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Reviewed, UniProtKB/Swiss-Prot Q9NUZ1 (ACOXL_HUMAN)

Last modified November 24, 2009. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Acyl-coenzyme A oxidase-like protein
      Short name=Acyl-CoA oxidase-like protein
    EC=1.3.3.-
Gene names
Name: ACOXL
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length547 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Cofactor

FAD By similarity.

Sequence similarities

Belongs to the acyl-CoA oxidase family.

Sequence caution

The sequence AAH22268.1 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processfatty acid metabolic process

Inferred from electronic annotation. Source: InterPro

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentperoxisome

Inferred from electronic annotation. Source: InterPro

   Molecular functionFAD binding

Inferred from electronic annotation. Source: InterPro

acyl-CoA dehydrogenase activity

Inferred from electronic annotation. Source: InterPro

acyl-CoA oxidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9NUZ1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9NUZ1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     354-383: Missing.
Isoform 3 (identifier: Q9NUZ1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     263-279: SRRQFGPKTKEEVKIIE → RSRIISQNCCSAPAGLY
     280-547: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 547547Acyl-coenzyme A oxidase-like protein
PRO_0000305100

Regions

Nucleotide binding350 – 3556FAD By similarity

Natural variations

Alternative sequence263 – 27917SRRQF…VKIIE → RSRIISQNCCSAPAGLY in isoform 3.
VSP_028237
Alternative sequence280 – 547268Missing in isoform 3.
VSP_028238
Alternative sequence354 – 38330Missing in isoform 2.
VSP_028239
Natural variant2551T → M: dbSNP rs1554005.
VAR_035164
Natural variant5351P → L: dbSNP rs17041850.
VAR_035165

Experimental info

Sequence conflict2191S → L in AAH22268. Ref.3
Sequence conflict5121C → R in BAA91970. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified September 2, 2008. Version 3.
Checksum: 7F2B9B961AAE2F08

FASTA54761,795
        10         20         30         40         50         60 
MRALTVQRVK FAMDLPLLKR AGQDLAEKTK NFVSRSLVIG EVLSMADMAT GVKCGIIYWL 

        70         80         90        100        110        120 
FGGAIRNLGS PEHVTKWFQP LQEQKYTGMF AMTERGHGSN ARGIQTEATF DLSAQEFVID 

       130        140        150        160        170        180 
TPCENAEKMY IGNAMYGNYA AVFAQLIIDG RSQGPHCFIV PVRDENGSLY PGVTAIDMMY 

       190        200        210        220        230        240 
KEGLHGVDNG ILIFDKVRIP RENLLDKFGS VAPDGQYHSP IRNKSARFNA MLAALTPSRL 

       250        260        270        280        290        300 
AVAFQAMGAM KLGLTIAIRY SHSRRQFGPK TKEEVKIIEH QTQTLRLMPH LATALALTFV 

       310        320        330        340        350        360 
SRYAGALLDE DVFQGKELVN SRSLQALVAG LKAYSTWENI RCLQDCRECT GGMGYMMENR 

       370        380        390        400        410        420 
ISGLKCDTDV FATFEGDDVV MLQVVGRELL AQYTKQYEEK PLFGLLQNWA ESVGDKLRTS 

       430        440        450        460        470        480 
FLAFNMDTVD DLAFLLKAVK FRERVLQRGL VARIYYKVKT KKEDFFHAWN SCLHHVASLS 

       490        500        510        520        530        540 
LAHTHRVTLE QFSLAVKSCP DQEDQTLLMK FCLLYGTKLV FQERAWYLEH KYLTPMASTR 


IRNQERC 

« Hide

Isoform 2.

Checksum: B5754E07F073B6C9
Show »

FASTA51758,428
Isoform 3.

Checksum: B1E0B26AAEA56D45
Show »

FASTA27930,737

References

[1]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed: 15815621] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 163-547 (ISOFORM 2).
Tissue: Placenta.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 162-547 (ISOFORM 1).
Tissue: Placenta.

Cross-references

Sequence databases

AC096670 Genomic DNA. Translation: AAY14796.1.
AC023131 Genomic DNA. Translation: AAY14838.1.
AC096591 Genomic DNA. Translation: AAY24074.1.
AC114776 Genomic DNA. No translation available.
CH471237 Genomic DNA. Translation: EAW50357.1.
BC022268 mRNA. Translation: AAH22268.1. Sequence problems.
BC131514 mRNA. Translation: AAI31515.2.
AK001904 mRNA. Translation: BAA91970.1. Different initiation.
IPIIPI00019534.
IPI00412291.
IPI00867540.
RefSeqNP_001098986.1.
NP_001136279.1.
NP_001136280.1.
UniGeneHs.253320

3D structure databases

HSSPHSSP built from PDB template 1IS2 based on UniProtKB P07872.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9NUZ1.

Genome annotation databases

EnsemblENST00000389811; ENSP00000374461; ENSG00000153093; Homo sapiens. [Genome view]
GeneID55289.
KEGGhsa:55289.
NMPDRfig|9606.3.peg.18471.
UCSCuc002tgr.2. human.
uc010fkc.1. human.

Organism-specific databases

CTD55289.
GeneCardsGC02P111206.
HGNCHGNC:25621. ACOXL.
PharmGKBPA134932567.
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ9NUZ1.

Gene expression databases

ArrayExpressQ9NUZ1.
BgeeQ9NUZ1.
CleanExHS_ACOXL.
GenevestigatorQ9NUZ1.

Family and domain databases

InterProIPR006090. Acyl-CoA_Oxase/DH_1.
IPR006091. Acyl-CoA_Oxase/DH_M.
IPR012258. Acyl-CoA_oxidase.
IPR009075. AcylCo_DH/oxidase_C.
IPR009100. AcylCoA_DH/oxidase.
IPR013764. AcylCoA_oxidase/DH_1/2_C.
[Graphical view]
Gene3DG3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit.
G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 2 hits.
PANTHERPTHR10909:SF11. Acyl-CoA_oxidase. 1 hit.
PfamPF00441. Acyl-CoA_dh_1. 1 hit.
PF02770. Acyl-CoA_dh_M. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACOXL_HUMAN
AccessionPrimary (citable) accession number: Q9NUZ1
Secondary accession number(s): A2RRB7 expand/collapse secondary AC list , B7WPB3, Q53R27, Q53R31, Q53SC6, Q8TCE7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: September 2, 2008
Last modified: November 24, 2009
This is version 64 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents