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Q9NUV9

- GIMA4_HUMAN

UniProt

Q9NUV9 - GIMA4_HUMAN

Protein

GTPase IMAP family member 4

Gene

GIMAP4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    May play a role in regulating lymphocyte apoptosis By similarity. Exhibits intrisinic GTPase activity. Shows a higher affinity for GDP over GTP (about 12-fold higher), and binding shows an absolute requirement for magnesium.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei58 – 581GTP
    Binding sitei191 – 1911GTP

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi37 – 459GTP
    Nucleotide bindingi155 – 1573GTP

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTPase IMAP family member 4
    Alternative name(s):
    Immunity-associated nucleotide 1 protein
    Short name:
    IAN-1
    Short name:
    hIAN1
    Immunity-associated protein 4
    Gene namesi
    Name:GIMAP4
    Synonyms:IAN1, IMAP4
    ORF Names:MSTP062
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:21872. GIMAP4.

    Subcellular locationi

    Cytoplasmcytosol 1 Publication

    GO - Cellular componenti

    1. cytosol Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA128394681.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 329329GTPase IMAP family member 4PRO_0000190987Add
    BLAST

    Post-translational modificationi

    Phosphorylated at very low levels in resting splenocytes. Rapidly and transiently phosphorylated in response to splenocyte activation By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9NUV9.
    PaxDbiQ9NUV9.
    PRIDEiQ9NUV9.

    PTM databases

    PhosphoSiteiQ9NUV9.

    Expressioni

    Tissue specificityi

    Highly expressed in spleen and peripheral blood leukocytes that contain mostly T- and B-lymphocytes. Expressed specifically in resting T- and B-lymphocytes and expression significantly decreases during B- or T-lymphocyte activation. Expressed at lower levels in thymus, ovary, colon and small intestine.1 Publication

    Gene expression databases

    ArrayExpressiQ9NUV9.
    BgeeiQ9NUV9.
    CleanExiHS_GIMAP4.
    GenevestigatoriQ9NUV9.

    Organism-specific databases

    HPAiHPA019135.
    HPA019137.
    HPA027198.

    Interactioni

    Protein-protein interaction databases

    BioGridi120589. 2 interactions.
    IntActiQ9NUV9. 1 interaction.
    STRINGi9606.ENSP00000255945.

    Structurei

    Secondary structure

    1
    329
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi30 – 367
    Helixi43 – 519
    Beta strandi70 – 767
    Beta strandi79 – 857
    Helixi97 – 10913
    Turni110 – 1123
    Beta strandi115 – 1228
    Helixi129 – 14517
    Helixi146 – 1483
    Beta strandi149 – 1546
    Helixi156 – 1583
    Helixi173 – 18210
    Beta strandi183 – 1886
    Helixi195 – 21521

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3LXXX-ray2.15A20-240[»]
    ProteinModelPortaliQ9NUV9.
    SMRiQ9NUV9. Positions 29-265.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9NUV9.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 230203AIG1-type GAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili188 – 300113Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG76898.
    HOGENOMiHOG000115747.
    HOVERGENiHBG004016.
    InParanoidiQ9NUV9.
    OrthoDBiEOG7XM2Z9.
    PhylomeDBiQ9NUV9.
    TreeFamiTF330845.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR006703. AIG1.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF04548. AIG1. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS51720. G_AIG1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9NUV9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAQYGSMSF NPSTPGASYG PGRQEPRNSQ LRIVLVGKTG AGKSATGNSI    50
    LGRKVFHSGT AAKSITKKCE KRSSSWKETE LVVVDTPGIF DTEVPNAETS 100
    KEIIRCILLT SPGPHALLLV VPLGRYTEEE HKATEKILKM FGERARSFMI 150
    LIFTRKDDLG DTNLHDYLRE APEDIQDLMD IFGDRYCALN NKATGAEQEA 200
    QRAQLLGLIQ RVVRENKEGC YTNRMYQRAE EEIQKQTQAM QELHRVELER 250
    EKARIREEYE EKIRKLEDKV EQEKRKKQME KKLAEQEAHY AVRQQRARTE 300
    VESKDGILEL IMTALQIASF ILLRLFAED 329
    Length:329
    Mass (Da):37,534
    Last modified:October 1, 2000 - v1
    Checksum:i9D64BA4FB1C5DF72
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti128 – 1281E → D.
    Corresponds to variant rs2293172 [ dbSNP | Ensembl ].
    VAR_017306

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF117333 mRNA. Translation: AAO15308.1.
    AK001972 mRNA. Translation: BAA92010.1.
    BC020657 mRNA. Translation: AAH20657.1.
    CCDSiCCDS5904.1.
    RefSeqiNP_060796.1. NM_018326.2.
    UniGeneiHs.647101.
    Hs.648582.

    Genome annotation databases

    EnsembliENST00000255945; ENSP00000255945; ENSG00000133574.
    GeneIDi55303.
    KEGGihsa:55303.
    UCSCiuc003whl.3. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF117333 mRNA. Translation: AAO15308.1 .
    AK001972 mRNA. Translation: BAA92010.1 .
    BC020657 mRNA. Translation: AAH20657.1 .
    CCDSi CCDS5904.1.
    RefSeqi NP_060796.1. NM_018326.2.
    UniGenei Hs.647101.
    Hs.648582.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3LXX X-ray 2.15 A 20-240 [» ]
    ProteinModelPortali Q9NUV9.
    SMRi Q9NUV9. Positions 29-265.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120589. 2 interactions.
    IntActi Q9NUV9. 1 interaction.
    STRINGi 9606.ENSP00000255945.

    PTM databases

    PhosphoSitei Q9NUV9.

    Proteomic databases

    MaxQBi Q9NUV9.
    PaxDbi Q9NUV9.
    PRIDEi Q9NUV9.

    Protocols and materials databases

    DNASUi 55303.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000255945 ; ENSP00000255945 ; ENSG00000133574 .
    GeneIDi 55303.
    KEGGi hsa:55303.
    UCSCi uc003whl.3. human.

    Organism-specific databases

    CTDi 55303.
    GeneCardsi GC07P150264.
    HGNCi HGNC:21872. GIMAP4.
    HPAi HPA019135.
    HPA019137.
    HPA027198.
    MIMi 608087. gene.
    neXtProti NX_Q9NUV9.
    PharmGKBi PA128394681.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG76898.
    HOGENOMi HOG000115747.
    HOVERGENi HBG004016.
    InParanoidi Q9NUV9.
    OrthoDBi EOG7XM2Z9.
    PhylomeDBi Q9NUV9.
    TreeFami TF330845.

    Miscellaneous databases

    ChiTaRSi GIMAP4. human.
    EvolutionaryTracei Q9NUV9.
    GeneWikii GIMAP4.
    GenomeRNAii 55303.
    NextBioi 59530.
    PROi Q9NUV9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NUV9.
    Bgeei Q9NUV9.
    CleanExi HS_GIMAP4.
    Genevestigatori Q9NUV9.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR006703. AIG1.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF04548. AIG1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS51720. G_AIG1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human immune associated nucleotide 1: a member of a new guanosine triphosphatase family expressed in resting T and B cells."
      Cambot M., Aresta S., Kahn-Perles B., de Gunzburg J., Romeo P.-H.
      Blood 99:3293-3301(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION.
      Tissue: T-cell lymphoma.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    5. Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    6. "Crystal structure of human GTPase imap family member 4."
      Structural genomics consortium (SGC)
      Submitted (MAR-2010) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 20-240 IN COMPLEX WITH MAGNESIUM AND GDP.

    Entry informationi

    Entry nameiGIMA4_HUMAN
    AccessioniPrimary (citable) accession number: Q9NUV9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 14, 2003
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3