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Q9NUU6 (F105A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inactive ubiquitin thioesterase FAM105A
Gene names
Name:FAM105A
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length356 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the peptidase C65 family. Otulin subfamily.

Contains 1 OTU domain.

Caution

Although highly similar to the deubiquitinase FAM105B, lacks the conserved active site at position 139 which is replaced by an Asp residue, and does not show deubiquitinase activity (Ref.5).

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 356356Inactive ubiquitin thioesterase FAM105A
PRO_0000274404

Regions

Domain128 – 356229OTU

Natural variations

Natural variant3191F → L.
Corresponds to variant rs16903574 [ dbSNP | Ensembl ].
VAR_030281

Experimental info

Sequence conflict3221N → I in BAD96451. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9NUU6 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 91EEC6C877D5315B

FASTA35642,196
        10         20         30         40         50         60 
MAATRSPTRA RERERSGAPA AGSDQVHSWM LATSQALDTV WRMAKGFVML AVSFLVAAIC 

        70         80         90        100        110        120 
YFRRLHLYSG HKLKWWIGYL QRKFKRNLSV EAEVDLLSYC AREWKGETPR NKLMRKAYEE 

       130        140        150        160        170        180 
LFWRHHIKCV RQVRRDNYDA LRSVLFQIFS QGISFPSWMK EKDIVKLPEK LLFSQGCNWI 

       190        200        210        220        230        240 
QQYSFGPEKY TGSNVFGKLR KYVELLKTQW TEFNGIRDYH KRGSMCNTLF SDAILEYKLY 

       250        260        270        280        290        300 
EALKFIMLYQ VTEVYEQMKT KKVIPSLFRL LFSRETSSDP LSFMMNHLNS VGDTCGLEQI 

       310        320        330        340        350 
DMFILGYSLE VKIKVFRLFK FNSRDFEVCY PEEPLRDWPE ISLLTENDRH YHIPVF 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[2]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 239-356.
Tissue: Lymph node.
[5]"The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis."
Rivkin E., Almeida S.M., Ceccarelli D.F., Juang Y.C., Maclean T.A., Srikumar T., Huang H., Dunham W.H., Fukumura R., Xie G., Gondo Y., Raught B., Gingras A.C., Sicheri F., Cordes S.P.
Nature 498:318-324(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: LACK OF ACTIVITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK001989 mRNA. Translation: BAA92023.1.
AK222731 mRNA. Translation: BAD96451.1.
BC011524 mRNA. Translation: AAH11524.1.
AL512750 mRNA. Translation: CAC21673.1.
RefSeqNP_061891.1. NM_019018.2.
UniGeneHs.155085.

3D structure databases

ProteinModelPortalQ9NUU6.
SMRQ9NUU6. Positions 86-355.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119988. 2 interactions.
STRING9606.ENSP00000274217.

PTM databases

PhosphoSiteQ9NUU6.

Polymorphism databases

DMDM74734394.

Proteomic databases

PaxDbQ9NUU6.
PRIDEQ9NUU6.

Protocols and materials databases

DNASU54491.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000274217; ENSP00000274217; ENSG00000145569.
GeneID54491.
KEGGhsa:54491.
UCSCuc003jfj.3. human.

Organism-specific databases

CTD54491.
GeneCardsGC05P014581.
H-InvDBHIX0004758.
HGNCHGNC:25629. FAM105A.
HPAHPA046638.
neXtProtNX_Q9NUU6.
PharmGKBPA142671788.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG38836.
HOGENOMHOG000294085.
HOVERGENHBG059856.
InParanoidQ9NUU6.
OMAHLNSVGD.
OrthoDBEOG76QFHQ.
PhylomeDBQ9NUU6.
TreeFamTF328709.

Gene expression databases

BgeeQ9NUU6.
CleanExHS_FAM105A.
GenevestigatorQ9NUU6.

Family and domain databases

InterProIPR023235. FAM105.
IPR023236. FAM105A.
[Graphical view]
PRINTSPR02055. PROTEINF105.
PR02056. PROTEINF105A.
ProtoNetSearch...

Other

ChiTaRSFAM105A. human.
GenomeRNAi54491.
NextBio56815.
PROQ9NUU6.

Entry information

Entry nameF105A_HUMAN
AccessionPrimary (citable) accession number: Q9NUU6
Secondary accession number(s): Q53H50, Q9H037
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 1, 2000
Last modified: February 19, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM