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Q9NUV9 (GIMA4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTPase IMAP family member 4
Alternative name(s):
Immunity-associated nucleotide 1 protein
Short name=IAN-1
Short name=hIAN1
Immunity-associated protein 4
Gene names
Name:GIMAP4
Synonyms:IAN1, IMAP4
ORF Names:MSTP062
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length329 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in regulating lymphocyte apoptosis By similarity. Exhibits intrisinic GTPase activity. Shows a higher affinity for GDP over GTP (about 12-fold higher), and binding shows an absolute requirement for magnesium.

Subcellular location

Cytoplasmcytosol Ref.5.

Tissue specificity

Highly expressed in spleen and peripheral blood leukocytes that contain mostly T- and B-lymphocytes. Expressed specifically in resting T- and B-lymphocytes and expression significantly decreases during B- or T-lymphocyte activation. Expressed at lower levels in thymus, ovary, colon and small intestine. Ref.5

Post-translational modification

Phosphorylated at very low levels in resting splenocytes. Rapidly and transiently phosphorylated in response to splenocyte activation By similarity.

Sequence similarities

Belongs to the IAN GTP-binding protein family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversityPolymorphism
   DomainCoiled coil
   LigandGTP-binding
Nucleotide-binding
   PTMPhosphoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytosol

Inferred from direct assay Ref.5. Source: UniProtKB

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 329329GTPase IMAP family member 4
PRO_0000190987

Regions

Nucleotide binding37 – 459GTP
Nucleotide binding155 – 1573GTP
Coiled coil188 – 300113 Potential

Sites

Binding site581GTP
Binding site1911GTP

Natural variations

Natural variant1281E → D.
Corresponds to variant rs2293172 [ dbSNP | Ensembl ].
VAR_017306

Secondary structure

......................... 329
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9NUV9 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 9D64BA4FB1C5DF72

FASTA32937,534
        10         20         30         40         50         60 
MAAQYGSMSF NPSTPGASYG PGRQEPRNSQ LRIVLVGKTG AGKSATGNSI LGRKVFHSGT 

        70         80         90        100        110        120 
AAKSITKKCE KRSSSWKETE LVVVDTPGIF DTEVPNAETS KEIIRCILLT SPGPHALLLV 

       130        140        150        160        170        180 
VPLGRYTEEE HKATEKILKM FGERARSFMI LIFTRKDDLG DTNLHDYLRE APEDIQDLMD 

       190        200        210        220        230        240 
IFGDRYCALN NKATGAEQEA QRAQLLGLIQ RVVRENKEGC YTNRMYQRAE EEIQKQTQAM 

       250        260        270        280        290        300 
QELHRVELER EKARIREEYE EKIRKLEDKV EQEKRKKQME KKLAEQEAHY AVRQQRARTE 

       310        320 
VESKDGILEL IMTALQIASF ILLRLFAED 

« Hide

References

« Hide 'large scale' references
[1]"Human immune associated nucleotide 1: a member of a new guanosine triphosphatase family expressed in resting T and B cells."
Cambot M., Aresta S., Kahn-Perles B., de Gunzburg J., Romeo P.-H.
Blood 99:3293-3301(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
Tissue: T-cell lymphoma.
[2]Liu Y.Q., Liu B., Zhao B., Wang X.Y., Song L., Ye J., Sheng H., Gao Y., Zhang C.L., Zhang J., Wei Y.J., Sun Y.H., Jiang Y.X., Zhao X.W., Liu S., Liu L.S., Ding J.F., Gao R.L. expand/collapse author list , Wu Q.Y., Quiang B.Q., Yuan J.G., Liew C.C., Zhao M.S., Hui R.T.
Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[5]"Structural insights into the mechanism of GTPase activation in the GIMAP family."
Schwefel D., Arasu B.S., Marino S.F., Lamprecht B., Kochert K., Rosenbaum E., Eichhorst J., Wiesner B., Behlke J., Rocks O., Mathas S., Daumke O.
Structure 21:550-559(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[6]"Crystal structure of human GTPase imap family member 4."
Structural genomics consortium (SGC)
Submitted (MAR-2010) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 20-240 IN COMPLEX WITH MAGNESIUM AND GDP.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF117333 mRNA. Translation: AAO15308.1.
AK001972 mRNA. Translation: BAA92010.1.
BC020657 mRNA. Translation: AAH20657.1.
RefSeqNP_060796.1. NM_018326.2.
UniGeneHs.647101.
Hs.648582.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3LXXX-ray2.15A20-240[»]
ProteinModelPortalQ9NUV9.
SMRQ9NUV9. Positions 29-265.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120589. 2 interactions.
IntActQ9NUV9. 1 interaction.
STRING9606.ENSP00000255945.

PTM databases

PhosphoSiteQ9NUV9.

Proteomic databases

PaxDbQ9NUV9.
PRIDEQ9NUV9.

Protocols and materials databases

DNASU55303.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000255945; ENSP00000255945; ENSG00000133574.
GeneID55303.
KEGGhsa:55303.
UCSCuc003whl.3. human.

Organism-specific databases

CTD55303.
GeneCardsGC07P150264.
HGNCHGNC:21872. GIMAP4.
HPAHPA019135.
HPA019137.
HPA027198.
MIM608087. gene.
neXtProtNX_Q9NUV9.
PharmGKBPA128394681.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG76898.
HOGENOMHOG000115747.
HOVERGENHBG004016.
InParanoidQ9NUV9.
OrthoDBEOG7XM2Z9.
PhylomeDBQ9NUV9.
TreeFamTF330845.

Gene expression databases

ArrayExpressQ9NUV9.
BgeeQ9NUV9.
CleanExHS_GIMAP4.
GenevestigatorQ9NUV9.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR006703. AIG1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF04548. AIG1. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Other

ChiTaRSGIMAP4. human.
EvolutionaryTraceQ9NUV9.
GeneWikiGIMAP4.
GenomeRNAi55303.
NextBio59530.
PROQ9NUV9.
SOURCESearch...

Entry information

Entry nameGIMA4_HUMAN
AccessionPrimary (citable) accession number: Q9NUV9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM