Q9NUV9 (GIMA4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTPase IMAP family member 4

Alternative name(s):
Immunity-associated nucleotide 1 protein
Short name=IAN-1
Short name=hIAN1
Immunity-associated protein 4

Gene names

Name:	GIMAP4
Synonyms:	IAN1, IMAP4
ORF Names:	MSTP062

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	329 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in regulating lymphocyte apoptosis By similarity. Exhibits intrisinic GTPase activity. Shows a higher affinity for GDP over GTP (about 12-fold higher), and binding shows an absolute requirement for magnesium.
Subcellular location	Cytoplasm › cytosol By similarity.
Tissue specificity	Highly expressed in spleen and peripheral blood leukocytes that contain mostly T- and B-lymphocytes. Expressed specifically in resting T- and B-lymphocytes and expression significantly decreases during B- or T-lymphocyte activation. Expressed at lower levels in thymus, ovary, colon and small intestine.
Post-translational modification	Phosphorylated at very low levels in resting splenocytes. Rapidly and transiently phosphorylated in response to splenocyte activation By similarity.
Sequence similarities	Belongs to the IAN GTP-binding protein family.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Domain	Coiled coil
Ligand	GTP-binding Nucleotide-binding
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from direct assay. Source: HPA
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 329

329

GTPase IMAP family member 4

PRO_0000190987

Regions

Nucleotide binding

37 – 45

9

GTP

Nucleotide binding

155 – 157

3

GTP

Coiled coil

188 – 300

113

Potential

Sites

Binding site

58

1

GTP

Binding site

191

1

GTP

Natural variations

Natural variant

128

1

E → D.
Corresponds to variant rs2293172 [ dbSNP | Ensembl ].

VAR_017306

Secondary structure

1

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329

Helix Strand Turn

Details...

Beta strand

30 – 36

7

Helix

43 – 51

9

Beta strand

70 – 76

7

Beta strand

79 – 85

7

Helix

97 – 109

13

Turn

110 – 112

3

Beta strand

115 – 122

8

Helix

129 – 145

17

Helix

146 – 148

3

Beta strand

149 – 154

6

Helix

156 – 158

3

Helix

173 – 182

10

Beta strand

183 – 188

6

Helix

195 – 215

21

Sequences

	Sequence		Length	Mass (Da)
	Q9NUV9 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 9D64BA4FB1C5DF72	FASTA	329	37,534
	10 20 30 40 50 60 MAAQYGSMSF NPSTPGASYG PGRQEPRNSQ LRIVLVGKTG AGKSATGNSI LGRKVFHSGT 70 80 90 100 110 120 AAKSITKKCE KRSSSWKETE LVVVDTPGIF DTEVPNAETS KEIIRCILLT SPGPHALLLV 130 140 150 160 170 180 VPLGRYTEEE HKATEKILKM FGERARSFMI LIFTRKDDLG DTNLHDYLRE APEDIQDLMD 190 200 210 220 230 240 IFGDRYCALN NKATGAEQEA QRAQLLGLIQ RVVRENKEGC YTNRMYQRAE EEIQKQTQAM 250 260 270 280 290 300 QELHRVELER EKARIREEYE EKIRKLEDKV EQEKRKKQME KKLAEQEAHY AVRQQRARTE 310 320 VESKDGILEL IMTALQIASF ILLRLFAED

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human immune associated nucleotide 1: a member of a new guanosine triphosphatase family expressed in resting T and B cells." Cambot M., Aresta S., Kahn-Perles B., de Gunzburg J., Romeo P.-H. Blood 99:3293-3301(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION. Tissue: T-cell lymphoma.
[2]	Liu Y.Q., Liu B., Zhao B., Wang X.Y., Song L., Ye J., Sheng H., Gao Y., Zhang C.L., Zhang J., Wei Y.J., Sun Y.H., Jiang Y.X., Zhao X.W., Liu S., Liu L.S., Ding J.F., Gao R.L. , Wu Q.Y., Quiang B.Q., Yuan J.G., Liew C.C., Zhao M.S., Hui R.T. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[5]	"Crystal structure of human GTPase imap family member 4." Structural genomics consortium (SGC) Submitted (MAR-2010) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 20-240 IN COMPLEX WITH MAGNESIUM AND GDP.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF117333 mRNA. Translation: AAO15308.1.
AK001972 mRNA. Translation: BAA92010.1.
BC020657 mRNA. Translation: AAH20657.1.

IPI

IPI00939265.

RefSeq

NP_060796.1. NM_018326.2.

UniGene

Hs.647101.
Hs.648582.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3LXX	X-ray	2.15	A	20-240	[»]

ProteinModelPortal

Q9NUV9.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9NUV9. 1 interaction.

STRING

9606.ENSP00000255945.

PTM databases

PhosphoSite

Q9NUV9.

Polymorphism databases

DMDM

38372394.

Proteomic databases

PaxDb

Q9NUV9.

PRIDE

Q9NUV9.

Protocols and materials databases

DNASU

55303.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000255945; ENSP00000255945; ENSG00000133574.

GeneID

55303.

KEGG

hsa:55303.

UCSC

uc003whl.3. human.

Organism-specific databases

CTD

55303.

GeneCards

GC07P150264.

HGNC

HGNC:21872. GIMAP4.

HPA

HPA019135.
HPA019137.
HPA027198.

MIM

608087. gene.

neXtProt

NX_Q9NUV9.

PharmGKB

PA128394681.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG76898.

HOGENOM

HOG000115747.

HOVERGEN

HBG004016.

InParanoid

Q9NUV9.

OrthoDB

EOG4B2SXS.

PhylomeDB

Q9NUV9.

Gene expression databases

ArrayExpress

Q9NUV9.

Bgee

Q9NUV9.

CleanEx

HS_GIMAP4.

Genevestigator

Q9NUV9.

GermOnline

ENSG00000133574. Homo sapiens.

Family and domain databases

InterPro

IPR006703. AIG1.
[Graphical view]

Pfam

PF04548. AIG1. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

GIMAP4. human.

EvolutionaryTrace

Q9NUV9.

GenomeRNAi

55303.

NextBio

59530.

SOURCE

Search...

Entry information

Entry name

GIMA4_HUMAN

Accession

Primary (citable) accession number: Q9NUV9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 14, 2003
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.