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Q9NUT2

- ABCB8_HUMAN

UniProt

Q9NUT2 - ABCB8_HUMAN

Protein

ATP-binding cassette sub-family B member 8, mitochondrial

Gene

ABCB8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 141 (01 Oct 2014)
      Sequence version 3 (03 Apr 2007)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi507 – 5148ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATPase activity, coupled to transmembrane movement of substances Source: RefGenome
    2. ATP binding Source: ProtInc
    3. transporter activity Source: ProtInc

    GO - Biological processi

    1. transmembrane transport Source: RefGenome
    2. transport Source: ProtInc

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi3.6.3.43. 2681.
    ReactomeiREACT_111108. Mitochondrial ABC transporters.

    Protein family/group databases

    TCDBi3.A.1.201.22. the atp-binding cassette (abc) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-binding cassette sub-family B member 8, mitochondrial
    Alternative name(s):
    Mitochondrial ATP-binding cassette 1
    Short name:
    M-ABC1
    Gene namesi
    Name:ABCB8
    Synonyms:MABC1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:49. ABCB8.

    Subcellular locationi

    Mitochondrion inner membrane 1 Publication; Multi-pass membrane protein 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. ATP-binding cassette (ABC) transporter complex Source: ProtInc
    2. integral component of membrane Source: RefGenome
    3. membrane Source: ProtInc
    4. mitochondrial envelope Source: ProtInc
    5. mitochondrial inner membrane Source: UniProtKB-SubCell
    6. mitochondrion Source: HPA
    7. nucleolus Source: HPA
    8. nucleus Source: HPA

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi512 – 5132GK → AR: Renders the protein unstable. 1 Publication

    Organism-specific databases

    PharmGKBiPA24390.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 5555Mitochondrion1 PublicationAdd
    BLAST
    Chaini56 – 735680ATP-binding cassette sub-family B member 8, mitochondrialPRO_0000000251Add
    BLAST

    Proteomic databases

    MaxQBiQ9NUT2.
    PaxDbiQ9NUT2.
    PRIDEiQ9NUT2.

    PTM databases

    PhosphoSiteiQ9NUT2.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiQ9NUT2.
    BgeeiQ9NUT2.
    CleanExiHS_ABCB8.
    GenevestigatoriQ9NUT2.

    Organism-specific databases

    HPAiHPA045187.

    Interactioni

    Subunit structurei

    Monomer.Curated

    Protein-protein interaction databases

    BioGridi116364. 10 interactions.
    IntActiQ9NUT2. 2 interactions.
    MINTiMINT-1381060.
    STRINGi9606.ENSP00000351717.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9NUT2.
    SMRiQ9NUT2. Positions 142-710.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei86 – 10217HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei145 – 16521HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei196 – 21621HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei296 – 31621HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei383 – 40321HelicalPROSITE-ProRule annotationAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini148 – 437290ABC transmembrane type-1PROSITE-ProRule annotationAdd
    BLAST
    Domaini472 – 709238ABC transporterPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation
    Contains 1 ABC transporter domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transit peptide, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1132.
    HOVERGENiHBG008358.
    InParanoidiQ9NUT2.
    KOiK05655.
    OMAiHVVGSRF.
    OrthoDBiEOG7Z3F4H.
    PhylomeDBiQ9NUT2.
    TreeFamiTF105196.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00664. ABC_membrane. 1 hit.
    PF00005. ABC_tran. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    SSF90123. SSF90123. 1 hit.
    PROSITEiPS50929. ABC_TM1F. 1 hit.
    PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9NUT2-1) [UniParc]FASTAAdd to Basket

