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Protein

TBC1 domain family member 23

Gene

TBC1D23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000036054-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
TBC1 domain family member 23
Alternative name(s):
HCV non-structural protein 4A-transactivated protein 1
Gene namesi
Name:TBC1D23
Synonyms:NS4ATP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:25622. TBC1D23.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000036054.
PharmGKBiPA142670829.

Polymorphism and mutation databases

BioMutaiTBC1D23.
DMDMi300669675.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002874971 – 699TBC1 domain family member 23Add BLAST699

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei300PhosphoserineCombined sources1
Modified residuei469PhosphoserineBy similarity1
Modified residuei474PhosphoserineCombined sources1
Modified residuei507PhosphoserineCombined sources1
Modified residuei514PhosphothreonineCombined sources1
Modified residuei520PhosphoserineCombined sources1
Modified residuei571PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9NUY8.
MaxQBiQ9NUY8.
PaxDbiQ9NUY8.
PeptideAtlasiQ9NUY8.
PRIDEiQ9NUY8.

PTM databases

iPTMnetiQ9NUY8.
PhosphoSitePlusiQ9NUY8.

Expressioni

Gene expression databases

BgeeiENSG00000036054.
CleanExiHS_TBC1D23.
ExpressionAtlasiQ9NUY8. baseline and differential.
GenevisibleiQ9NUY8. HS.

Organism-specific databases

HPAiHPA038151.
HPA038152.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CAGE1Q8TC203EBI-2853126,EBI-10196469
KRTAP10-8P604103EBI-2853126,EBI-10171774
KRTAP10-9P604113EBI-10314276,EBI-10172052
KRTAP4-12Q9BQ663EBI-2853126,EBI-739863
SSBP3Q9BWW43EBI-10314276,EBI-2902395
WDR62O433793EBI-2853126,EBI-714790

Protein-protein interaction databases

BioGridi120889. 19 interactors.
IntActiQ9NUY8. 11 interactors.
STRINGi9606.ENSP00000377700.

Structurei

3D structure databases

ProteinModelPortaliQ9NUY8.
SMRiQ9NUY8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 225Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST182
Domaini334 – 446RhodanesePROSITE-ProRule annotationAdd BLAST113

Sequence similaritiesi

Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation
Contains 1 rhodanese domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3636. Eukaryota.
ENOG410Z3CX. LUCA.
GeneTreeiENSGT00390000000191.
HOGENOMiHOG000043921.
HOVERGENiHBG055636.
InParanoidiQ9NUY8.
OMAiSGHMFPS.
OrthoDBiEOG091G02UC.
PhylomeDBiQ9NUY8.
TreeFamiTF105892.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
InterProiIPR000195. Rab-GTPase-TBC_dom.
IPR001763. Rhodanese-like_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
SSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
PS50086. TBC_RABGAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9NUY8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEGEDVPPL PTSSGDGWEK DLEEALEAGG CDLETLRNII QGRPLPADLR
60 70 80 90 100
AKVWKIALNV AGKGDSLASW DGILDLPEQN TIHKDCLQFI DQLSVPEEKA
110 120 130 140 150
AELLLDIESV ITFYCKSRNI KYSTSLSWIH LLKPLVHLQL PRSDLYNCFY
160 170 180 190 200
AIMNKYIPRD CSQKGRPFHL FRLLIQYHEP ELCSYLDTKK ITPDSYALNW
210 220 230 240 250
LGSLFACYCS TEVTQAIWDG YLQQADPFFI YFLMLIILVN AKEVILTQES
260 270 280 290 300
DSKEEVIKFL ENTPSSLNIE DIEDLFSLAQ YYCSKTPASF RKDNHHLFGS
310 320 330 340 350
TLLGIKDDDA DLSQALCLAI SVSEILQANQ LQGEGVRFFV VDCRPAEQYN
360 370 380 390 400
AGHLSTAFHL DSDLMLQNPS EFAQSVKSLL EAQKQSIESG SIAGGEHLCF
410 420 430 440 450
MGSGREEEDM YMNMVLAHFL QKNKEYVSIA SGGFMALQQH LADINVDGPE
460 470 480 490 500
NGYGHWIAST SGSRSSINSV DGESPNGSSD RGMKSLVNKM TVALKTKSVN
510 520 530 540 550
VREKVISFIE NTSTPVDRMS FNLPWPDRSC TERHVSSSDR VGKPYRGVKP
560 570 580 590 600
VFSIGDEEEY DTDEIDSSSM SDDDRKEVVN IQTWINKPDV KHHFPCKEVK
610 620 630 640 650
ESGHMFPSHL LVTATHMYCL REIVSRKGLA YIQSRQALNS VVKITSKKKH
660 670 680 690
PELITFKYGN SSASGIEILA IERYLIPNAG DATKAIKQQI MKVLDALES
Length:699
Mass (Da):78,322
Last modified:July 13, 2010 - v3
Checksum:iC0AEB80E044B0F98
GO
Isoform 2 (identifier: Q9NUY8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     518-532: Missing.

