Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9NUT2

- ABCB8_HUMAN

UniProt

Q9NUT2 - ABCB8_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

ATP-binding cassette sub-family B member 8, mitochondrial

Gene

ABCB8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi507 – 5148ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATPase activity, coupled to transmembrane movement of substances Source: RefGenome
  2. ATP binding Source: ProtInc
  3. transporter activity Source: ProtInc

GO - Biological processi

  1. transmembrane transport Source: RefGenome
  2. transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.3.43. 2681.
ReactomeiREACT_111108. Mitochondrial ABC transporters.

Protein family/group databases

TCDBi3.A.1.201.22. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family B member 8, mitochondrial
Alternative name(s):
Mitochondrial ATP-binding cassette 1
Short name:
M-ABC1
Gene namesi
Name:ABCB8
Synonyms:MABC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:49. ABCB8.

Subcellular locationi

Mitochondrion inner membrane 1 Publication; Multi-pass membrane protein 1 PublicationPROSITE-ProRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei86 – 10217HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei145 – 16521HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei196 – 21621HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei296 – 31621HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei383 – 40321HelicalPROSITE-ProRule annotationAdd
BLAST

GO - Cellular componenti

  1. ATP-binding cassette (ABC) transporter complex Source: ProtInc
  2. integral component of membrane Source: RefGenome
  3. membrane Source: ProtInc
  4. mitochondrial envelope Source: ProtInc
  5. mitochondrial inner membrane Source: UniProtKB-KW
  6. mitochondrion Source: HPA
  7. nucleolus Source: HPA
  8. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi512 – 5132GK → AR: Renders the protein unstable. 1 Publication

Organism-specific databases

PharmGKBiPA24390.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 5555Mitochondrion1 PublicationAdd
BLAST
Chaini56 – 735680ATP-binding cassette sub-family B member 8, mitochondrialPRO_0000000251Add
BLAST

Proteomic databases

MaxQBiQ9NUT2.
PaxDbiQ9NUT2.
PRIDEiQ9NUT2.

PTM databases

PhosphoSiteiQ9NUT2.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiQ9NUT2.
CleanExiHS_ABCB8.
ExpressionAtlasiQ9NUT2. baseline and differential.
GenevestigatoriQ9NUT2.

Organism-specific databases

HPAiHPA045187.

Interactioni

Subunit structurei

Monomer.Curated

Protein-protein interaction databases

BioGridi116364. 13 interactions.
IntActiQ9NUT2. 2 interactions.
MINTiMINT-1381060.
STRINGi9606.ENSP00000351717.

Structurei

3D structure databases

ProteinModelPortaliQ9NUT2.
SMRiQ9NUT2. Positions 142-710.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini148 – 437290ABC transmembrane type-1PROSITE-ProRule annotationAdd
BLAST
Domaini472 – 709238ABC transporterPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation
Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1132.
GeneTreeiENSGT00550000074497.
HOVERGENiHBG008358.
InParanoidiQ9NUT2.
KOiK05655.
OMAiHVVGSRF.
OrthoDBiEOG7Z3F4H.
PhylomeDBiQ9NUT2.
TreeFamiTF105196.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9NUT2-1) [UniParc]FASTAAdd to Basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLVHLFRVGI RGGPFPGRLL PPLRFQTFSA VRNTWRNGKT GQLHKAEGEY
60 70 80 90 100
SDGYRSSSLL RAVAHLRSQL WAHLPRAPLA PRWSPSAWCW VGGALLGPMV
110 120 130 140 150
LSKHPHLCLV ALCEAEEAPP ASSTPHVVGS RFNWKLFWQF LHPHLLVLGV
160 170 180 190 200
AVVLALGAAL VNVQIPLLLG QLVEVVAKYT RDHVGSFMTE SQNLSTHLLI
210 220 230 240 250
LYGVQGLLTF GYLVLLSHVG ERMAVDMRRA LFSSLLRQDI TFFDANKTGQ
260 270 280 290 300
LVSRLTTDVQ EFKSSFKLVI SQGLRSCTQV AGCLVSLSML STRLTLLLMV
310 320 330 340 350
ATPALMGVGT LMGSGLRKLS RQCQEQIARA MGVADEALGN VRTVRAFAME
360 370 380 390 400
QREEERYGAE LEACRCRAEE LGRGIALFQG LSNIAFNCMV LGTLFIGGSL
410 420 430 440 450
VAGQQLTGGD LMSFLVASQT VQRSMANLSV LFGQVVRGLS AGARVFEYMA
460 470 480 490 500
LNPCIPLSGG CCVPKEQLRG SVTFQNVCFS YPCRPGFEVL KDFTLTLPPG
510 520 530 540 550
KIVALVGQSG GGKTTVASLL ERFYDPTAGV VMLDGRDLRT LDPSWLRGQV
560 570 580 590 600
VGFISQEPVL FGTTIMENIR FGKLEASDEE VYTAAREANA HEFITSFPEG
610 620 630 640 650
YNTVVGERGT TLSGGQKQRL AIARALIKQP TVLILDEATS ALDAESERVV
660 670 680 690 700
QEALDRASAG RTVLVIAHRL STVRGAHCIV VMADGRVWEA GTHEELLKKG
710 720 730
GLYAELIRRQ ALDAPRTAAP PPKKPEGPRS HQHKS
Length:735
Mass (Da):79,989
Last modified:April 3, 2007 - v3
Checksum:iB7E02B063E6C6F3B
GO
Isoform 2 (identifier: Q9NUT2-2) [UniParc]FASTAAdd to Basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     33-49: Missing.

Note: No experimental confirmation available.

Show »
Length:718
Mass (Da):78,081
Checksum:iB082E28433C7BC0D
GO
Isoform 3 (identifier: Q9NUT2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     33-49: Missing.
     665-689: Missing.

Note: No experimental confirmation available.

Show »
Length:693
Mass (Da):75,323
Checksum:i7542049429217452
GO
Isoform 4 (identifier: Q9NUT2-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: MLVHLFRVGI...HLLVLGVAVV → MRVKLLLPAA...PPLPDILSCQ

Note: No experimental confirmation available.

Show »
Length:630
Mass (Da):68,067
Checksum:iAEA1BF297F630D76
GO
Isoform 5 (identifier: Q9NUT2-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-187: Missing.

Note: No experimental confirmation available.

Show »
Length:548
Mass (Da):59,383
Checksum:i2BE5FFBF0F98917C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti174 – 1741E → K in AAD15748. (PubMed:9878413)Curated
Sequence conflicti239 – 2391D → N in AAD15748. (PubMed:9878413)Curated
Sequence conflicti278 – 2781T → S in AAD15748. (PubMed:9878413)Curated
Sequence conflicti299 – 2991M → T in BAG57613. (PubMed:14702039)Curated
Sequence conflicti326 – 3261Q → H in AAD15748. (PubMed:9878413)Curated
Sequence conflicti347 – 3471F → L in AAD15748. (PubMed:9878413)Curated
Sequence conflicti365 – 3651R → H in BAA92038. (PubMed:14702039)Curated
Sequence conflicti487 – 4871F → Y in BAG57613. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti152 – 1521V → I.1 Publication
Corresponds to variant rs4148844 [ dbSNP | Ensembl ].
VAR_013331
Natural varianti165 – 1651I → T in a breast cancer sample; somatic mutation. 1 Publication
VAR_035733
Natural varianti690 – 6901A → G in a breast cancer sample; somatic mutation. 1 Publication
VAR_035734

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 187187Missing in isoform 5. 1 PublicationVSP_056744Add
BLAST
Alternative sequencei1 – 153153MLVHL…GVAVV → MRVKLLLPAAPVLPRQHAGA FISGRDSGWPIPRQAATAPP LPDILSCQ in isoform 4. 1 PublicationVSP_056745Add
BLAST
Alternative sequencei33 – 4917Missing in isoform 2 and isoform 3. 4 PublicationsVSP_000026Add
BLAST
Alternative sequencei665 – 68925Missing in isoform 3. 1 PublicationVSP_055297Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047690 mRNA. Translation: AAD15748.1.
AK002018 mRNA. Translation: BAA92038.1.
AK024401 mRNA. Translation: BAG51294.1.
AK222911 mRNA. Translation: BAD96631.1.
AK294344 mRNA. Translation: BAG57613.1.
AK314721 mRNA. Translation: BAG37265.1.
AC010973 Genomic DNA. No translation available.
CH471173 Genomic DNA. Translation: EAW54057.1.
CH471173 Genomic DNA. Translation: EAW54061.1.
CH471173 Genomic DNA. Translation: EAW54062.1.
BC141814 mRNA. Translation: AAI41815.1.
BC141836 mRNA. Translation: AAI41837.1.
BC151235 mRNA. Translation: AAI51236.1.
CCDSiCCDS5913.1. [Q9NUT2-2]
CCDS64799.1. [Q9NUT2-1]
CCDS64800.1. [Q9NUT2-3]
RefSeqiNP_001269220.1. NM_001282291.1. [Q9NUT2-1]
NP_001269221.1. NM_001282292.1. [Q9NUT2-3]
NP_001269222.1. NM_001282293.1. [Q9NUT2-4]
NP_009119.2. NM_007188.4. [Q9NUT2-2]
UniGeneiHs.647118.

Genome annotation databases

EnsembliENST00000297504; ENSP00000297504; ENSG00000197150. [Q9NUT2-1]
ENST00000358849; ENSP00000351717; ENSG00000197150. [Q9NUT2-2]
ENST00000498578; ENSP00000418271; ENSG00000197150. [Q9NUT2-3]
ENST00000542328; ENSP00000438776; ENSG00000197150. [Q9NUT2-4]
GeneIDi11194.
KEGGihsa:11194.
UCSCiuc003wik.4. human. [Q9NUT2-2]
uc003wil.4. human. [Q9NUT2-1]
uc010lpx.3. human.

Polymorphism databases

DMDMi143811358.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF047690 mRNA. Translation: AAD15748.1 .
AK002018 mRNA. Translation: BAA92038.1 .
AK024401 mRNA. Translation: BAG51294.1 .
AK222911 mRNA. Translation: BAD96631.1 .
AK294344 mRNA. Translation: BAG57613.1 .
AK314721 mRNA. Translation: BAG37265.1 .
AC010973 Genomic DNA. No translation available.
CH471173 Genomic DNA. Translation: EAW54057.1 .
CH471173 Genomic DNA. Translation: EAW54061.1 .
CH471173 Genomic DNA. Translation: EAW54062.1 .
BC141814 mRNA. Translation: AAI41815.1 .
BC141836 mRNA. Translation: AAI41837.1 .
BC151235 mRNA. Translation: AAI51236.1 .
CCDSi CCDS5913.1. [Q9NUT2-2 ]
CCDS64799.1. [Q9NUT2-1 ]
CCDS64800.1. [Q9NUT2-3 ]
RefSeqi NP_001269220.1. NM_001282291.1. [Q9NUT2-1 ]
NP_001269221.1. NM_001282292.1. [Q9NUT2-3 ]
NP_001269222.1. NM_001282293.1. [Q9NUT2-4 ]
NP_009119.2. NM_007188.4. [Q9NUT2-2 ]
UniGenei Hs.647118.

3D structure databases

ProteinModelPortali Q9NUT2.
SMRi Q9NUT2. Positions 142-710.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116364. 13 interactions.
IntActi Q9NUT2. 2 interactions.
MINTi MINT-1381060.
STRINGi 9606.ENSP00000351717.

Chemistry

DrugBanki DB00997. Doxorubicin.

Protein family/group databases

TCDBi 3.A.1.201.22. the atp-binding cassette (abc) superfamily.

PTM databases

PhosphoSitei Q9NUT2.

Polymorphism databases

DMDMi 143811358.

Proteomic databases

MaxQBi Q9NUT2.
PaxDbi Q9NUT2.
PRIDEi Q9NUT2.

Protocols and materials databases

DNASUi 11194.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000297504 ; ENSP00000297504 ; ENSG00000197150 . [Q9NUT2-1 ]
ENST00000358849 ; ENSP00000351717 ; ENSG00000197150 . [Q9NUT2-2 ]
ENST00000498578 ; ENSP00000418271 ; ENSG00000197150 . [Q9NUT2-3 ]
ENST00000542328 ; ENSP00000438776 ; ENSG00000197150 . [Q9NUT2-4 ]
GeneIDi 11194.
KEGGi hsa:11194.
UCSCi uc003wik.4. human. [Q9NUT2-2 ]
uc003wil.4. human. [Q9NUT2-1 ]
uc010lpx.3. human.

Organism-specific databases

CTDi 11194.
GeneCardsi GC07P150725.
H-InvDB HIX0007220.
HGNCi HGNC:49. ABCB8.
HPAi HPA045187.
MIMi 605464. gene.
neXtProti NX_Q9NUT2.
PharmGKBi PA24390.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1132.
GeneTreei ENSGT00550000074497.
HOVERGENi HBG008358.
InParanoidi Q9NUT2.
KOi K05655.
OMAi HVVGSRF.
OrthoDBi EOG7Z3F4H.
PhylomeDBi Q9NUT2.
TreeFami TF105196.

Enzyme and pathway databases

BRENDAi 3.6.3.43. 2681.
Reactomei REACT_111108. Mitochondrial ABC transporters.

Miscellaneous databases

ChiTaRSi ABCB8. human.
GeneWikii ABCB8.
GenomeRNAii 11194.
NextBioi 35462090.
PROi Q9NUT2.
SOURCEi Search...

Gene expression databases

Bgeei Q9NUT2.
CleanExi HS_ABCB8.
ExpressionAtlasi Q9NUT2. baseline and differential.
Genevestigatori Q9NUT2.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEi PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a mammalian mitochondrial ATP-binding cassette membrane protein."
    Hogue D.L., Liu L., Ling V.
    J. Mol. Biol. 285:379-389(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), MUTAGENESIS.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 4 AND 5).
    Tissue: Amygdala, Placenta and Tongue.
  3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Kidney.
  4. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
  7. "Targeting of the mitochondrial membrane proteins to the cell surface for functional studies."
    Ardehali H., Xue T., Dong P., Machamer C.
    Biochem. Biophys. Res. Commun. 338:1143-1151(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TRANSIT PEPTIDE CLEAVAGE SITE.
  8. "Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population."
    Saito S., Iida A., Sekine A., Miura Y., Ogawa C., Kawauchi S., Higuchi S., Nakamura Y.
    J. Hum. Genet. 47:38-50(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ILE-152.
  9. Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-165 AND GLY-690.

Entry informationi

Entry nameiABCB8_HUMAN
AccessioniPrimary (citable) accession number: Q9NUT2
Secondary accession number(s): A5D8W3
, B2RBL8, B3KND2, B4DG02, G3XAP3, O95787, Q53GM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: April 3, 2007
Last modified: November 26, 2014
This is version 143 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3