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Protein

Inactive ubiquitin thioesterase FAM105A

Gene

FAM105A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei136By similarity1
Active sitei350By similarity1

Enzyme and pathway databases

BioCyciZFISH:ENSG00000145569-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive ubiquitin thioesterase FAM105A
Gene namesi
Name:FAM105A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:25629. FAM105A.

Pathology & Biotechi

Organism-specific databases

DisGeNETi54491.
OpenTargetsiENSG00000145569.
PharmGKBiPA142671788.

Polymorphism and mutation databases

BioMutaiFAM105A.
DMDMi74734394.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002744041 – 356Inactive ubiquitin thioesterase FAM105AAdd BLAST356

Proteomic databases

EPDiQ9NUU6.
MaxQBiQ9NUU6.
PaxDbiQ9NUU6.
PeptideAtlasiQ9NUU6.
PRIDEiQ9NUU6.

PTM databases

iPTMnetiQ9NUU6.
PhosphoSitePlusiQ9NUU6.

Expressioni

Gene expression databases

BgeeiENSG00000145569.
CleanExiHS_FAM105A.
GenevisibleiQ9NUU6. HS.

Organism-specific databases

HPAiHPA046638.

Interactioni

Protein-protein interaction databases

BioGridi119988. 2 interactors.
STRINGi9606.ENSP00000274217.

Structurei

3D structure databases

ProteinModelPortaliQ9NUU6.
SMRiQ9NUU6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini128 – 356OTUPROSITE-ProRule annotationAdd BLAST229

Sequence similaritiesi

Belongs to the peptidase C65 family. Otulin subfamily.Curated
Contains 1 OTU domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IK5W. Eukaryota.
ENOG410YCV8. LUCA.
GeneTreeiENSGT00390000009802.
HOGENOMiHOG000294085.
HOVERGENiHBG059856.
InParanoidiQ9NUU6.
OMAiQVKRDNY.
OrthoDBiEOG091G0BXG.
PhylomeDBiQ9NUU6.
TreeFamiTF328709.

Family and domain databases

InterProiIPR023235. FAM105.
IPR023236. FAM105A.
[Graphical view]
PfamiPF16218. Peptidase_C101. 1 hit.
[Graphical view]
PRINTSiPR02055. PROTEINF105.
PR02056. PROTEINF105A.

Sequencei

Sequence statusi: Complete.

Q9NUU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATRSPTRA RERERSGAPA AGSDQVHSWM LATSQALDTV WRMAKGFVML
60 70 80 90 100
AVSFLVAAIC YFRRLHLYSG HKLKWWIGYL QRKFKRNLSV EAEVDLLSYC
110 120 130 140 150
AREWKGETPR NKLMRKAYEE LFWRHHIKCV RQVRRDNYDA LRSVLFQIFS
160 170 180 190 200
QGISFPSWMK EKDIVKLPEK LLFSQGCNWI QQYSFGPEKY TGSNVFGKLR
210 220 230 240 250
KYVELLKTQW TEFNGIRDYH KRGSMCNTLF SDAILEYKLY EALKFIMLYQ
260 270 280 290 300
VTEVYEQMKT KKVIPSLFRL LFSRETSSDP LSFMMNHLNS VGDTCGLEQI
310 320 330 340 350
DMFILGYSLE VKIKVFRLFK FNSRDFEVCY PEEPLRDWPE ISLLTENDRH

YHIPVF
Length:356
Mass (Da):42,196
Last modified:October 1, 2000 - v1
Checksum:i91EEC6C877D5315B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti322N → I in BAD96451 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030281319F → L.Corresponds to variant rs16903574dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001989 mRNA. Translation: BAA92023.1.
AK222731 mRNA. Translation: BAD96451.1.
BC011524 mRNA. Translation: AAH11524.1.
AL512750 mRNA. Translation: CAC21673.1.
CCDSiCCDS3884.1.
RefSeqiNP_061891.1. NM_019018.2.
UniGeneiHs.155085.

Genome annotation databases

EnsembliENST00000274217; ENSP00000274217; ENSG00000145569.
GeneIDi54491.
KEGGihsa:54491.
UCSCiuc003jfj.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001989 mRNA. Translation: BAA92023.1.
AK222731 mRNA. Translation: BAD96451.1.
BC011524 mRNA. Translation: AAH11524.1.
AL512750 mRNA. Translation: CAC21673.1.
CCDSiCCDS3884.1.
RefSeqiNP_061891.1. NM_019018.2.
UniGeneiHs.155085.

3D structure databases

ProteinModelPortaliQ9NUU6.
SMRiQ9NUU6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119988. 2 interactors.
STRINGi9606.ENSP00000274217.

PTM databases

iPTMnetiQ9NUU6.
PhosphoSitePlusiQ9NUU6.

Polymorphism and mutation databases

BioMutaiFAM105A.
DMDMi74734394.

Proteomic databases

EPDiQ9NUU6.
MaxQBiQ9NUU6.
PaxDbiQ9NUU6.
PeptideAtlasiQ9NUU6.
PRIDEiQ9NUU6.

Protocols and materials databases

DNASUi54491.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274217; ENSP00000274217; ENSG00000145569.
GeneIDi54491.
KEGGihsa:54491.
UCSCiuc003jfj.4. human.

Organism-specific databases

CTDi54491.
DisGeNETi54491.
GeneCardsiFAM105A.
H-InvDBHIX0004758.
HGNCiHGNC:25629. FAM105A.
HPAiHPA046638.
neXtProtiNX_Q9NUU6.
OpenTargetsiENSG00000145569.
PharmGKBiPA142671788.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK5W. Eukaryota.
ENOG410YCV8. LUCA.
GeneTreeiENSGT00390000009802.
HOGENOMiHOG000294085.
HOVERGENiHBG059856.
InParanoidiQ9NUU6.
OMAiQVKRDNY.
OrthoDBiEOG091G0BXG.
PhylomeDBiQ9NUU6.
TreeFamiTF328709.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000145569-MONOMER.

Miscellaneous databases

ChiTaRSiFAM105A. human.
GenomeRNAii54491.
PROiQ9NUU6.

Gene expression databases

BgeeiENSG00000145569.
CleanExiHS_FAM105A.
GenevisibleiQ9NUU6. HS.

Family and domain databases

InterProiIPR023235. FAM105.
IPR023236. FAM105A.
[Graphical view]
PfamiPF16218. Peptidase_C101. 1 hit.
[Graphical view]
PRINTSiPR02055. PROTEINF105.
PR02056. PROTEINF105A.
ProtoNetiSearch...

Entry informationi

Entry nameiF105A_HUMAN
AccessioniPrimary (citable) accession number: Q9NUU6
Secondary accession number(s): Q53H50, Q9H037
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Although highly similar to the deubiquitinase FAM105B, lacks the conserved active site at position 139 which is replaced by an Asp residue, and does not show deubiquitinase activity.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.