    Also known as: Long

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLVHLFRVGI RGGPFPGRLL PPLRFQTFSA VRNTWRNGKT GQLHKAEGEY    50
    SDGYRSSSLL RAVAHLRSQL WAHLPRAPLA PRWSPSAWCW VGGALLGPMV 100
    LSKHPHLCLV ALCEAEEAPP ASSTPHVVGS RFNWKLFWQF LHPHLLVLGV 150
    AVVLALGAAL VNVQIPLLLG QLVEVVAKYT RDHVGSFMTE SQNLSTHLLI 200
    LYGVQGLLTF GYLVLLSHVG ERMAVDMRRA LFSSLLRQDI TFFDANKTGQ 250
    LVSRLTTDVQ EFKSSFKLVI SQGLRSCTQV AGCLVSLSML STRLTLLLMV 300
    ATPALMGVGT LMGSGLRKLS RQCQEQIARA MGVADEALGN VRTVRAFAME 350
    QREEERYGAE LEACRCRAEE LGRGIALFQG LSNIAFNCMV LGTLFIGGSL 400
    VAGQQLTGGD LMSFLVASQT VQRSMANLSV LFGQVVRGLS AGARVFEYMA 450
    LNPCIPLSGG CCVPKEQLRG SVTFQNVCFS YPCRPGFEVL KDFTLTLPPG 500
    KIVALVGQSG GGKTTVASLL ERFYDPTAGV VMLDGRDLRT LDPSWLRGQV 550
    VGFISQEPVL FGTTIMENIR FGKLEASDEE VYTAAREANA HEFITSFPEG 600
    YNTVVGERGT TLSGGQKQRL AIARALIKQP TVLILDEATS ALDAESERVV 650
    QEALDRASAG RTVLVIAHRL STVRGAHCIV VMADGRVWEA GTHEELLKKG 700
    GLYAELIRRQ ALDAPRTAAP PPKKPEGPRS HQHKS 735
    Length:735
    Mass (Da):79,989
    Last modified:April 3, 2007 - v3
    Checksum:iB7E02B063E6C6F3B
    GO
    Isoform 2 (identifier: Q9NUT2-2) [UniParc]FASTAAdd to Basket

    Also known as: Short

    The sequence of this isoform differs from the canonical sequence as follows:
         33-49: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:718
    Mass (Da):78,081
    Checksum:iB082E28433C7BC0D
    GO
    Isoform 3 (identifier: Q9NUT2-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         33-49: Missing.
         665-689: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:693
    Mass (Da):75,323
    Checksum:i7542049429217452
    GO
    Isoform 4 (identifier: Q9NUT2-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-153: MLVHLFRVGI...HLLVLGVAVV → MRVKLLLPAA...PPLPDILSCQ

    Note: No experimental confirmation available.

    Show »
    Length:630
    Mass (Da):68,067
    Checksum:iAEA1BF297F630D76
    GO
    Isoform 5 (identifier: Q9NUT2-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-187: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:548
    Mass (Da):59,383
    Checksum:i2BE5FFBF0F98917C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti174 – 1741E → K in AAD15748. (PubMed:9878413)Curated
    Sequence conflicti239 – 2391D → N in AAD15748. (PubMed:9878413)Curated
    Sequence conflicti278 – 2781T → S in AAD15748. (PubMed:9878413)Curated
    Sequence conflicti299 – 2991M → T in BAG57613. (PubMed:14702039)Curated
    Sequence conflicti326 – 3261Q → H in AAD15748. (PubMed:9878413)Curated
    Sequence conflicti347 – 3471F → L in AAD15748. (PubMed:9878413)Curated
    Sequence conflicti365 – 3651R → H in BAA92038. (PubMed:14702039)Curated
    Sequence conflicti487 – 4871F → Y in BAG57613. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti152 – 1521V → I.1 Publication
    Corresponds to variant rs4148844 [ dbSNP | Ensembl ].
    VAR_013331
    Natural varianti165 – 1651I → T in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035733
    Natural varianti690 – 6901A → G in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035734

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 187187Missing in isoform 5. 1 PublicationVSP_056744Add
    BLAST
    Alternative sequencei1 – 153153MLVHL…GVAVV → MRVKLLLPAAPVLPRQHAGA FISGRDSGWPIPRQAATAPP LPDILSCQ in isoform 4. 1 PublicationVSP_056745Add
    BLAST
    Alternative sequencei33 – 4917Missing in isoform 2 and isoform 3. 4 PublicationsVSP_000026Add
    BLAST
    Alternative sequencei665 – 68925Missing in isoform 3. 1 PublicationVSP_055297Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF047690 mRNA. Translation: AAD15748.1.
    AK002018 mRNA. Translation: BAA92038.1.
    AK024401 mRNA. Translation: BAG51294.1.
    AK222911 mRNA. Translation: BAD96631.1.
    AK294344 mRNA. Translation: BAG57613.1.
    AK314721 mRNA. Translation: BAG37265.1.
    AC010973 Genomic DNA. No translation available.
    CH471173 Genomic DNA. Translation: EAW54057.1.
    CH471173 Genomic DNA. Translation: EAW54061.1.
    CH471173 Genomic DNA. Translation: EAW54062.1.
    BC141814 mRNA. Translation: AAI41815.1.
    BC141836 mRNA. Translation: AAI41837.1.
    BC151235 mRNA. Translation: AAI51236.1.
    CCDSiCCDS5913.1. [Q9NUT2-2]
    CCDS64799.1. [Q9NUT2-1]
    CCDS64800.1. [Q9NUT2-3]
    RefSeqiNP_001269220.1. NM_001282291.1. [Q9NUT2-1]
    NP_001269221.1. NM_001282292.1.
    NP_001269222.1. NM_001282293.1.
    NP_009119.2. NM_007188.4. [Q9NUT2-2]
    UniGeneiHs.647118.

    Genome annotation databases

    EnsembliENST00000297504; ENSP00000297504; ENSG00000197150. [Q9NUT2-1]
    ENST00000358849; ENSP00000351717; ENSG00000197150. [Q9NUT2-2]
    ENST00000498578; ENSP00000418271; ENSG00000197150. [Q9NUT2-3]
    ENST00000542328; ENSP00000438776; ENSG00000197150.
    GeneIDi11194.
    KEGGihsa:11194.
    UCSCiuc003wik.4. human. [Q9NUT2-2]
    uc003wil.4. human. [Q9NUT2-1]
    uc011kvd.2. human.

    Polymorphism databases

    DMDMi143811358.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    ABCMdb

    Database for mutations in ABC proteins

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF047690 mRNA. Translation: AAD15748.1 .
    AK002018 mRNA. Translation: BAA92038.1 .
    AK024401 mRNA. Translation: BAG51294.1 .
    AK222911 mRNA. Translation: BAD96631.1 .
    AK294344 mRNA. Translation: BAG57613.1 .
    AK314721 mRNA. Translation: BAG37265.1 .
    AC010973 Genomic DNA. No translation available.
    CH471173 Genomic DNA. Translation: EAW54057.1 .
    CH471173 Genomic DNA. Translation: EAW54061.1 .
    CH471173 Genomic DNA. Translation: EAW54062.1 .
    BC141814 mRNA. Translation: AAI41815.1 .
    BC141836 mRNA. Translation: AAI41837.1 .
    BC151235 mRNA. Translation: AAI51236.1 .
    CCDSi CCDS5913.1. [Q9NUT2-2 ]
    CCDS64799.1. [Q9NUT2-1 ]
    CCDS64800.1. [Q9NUT2-3 ]
    RefSeqi NP_001269220.1. NM_001282291.1. [Q9NUT2-1 ]
    NP_001269221.1. NM_001282292.1.
    NP_001269222.1. NM_001282293.1.
    NP_009119.2. NM_007188.4. [Q9NUT2-2 ]
    UniGenei Hs.647118.

