Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

AP-5 complex subunit sigma-1

Gene

AP5S1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:20613862, it is required for efficient homologous recombination DNA double-strand break repair.2 Publications

GO - Biological processi

  • double-strand break repair via homologous recombination Source: UniProtKB
  • endosomal transport Source: UniProtKB
  • protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
AP-5 complex subunit sigma-1
Alternative name(s):
Adaptor-related protein complex 5 sigma subunit
Short name:
Sigma5
Gene namesi
Name:AP5S1
Synonyms:C20orf29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15875. AP5S1.

Subcellular locationi

GO - Cellular componenti

  • AP-type membrane coat adaptor complex Source: UniProtKB
  • cytoplasm Source: HPA
  • cytosol Source: UniProtKB-SubCell
  • late endosome Source: UniProtKB
  • late endosome membrane Source: UniProtKB-SubCell
  • lysosomal membrane Source: UniProtKB-SubCell
  • lysosome Source: UniProtKB
  • nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25744.

Polymorphism and mutation databases

BioMutaiAP5S1.
DMDMi23396535.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 200200AP-5 complex subunit sigma-1PRO_0000079423Add
BLAST

Proteomic databases

EPDiQ9NUS5.
MaxQBiQ9NUS5.
PaxDbiQ9NUS5.
PeptideAtlasiQ9NUS5.
PRIDEiQ9NUS5.

Expressioni

Gene expression databases

BgeeiQ9NUS5.
CleanExiHS_C20orf29.
ExpressionAtlasiQ9NUS5. baseline and differential.
GenevisibleiQ9NUS5. HS.

Organism-specific databases

HPAiCAB034200.
HPA048244.

Interactioni

Subunit structurei

Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1. Interacts with ZFYVE26 and SPG11.2 Publications

Protein-protein interaction databases

DIPiDIP-60182N.
IntActiQ9NUS5. 2 interactions.
STRINGi9606.ENSP00000246041.

Structurei

3D structure databases

ProteinModelPortaliQ9NUS5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IYQV. Eukaryota.
ENOG4111NAX. LUCA.
GeneTreeiENSGT00390000013178.
HOGENOMiHOG000231696.
HOVERGENiHBG051157.
InParanoidiQ9NUS5.
KOiK19024.
OMAiSMCQLQQ.
PhylomeDBiQ9NUS5.
TreeFamiTF332332.

Family and domain databases

InterProiIPR029392. AP-5_subunit_s1.
[Graphical view]
PANTHERiPTHR16120. PTHR16120. 1 hit.
PfamiPF15001. AP-5_subunit_s1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9NUS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHAFLIHTL RAPNTEDTGL CRVLYSCVFG AEKSPDDPRP HGAERDRLLR
60 70 80 90 100
KEQILAVARQ VESMCRLQQQ ASGRPPMDLQ PQSSDEQVPL HEAPRGAFRL
110 120 130 140 150
AAENPFQEPR TVVWLGVLSL GFALVLDAHE NLLLAEGTLR LLTRLLLDHL
160 170 180 190 200
RLLAPSTSLL LRADRIEGIL TRFLPHGQLL FLNDQFVQGL EKEFSAAWPR
Length:200
Mass (Da):22,522
Last modified:October 1, 2000 - v1
Checksum:iB007496045724E34
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002030 mRNA. Translation: BAA92045.1.
AK093332 mRNA. Translation: BAG52692.1.
AL109804 Genomic DNA. Translation: CAC17552.1.
CH471133 Genomic DNA. Translation: EAX10483.1.
CH471133 Genomic DNA. Translation: EAX10484.1.
CH471133 Genomic DNA. Translation: EAX10485.1.
CH471133 Genomic DNA. Translation: EAX10486.1.
BC043344 mRNA. Translation: AAH43344.1.
CCDSiCCDS13070.1.
RefSeqiNP_001191375.1. NM_001204446.1.
NP_001191376.1. NM_001204447.1.
NP_060817.1. NM_018347.2.
UniGeneiHs.104806.

Genome annotation databases

EnsembliENST00000246041; ENSP00000246041; ENSG00000125843.
ENST00000379567; ENSP00000368886; ENSG00000125843.
ENST00000615891; ENSP00000481750; ENSG00000125843.
GeneIDi55317.
KEGGihsa:55317.
UCSCiuc002wjs.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002030 mRNA. Translation: BAA92045.1.
AK093332 mRNA. Translation: BAG52692.1.
AL109804 Genomic DNA. Translation: CAC17552.1.
CH471133 Genomic DNA. Translation: EAX10483.1.
CH471133 Genomic DNA. Translation: EAX10484.1.
CH471133 Genomic DNA. Translation: EAX10485.1.
CH471133 Genomic DNA. Translation: EAX10486.1.
BC043344 mRNA. Translation: AAH43344.1.
CCDSiCCDS13070.1.
RefSeqiNP_001191375.1. NM_001204446.1.
NP_001191376.1. NM_001204447.1.
NP_060817.1. NM_018347.2.
UniGeneiHs.104806.

3D structure databases

ProteinModelPortaliQ9NUS5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60182N.
IntActiQ9NUS5. 2 interactions.
STRINGi9606.ENSP00000246041.

Polymorphism and mutation databases

BioMutaiAP5S1.
DMDMi23396535.

Proteomic databases

EPDiQ9NUS5.
MaxQBiQ9NUS5.
PaxDbiQ9NUS5.
PeptideAtlasiQ9NUS5.
PRIDEiQ9NUS5.

Protocols and materials databases

DNASUi55317.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246041; ENSP00000246041; ENSG00000125843.
ENST00000379567; ENSP00000368886; ENSG00000125843.
ENST00000615891; ENSP00000481750; ENSG00000125843.
GeneIDi55317.
KEGGihsa:55317.
UCSCiuc002wjs.3. human.

Organism-specific databases

CTDi55317.
GeneCardsiAP5S1.
H-InvDBHIX0015604.
HGNCiHGNC:15875. AP5S1.
HPAiCAB034200.
HPA048244.
MIMi614824. gene.
neXtProtiNX_Q9NUS5.
PharmGKBiPA25744.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYQV. Eukaryota.
ENOG4111NAX. LUCA.
GeneTreeiENSGT00390000013178.
HOGENOMiHOG000231696.
HOVERGENiHBG051157.
InParanoidiQ9NUS5.
KOiK19024.
OMAiSMCQLQQ.
PhylomeDBiQ9NUS5.
TreeFamiTF332332.

Miscellaneous databases

GenomeRNAii55317.
PROiQ9NUS5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9NUS5.
CleanExiHS_C20orf29.
ExpressionAtlasiQ9NUS5. baseline and differential.
GenevisibleiQ9NUS5. HS.

Family and domain databases

InterProiIPR029392. AP-5_subunit_s1.
[Graphical view]
PANTHERiPTHR16120. PTHR16120. 1 hit.
PfamiPF15001. AP-5_subunit_s1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta and Testis.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymph.
  5. Cited for: FUNCTION, INTERACTION WITH AP5Z1; AP5B1; ZFYVE26 AND SPG11.
  6. Cited for: FUNCTION IN ENDOSOME TRANSPORT, IDENTIFICATION AS PART OF AP-5, SUBCELLULAR LOCATION, INTERACTION WITH AP5B1 AND AP5M1.

Entry informationi

Entry nameiAP5S1_HUMAN
AccessioniPrimary (citable) accession number: Q9NUS5
Secondary accession number(s): B3KSD0, D3DVY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.