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Q9NUU6

- F105A_HUMAN

UniProt

Q9NUU6 - F105A_HUMAN

Protein

Inactive ubiquitin thioesterase FAM105A

Gene

FAM105A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inactive ubiquitin thioesterase FAM105A
    Gene namesi
    Name:FAM105A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:25629. FAM105A.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671788.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 356356Inactive ubiquitin thioesterase FAM105APRO_0000274404Add
    BLAST

    Proteomic databases

    MaxQBiQ9NUU6.
    PaxDbiQ9NUU6.
    PRIDEiQ9NUU6.

    PTM databases

    PhosphoSiteiQ9NUU6.

    Expressioni

    Gene expression databases

    BgeeiQ9NUU6.
    CleanExiHS_FAM105A.
    GenevestigatoriQ9NUU6.

    Organism-specific databases

    HPAiHPA046638.

    Interactioni

    Protein-protein interaction databases

    BioGridi119988. 2 interactions.
    STRINGi9606.ENSP00000274217.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NUU6.
    SMRiQ9NUU6. Positions 88-355.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini128 – 356229OTUAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C65 family. Otulin subfamily.Curated
    Contains 1 OTU domain.Curated

    Phylogenomic databases

    eggNOGiNOG38836.
    HOGENOMiHOG000294085.
    HOVERGENiHBG059856.
    InParanoidiQ9NUU6.
    OMAiHLNSVGD.
    OrthoDBiEOG76QFHQ.
    PhylomeDBiQ9NUU6.
    TreeFamiTF328709.

    Family and domain databases

    InterProiIPR023235. FAM105.
    IPR023236. FAM105A.
    [Graphical view]
    PRINTSiPR02055. PROTEINF105.
    PR02056. PROTEINF105A.

    Sequencei

    Sequence statusi: Complete.

    Q9NUU6-1 [UniParc]FASTAAdd to Basket

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    MAATRSPTRA RERERSGAPA AGSDQVHSWM LATSQALDTV WRMAKGFVML    50
    AVSFLVAAIC YFRRLHLYSG HKLKWWIGYL QRKFKRNLSV EAEVDLLSYC 100
    AREWKGETPR NKLMRKAYEE LFWRHHIKCV RQVRRDNYDA LRSVLFQIFS 150
    QGISFPSWMK EKDIVKLPEK LLFSQGCNWI QQYSFGPEKY TGSNVFGKLR 200
    KYVELLKTQW TEFNGIRDYH KRGSMCNTLF SDAILEYKLY EALKFIMLYQ 250
    VTEVYEQMKT KKVIPSLFRL LFSRETSSDP LSFMMNHLNS VGDTCGLEQI 300
    DMFILGYSLE VKIKVFRLFK FNSRDFEVCY PEEPLRDWPE ISLLTENDRH 350
    YHIPVF 356
    Length:356
    Mass (Da):42,196
    Last modified:October 1, 2000 - v1
    Checksum:i91EEC6C877D5315B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti322 – 3221N → I in BAD96451. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti319 – 3191F → L.
    Corresponds to variant rs16903574 [ dbSNP | Ensembl ].
    VAR_030281

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001989 mRNA. Translation: BAA92023.1.
    AK222731 mRNA. Translation: BAD96451.1.
    BC011524 mRNA. Translation: AAH11524.1.
    AL512750 mRNA. Translation: CAC21673.1.
    CCDSiCCDS3884.1.
    RefSeqiNP_061891.1. NM_019018.2.
    UniGeneiHs.155085.

    Genome annotation databases

    EnsembliENST00000274217; ENSP00000274217; ENSG00000145569.
    GeneIDi54491.
    KEGGihsa:54491.
    UCSCiuc003jfj.3. human.

    Polymorphism databases

    DMDMi74734394.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK001989 mRNA. Translation: BAA92023.1 .
    AK222731 mRNA. Translation: BAD96451.1 .
    BC011524 mRNA. Translation: AAH11524.1 .
    AL512750 mRNA. Translation: CAC21673.1 .
    CCDSi CCDS3884.1.
    RefSeqi NP_061891.1. NM_019018.2.
    UniGenei Hs.155085.

    3D structure databases

    ProteinModelPortali Q9NUU6.
    SMRi Q9NUU6. Positions 88-355.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119988. 2 interactions.
    STRINGi 9606.ENSP00000274217.

    PTM databases

    PhosphoSitei Q9NUU6.

    Polymorphism databases

    DMDMi 74734394.

    Proteomic databases

    MaxQBi Q9NUU6.
    PaxDbi Q9NUU6.
    PRIDEi Q9NUU6.

    Protocols and materials databases

    DNASUi 54491.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000274217 ; ENSP00000274217 ; ENSG00000145569 .
    GeneIDi 54491.
    KEGGi hsa:54491.
    UCSCi uc003jfj.3. human.

    Organism-specific databases

    CTDi 54491.
    GeneCardsi GC05P014581.
    H-InvDB HIX0004758.
    HGNCi HGNC:25629. FAM105A.
    HPAi HPA046638.
    neXtProti NX_Q9NUU6.
    PharmGKBi PA142671788.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG38836.
    HOGENOMi HOG000294085.
    HOVERGENi HBG059856.
    InParanoidi Q9NUU6.
    OMAi HLNSVGD.
    OrthoDBi EOG76QFHQ.
    PhylomeDBi Q9NUU6.
    TreeFami TF328709.

    Miscellaneous databases

    ChiTaRSi FAM105A. human.
    GenomeRNAii 54491.
    NextBioi 56815.
    PROi Q9NUU6.

    Gene expression databases

    Bgeei Q9NUU6.
    CleanExi HS_FAM105A.
    Genevestigatori Q9NUU6.

    Family and domain databases

    InterProi IPR023235. FAM105.
    IPR023236. FAM105A.
    [Graphical view ]
    PRINTSi PR02055. PROTEINF105.
    PR02056. PROTEINF105A.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    2. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 239-356.
      Tissue: Lymph node.
    5. Cited for: LACK OF ACTIVITY.

    Entry informationi

    Entry nameiF105A_HUMAN
    AccessioniPrimary (citable) accession number: Q9NUU6
    Secondary accession number(s): Q53H50, Q9H037
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Although highly similar to the deubiquitinase FAM105B, lacks the conserved active site at position 139 which is replaced by an Asp residue, and does not show deubiquitinase activity.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Peptidase families
      Classification of peptidase families and list of entries
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3