Show »
Length:684
Mass (Da):76,501
Checksum:i06960AE231A64926
GO

Sequence cautioni

The sequence AAH10221 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH20955 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA91881 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66S → C in BAH16653 (PubMed:19077034).Curated1
Sequence conflicti66S → C in BAA91973 (PubMed:14702039).Curated1
Sequence conflicti170L → P in BAH16653 (PubMed:19077034).Curated1
Sequence conflicti170L → P in BAA91973 (PubMed:14702039).Curated1
Sequence conflicti360L → S in BAA91973 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_025519518 – 532Missing in isoform 2. 3 PublicationsAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB449910 mRNA. Translation: BAH16653.1.
AK001750 mRNA. Translation: BAA91881.1. Different initiation.
AK001908 mRNA. Translation: BAA91973.1.
AC078783 Genomic DNA. No translation available.
AC093003 Genomic DNA. No translation available.
BC010221 mRNA. Translation: AAH10221.1. Different initiation.
BC020955 mRNA. Translation: AAH20955.1. Different initiation.
AL713684 mRNA. Translation: CAD28488.1.
AY740521 mRNA. Translation: AAW66944.1.
CCDSiCCDS2936.1. [Q9NUY8-2]
CCDS56265.1. [Q9NUY8-1]
RefSeqiNP_001186127.1. NM_001199198.2. [Q9NUY8-1]
NP_060779.2. NM_018309.4. [Q9NUY8-2]
UniGeneiHs.477003.

Genome annotation databases

EnsembliENST00000344949; ENSP00000340693; ENSG00000036054. [Q9NUY8-2]
ENST00000394144; ENSP00000377700; ENSG00000036054. [Q9NUY8-1]
GeneIDi55773.
KEGGihsa:55773.
UCSCiuc003dts.5. human. [Q9NUY8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB449910 mRNA. Translation: BAH16653.1.
AK001750 mRNA. Translation: BAA91881.1. Different initiation.
AK001908 mRNA. Translation: BAA91973.1.
AC078783 Genomic DNA. No translation available.
AC093003 Genomic DNA. No translation available.
BC010221 mRNA. Translation: AAH10221.1. Different initiation.
BC020955 mRNA. Translation: AAH20955.1. Different initiation.
AL713684 mRNA. Translation: CAD28488.1.
AY740521 mRNA. Translation: AAW66944.1.
CCDSiCCDS2936.1. [Q9NUY8-2]
CCDS56265.1. [Q9NUY8-1]
RefSeqiNP_001186127.1. NM_001199198.2. [Q9NUY8-1]
NP_060779.2. NM_018309.4. [Q9NUY8-2]
UniGeneiHs.477003.

3D structure databases

ProteinModelPortaliQ9NUY8.
SMRiQ9NUY8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120889. 19 interactors.
IntActiQ9NUY8. 11 interactors.
STRINGi9606.ENSP00000377700.

PTM databases

iPTMnetiQ9NUY8.
PhosphoSitePlusiQ9NUY8.

Polymorphism and mutation databases

BioMutaiTBC1D23.
DMDMi300669675.

Proteomic databases

EPDiQ9NUY8.
MaxQBiQ9NUY8.
PaxDbiQ9NUY8.
PeptideAtlasiQ9NUY8.
PRIDEiQ9NUY8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344949; ENSP00000340693; ENSG00000036054. [Q9NUY8-2]
ENST00000394144; ENSP00000377700; ENSG00000036054. [Q9NUY8-1]
GeneIDi55773.
KEGGihsa:55773.
UCSCiuc003dts.5. human. [Q9NUY8-1]

Organism-specific databases

CTDi55773.
GeneCardsiTBC1D23.
H-InvDBHIX0003503.
HGNCiHGNC:25622. TBC1D23.
HPAiHPA038151.
HPA038152.
neXtProtiNX_Q9NUY8.
OpenTargetsiENSG00000036054.
PharmGKBiPA142670829.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3636. Eukaryota.
ENOG410Z3CX. LUCA.
GeneTreeiENSGT00390000000191.
HOGENOMiHOG000043921.
HOVERGENiHBG055636.
InParanoidiQ9NUY8.
OMAiSGHMFPS.
OrthoDBiEOG091G02UC.
PhylomeDBiQ9NUY8.
TreeFamiTF105892.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000036054-MONOMER.

Miscellaneous databases

GenomeRNAii55773.
PROiQ9NUY8.

Gene expression databases

BgeeiENSG00000036054.
CleanExiHS_TBC1D23.
ExpressionAtlasiQ9NUY8. baseline and differential.
GenevisibleiQ9NUY8. HS.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
InterProiIPR000195. Rab-GTPase-TBC_dom.
IPR001763. Rhodanese-like_dom.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
SMARTiSM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
SSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
PS50086. TBC_RABGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBC23_HUMAN
AccessioniPrimary (citable) accession number: Q9NUY8
Secondary accession number(s): B9A6M5
, Q8TCN8, Q8WUB7, Q96D90, Q9NV75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 13, 2010
Last modified: November 30, 2016
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.