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Protein

GTPase IMAP family member 4

Gene

GIMAP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in regulating lymphocyte apoptosis (By similarity). Exhibits intrisinic GTPase activity. Shows a higher affinity for GDP over GTP (about 12-fold higher), and binding shows an absolute requirement for magnesium.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei58 – 581GTP
Binding sitei191 – 1911GTP

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi37 – 459GTP
Nucleotide bindingi155 – 1573GTP

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase IMAP family member 4
Alternative name(s):
Immunity-associated nucleotide 1 protein
Short name:
IAN-1
Short name:
hIAN1
Immunity-associated protein 4
Gene namesi
Name:GIMAP4
Synonyms:IAN1, IMAP4
ORF Names:MSTP062
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21872. GIMAP4.

Subcellular locationi

  1. Cytoplasmcytosol 1 Publication

GO - Cellular componenti

  1. cytosol Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394681.

Polymorphism and mutation databases

BioMutaiGIMAP4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329GTPase IMAP family member 4PRO_0000190987Add
BLAST

Post-translational modificationi

Phosphorylated at very low levels in resting splenocytes. Rapidly and transiently phosphorylated in response to splenocyte activation (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9NUV9.
PaxDbiQ9NUV9.
PRIDEiQ9NUV9.

PTM databases

PhosphoSiteiQ9NUV9.

Expressioni

Tissue specificityi

Highly expressed in spleen and peripheral blood leukocytes that contain mostly T- and B-lymphocytes. Expressed specifically in resting T- and B-lymphocytes and expression significantly decreases during B- or T-lymphocyte activation. Expressed at lower levels in thymus, ovary, colon and small intestine.1 Publication

Gene expression databases

BgeeiQ9NUV9.
CleanExiHS_GIMAP4.
ExpressionAtlasiQ9NUV9. baseline and differential.
GenevestigatoriQ9NUV9.

Organism-specific databases

HPAiHPA019135.
HPA019137.
HPA027198.

Interactioni

Protein-protein interaction databases

BioGridi120589. 2 interactions.
IntActiQ9NUV9. 1 interaction.
STRINGi9606.ENSP00000255945.

Structurei

Secondary structure

1
329
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi30 – 367Combined sources
Helixi43 – 519Combined sources
Beta strandi70 – 767Combined sources
Beta strandi79 – 857Combined sources
Helixi97 – 10913Combined sources
Turni110 – 1123Combined sources
Beta strandi115 – 1228Combined sources
Helixi129 – 14517Combined sources
Helixi146 – 1483Combined sources
Beta strandi149 – 1546Combined sources
Helixi156 – 1583Combined sources
Helixi173 – 18210Combined sources
Beta strandi183 – 1886Combined sources
Helixi195 – 21521Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3LXXX-ray2.15A20-240[»]
ProteinModelPortaliQ9NUV9.
SMRiQ9NUV9. Positions 29-265.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9NUV9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 230203AIG1-type GAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili188 – 300113Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG76898.
GeneTreeiENSGT00760000118989.
HOGENOMiHOG000115747.
HOVERGENiHBG004016.
InParanoidiQ9NUV9.
OrthoDBiEOG7XM2Z9.
PhylomeDBiQ9NUV9.
TreeFamiTF330845.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR006703. G_AIG1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF04548. AIG1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51720. G_AIG1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NUV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQYGSMSF NPSTPGASYG PGRQEPRNSQ LRIVLVGKTG AGKSATGNSI
60 70 80 90 100
LGRKVFHSGT AAKSITKKCE KRSSSWKETE LVVVDTPGIF DTEVPNAETS
110 120 130 140 150
KEIIRCILLT SPGPHALLLV VPLGRYTEEE HKATEKILKM FGERARSFMI
160 170 180 190 200
LIFTRKDDLG DTNLHDYLRE APEDIQDLMD IFGDRYCALN NKATGAEQEA
210 220 230 240 250
QRAQLLGLIQ RVVRENKEGC YTNRMYQRAE EEIQKQTQAM QELHRVELER
260 270 280 290 300
EKARIREEYE EKIRKLEDKV EQEKRKKQME KKLAEQEAHY AVRQQRARTE
310 320
VESKDGILEL IMTALQIASF ILLRLFAED
Length:329
Mass (Da):37,534
Last modified:October 1, 2000 - v1
Checksum:i9D64BA4FB1C5DF72
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti128 – 1281E → D.
Corresponds to variant rs2293172 [ dbSNP | Ensembl ].
VAR_017306

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117333 mRNA. Translation: AAO15308.1.
AK001972 mRNA. Translation: BAA92010.1.
BC020657 mRNA. Translation: AAH20657.1.
CCDSiCCDS5904.1.
RefSeqiNP_060796.1. NM_018326.2.
UniGeneiHs.647101.
Hs.648582.

Genome annotation databases

EnsembliENST00000255945; ENSP00000255945; ENSG00000133574.
GeneIDi55303.
KEGGihsa:55303.
UCSCiuc003whl.3. human.

Polymorphism and mutation databases

BioMutaiGIMAP4.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117333 mRNA. Translation: AAO15308.1.
AK001972 mRNA. Translation: BAA92010.1.
BC020657 mRNA. Translation: AAH20657.1.
CCDSiCCDS5904.1.
RefSeqiNP_060796.1. NM_018326.2.
UniGeneiHs.647101.
Hs.648582.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3LXXX-ray2.15A20-240[»]
ProteinModelPortaliQ9NUV9.
SMRiQ9NUV9. Positions 29-265.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120589. 2 interactions.
IntActiQ9NUV9. 1 interaction.
STRINGi9606.ENSP00000255945.

PTM databases

PhosphoSiteiQ9NUV9.

Polymorphism and mutation databases

BioMutaiGIMAP4.

Proteomic databases

MaxQBiQ9NUV9.
PaxDbiQ9NUV9.
PRIDEiQ9NUV9.

Protocols and materials databases

DNASUi55303.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000255945; ENSP00000255945; ENSG00000133574.
GeneIDi55303.
KEGGihsa:55303.
UCSCiuc003whl.3. human.

Organism-specific databases

CTDi55303.
GeneCardsiGC07P150264.
HGNCiHGNC:21872. GIMAP4.
HPAiHPA019135.
HPA019137.
HPA027198.
MIMi608087. gene.
neXtProtiNX_Q9NUV9.
PharmGKBiPA128394681.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG76898.
GeneTreeiENSGT00760000118989.
HOGENOMiHOG000115747.
HOVERGENiHBG004016.
InParanoidiQ9NUV9.
OrthoDBiEOG7XM2Z9.
PhylomeDBiQ9NUV9.
TreeFamiTF330845.

Miscellaneous databases

ChiTaRSiGIMAP4. human.
EvolutionaryTraceiQ9NUV9.
GeneWikiiGIMAP4.
GenomeRNAii55303.
NextBioi59530.
PROiQ9NUV9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NUV9.
CleanExiHS_GIMAP4.
ExpressionAtlasiQ9NUV9. baseline and differential.
GenevestigatoriQ9NUV9.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR006703. G_AIG1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF04548. AIG1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51720. G_AIG1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Human immune associated nucleotide 1: a member of a new guanosine triphosphatase family expressed in resting T and B cells."
    Cambot M., Aresta S., Kahn-Perles B., de Gunzburg J., Romeo P.-H.
    Blood 99:3293-3301(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
    Tissue: T-cell lymphoma.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  5. Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  7. "Crystal structure of human GTPase imap family member 4."
    Structural genomics consortium (SGC)
    Submitted (MAR-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 20-240 IN COMPLEX WITH MAGNESIUM AND GDP.

Entry informationi

Entry nameiGIMA4_HUMAN
AccessioniPrimary (citable) accession number: Q9NUV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: October 1, 2000
Last modified: April 29, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.