKTK NFVSRSLVIG EVLSMADMAT    50
    GVKCGIIYWL FGGAIRNLGS PEHVTKWFQP LQEQKYTGMF AMTERGHGSN 100
    ARGIQTEATF DLSAQEFVID TPCENAEKMY IGNAMYGNYA AVFAQLIIDG 150
    RSQGPHCFIV PVRDENGSLY PGVTAIDMMY KEGLHGVDNG ILIFDKVRIP 200
    RENLLDKFGS VAPDGQYHSP IRNKSARFNA MLAALTPSRL AVAFQAMGAM 250
    KLGLTIAIRY SHSRRQFGPK TKEEVKIIEH QTQTLRLMPH LATALALTFV 300
    SRYAGALLDE DVFQGKELVN SRSLQALVAG LKAYSTWENI RCLQDCRECT 350
    GGMGYMMENR ISGLKCDTDV FATFEGDDVV MLQVVGRELL AQYTKQYEEK 400
    PLFGLLQNWA ESVGDKLRTS FLAFNMDTVD DLAFLLKAVK FRERVLQRGL 450
    VARIYYKVKT KKEDFFHAWN SCLHHVASLS LAHTHRVTLE QFSLAVKSCP 500
    DQEDQTLLMK FCLLYGTKLV FQERAWYLEH KYLTPMASTR IRNQERC 547
    Length:547
    Mass (Da):61,795
    Last modified:September 2, 2008 - v3
    Checksum:i7F2B9B961AAE2F08
    GO
    Isoform 2 (identifier: Q9NUZ1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         354-383: Missing.

    Show »
    Length:517
    Mass (Da):58,428
    Checksum:iB5754E07F073B6C9
    GO
    Isoform 3 (identifier: Q9NUZ1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         263-279: SRRQFGPKTKEEVKIIE → RSRIISQNCCSAPAGLY
         280-547: Missing.

    Show »
    Length:279
    Mass (Da):30,737
    Checksum:iB1E0B26AAEA56D45
    GO
    Isoform 4 (identifier: Q9NUZ1-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         354-383: Missing.
         544-547: QERC → QLLDLCDSVKDDARRVISTFNIPHTYLHAPIAGISNPRAAWAFYPAPLQPRPREEARSRRPKLGAKL

    Show »
    Length:580
    Mass (Da):65,457
    Checksum:i9DE724781D7ED1AA
    GO

    Sequence cautioni

    The sequence BAA91970.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti219 – 2191S → L in AAH22268. (PubMed:15489334)Curated
    Sequence conflicti512 – 5121C → R in BAA91970. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti255 – 2551T → M.
    Corresponds to variant rs1554005 [ dbSNP | Ensembl ].
    VAR_035164
    Natural varianti535 – 5351P → L.
    Corresponds to variant rs17041850 [ dbSNP | Ensembl ].
    VAR_035165

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei263 – 27917SRRQF…VKIIE → RSRIISQNCCSAPAGLY in isoform 3. 1 PublicationVSP_028237Add
    BLAST
    Alternative sequencei280 – 547268Missing in isoform 3. 1 PublicationVSP_028238Add
    BLAST
    Alternative sequencei354 – 38330Missing in isoform 2 and isoform 4. 1 PublicationVSP_028239Add
    BLAST
    Alternative sequencei544 – 5474QERC → QLLDLCDSVKDDARRVISTF NIPHTYLHAPIAGISNPRAA WAFYPAPLQPRPREEARSRR PKLGAKL in isoform 4. CuratedVSP_046900

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC096670 Genomic DNA. Translation: AAY14796.1.
    AC023131 Genomic DNA. Translation: AAY14838.1.
    AC096591 Genomic DNA. Translation: AAY24074.1.
    AC114776 Genomic DNA. No translation available.
    CH471237 Genomic DNA. Translation: EAW50357.1.
    BC022268 mRNA. Translation: AAH22268.1. Sequence problems.
    BC131514 mRNA. Translation: AAI31515.2.
    AK001904 mRNA. Translation: BAA91970.1. Different initiation.
    CCDSiCCDS46389.1. [Q9NUZ1-4]
    RefSeqiNP_001136279.1. NM_001142807.1. [Q9NUZ1-4]
    UniGeneiHs.253320.

    Genome annotation databases

    EnsembliENST00000340561; ENSP00000343717; ENSG00000153093. [Q9NUZ1-3]
    ENST00000389811; ENSP00000374461; ENSG00000153093. [Q9NUZ1-1]
    ENST00000417074; ENSP00000387832; ENSG00000153093.
    ENST00000439055; ENSP00000407761; ENSG00000153093. [Q9NUZ1-4]
    GeneIDi55289.
    KEGGihsa:55289.
    UCSCiuc021vmm.1. human. [Q9NUZ1-1]
    uc021vmn.1. human. [Q9NUZ1-2]

    Polymorphism databases

    DMDMi205371797.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC096670 Genomic DNA. Translation: AAY14796.1 .
    AC023131 Genomic DNA. Translation: AAY14838.1 .
    AC096591 Genomic DNA. Translation: AAY24074.1 .
    AC114776 Genomic DNA. No translation available.
    CH471237 Genomic DNA. Translation: EAW50357.1 .
    BC022268 mRNA. Translation: AAH22268.1 . Sequence problems.
    BC131514 mRNA. Translation: AAI31515.2 .
    AK001904 mRNA. Translation: BAA91970.1 . Different initiation.
    CCDSi CCDS46389.1. [Q9NUZ1-4 ]
    RefSeqi NP_001136279.1. NM_001142807.1. [Q9NUZ1-4 ]
    UniGenei Hs.253320.

    3D structure databases

    ProteinModelPortali Q9NUZ1.
    SMRi Q9NUZ1. Positions 11-534.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120577. 1 interaction.

    PTM databases

    PhosphoSitei Q9NUZ1.

    Polymorphism databases

    DMDMi 205371797.

    Proteomic databases

    PaxDbi Q9NUZ1.
    PRIDEi Q9NUZ1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000340561 ; ENSP00000343717 ; ENSG00000153093 . [Q9NUZ1-3 ]
    ENST00000389811 ; ENSP00000374461 ; ENSG00000153093 . [Q9NUZ1-1 ]
    ENST00000417074 ; ENSP00000387832 ; ENSG00000153093 .
    ENST00000439055 ; ENSP00000407761 ; ENSG00000153093 . [Q9NUZ1-4 ]
    GeneIDi 55289.
    KEGGi hsa:55289.
    UCSCi uc021vmm.1. human. [Q9NUZ1-1 ]
    uc021vmn.1. human. [Q9NUZ1-2 ]

    Organism-specific databases

    CTDi 55289.
    GeneCardsi GC02P112268.
    HGNCi HGNC:25621. ACOXL.
    HPAi HPA035392.
    HPA035393.
    neXtProti NX_Q9NUZ1.
    PharmGKBi PA134932567.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1960.
    HOVERGENi HBG105796.
    InParanoidi Q9NUZ1.
    OMAi HKYLTPM.
    OrthoDBi EOG7NSB1S.
    PhylomeDBi Q9NUZ1.
    TreeFami TF354292.

    Miscellaneous databases

    ChiTaRSi ACOXL. human.
    GenomeRNAii 55289.
    NextBioi 59470.
    PROi Q9NUZ1.

    Gene expression databases

    ArrayExpressi Q9NUZ1.
    Bgeei Q9NUZ1.
    CleanExi HS_ACOXL.
    Genevestigatori Q9NUZ1.

    Family and domain databases

    Gene3Di 2.40.110.10. 1 hit.
    InterProi IPR006091. Acyl-CoA_Oxase/DH_cen-dom.
    IPR002655. Acyl-CoA_oxidase_C.
    IPR009075. AcylCo_DH/oxidase_C.
    IPR009100. AcylCoA_DH/oxidase_NM_dom.
    [Graphical view ]
    Pfami PF01756. ACOX. 1 hit.
    PF00441. Acyl-CoA_dh_1. 1 hit.
    PF02770. Acyl-CoA_dh_M. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47203. SSF47203. 2 hits.
    SSF56645. SSF56645. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 163-547 (ISOFORM 2).
      Tissue: Placenta.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 162-547 (ISOFORM 1).
      Tissue: Placenta.

    Entry informationi

    Entry nameiACOXL_HUMAN
    AccessioniPrimary (citable) accession number: Q9NUZ1
    Secondary accession number(s): A2RRB7
    , B7WPB3, B7WPP7, E9PB20, Q53R27, Q53R31, Q53SC6, Q8TCE7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 108 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3