    3D structure databases

    ProteinModelPortali Q9NUT2.
    SMRi Q9NUT2. Positions 142-710.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116364. 10 interactions.
    IntActi Q9NUT2. 2 interactions.
    MINTi MINT-1381060.
    STRINGi 9606.ENSP00000351717.

    Chemistry

    DrugBanki DB00997. Doxorubicin.

    Protein family/group databases

    TCDBi 3.A.1.201.22. the atp-binding cassette (abc) superfamily.

    PTM databases

    PhosphoSitei Q9NUT2.

    Polymorphism databases

    DMDMi 143811358.

    Proteomic databases

    MaxQBi Q9NUT2.
    PaxDbi Q9NUT2.
    PRIDEi Q9NUT2.

    Protocols and materials databases

    DNASUi 11194.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000297504 ; ENSP00000297504 ; ENSG00000197150 . [Q9NUT2-1 ]
    ENST00000358849 ; ENSP00000351717 ; ENSG00000197150 . [Q9NUT2-2 ]
    ENST00000498578 ; ENSP00000418271 ; ENSG00000197150 . [Q9NUT2-3 ]
    ENST00000542328 ; ENSP00000438776 ; ENSG00000197150 .
    GeneIDi 11194.
    KEGGi hsa:11194.
    UCSCi uc003wik.4. human. [Q9NUT2-2 ]
    uc003wil.4. human. [Q9NUT2-1 ]
    uc011kvd.2. human.

    Organism-specific databases

    CTDi 11194.
    GeneCardsi GC07P150725.
    H-InvDB HIX0007220.
    HGNCi HGNC:49. ABCB8.
    HPAi HPA045187.
    MIMi 605464. gene.
    neXtProti NX_Q9NUT2.
    PharmGKBi PA24390.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1132.
    HOVERGENi HBG008358.
    InParanoidi Q9NUT2.
    KOi K05655.
    OMAi HVVGSRF.
    OrthoDBi EOG7Z3F4H.
    PhylomeDBi Q9NUT2.
    TreeFami TF105196.

    Enzyme and pathway databases

    BRENDAi 3.6.3.43. 2681.
    Reactomei REACT_111108. Mitochondrial ABC transporters.

    Miscellaneous databases

    GeneWikii ABCB8.
    GenomeRNAii 11194.
    NextBioi 35462090.
    PROi Q9NUT2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9NUT2.
    Bgeei Q9NUT2.
    CleanExi HS_ABCB8.
    Genevestigatori Q9NUT2.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00664. ABC_membrane. 1 hit.
    PF00005. ABC_tran. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    SSF90123. SSF90123. 1 hit.
    PROSITEi PS50929. ABC_TM1F. 1 hit.
    PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of a mammalian mitochondrial ATP-binding cassette membrane protein."
      Hogue D.L., Liu L., Ling V.
      J. Mol. Biol. 285:379-389(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), MUTAGENESIS.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 4 AND 5).
      Tissue: Amygdala, Placenta and Tongue.
    3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Kidney.
    4. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    7. "Targeting of the mitochondrial membrane proteins to the cell surface for functional studies."
      Ardehali H., Xue T., Dong P., Machamer C.
      Biochem. Biophys. Res. Commun. 338:1143-1151(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TRANSIT PEPTIDE CLEAVAGE SITE.
    8. "Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population."
      Saito S., Iida A., Sekine A., Miura Y., Ogawa C., Kawauchi S., Higuchi S., Nakamura Y.
      J. Hum. Genet. 47:38-50(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT ILE-152.
    9. Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-165 AND GLY-690.

    Entry informationi

    Entry nameiABCB8_HUMAN
    AccessioniPrimary (citable) accession number: Q9NUT2
    Secondary accession number(s): A5D8W3
    , B2RBL8, B3KND2, B4DG02, G3XAP3, O95787, Q53GM0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: April 3, 2007
    Last modified: October 1, 2014
    This is version 141 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3