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Protein

AP-5 complex subunit sigma-1

Gene

AP5S1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:20613862, it is required for efficient homologous recombination DNA double-strand break repair.2 Publications

GO - Biological processi

  • double-strand break repair via homologous recombination Source: UniProtKB
  • endosomal transport Source: UniProtKB
  • protein transport Source: UniProtKB-KW

Keywordsi

Biological processDNA damage, DNA repair, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
AP-5 complex subunit sigma-1
Alternative name(s):
Adaptor-related protein complex 5 sigma subunit
Short name:
Sigma5
Gene namesi
Name:AP5S1
Synonyms:C20orf29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15875. AP5S1.

Subcellular locationi

GO - Cellular componenti

  • AP-type membrane coat adaptor complex Source: UniProtKB
  • cytosol Source: HPA
  • late endosome Source: UniProtKB
  • late endosome membrane Source: UniProtKB-SubCell
  • lysosomal membrane Source: UniProtKB-SubCell
  • lysosome Source: UniProtKB
  • nucleoplasm Source: HPA
  • plasma membrane Source: HPA

Keywords - Cellular componenti

Cytoplasm, Endosome, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000125843.
PharmGKBiPA25744.

Polymorphism and mutation databases

BioMutaiAP5S1.
DMDMi23396535.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000794231 – 200AP-5 complex subunit sigma-1Add BLAST200

Proteomic databases

EPDiQ9NUS5.
MaxQBiQ9NUS5.
PaxDbiQ9NUS5.
PeptideAtlasiQ9NUS5.
PRIDEiQ9NUS5.

PTM databases

PhosphoSitePlusiQ9NUS5.

Expressioni

Gene expression databases

BgeeiENSG00000125843.
CleanExiHS_C20orf29.
ExpressionAtlasiQ9NUS5. baseline and differential.
GenevisibleiQ9NUS5. HS.

Organism-specific databases

HPAiCAB034200.
HPA048244.

Interactioni

Subunit structurei

Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1. Interacts with ZFYVE26 and SPG11.2 Publications

Protein-protein interaction databases

BioGridi120599. 10 interactors.
DIPiDIP-60182N.
IntActiQ9NUS5. 2 interactors.
STRINGi9606.ENSP00000246041.

Structurei

3D structure databases

ProteinModelPortaliQ9NUS5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IYQV. Eukaryota.
ENOG4111NAX. LUCA.
GeneTreeiENSGT00390000013178.
HOGENOMiHOG000231696.
HOVERGENiHBG051157.
InParanoidiQ9NUS5.
KOiK19024.
OMAiDEPVPLH.
OrthoDBiEOG091G0Y3T.
PhylomeDBiQ9NUS5.
TreeFamiTF332332.

Family and domain databases

InterProiView protein in InterPro
IPR029392. AP-5_subunit_s1.
PANTHERiPTHR16120. PTHR16120. 1 hit.
PfamiView protein in Pfam
PF15001. AP-5_subunit_s1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9NUS5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHAFLIHTL RAPNTEDTGL CRVLYSCVFG AEKSPDDPRP HGAERDRLLR
60 70 80 90 100
KEQILAVARQ VESMCRLQQQ ASGRPPMDLQ PQSSDEQVPL HEAPRGAFRL
110 120 130 140 150
AAENPFQEPR TVVWLGVLSL GFALVLDAHE NLLLAEGTLR LLTRLLLDHL
160 170 180 190 200
RLLAPSTSLL LRADRIEGIL TRFLPHGQLL FLNDQFVQGL EKEFSAAWPR
Length:200
Mass (Da):22,522
Last modified:October 1, 2000 - v1
Checksum:iB007496045724E34
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002030 mRNA. Translation: BAA92045.1.
AK093332 mRNA. Translation: BAG52692.1.
AL109804 Genomic DNA. Translation: CAC17552.1.
CH471133 Genomic DNA. Translation: EAX10483.1.
CH471133 Genomic DNA. Translation: EAX10484.1.
CH471133 Genomic DNA. Translation: EAX10485.1.
CH471133 Genomic DNA. Translation: EAX10486.1.
BC043344 mRNA. Translation: AAH43344.1.
CCDSiCCDS13070.1.
RefSeqiNP_001191375.1. NM_001204446.1.
NP_001191376.1. NM_001204447.1.
NP_060817.1. NM_018347.2.
UniGeneiHs.104806.

Genome annotation databases

EnsembliENST00000246041; ENSP00000246041; ENSG00000125843.
ENST00000379567; ENSP00000368886; ENSG00000125843.
ENST00000615891; ENSP00000481750; ENSG00000125843.
GeneIDi55317.
KEGGihsa:55317.
UCSCiuc002wjs.3. human.

Similar proteinsi

Entry informationi

Entry nameiAP5S1_HUMAN
AccessioniPrimary (citable) accession number: Q9NUS5
Secondary accession number(s): B3KSD0, D3DVY7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: October 1, 2000
Last modified: August 30, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot