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Q9NUZ1 (ACOXL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acyl-coenzyme A oxidase-like protein

Short name=Acyl-CoA oxidase-like protein
EC=1.3.3.-
Gene names
Name:ACOXL
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length547 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Cofactor

FAD By similarity.

Sequence similarities

Belongs to the acyl-CoA oxidase family.

Sequence caution

The sequence AAH22268.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.

The sequence BAA91970.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NUZ1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NUZ1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     354-383: Missing.
Isoform 3 (identifier: Q9NUZ1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     263-279: SRRQFGPKTKEEVKIIE → RSRIISQNCCSAPAGLY
     280-547: Missing.
Isoform 4 (identifier: Q9NUZ1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     354-383: Missing.
     544-547: QERC → QLLDLCDSVKDDARRVISTFNIPHTYLHAPIAGISNPRAAWAFYPAPLQPRPREEARSRRPKLGAKL

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 547547Acyl-coenzyme A oxidase-like protein
PRO_0000305100

Regions

Nucleotide binding350 – 3556FAD By similarity

Natural variations

Alternative sequence263 – 27917SRRQF…VKIIE → RSRIISQNCCSAPAGLY in isoform 3.
VSP_028237
Alternative sequence280 – 547268Missing in isoform 3.
VSP_028238
Alternative sequence354 – 38330Missing in isoform 2 and isoform 4.
VSP_028239
Alternative sequence544 – 5474QERC → QLLDLCDSVKDDARRVISTF NIPHTYLHAPIAGISNPRAA WAFYPAPLQPRPREEARSRR PKLGAKL in isoform 4.
VSP_046900
Natural variant2551T → M.
Corresponds to variant rs1554005 [ dbSNP | Ensembl ].
VAR_035164
Natural variant5351P → L.
Corresponds to variant rs17041850 [ dbSNP | Ensembl ].
VAR_035165

Experimental info

Sequence conflict2191S → L in AAH22268. Ref.3
Sequence conflict5121C → R in BAA91970. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified September 2, 2008. Version 3.
Checksum: 7F2B9B961AAE2F08

FASTA54761,795
        10         20         30         40         50         60 
MRALTVQRVK FAMDLPLLKR AGQDLAEKTK NFVSRSLVIG EVLSMADMAT GVKCGIIYWL 

        70         80         90        100        110        120 
FGGAIRNLGS PEHVTKWFQP LQEQKYTGMF AMTERGHGSN ARGIQTEATF DLSAQEFVID 

       130        140        150        160        170        180 
TPCENAEKMY IGNAMYGNYA AVFAQLIIDG RSQGPHCFIV PVRDENGSLY PGVTAIDMMY 

       190        200        210        220        230        240 
KEGLHGVDNG ILIFDKVRIP RENLLDKFGS VAPDGQYHSP IRNKSARFNA MLAALTPSRL 

       250        260        270        280        290        300 
AVAFQAMGAM KLGLTIAIRY SHSRRQFGPK TKEEVKIIEH QTQTLRLMPH LATALALTFV 

       310        320        330        340        350        360 
SRYAGALLDE DVFQGKELVN SRSLQALVAG LKAYSTWENI RCLQDCRECT GGMGYMMENR 

       370        380        390        400        410        420 
ISGLKCDTDV FATFEGDDVV MLQVVGRELL AQYTKQYEEK PLFGLLQNWA ESVGDKLRTS 

       430        440        450        460        470        480 
FLAFNMDTVD DLAFLLKAVK FRERVLQRGL VARIYYKVKT KKEDFFHAWN SCLHHVASLS 

       490        500        510        520        530        540 
LAHTHRVTLE QFSLAVKSCP DQEDQTLLMK FCLLYGTKLV FQERAWYLEH KYLTPMASTR 


IRNQERC 

« Hide

Isoform 2 [UniParc].

Checksum: B5754E07F073B6C9
Show »

FASTA51758,428
Isoform 3 [UniParc].

Checksum: B1E0B26AAEA56D45
Show »

FASTA27930,737
Isoform 4 [UniParc].

Checksum: 9DE724781D7ED1AA
Show »

FASTA58065,457

References

[1]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 163-547 (ISOFORM 2).
Tissue: Placenta.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 162-547 (ISOFORM 1).
Tissue: Placenta.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC096670 Genomic DNA. Translation: AAY14796.1.
AC023131 Genomic DNA. Translation: AAY14838.1.
AC096591 Genomic DNA. Translation: AAY24074.1.
AC114776 Genomic DNA. No translation available.
CH471237 Genomic DNA. Translation: EAW50357.1.
BC022268 mRNA. Translation: AAH22268.1. Sequence problems.
BC131514 mRNA. Translation: AAI31515.2.
AK001904 mRNA. Translation: BAA91970.1. Different initiation.
RefSeqNP_001136279.1. NM_001142807.1.
UniGeneHs.253320.

3D structure databases

ProteinModelPortalQ9NUZ1.
SMRQ9NUZ1. Positions 2-546.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120577. 1 interaction.

PTM databases

PhosphoSiteQ9NUZ1.

Polymorphism databases

DMDM205371797.

Proteomic databases

PaxDbQ9NUZ1.
PRIDEQ9NUZ1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000340561; ENSP00000343717; ENSG00000153093. [Q9NUZ1-3]
ENST00000389811; ENSP00000374461; ENSG00000153093. [Q9NUZ1-1]
ENST00000417074; ENSP00000387832; ENSG00000153093.
ENST00000439055; ENSP00000407761; ENSG00000153093. [Q9NUZ1-4]
GeneID55289.
KEGGhsa:55289.
UCSCuc021vmm.1. human. [Q9NUZ1-1]
uc021vmn.1. human. [Q9NUZ1-2]

Organism-specific databases

CTD55289.
GeneCardsGC02P112268.
HGNCHGNC:25621. ACOXL.
HPAHPA035392.
HPA035393.
neXtProtNX_Q9NUZ1.
PharmGKBPA134932567.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1960.
HOVERGENHBG105796.
InParanoidQ9NUZ1.
OMAHKYLTPM.
OrthoDBEOG7NSB1S.
PhylomeDBQ9NUZ1.
TreeFamTF354292.

Gene expression databases

ArrayExpressQ9NUZ1.
BgeeQ9NUZ1.
CleanExHS_ACOXL.
GenevestigatorQ9NUZ1.

Family and domain databases

Gene3D2.40.110.10. 1 hit.
InterProIPR006091. Acyl-CoA_Oxase/DH_cen-dom.
IPR012258. Acyl-CoA_oxidase.
IPR002655. Acyl-CoA_oxidase_C.
IPR009075. AcylCo_DH/oxidase_C.
IPR009100. AcylCoA_DH/oxidase_NM_dom.
[Graphical view]
PANTHERPTHR10909:SF11. PTHR10909:SF11. 1 hit.
PfamPF01756. ACOX. 1 hit.
PF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
[Graphical view]
SUPFAMSSF47203. SSF47203. 2 hits.
SSF56645. SSF56645. 1 hit.
ProtoNetSearch...

Other

ChiTaRSACOXL. human.
GenomeRNAi55289.
NextBio59470.
PROQ9NUZ1.

Entry information

Entry nameACOXL_HUMAN
AccessionPrimary (citable) accession number: Q9NUZ1
Secondary accession number(s): A2RRB7 expand/collapse secondary AC list , B7WPB3, B7WPP7, E9PB20, Q53R27, Q53R31, Q53SC6, Q8TCE7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: September 2, 2008
Last modified: April 16, 2014
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM